Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H638_LEIDO

TriTrypDb:

LdBPK_080270.1 , LdCL_080007600 , LDHU3_08.0330

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H638

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H638

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	203	207	PF00656	0.769
CLV_NRD_NRD_1	124	126	PF00675	0.743
CLV_NRD_NRD_1	233	235	PF00675	0.747
CLV_NRD_NRD_1	321	323	PF00675	0.713
CLV_NRD_NRD_1	330	332	PF00675	0.661
CLV_NRD_NRD_1	346	348	PF00675	0.720
CLV_NRD_NRD_1	433	435	PF00675	0.523
CLV_PCSK_FUR_1	142	146	PF00082	0.714
CLV_PCSK_FUR_1	328	332	PF00082	0.681
CLV_PCSK_KEX2_1	144	146	PF00082	0.708
CLV_PCSK_KEX2_1	233	235	PF00082	0.748
CLV_PCSK_KEX2_1	321	323	PF00082	0.713
CLV_PCSK_KEX2_1	328	330	PF00082	0.573
CLV_PCSK_KEX2_1	344	346	PF00082	0.748
CLV_PCSK_KEX2_1	425	427	PF00082	0.658
CLV_PCSK_KEX2_1	433	435	PF00082	0.547
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.708
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.748
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.658
CLV_PCSK_SKI1_1	103	107	PF00082	0.735
CLV_PCSK_SKI1_1	160	164	PF00082	0.691
CLV_PCSK_SKI1_1	295	299	PF00082	0.834
CLV_PCSK_SKI1_1	333	337	PF00082	0.648
DEG_APCC_DBOX_1	159	167	PF00400	0.710
DEG_APCC_DBOX_1	27	35	PF00400	0.821
DEG_Nend_UBRbox_1	1	4	PF02207	0.840
DEG_SCF_FBW7_1	1	8	PF00400	0.699
DEG_SPOP_SBC_1	184	188	PF00917	0.754
DEG_SPOP_SBC_1	200	204	PF00917	0.569
DEG_SPOP_SBC_1	22	26	PF00917	0.791
DOC_ANK_TNKS_1	425	432	PF00023	0.586
DOC_CYCLIN_RxL_1	408	419	PF00134	0.667
DOC_MAPK_gen_1	408	418	PF00069	0.668
DOC_PP2B_LxvP_1	301	304	PF13499	0.817
DOC_PP2B_LxvP_1	32	35	PF13499	0.778
DOC_USP7_MATH_1	124	128	PF00917	0.690
DOC_USP7_MATH_1	184	188	PF00917	0.786
DOC_USP7_MATH_1	194	198	PF00917	0.703
DOC_USP7_MATH_1	200	204	PF00917	0.614
DOC_USP7_MATH_1	221	225	PF00917	0.713
DOC_USP7_MATH_1	259	263	PF00917	0.843
DOC_USP7_MATH_1	281	285	PF00917	0.636
DOC_USP7_MATH_1	52	56	PF00917	0.750
DOC_USP7_MATH_1	59	63	PF00917	0.792
DOC_USP7_MATH_1	98	102	PF00917	0.780
DOC_WW_Pin1_4	1	6	PF00397	0.803
DOC_WW_Pin1_4	180	185	PF00397	0.812
DOC_WW_Pin1_4	237	242	PF00397	0.775
DOC_WW_Pin1_4	247	252	PF00397	0.729
DOC_WW_Pin1_4	262	267	PF00397	0.597
DOC_WW_Pin1_4	290	295	PF00397	0.745
DOC_WW_Pin1_4	305	310	PF00397	0.633
DOC_WW_Pin1_4	346	351	PF00397	0.787
DOC_WW_Pin1_4	72	77	PF00397	0.837
LIG_14-3-3_CanoR_1	147	152	PF00244	0.618
LIG_14-3-3_CanoR_1	223	230	PF00244	0.775
LIG_14-3-3_CanoR_1	267	274	PF00244	0.836
LIG_14-3-3_CanoR_1	333	338	PF00244	0.680
LIG_14-3-3_CanoR_1	87	93	PF00244	0.748
LIG_BRCT_BRCA1_1	225	229	PF00533	0.779
LIG_Clathr_ClatBox_1	415	419	PF01394	0.652
LIG_FHA_1	177	183	PF00498	0.804
LIG_FHA_1	368	374	PF00498	0.679
LIG_FHA_1	387	393	PF00498	0.546
LIG_FHA_2	22	28	PF00498	0.800
LIG_FHA_2	347	353	PF00498	0.797
LIG_FHA_2	377	383	PF00498	0.677
LIG_FHA_2	422	428	PF00498	0.649
LIG_LIR_Nem_3	104	110	PF02991	0.721
LIG_LIR_Nem_3	113	118	PF02991	0.513
LIG_NRBOX	411	417	PF00104	0.663
LIG_PDZ_Class_2	433	438	PF00595	0.694
LIG_RPA_C_Fungi	334	346	PF08784	0.700
LIG_SH2_CRK	115	119	PF00017	0.657
LIG_SH2_STAP1	151	155	PF00017	0.680
LIG_SH2_STAP1	337	341	PF00017	0.585
LIG_SH3_3	294	300	PF00018	0.828
LIG_SH3_3	37	43	PF00018	0.800
LIG_SH3_3	70	76	PF00018	0.782
LIG_SUMO_SIM_par_1	414	419	PF11976	0.655
LIG_WRPW_2	107	110	PF00400	0.713
LIG_WW_3	235	239	PF00397	0.836
LIG_WW_3	303	307	PF00397	0.799
MOD_CDC14_SPxK_1	8	11	PF00782	0.815
MOD_CDK_SPK_2	262	267	PF00069	0.772
MOD_CDK_SPK_2	290	295	PF00069	0.764
MOD_CDK_SPxK_1	5	11	PF00069	0.814
MOD_CK1_1	10	16	PF00069	0.801
MOD_CK1_1	101	107	PF00069	0.575
MOD_CK1_1	111	117	PF00069	0.405
MOD_CK1_1	183	189	PF00069	0.816
MOD_CK1_1	199	205	PF00069	0.579
MOD_CK1_1	23	29	PF00069	0.574
MOD_CK1_1	261	267	PF00069	0.775
MOD_CK1_1	293	299	PF00069	0.626
MOD_CK1_1	376	382	PF00069	0.706
MOD_CK1_1	55	61	PF00069	0.704
MOD_CK1_1	91	97	PF00069	0.801
MOD_CK2_1	21	27	PF00069	0.800
MOD_CK2_1	281	287	PF00069	0.829
MOD_CK2_1	421	427	PF00069	0.515
MOD_GlcNHglycan	103	106	PF01048	0.699
MOD_GlcNHglycan	12	15	PF01048	0.822
MOD_GlcNHglycan	126	129	PF01048	0.690
MOD_GlcNHglycan	187	190	PF01048	0.749
MOD_GlcNHglycan	198	201	PF01048	0.728
MOD_GlcNHglycan	219	222	PF01048	0.809
MOD_GlcNHglycan	223	226	PF01048	0.805
MOD_GlcNHglycan	261	264	PF01048	0.843
MOD_GlcNHglycan	269	272	PF01048	0.714
MOD_GlcNHglycan	283	286	PF01048	0.607
MOD_GlcNHglycan	301	304	PF01048	0.645
MOD_GlcNHglycan	356	360	PF01048	0.794
MOD_GlcNHglycan	362	365	PF01048	0.738
MOD_GlcNHglycan	375	378	PF01048	0.546
MOD_GlcNHglycan	392	395	PF01048	0.499
MOD_GlcNHglycan	54	57	PF01048	0.743
MOD_GlcNHglycan	61	64	PF01048	0.734
MOD_GSK3_1	1	8	PF00069	0.757
MOD_GSK3_1	110	117	PF00069	0.624
MOD_GSK3_1	176	183	PF00069	0.805
MOD_GSK3_1	18	25	PF00069	0.558
MOD_GSK3_1	195	202	PF00069	0.532
MOD_GSK3_1	205	212	PF00069	0.674
MOD_GSK3_1	213	220	PF00069	0.548
MOD_GSK3_1	257	264	PF00069	0.835
MOD_GSK3_1	281	288	PF00069	0.701
MOD_GSK3_1	30	37	PF00069	0.672
MOD_GSK3_1	386	393	PF00069	0.657
MOD_GSK3_1	55	62	PF00069	0.741
MOD_GSK3_1	72	79	PF00069	0.674
MOD_N-GLC_1	101	106	PF02516	0.751
MOD_N-GLC_1	180	185	PF02516	0.812
MOD_NEK2_1	20	25	PF00069	0.738
MOD_NEK2_1	386	391	PF00069	0.659
MOD_NEK2_1	421	426	PF00069	0.644
MOD_PIKK_1	339	345	PF00454	0.706
MOD_PKA_2	124	130	PF00069	0.692
MOD_PKA_2	194	200	PF00069	0.832
MOD_PKA_2	86	92	PF00069	0.752
MOD_PKB_1	145	153	PF00069	0.624
MOD_PKB_1	193	201	PF00069	0.770
MOD_PKB_1	331	339	PF00069	0.682
MOD_Plk_4	114	120	PF00069	0.656
MOD_Plk_4	293	299	PF00069	0.702
MOD_ProDKin_1	1	7	PF00069	0.802
MOD_ProDKin_1	180	186	PF00069	0.812
MOD_ProDKin_1	237	243	PF00069	0.777
MOD_ProDKin_1	247	253	PF00069	0.732
MOD_ProDKin_1	262	268	PF00069	0.595
MOD_ProDKin_1	290	296	PF00069	0.746
MOD_ProDKin_1	305	311	PF00069	0.633
MOD_ProDKin_1	346	352	PF00069	0.789
MOD_ProDKin_1	72	78	PF00069	0.837
TRG_DiLeu_BaEn_1	27	32	PF01217	0.821
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.665
TRG_ENDOCYTIC_2	115	118	PF00928	0.659
TRG_ER_diArg_1	320	322	PF00400	0.712
TRG_ER_diArg_1	328	331	PF00400	0.558
TRG_ER_diArg_1	345	347	PF00400	0.765
TRG_ER_diArg_1	432	434	PF00400	0.666
TRG_NLS_Bipartite_1	328	348	PF00514	0.703
TRG_NLS_MonoCore_2	343	348	PF00514	0.690
TRG_NLS_MonoExtC_3	343	348	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HTH7	Leishmania infantum	99%	100%
E9AMA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIE3	Leishmania major	89%	100%