Ribosomal_protein_L2_putative/GeneDB:LmjF.08.0280

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L2, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H640_LEIDO

TriTrypDb:

LdBPK_080290.1 , LdCL_080007800 , LDHU3_08.0350

Length:

380

Annotations

Annotations by Jardim et al.

Ribosomal Protein, ribosomal L2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A0A3S5H640

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H640

PDB structure(s): 7aih_BL , 7ane_BL

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.443
CLV_NRD_NRD_1	166	168	PF00675	0.436
CLV_NRD_NRD_1	277	279	PF00675	0.219
CLV_PCSK_KEX2_1	134	136	PF00082	0.399
CLV_PCSK_KEX2_1	153	155	PF00082	0.565
CLV_PCSK_KEX2_1	277	279	PF00082	0.219
CLV_PCSK_KEX2_1	291	293	PF00082	0.255
CLV_PCSK_KEX2_1	309	311	PF00082	0.230
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.440
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.256
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.149
CLV_PCSK_PC7_1	287	293	PF00082	0.250
CLV_PCSK_SKI1_1	12	16	PF00082	0.537
CLV_PCSK_SKI1_1	127	131	PF00082	0.491
CLV_PCSK_SKI1_1	169	173	PF00082	0.472
DOC_CKS1_1	326	331	PF01111	0.553
DOC_MAPK_gen_1	167	174	PF00069	0.345
DOC_MAPK_MEF2A_6	59	68	PF00069	0.571
DOC_PP2B_LxvP_1	257	260	PF13499	0.432
DOC_PP2B_LxvP_1	7	10	PF13499	0.596
DOC_USP7_UBL2_3	153	157	PF12436	0.373
DOC_USP7_UBL2_3	303	307	PF12436	0.450
DOC_WW_Pin1_4	2	7	PF00397	0.643
DOC_WW_Pin1_4	320	325	PF00397	0.475
DOC_WW_Pin1_4	70	75	PF00397	0.525
DOC_WW_Pin1_4	86	91	PF00397	0.584
DOC_WW_Pin1_4	98	103	PF00397	0.494
LIG_14-3-3_CanoR_1	167	172	PF00244	0.402
LIG_14-3-3_CanoR_1	310	315	PF00244	0.442
LIG_14-3-3_CanoR_1	358	363	PF00244	0.593
LIG_APCC_ABBA_1	55	60	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.501
LIG_CSL_BTD_1	87	90	PF09270	0.487
LIG_deltaCOP1_diTrp_1	106	110	PF00928	0.326
LIG_deltaCOP1_diTrp_1	86	91	PF00928	0.478
LIG_FHA_1	209	215	PF00498	0.432
LIG_FHA_1	240	246	PF00498	0.432
LIG_FHA_1	306	312	PF00498	0.432
LIG_FHA_1	63	69	PF00498	0.530
LIG_FHA_2	326	332	PF00498	0.599
LIG_FHA_2	359	365	PF00498	0.487
LIG_HCF-1_HBM_1	75	78	PF13415	0.591
LIG_LIR_Nem_3	106	110	PF02991	0.382
LIG_LIR_Nem_3	170	174	PF02991	0.333
LIG_LIR_Nem_3	188	192	PF02991	0.284
LIG_LIR_Nem_3	45	51	PF02991	0.501
LIG_LIR_Nem_3	52	58	PF02991	0.483
LIG_LIR_Nem_3	86	91	PF02991	0.498
LIG_LIR_Nem_3	99	103	PF02991	0.532
LIG_MYND_1	252	256	PF01753	0.419
LIG_MYND_1	6	10	PF01753	0.544
LIG_Pex14_1	345	349	PF04695	0.443
LIG_Pex14_2	171	175	PF04695	0.308
LIG_PTB_Apo_2	176	183	PF02174	0.355
LIG_PTB_Apo_2	195	202	PF02174	0.407
LIG_PTB_Phospho_1	176	182	PF10480	0.358
LIG_SH2_CRK	100	104	PF00017	0.498
LIG_SH2_CRK	189	193	PF00017	0.375
LIG_SH2_GRB2like	177	180	PF00017	0.362
LIG_SH2_NCK_1	197	201	PF00017	0.429
LIG_SH2_SRC	177	180	PF00017	0.362
LIG_SH2_STAP1	51	55	PF00017	0.484
LIG_SH2_STAP1	78	82	PF00017	0.549
LIG_SH2_STAT3	283	286	PF00017	0.412
LIG_SH2_STAT5	100	103	PF00017	0.487
LIG_SH2_STAT5	115	118	PF00017	0.516
LIG_SH2_STAT5	182	185	PF00017	0.367
LIG_SH2_STAT5	349	352	PF00017	0.368
LIG_SH2_STAT5	51	54	PF00017	0.494
LIG_SH2_STAT5	70	73	PF00017	0.519
LIG_SH3_3	160	166	PF00018	0.387
LIG_SH3_3	296	302	PF00018	0.428
LIG_SH3_3	68	74	PF00018	0.539
LIG_SUMO_SIM_par_1	210	216	PF11976	0.419
LIG_SUMO_SIM_par_1	255	261	PF11976	0.419
LIG_TRAF2_1	293	296	PF00917	0.476
LIG_TRFH_1	28	32	PF08558	0.689
LIG_TYR_ITIM	187	192	PF00017	0.342
MOD_CK1_1	290	296	PF00069	0.490
MOD_CK2_1	210	216	PF00069	0.432
MOD_CK2_1	290	296	PF00069	0.476
MOD_Cter_Amidation	275	278	PF01082	0.219
MOD_GlcNHglycan	119	122	PF01048	0.418
MOD_GlcNHglycan	239	242	PF01048	0.227
MOD_GlcNHglycan	346	349	PF01048	0.395
MOD_GSK3_1	119	126	PF00069	0.392
MOD_GSK3_1	204	211	PF00069	0.373
MOD_GSK3_1	305	312	PF00069	0.428
MOD_GSK3_1	364	371	PF00069	0.497
MOD_N-GLC_1	287	292	PF02516	0.281
MOD_N-GLC_1	358	363	PF02516	0.512
MOD_NEK2_1	266	271	PF00069	0.475
MOD_PIKK_1	22	28	PF00454	0.563
MOD_PIKK_1	37	43	PF00454	0.646
MOD_PIKK_1	76	82	PF00454	0.538
MOD_PKA_1	167	173	PF00069	0.400
MOD_PKA_1	309	315	PF00069	0.419
MOD_PKA_2	237	243	PF00069	0.419
MOD_PKA_2	247	253	PF00069	0.419
MOD_PKA_2	309	315	PF00069	0.442
MOD_PKA_2	37	43	PF00069	0.662
MOD_Plk_1	215	221	PF00069	0.419
MOD_Plk_1	358	364	PF00069	0.593
MOD_Plk_2-3	222	228	PF00069	0.419
MOD_Plk_2-3	49	55	PF00069	0.482
MOD_Plk_4	167	173	PF00069	0.389
MOD_ProDKin_1	2	8	PF00069	0.644
MOD_ProDKin_1	320	326	PF00069	0.475
MOD_ProDKin_1	70	76	PF00069	0.522
MOD_ProDKin_1	86	92	PF00069	0.586
MOD_ProDKin_1	98	104	PF00069	0.498
MOD_SUMO_for_1	32	35	PF00179	0.583
MOD_SUMO_rev_2	25	34	PF00179	0.575
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.450
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.721
TRG_ENDOCYTIC_2	100	103	PF00928	0.492
TRG_ENDOCYTIC_2	143	146	PF00928	0.504
TRG_ENDOCYTIC_2	189	192	PF00928	0.365
TRG_ER_diArg_1	133	135	PF00400	0.444
TRG_ER_diArg_1	351	354	PF00400	0.373
TRG_NLS_Bipartite_1	153	171	PF00514	0.388
TRG_NLS_MonoExtN_4	166	171	PF00514	0.396
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEP9	Leptomonas seymouri	92%	95%
A0A0S4KG37	Bodo saltans	78%	92%
A0A1X0NNZ0	Trypanosomatidae	89%	89%
A0A3R7NN14	Trypanosoma rangeli	88%	89%
A4GGF8	Phaseolus vulgaris	27%	100%
A4H598	Leishmania braziliensis	97%	100%
A4HTH9	Leishmania infantum	100%	100%
A5IYY3	Mycoplasmopsis agalactiae (strain NCTC 10123 / CIP 59.7 / PG2)	26%	100%
A6MMG4	Chloranthus spicatus	27%	100%
A6MMI6	Chloranthus spicatus	26%	100%
A6MMY6	Illicium oligandrum	26%	100%
A9L9D7	Lemna minor	26%	100%
B3PMP4	Metamycoplasma arthritidis (strain 158L3-1)	26%	100%
C1A6Q8	Gemmatimonas aurantiaca (strain T-27 / DSM 14586 / JCM 11422 / NBRC 100505)	27%	100%
C9ZPK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	92%
E9AMA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P18663	Glycine max	27%	100%
Q03ZP2	Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y)	25%	100%
Q06GT2	Drimys granadensis	27%	100%
Q09FY3	Platanus occidentalis	27%	100%
Q0G9F5	Liriodendron tulipifera	26%	100%
Q0G9H8	Liriodendron tulipifera	26%	100%
Q23888	Dictyostelium discoideum	25%	100%
Q2PMM3	Glycine max	27%	100%
Q49KT4	Eucalyptus globulus subsp. globulus	27%	100%
Q4A5C4	Mycoplasmopsis synoviae (strain 53)	26%	100%
Q4QIE1	Leishmania major	99%	100%
Q8LVH2	Phaseolus angularis	27%	100%
Q9B1H9	Lotus japonicus	27%	100%