LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S5H635_LEIDO
TriTrypDb:
LdBPK_080220.1 * , LdCL_080007100 , LDHU3_08.0280
Length:
501

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H635
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H635

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 173 177 PF00656 0.734
CLV_C14_Caspase3-7 320 324 PF00656 0.716
CLV_NRD_NRD_1 178 180 PF00675 0.860
CLV_NRD_NRD_1 191 193 PF00675 0.620
CLV_NRD_NRD_1 299 301 PF00675 0.742
CLV_NRD_NRD_1 413 415 PF00675 0.729
CLV_NRD_NRD_1 5 7 PF00675 0.748
CLV_PCSK_FUR_1 296 300 PF00082 0.619
CLV_PCSK_FUR_1 411 415 PF00082 0.732
CLV_PCSK_KEX2_1 117 119 PF00082 0.843
CLV_PCSK_KEX2_1 178 180 PF00082 0.860
CLV_PCSK_KEX2_1 191 193 PF00082 0.620
CLV_PCSK_KEX2_1 298 300 PF00082 0.678
CLV_PCSK_KEX2_1 4 6 PF00082 0.754
CLV_PCSK_KEX2_1 413 415 PF00082 0.729
CLV_PCSK_KEX2_1 461 463 PF00082 0.719
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.804
CLV_PCSK_PC1ET2_1 461 463 PF00082 0.719
CLV_PCSK_SKI1_1 151 155 PF00082 0.663
CLV_PCSK_SKI1_1 184 188 PF00082 0.777
DEG_SPOP_SBC_1 287 291 PF00917 0.755
DOC_ANK_TNKS_1 104 111 PF00023 0.727
DOC_MAPK_gen_1 411 421 PF00069 0.720
DOC_MAPK_MEF2A_6 244 251 PF00069 0.804
DOC_PP2B_LxvP_1 270 273 PF13499 0.770
DOC_PP2B_LxvP_1 356 359 PF13499 0.686
DOC_PP4_FxxP_1 252 255 PF00568 0.681
DOC_USP7_MATH_1 15 19 PF00917 0.754
DOC_USP7_MATH_1 264 268 PF00917 0.780
DOC_USP7_MATH_1 287 291 PF00917 0.817
DOC_USP7_MATH_1 364 368 PF00917 0.623
DOC_USP7_MATH_1 39 43 PF00917 0.809
DOC_USP7_MATH_1 433 437 PF00917 0.671
DOC_USP7_MATH_1 44 48 PF00917 0.785
DOC_USP7_MATH_1 54 58 PF00917 0.634
DOC_WW_Pin1_4 217 222 PF00397 0.766
DOC_WW_Pin1_4 265 270 PF00397 0.844
DOC_WW_Pin1_4 272 277 PF00397 0.730
DOC_WW_Pin1_4 447 452 PF00397 0.613
LIG_14-3-3_CanoR_1 170 176 PF00244 0.673
LIG_14-3-3_CanoR_1 288 293 PF00244 0.770
LIG_14-3-3_CanoR_1 435 444 PF00244 0.568
LIG_ActinCP_TwfCPI_2 252 259 PF01115 0.711
LIG_APCC_ABBA_1 120 125 PF00400 0.832
LIG_BIR_III_2 218 222 PF00653 0.696
LIG_BIR_III_2 263 267 PF00653 0.652
LIG_BRCT_BRCA1_1 439 443 PF00533 0.765
LIG_deltaCOP1_diTrp_1 158 162 PF00928 0.650
LIG_FHA_1 27 33 PF00498 0.679
LIG_FHA_2 171 177 PF00498 0.803
LIG_FHA_2 466 472 PF00498 0.757
LIG_Integrin_RGD_1 107 109 PF01839 0.764
LIG_Integrin_RGD_1 192 194 PF01839 0.708
LIG_LIR_Apic_2 31 36 PF02991 0.783
LIG_LIR_Apic_2 404 410 PF02991 0.747
LIG_LIR_Gen_1 440 451 PF02991 0.670
LIG_LIR_Nem_3 440 446 PF02991 0.767
LIG_MYND_1 269 273 PF01753 0.766
LIG_Pex14_2 443 447 PF04695 0.755
LIG_PTAP_UEV_1 93 98 PF05743 0.796
LIG_SH2_CRK 33 37 PF00017 0.703
LIG_SH2_SRC 407 410 PF00017 0.778
LIG_SH2_STAT5 119 122 PF00017 0.646
LIG_SH2_STAT5 407 410 PF00017 0.778
LIG_SH3_1 33 39 PF00018 0.700
LIG_SH3_3 138 144 PF00018 0.626
LIG_SH3_3 263 269 PF00018 0.748
LIG_SH3_3 270 276 PF00018 0.696
LIG_SH3_3 33 39 PF00018 0.700
LIG_SH3_3 449 455 PF00018 0.713
LIG_SH3_3 472 478 PF00018 0.571
LIG_SH3_3 494 500 PF00018 0.634
LIG_SH3_3 91 97 PF00018 0.834
LIG_SUMO_SIM_par_1 267 275 PF11976 0.840
LIG_TRAF2_1 122 125 PF00917 0.827
LIG_TRAF2_1 56 59 PF00917 0.830
LIG_TRAF2_1 83 86 PF00917 0.650
LIG_TRFH_1 406 410 PF08558 0.781
LIG_WW_3 1 5 PF00397 0.748
LIG_WW_3 143 147 PF00397 0.671
MOD_CK1_1 101 107 PF00069 0.703
MOD_CK1_1 275 281 PF00069 0.819
MOD_CK1_1 282 288 PF00069 0.695
MOD_CK1_1 347 353 PF00069 0.676
MOD_CK1_1 434 440 PF00069 0.775
MOD_CK1_1 450 456 PF00069 0.627
MOD_CK2_1 299 305 PF00069 0.808
MOD_CK2_1 315 321 PF00069 0.558
MOD_CK2_1 52 58 PF00069 0.797
MOD_Cter_Amidation 176 179 PF01082 0.742
MOD_DYRK1A_RPxSP_1 265 269 PF00069 0.730
MOD_GlcNHglycan 100 103 PF01048 0.776
MOD_GlcNHglycan 124 130 PF01048 0.722
MOD_GlcNHglycan 162 165 PF01048 0.761
MOD_GlcNHglycan 283 287 PF01048 0.735
MOD_GlcNHglycan 301 304 PF01048 0.541
MOD_GlcNHglycan 317 320 PF01048 0.514
MOD_GlcNHglycan 346 349 PF01048 0.804
MOD_GlcNHglycan 351 354 PF01048 0.772
MOD_GlcNHglycan 367 370 PF01048 0.596
MOD_GlcNHglycan 396 399 PF01048 0.604
MOD_GlcNHglycan 428 431 PF01048 0.670
MOD_GlcNHglycan 54 57 PF01048 0.766
MOD_GlcNHglycan 78 81 PF01048 0.750
MOD_GSK3_1 271 278 PF00069 0.813
MOD_GSK3_1 282 289 PF00069 0.633
MOD_GSK3_1 310 317 PF00069 0.728
MOD_GSK3_1 382 389 PF00069 0.783
MOD_GSK3_1 390 397 PF00069 0.639
MOD_GSK3_1 431 438 PF00069 0.679
MOD_LATS_1 182 188 PF00433 0.641
MOD_N-GLC_1 279 284 PF02516 0.772
MOD_NEK2_1 310 315 PF00069 0.828
MOD_NEK2_1 426 431 PF00069 0.652
MOD_NEK2_2 112 117 PF00069 0.759
MOD_NEK2_2 28 33 PF00069 0.838
MOD_PKA_1 299 305 PF00069 0.730
MOD_PKA_2 194 200 PF00069 0.677
MOD_PKA_2 264 270 PF00069 0.750
MOD_PKA_2 287 293 PF00069 0.782
MOD_PKA_2 299 305 PF00069 0.602
MOD_PKA_2 310 316 PF00069 0.609
MOD_PKA_2 394 400 PF00069 0.758
MOD_PKA_2 401 407 PF00069 0.638
MOD_PKA_2 434 440 PF00069 0.589
MOD_Plk_1 305 311 PF00069 0.681
MOD_Plk_4 305 311 PF00069 0.704
MOD_Plk_4 331 337 PF00069 0.746
MOD_Plk_4 438 444 PF00069 0.610
MOD_ProDKin_1 217 223 PF00069 0.766
MOD_ProDKin_1 265 271 PF00069 0.844
MOD_ProDKin_1 272 278 PF00069 0.730
MOD_ProDKin_1 447 453 PF00069 0.618
TRG_DiLeu_BaLyEn_6 266 271 PF01217 0.767
TRG_DiLeu_BaLyEn_6 374 379 PF01217 0.717
TRG_ER_diArg_1 296 299 PF00400 0.746
TRG_ER_diArg_1 3 6 PF00400 0.750
TRG_ER_diArg_1 412 414 PF00400 0.717
TRG_NLS_MonoExtC_3 212 218 PF00514 0.815
TRG_NLS_MonoExtN_4 210 217 PF00514 0.813
TRG_Pf-PMV_PEXEL_1 259 263 PF00026 0.732
TRG_Pf-PMV_PEXEL_1 360 365 PF00026 0.757

Homologs

Protein Taxonomy Sequence identity Coverage
A4H588 Leishmania braziliensis 51% 100%
A4HTH2 Leishmania infantum 99% 100%
E9AMA0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
Q4QIE8 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS