Inositol phosphosphingolipid phospholipase C-Like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Inositol phosphosphingolipids phospholipase C

Species:

Leishmania donovani

UniProt:

A0A3S5H634_LEIDO

TriTrypDb:

LdBPK_080210.1 , LdCL_080007000 , LDHU3_08.0270

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	5
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071944	cell periphery	2	1
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H634

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H634

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006672	ceramide metabolic process	4	1
GO:0006684	sphingomyelin metabolic process	4	1
GO:0006685	sphingomyelin catabolic process	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009268	response to pH	3	1
GO:0009395	phospholipid catabolic process	5	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0010447	response to acidic pH	4	1
GO:0016042	lipid catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030149	sphingolipid catabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046466	membrane lipid catabolic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046513	ceramide biosynthetic process	5	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071467	cellular response to pH	4	1
GO:0071468	cellular response to acidic pH	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0104004	cellular response to environmental stimulus	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004620	phospholipase activity	5	11
GO:0004767	sphingomyelin phosphodiesterase activity	6	11
GO:0008081	phosphoric diester hydrolase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0003676	nucleic acid binding	3	3
GO:0003743	translation initiation factor activity	4	3
GO:0005488	binding	1	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.241
CLV_C14_Caspase3-7	300	304	PF00656	0.398
CLV_NRD_NRD_1	360	362	PF00675	0.660
CLV_NRD_NRD_1	467	469	PF00675	0.478
CLV_NRD_NRD_1	76	78	PF00675	0.521
CLV_PCSK_KEX2_1	166	168	PF00082	0.530
CLV_PCSK_KEX2_1	218	220	PF00082	0.534
CLV_PCSK_KEX2_1	344	346	PF00082	0.729
CLV_PCSK_KEX2_1	467	469	PF00082	0.478
CLV_PCSK_KEX2_1	579	581	PF00082	0.624
CLV_PCSK_KEX2_1	76	78	PF00082	0.492
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.460
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.534
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.729
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.624
CLV_PCSK_SKI1_1	15	19	PF00082	0.546
CLV_PCSK_SKI1_1	249	253	PF00082	0.597
CLV_PCSK_SKI1_1	268	272	PF00082	0.526
CLV_PCSK_SKI1_1	287	291	PF00082	0.553
CLV_PCSK_SKI1_1	579	583	PF00082	0.616
DEG_SPOP_SBC_1	398	402	PF00917	0.464
DOC_CYCLIN_RxL_1	166	176	PF00134	0.330
DOC_CYCLIN_RxL_1	263	275	PF00134	0.361
DOC_MAPK_gen_1	166	173	PF00069	0.341
DOC_MAPK_gen_1	28	36	PF00069	0.358
DOC_MAPK_MEF2A_6	121	130	PF00069	0.282
DOC_PP1_RVXF_1	13	20	PF00149	0.375
DOC_PP2B_LxvP_1	228	231	PF13499	0.353
DOC_PP4_FxxP_1	285	288	PF00568	0.349
DOC_USP7_MATH_1	548	552	PF00917	0.802
DOC_USP7_MATH_1	559	563	PF00917	0.818
DOC_USP7_MATH_1	611	615	PF00917	0.502
DOC_USP7_UBL2_3	358	362	PF12436	0.529
DOC_WW_Pin1_4	405	410	PF00397	0.540
DOC_WW_Pin1_4	417	422	PF00397	0.418
DOC_WW_Pin1_4	534	539	PF00397	0.739
DOC_WW_Pin1_4	544	549	PF00397	0.733
DOC_WW_Pin1_4	581	586	PF00397	0.779
DOC_WW_Pin1_4	63	68	PF00397	0.330
LIG_14-3-3_CanoR_1	15	20	PF00244	0.356
LIG_14-3-3_CanoR_1	174	181	PF00244	0.282
LIG_14-3-3_CanoR_1	249	254	PF00244	0.273
LIG_14-3-3_CanoR_1	425	431	PF00244	0.391
LIG_14-3-3_CanoR_1	580	585	PF00244	0.805
LIG_14-3-3_CanoR_1	71	76	PF00244	0.373
LIG_14-3-3_CanoR_1	77	83	PF00244	0.339
LIG_14-3-3_CanoR_1	92	100	PF00244	0.282
LIG_Actin_WH2_2	220	237	PF00022	0.330
LIG_ActinCP_TwfCPI_2	285	293	PF01115	0.261
LIG_APCC_ABBA_1	111	116	PF00400	0.353
LIG_APCC_Cbox_1	168	174	PF00515	0.353
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	255	259	PF00533	0.233
LIG_BRCT_BRCA1_1	381	385	PF00533	0.411
LIG_BRCT_BRCA1_1	613	617	PF00533	0.430
LIG_BRCT_BRCA1_1	95	99	PF00533	0.295
LIG_Clathr_ClatBox_1	269	273	PF01394	0.362
LIG_EH1_1	384	392	PF00400	0.382
LIG_FHA_1	100	106	PF00498	0.254
LIG_FHA_1	147	153	PF00498	0.285
LIG_FHA_1	16	22	PF00498	0.269
LIG_FHA_1	190	196	PF00498	0.282
LIG_FHA_1	351	357	PF00498	0.581
LIG_FHA_1	400	406	PF00498	0.541
LIG_FHA_1	412	418	PF00498	0.498
LIG_FHA_1	493	499	PF00498	0.722
LIG_FHA_1	524	530	PF00498	0.698
LIG_FHA_1	618	624	PF00498	0.449
LIG_FHA_2	131	137	PF00498	0.330
LIG_FHA_2	250	256	PF00498	0.273
LIG_FHA_2	318	324	PF00498	0.424
LIG_FHA_2	37	43	PF00498	0.386
LIG_FHA_2	418	424	PF00498	0.376
LIG_FHA_2	427	433	PF00498	0.312
LIG_FHA_2	489	495	PF00498	0.679
LIG_LIR_Gen_1	180	186	PF02991	0.319
LIG_LIR_Gen_1	256	267	PF02991	0.333
LIG_LIR_Gen_1	335	341	PF02991	0.496
LIG_LIR_Gen_1	42	49	PF02991	0.326
LIG_LIR_Gen_1	447	458	PF02991	0.365
LIG_LIR_Gen_1	56	65	PF02991	0.204
LIG_LIR_Nem_3	168	173	PF02991	0.267
LIG_LIR_Nem_3	180	184	PF02991	0.270
LIG_LIR_Nem_3	264	270	PF02991	0.357
LIG_LIR_Nem_3	335	340	PF02991	0.473
LIG_LIR_Nem_3	42	47	PF02991	0.334
LIG_LIR_Nem_3	447	453	PF02991	0.365
LIG_LIR_Nem_3	56	61	PF02991	0.213
LIG_LIR_Nem_3	594	598	PF02991	0.623
LIG_LIR_Nem_3	72	78	PF02991	0.286
LIG_LYPXL_yS_3	108	111	PF13949	0.350
LIG_Pex14_2	58	62	PF04695	0.394
LIG_Pex14_2	78	82	PF04695	0.299
LIG_Pex14_2	99	103	PF04695	0.386
LIG_REV1ctd_RIR_1	115	125	PF16727	0.362
LIG_REV1ctd_RIR_1	282	287	PF16727	0.330
LIG_SH2_CRK	44	48	PF00017	0.282
LIG_SH2_CRK	450	454	PF00017	0.480
LIG_SH2_NCK_1	156	160	PF00017	0.330
LIG_SH2_NCK_1	485	489	PF00017	0.657
LIG_SH2_STAP1	148	152	PF00017	0.295
LIG_SH2_STAP1	44	48	PF00017	0.282
LIG_SH2_STAP1	485	489	PF00017	0.666
LIG_SH2_STAP1	608	612	PF00017	0.657
LIG_SH2_STAT5	148	151	PF00017	0.334
LIG_SH2_STAT5	170	173	PF00017	0.266
LIG_SH2_STAT5	266	269	PF00017	0.377
LIG_SH2_STAT5	437	440	PF00017	0.363
LIG_SH2_STAT5	73	76	PF00017	0.290
LIG_SH3_3	125	131	PF00018	0.325
LIG_SH3_3	224	230	PF00018	0.280
LIG_SH3_3	321	327	PF00018	0.394
LIG_SH3_3	495	501	PF00018	0.736
LIG_SH3_3	555	561	PF00018	0.812
LIG_SH3_4	358	365	PF00018	0.431
LIG_Sin3_3	454	461	PF02671	0.266
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.282
LIG_SUMO_SIM_anti_2	455	460	PF11976	0.448
LIG_SUMO_SIM_par_1	149	157	PF11976	0.360
LIG_SUMO_SIM_par_1	45	51	PF11976	0.282
LIG_TRAF2_1	240	243	PF00917	0.302
LIG_TRAF2_1	471	474	PF00917	0.685
LIG_TYR_ITSM	446	453	PF00017	0.384
LIG_UBA3_1	212	218	PF00899	0.335
LIG_UBA3_1	390	397	PF00899	0.357
LIG_WRC_WIRS_1	16	21	PF05994	0.291
LIG_WW_3	229	233	PF00397	0.353
MOD_CK1_1	160	166	PF00069	0.351
MOD_CK1_1	189	195	PF00069	0.301
MOD_CK1_1	2	8	PF00069	0.506
MOD_CK1_1	204	210	PF00069	0.317
MOD_CK1_1	261	267	PF00069	0.365
MOD_CK1_1	408	414	PF00069	0.526
MOD_CK1_1	531	537	PF00069	0.722
MOD_CK2_1	317	323	PF00069	0.421
MOD_CK2_1	36	42	PF00069	0.359
MOD_CK2_1	362	368	PF00069	0.585
MOD_CK2_1	404	410	PF00069	0.540
MOD_CK2_1	417	423	PF00069	0.383
MOD_CK2_1	467	473	PF00069	0.662
MOD_CK2_1	580	586	PF00069	0.762
MOD_Cter_Amidation	342	345	PF01082	0.723
MOD_Cter_Amidation	359	362	PF01082	0.784
MOD_GlcNHglycan	135	140	PF01048	0.534
MOD_GlcNHglycan	329	332	PF01048	0.734
MOD_GlcNHglycan	370	373	PF01048	0.771
MOD_GlcNHglycan	469	472	PF01048	0.459
MOD_GlcNHglycan	476	479	PF01048	0.455
MOD_GlcNHglycan	609	612	PF01048	0.501
MOD_GlcNHglycan	614	617	PF01048	0.431
MOD_GlcNHglycan	84	87	PF01048	0.489
MOD_GSK3_1	143	150	PF00069	0.350
MOD_GSK3_1	157	164	PF00069	0.182
MOD_GSK3_1	173	180	PF00069	0.207
MOD_GSK3_1	185	192	PF00069	0.296
MOD_GSK3_1	249	256	PF00069	0.294
MOD_GSK3_1	258	265	PF00069	0.348
MOD_GSK3_1	360	367	PF00069	0.517
MOD_GSK3_1	404	411	PF00069	0.548
MOD_GSK3_1	440	447	PF00069	0.411
MOD_GSK3_1	488	495	PF00069	0.625
MOD_GSK3_1	544	551	PF00069	0.777
MOD_GSK3_1	565	572	PF00069	0.795
MOD_GSK3_1	607	614	PF00069	0.643
MOD_GSK3_1	78	85	PF00069	0.362
MOD_N-GLC_1	201	206	PF02516	0.496
MOD_N-GLC_1	350	355	PF02516	0.783
MOD_N-GLC_1	617	622	PF02516	0.402
MOD_NEK2_1	147	152	PF00069	0.280
MOD_NEK2_1	173	178	PF00069	0.327
MOD_NEK2_1	184	189	PF00069	0.278
MOD_NEK2_1	201	206	PF00069	0.209
MOD_NEK2_1	262	267	PF00069	0.330
MOD_NEK2_1	404	409	PF00069	0.552
MOD_NEK2_1	607	612	PF00069	0.664
MOD_NEK2_1	617	622	PF00069	0.335
MOD_NEK2_1	78	83	PF00069	0.318
MOD_NEK2_1	99	104	PF00069	0.334
MOD_NEK2_2	504	509	PF00069	0.691
MOD_NEK2_2	523	528	PF00069	0.537
MOD_PIKK_1	157	163	PF00454	0.321
MOD_PIKK_1	173	179	PF00454	0.212
MOD_PIKK_1	201	207	PF00454	0.296
MOD_PIKK_1	275	281	PF00454	0.353
MOD_PIKK_1	440	446	PF00454	0.416
MOD_PIKK_1	93	99	PF00454	0.302
MOD_PKA_1	467	473	PF00069	0.658
MOD_PKA_1	579	585	PF00069	0.818
MOD_PKA_2	173	179	PF00069	0.282
MOD_PKA_2	189	195	PF00069	0.282
MOD_PKA_2	360	366	PF00069	0.526
MOD_PKA_2	467	473	PF00069	0.629
MOD_PKA_2	492	498	PF00069	0.700
MOD_PKA_2	579	585	PF00069	0.818
MOD_Plk_1	143	149	PF00069	0.311
MOD_Plk_2-3	51	57	PF00069	0.287
MOD_Plk_4	143	149	PF00069	0.323
MOD_Plk_4	223	229	PF00069	0.308
MOD_Plk_4	262	268	PF00069	0.340
MOD_Plk_4	426	432	PF00069	0.357
MOD_Plk_4	78	84	PF00069	0.362
MOD_ProDKin_1	405	411	PF00069	0.540
MOD_ProDKin_1	417	423	PF00069	0.411
MOD_ProDKin_1	534	540	PF00069	0.740
MOD_ProDKin_1	544	550	PF00069	0.733
MOD_ProDKin_1	581	587	PF00069	0.778
MOD_ProDKin_1	63	69	PF00069	0.330
MOD_SUMO_for_1	270	273	PF00179	0.353
MOD_SUMO_for_1	471	474	PF00179	0.661
TRG_DiLeu_BaEn_1	56	61	PF01217	0.362
TRG_ENDOCYTIC_2	108	111	PF00928	0.350
TRG_ENDOCYTIC_2	156	159	PF00928	0.332
TRG_ENDOCYTIC_2	170	173	PF00928	0.211
TRG_ENDOCYTIC_2	266	269	PF00928	0.322
TRG_ENDOCYTIC_2	378	381	PF00928	0.440
TRG_ENDOCYTIC_2	44	47	PF00928	0.282
TRG_ENDOCYTIC_2	450	453	PF00928	0.405
TRG_ER_diArg_1	466	468	PF00400	0.652
TRG_ER_diArg_1	75	77	PF00400	0.339
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P935	Leptomonas seymouri	57%	100%
A0A1X0NNY2	Trypanosomatidae	40%	100%
A0A422NTR5	Trypanosoma rangeli	44%	100%
A4H587	Leishmania braziliensis	73%	100%
A4HTH1	Leishmania infantum	100%	100%
C9ZPP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AM99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4QIE9	Leishmania major	93%	100%
V5BLM5	Trypanosoma cruzi	38%	100%