Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H633_LEIDO

TriTrypDb:

LdBPK_080200.1 , LdCL_080006900 , LDHU3_08.0260

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S5H633

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H633

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.456
CLV_NRD_NRD_1	187	189	PF00675	0.372
CLV_NRD_NRD_1	377	379	PF00675	0.383
CLV_NRD_NRD_1	565	567	PF00675	0.422
CLV_NRD_NRD_1	74	76	PF00675	0.336
CLV_PCSK_KEX2_1	187	189	PF00082	0.372
CLV_PCSK_KEX2_1	377	379	PF00082	0.338
CLV_PCSK_KEX2_1	596	598	PF00082	0.451
CLV_PCSK_KEX2_1	74	76	PF00082	0.336
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.451
CLV_PCSK_SKI1_1	137	141	PF00082	0.620
CLV_PCSK_SKI1_1	2	6	PF00082	0.591
CLV_PCSK_SKI1_1	239	243	PF00082	0.385
CLV_PCSK_SKI1_1	377	381	PF00082	0.336
CLV_PCSK_SKI1_1	49	53	PF00082	0.395
CLV_PCSK_SKI1_1	520	524	PF00082	0.599
CLV_PCSK_SKI1_1	634	638	PF00082	0.439
CLV_PCSK_SKI1_1	894	898	PF00082	0.452
DEG_APCC_DBOX_1	155	163	PF00400	0.280
DEG_APCC_DBOX_1	376	384	PF00400	0.589
DEG_APCC_DBOX_1	794	802	PF00400	0.264
DEG_Nend_UBRbox_1	1	4	PF02207	0.414
DEG_SPOP_SBC_1	514	518	PF00917	0.382
DOC_CDC14_PxL_1	264	272	PF14671	0.362
DOC_CKS1_1	315	320	PF01111	0.620
DOC_CKS1_1	431	436	PF01111	0.362
DOC_CKS1_1	499	504	PF01111	0.390
DOC_CKS1_1	572	577	PF01111	0.614
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.467
DOC_MAPK_gen_1	193	201	PF00069	0.605
DOC_MAPK_gen_1	374	383	PF00069	0.578
DOC_MAPK_gen_1	564	572	PF00069	0.587
DOC_MAPK_MEF2A_6	374	383	PF00069	0.582
DOC_MAPK_MEF2A_6	564	572	PF00069	0.587
DOC_MAPK_MEF2A_6	785	792	PF00069	0.374
DOC_MAPK_MEF2A_6	795	802	PF00069	0.279
DOC_MAPK_NFAT4_5	785	793	PF00069	0.310
DOC_MAPK_NFAT4_5	795	803	PF00069	0.271
DOC_PP1_RVXF_1	697	704	PF00149	0.662
DOC_PP2B_LxvP_1	199	202	PF13499	0.654
DOC_PP2B_LxvP_1	351	354	PF13499	0.475
DOC_PP4_FxxP_1	449	452	PF00568	0.428
DOC_PP4_FxxP_1	572	575	PF00568	0.611
DOC_USP7_MATH_1	160	164	PF00917	0.319
DOC_USP7_MATH_1	202	206	PF00917	0.620
DOC_USP7_MATH_1	223	227	PF00917	0.686
DOC_USP7_MATH_1	309	313	PF00917	0.552
DOC_USP7_MATH_1	352	356	PF00917	0.338
DOC_USP7_MATH_1	453	457	PF00917	0.504
DOC_USP7_MATH_1	514	518	PF00917	0.420
DOC_USP7_MATH_1	622	626	PF00917	0.711
DOC_USP7_MATH_1	680	684	PF00917	0.295
DOC_USP7_MATH_1	686	690	PF00917	0.304
DOC_USP7_MATH_1	738	742	PF00917	0.756
DOC_USP7_MATH_1	80	84	PF00917	0.587
DOC_USP7_MATH_1	837	841	PF00917	0.430
DOC_USP7_MATH_2	64	70	PF00917	0.597
DOC_WW_Pin1_4	226	231	PF00397	0.678
DOC_WW_Pin1_4	314	319	PF00397	0.597
DOC_WW_Pin1_4	388	393	PF00397	0.656
DOC_WW_Pin1_4	430	435	PF00397	0.499
DOC_WW_Pin1_4	448	453	PF00397	0.410
DOC_WW_Pin1_4	498	503	PF00397	0.457
DOC_WW_Pin1_4	534	539	PF00397	0.470
DOC_WW_Pin1_4	571	576	PF00397	0.620
DOC_WW_Pin1_4	603	608	PF00397	0.747
LIG_14-3-3_CanoR_1	146	155	PF00244	0.455
LIG_14-3-3_CanoR_1	156	160	PF00244	0.224
LIG_14-3-3_CanoR_1	2	8	PF00244	0.407
LIG_14-3-3_CanoR_1	387	392	PF00244	0.660
LIG_14-3-3_CanoR_1	401	411	PF00244	0.561
LIG_14-3-3_CanoR_1	49	54	PF00244	0.595
LIG_14-3-3_CanoR_1	506	514	PF00244	0.450
LIG_14-3-3_CanoR_1	74	80	PF00244	0.538
LIG_14-3-3_CanoR_1	742	752	PF00244	0.639
LIG_14-3-3_CanoR_1	795	801	PF00244	0.355
LIG_14-3-3_CanoR_1	850	858	PF00244	0.469
LIG_Actin_WH2_2	772	787	PF00022	0.333
LIG_AP2alpha_1	445	449	PF02296	0.429
LIG_BIR_III_2	61	65	PF00653	0.590
LIG_BRCT_BRCA1_1	354	358	PF00533	0.292
LIG_Clathr_ClatBox_1	269	273	PF01394	0.299
LIG_Clathr_ClatBox_1	904	908	PF01394	0.627
LIG_deltaCOP1_diTrp_1	409	417	PF00928	0.602
LIG_deltaCOP1_diTrp_1	509	515	PF00928	0.422
LIG_EH1_1	542	550	PF00400	0.362
LIG_EH1_1	785	793	PF00400	0.310
LIG_eIF4E_1	543	549	PF01652	0.362
LIG_EVH1_2	568	572	PF00568	0.639
LIG_FHA_1	21	27	PF00498	0.245
LIG_FHA_1	314	320	PF00498	0.567
LIG_FHA_1	343	349	PF00498	0.349
LIG_FHA_1	358	364	PF00498	0.234
LIG_FHA_1	506	512	PF00498	0.444
LIG_FHA_1	572	578	PF00498	0.685
LIG_FHA_1	743	749	PF00498	0.646
LIG_FHA_1	764	770	PF00498	0.329
LIG_FHA_1	774	780	PF00498	0.265
LIG_FHA_1	810	816	PF00498	0.631
LIG_FHA_1	850	856	PF00498	0.376
LIG_FHA_1	887	893	PF00498	0.589
LIG_FHA_1	9	15	PF00498	0.296
LIG_FHA_2	146	152	PF00498	0.442
LIG_FHA_2	442	448	PF00498	0.493
LIG_FHA_2	459	465	PF00498	0.403
LIG_FHA_2	56	62	PF00498	0.611
LIG_GBD_Chelix_1	287	295	PF00786	0.362
LIG_LIR_Apic_2	447	452	PF02991	0.428
LIG_LIR_Apic_2	571	575	PF02991	0.610
LIG_LIR_Gen_1	158	169	PF02991	0.434
LIG_LIR_Gen_1	355	365	PF02991	0.292
LIG_LIR_Gen_1	397	407	PF02991	0.567
LIG_LIR_Gen_1	444	453	PF02991	0.428
LIG_LIR_Gen_1	6	14	PF02991	0.260
LIG_LIR_Gen_1	776	784	PF02991	0.691
LIG_LIR_Nem_3	158	164	PF02991	0.319
LIG_LIR_Nem_3	355	361	PF02991	0.292
LIG_LIR_Nem_3	444	448	PF02991	0.425
LIG_LIR_Nem_3	508	513	PF02991	0.418
LIG_LIR_Nem_3	537	543	PF02991	0.497
LIG_LIR_Nem_3	561	565	PF02991	0.413
LIG_LIR_Nem_3	6	10	PF02991	0.260
LIG_LIR_Nem_3	776	780	PF02991	0.339
LIG_LIR_Nem_3	89	95	PF02991	0.575
LIG_MAD2	378	386	PF02301	0.601
LIG_NRBOX	181	187	PF00104	0.580
LIG_NRBOX	826	832	PF00104	0.362
LIG_PAM2_1	768	780	PF00658	0.299
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.465
LIG_Pex14_1	289	293	PF04695	0.362
LIG_Pex14_1	372	376	PF04695	0.542
LIG_Pex14_2	445	449	PF04695	0.429
LIG_SH2_CRK	376	380	PF00017	0.536
LIG_SH2_CRK	419	423	PF00017	0.264
LIG_SH2_CRK	872	876	PF00017	0.416
LIG_SH2_CRK	92	96	PF00017	0.572
LIG_SH2_GRB2like	494	497	PF00017	0.475
LIG_SH2_GRB2like	532	535	PF00017	0.414
LIG_SH2_NCK_1	495	499	PF00017	0.403
LIG_SH2_PTP2	543	546	PF00017	0.362
LIG_SH2_SRC	119	122	PF00017	0.319
LIG_SH2_SRC	85	88	PF00017	0.590
LIG_SH2_STAP1	419	423	PF00017	0.351
LIG_SH2_STAP1	578	582	PF00017	0.576
LIG_SH2_STAP1	81	85	PF00017	0.567
LIG_SH2_STAT3	578	581	PF00017	0.652
LIG_SH2_STAT5	119	122	PF00017	0.279
LIG_SH2_STAT5	399	402	PF00017	0.600
LIG_SH2_STAT5	532	535	PF00017	0.414
LIG_SH2_STAT5	543	546	PF00017	0.299
LIG_SH2_STAT5	644	647	PF00017	0.551
LIG_SH2_STAT5	762	765	PF00017	0.362
LIG_SH2_STAT5	85	88	PF00017	0.581
LIG_SH3_3	167	173	PF00018	0.279
LIG_SH3_3	212	218	PF00018	0.718
LIG_SH3_3	380	386	PF00018	0.586
LIG_SH3_3	428	434	PF00018	0.362
LIG_SH3_3	449	455	PF00018	0.437
LIG_SH3_3	562	568	PF00018	0.703
LIG_SH3_3	606	612	PF00018	0.694
LIG_SH3_3	74	80	PF00018	0.513
LIG_SH3_3	92	98	PF00018	0.562
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.362
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.362
LIG_SUMO_SIM_anti_2	360	367	PF11976	0.225
LIG_SUMO_SIM_anti_2	556	561	PF11976	0.362
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.333
LIG_SUMO_SIM_anti_2	796	802	PF11976	0.362
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.264
LIG_SUMO_SIM_par_1	18	23	PF11976	0.318
LIG_SUMO_SIM_par_1	267	273	PF11976	0.299
LIG_SUMO_SIM_par_1	343	350	PF11976	0.355
LIG_SUMO_SIM_par_1	360	367	PF11976	0.208
LIG_SUMO_SIM_par_1	427	433	PF11976	0.362
LIG_SUMO_SIM_par_1	544	550	PF11976	0.401
LIG_SUMO_SIM_par_1	556	561	PF11976	0.226
LIG_SUMO_SIM_par_1	799	805	PF11976	0.350
LIG_TRAF2_1	640	643	PF00917	0.627
LIG_TRAF2_1	906	909	PF00917	0.666
LIG_TYR_ITIM	541	546	PF00017	0.362
LIG_TYR_ITIM	870	875	PF00017	0.416
LIG_UBA3_1	19	24	PF00899	0.292
LIG_WRC_WIRS_1	4	9	PF05994	0.487
LIG_WRC_WIRS_1	442	447	PF05994	0.526
LIG_WRC_WIRS_1	559	564	PF05994	0.483
MOD_CDC14_SPxK_1	451	454	PF00782	0.606
MOD_CDK_SPxK_1	448	454	PF00069	0.596
MOD_CK1_1	226	232	PF00069	0.612
MOD_CK1_1	258	264	PF00069	0.333
MOD_CK1_1	390	396	PF00069	0.556
MOD_CK1_1	458	464	PF00069	0.635
MOD_CK1_1	571	577	PF00069	0.514
MOD_CK1_1	657	663	PF00069	0.299
MOD_CK1_1	768	774	PF00069	0.318
MOD_CK1_1	839	845	PF00069	0.609
MOD_CK2_1	226	232	PF00069	0.597
MOD_CK2_1	458	464	PF00069	0.544
MOD_CK2_1	637	643	PF00069	0.541
MOD_CMANNOS	126	129	PF00535	0.449
MOD_GlcNHglycan	368	371	PF01048	0.436
MOD_GlcNHglycan	457	460	PF01048	0.714
MOD_GlcNHglycan	49	52	PF01048	0.602
MOD_GlcNHglycan	619	622	PF01048	0.695
MOD_GlcNHglycan	624	627	PF01048	0.786
MOD_GlcNHglycan	656	659	PF01048	0.468
MOD_GlcNHglycan	661	664	PF01048	0.369
MOD_GlcNHglycan	714	717	PF01048	0.614
MOD_GlcNHglycan	723	727	PF01048	0.507
MOD_GlcNHglycan	839	842	PF01048	0.624
MOD_GlcNHglycan	92	95	PF01048	0.484
MOD_GSK3_1	226	233	PF00069	0.594
MOD_GSK3_1	305	312	PF00069	0.491
MOD_GSK3_1	340	347	PF00069	0.367
MOD_GSK3_1	454	461	PF00069	0.572
MOD_GSK3_1	520	527	PF00069	0.502
MOD_GSK3_1	657	664	PF00069	0.286
MOD_GSK3_1	686	693	PF00069	0.264
MOD_GSK3_1	738	745	PF00069	0.567
MOD_GSK3_1	75	82	PF00069	0.478
MOD_GSK3_1	765	772	PF00069	0.286
MOD_GSK3_1	86	93	PF00069	0.425
MOD_N-GLC_1	207	212	PF02516	0.470
MOD_N-GLC_1	473	478	PF02516	0.584
MOD_N-GLC_1	528	533	PF02516	0.572
MOD_N-GLC_2	414	416	PF02516	0.438
MOD_NEK2_1	138	143	PF00069	0.455
MOD_NEK2_1	155	160	PF00069	0.474
MOD_NEK2_1	20	25	PF00069	0.292
MOD_NEK2_1	255	260	PF00069	0.362
MOD_NEK2_1	26	31	PF00069	0.456
MOD_NEK2_1	282	287	PF00069	0.299
MOD_NEK2_1	313	318	PF00069	0.480
MOD_NEK2_1	342	347	PF00069	0.432
MOD_NEK2_1	357	362	PF00069	0.377
MOD_NEK2_1	402	407	PF00069	0.518
MOD_NEK2_1	429	434	PF00069	0.362
MOD_NEK2_1	47	52	PF00069	0.496
MOD_NEK2_1	475	480	PF00069	0.568
MOD_NEK2_1	558	563	PF00069	0.302
MOD_NEK2_1	656	661	PF00069	0.313
MOD_NEK2_1	763	768	PF00069	0.346
MOD_NEK2_1	775	780	PF00069	0.349
MOD_NEK2_1	802	807	PF00069	0.557
MOD_NEK2_2	418	423	PF00069	0.362
MOD_NEK2_2	874	879	PF00069	0.362
MOD_PIKK_1	75	81	PF00454	0.403
MOD_PKA_1	721	727	PF00069	0.559
MOD_PKA_2	145	151	PF00069	0.581
MOD_PKA_2	155	161	PF00069	0.243
MOD_PKA_2	194	200	PF00069	0.520
MOD_PKA_2	407	413	PF00069	0.484
MOD_PKA_2	505	511	PF00069	0.508
MOD_PKA_2	794	800	PF00069	0.355
MOD_PKA_2	849	855	PF00069	0.583
MOD_Plk_1	230	236	PF00069	0.572
MOD_Plk_1	309	315	PF00069	0.446
MOD_Plk_1	473	479	PF00069	0.514
MOD_Plk_1	528	534	PF00069	0.572
MOD_Plk_1	55	61	PF00069	0.549
MOD_Plk_4	210	216	PF00069	0.479
MOD_Plk_4	230	236	PF00069	0.530
MOD_Plk_4	255	261	PF00069	0.362
MOD_Plk_4	26	32	PF00069	0.414
MOD_Plk_4	282	288	PF00069	0.299
MOD_Plk_4	344	350	PF00069	0.400
MOD_Plk_4	357	363	PF00069	0.321
MOD_Plk_4	38	44	PF00069	0.437
MOD_Plk_4	407	413	PF00069	0.524
MOD_Plk_4	418	424	PF00069	0.255
MOD_Plk_4	441	447	PF00069	0.566
MOD_Plk_4	49	55	PF00069	0.639
MOD_Plk_4	490	496	PF00069	0.592
MOD_Plk_4	528	534	PF00069	0.612
MOD_Plk_4	553	559	PF00069	0.367
MOD_Plk_4	66	72	PF00069	0.362
MOD_Plk_4	661	667	PF00069	0.266
MOD_Plk_4	680	686	PF00069	0.499
MOD_Plk_4	765	771	PF00069	0.337
MOD_Plk_4	796	802	PF00069	0.451
MOD_Plk_4	8	14	PF00069	0.294
MOD_Plk_4	80	86	PF00069	0.436
MOD_ProDKin_1	226	232	PF00069	0.597
MOD_ProDKin_1	314	320	PF00069	0.485
MOD_ProDKin_1	388	394	PF00069	0.560
MOD_ProDKin_1	430	436	PF00069	0.499
MOD_ProDKin_1	448	454	PF00069	0.507
MOD_ProDKin_1	498	504	PF00069	0.567
MOD_ProDKin_1	534	540	PF00069	0.587
MOD_ProDKin_1	571	577	PF00069	0.516
MOD_ProDKin_1	603	609	PF00069	0.692
MOD_SUMO_for_1	330	333	PF00179	0.513
MOD_SUMO_for_1	614	617	PF00179	0.655
TRG_DiLeu_BaEn_1	8	13	PF01217	0.319
TRG_DiLeu_BaEn_1	900	905	PF01217	0.531
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.442
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.299
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.362
TRG_ENDOCYTIC_2	376	379	PF00928	0.405
TRG_ENDOCYTIC_2	399	402	PF00928	0.445
TRG_ENDOCYTIC_2	419	422	PF00928	0.180
TRG_ENDOCYTIC_2	543	546	PF00928	0.362
TRG_ENDOCYTIC_2	762	765	PF00928	0.362
TRG_ENDOCYTIC_2	872	875	PF00928	0.416
TRG_ENDOCYTIC_2	92	95	PF00928	0.444
TRG_ER_diArg_1	186	188	PF00400	0.445
TRG_ER_diArg_1	376	378	PF00400	0.473
TRG_ER_diArg_1	386	389	PF00400	0.501
TRG_ER_diArg_1	563	566	PF00400	0.495
TRG_ER_diArg_1	630	633	PF00400	0.744
TRG_ER_diArg_1	73	75	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.664
TRG_Pf-PMV_PEXEL_1	868	873	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9F4	Leptomonas seymouri	45%	100%
A4HTH0	Leishmania infantum	100%	100%
E9AM98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIF0	Leishmania major	91%	100%