Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S5H632_LEIDO

TriTrypDb:

LdBPK_080180.1 , LdCL_080006700 , LDHU3_08.0210

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7

Expansion

Sequence features

A0A3S5H632

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H632

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	5
GO:0006952	defense response	3	5
GO:0050896	response to stimulus	1	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.423
CLV_MEL_PAP_1	465	471	PF00089	0.562
CLV_NRD_NRD_1	117	119	PF00675	0.600
CLV_NRD_NRD_1	201	203	PF00675	0.655
CLV_NRD_NRD_1	204	206	PF00675	0.625
CLV_NRD_NRD_1	228	230	PF00675	0.530
CLV_NRD_NRD_1	521	523	PF00675	0.584
CLV_NRD_NRD_1	525	527	PF00675	0.578
CLV_NRD_NRD_1	57	59	PF00675	0.698
CLV_PCSK_FUR_1	199	203	PF00082	0.714
CLV_PCSK_KEX2_1	117	119	PF00082	0.601
CLV_PCSK_KEX2_1	201	203	PF00082	0.674
CLV_PCSK_KEX2_1	204	206	PF00082	0.594
CLV_PCSK_KEX2_1	228	230	PF00082	0.534
CLV_PCSK_KEX2_1	521	523	PF00082	0.584
CLV_PCSK_KEX2_1	525	527	PF00082	0.578
CLV_PCSK_KEX2_1	57	59	PF00082	0.698
CLV_PCSK_PC7_1	517	523	PF00082	0.471
CLV_PCSK_SKI1_1	181	185	PF00082	0.605
CLV_PCSK_SKI1_1	242	246	PF00082	0.572
CLV_PCSK_SKI1_1	258	262	PF00082	0.397
CLV_PCSK_SKI1_1	287	291	PF00082	0.481
CLV_PCSK_SKI1_1	34	38	PF00082	0.620
CLV_PCSK_SKI1_1	364	368	PF00082	0.406
CLV_PCSK_SKI1_1	517	521	PF00082	0.580
DEG_APCC_DBOX_1	306	314	PF00400	0.494
DEG_APCC_DBOX_1	516	524	PF00400	0.508
DEG_Nend_UBRbox_1	1	4	PF02207	0.452
DEG_SCF_FBW7_1	183	188	PF00400	0.668
DEG_SPOP_SBC_1	185	189	PF00917	0.747
DOC_CDC14_PxL_1	300	308	PF14671	0.449
DOC_CDC14_PxL_1	377	385	PF14671	0.471
DOC_CDC14_PxL_1	472	480	PF14671	0.430
DOC_CYCLIN_RxL_1	199	210	PF00134	0.707
DOC_CYCLIN_RxL_1	358	370	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.560
DOC_MAPK_gen_1	199	208	PF00069	0.735
DOC_MAPK_gen_1	31	41	PF00069	0.586
DOC_MAPK_gen_1	521	530	PF00069	0.595
DOC_MAPK_gen_1	57	65	PF00069	0.669
DOC_MAPK_MEF2A_6	57	65	PF00069	0.580
DOC_PP1_RVXF_1	296	303	PF00149	0.487
DOC_PP2B_LxvP_1	344	347	PF13499	0.443
DOC_PP2B_LxvP_1	505	508	PF13499	0.416
DOC_USP7_MATH_1	22	26	PF00917	0.636
DOC_USP7_MATH_1	227	231	PF00917	0.569
DOC_USP7_MATH_1	325	329	PF00917	0.640
DOC_USP7_MATH_1	351	355	PF00917	0.497
DOC_USP7_MATH_1	357	361	PF00917	0.455
DOC_USP7_MATH_1	508	512	PF00917	0.520
DOC_USP7_MATH_1	93	97	PF00917	0.571
DOC_USP7_UBL2_3	101	105	PF12436	0.607
DOC_WW_Pin1_4	144	149	PF00397	0.785
DOC_WW_Pin1_4	16	21	PF00397	0.754
DOC_WW_Pin1_4	174	179	PF00397	0.678
DOC_WW_Pin1_4	181	186	PF00397	0.696
DOC_WW_Pin1_4	316	321	PF00397	0.519
DOC_WW_Pin1_4	403	408	PF00397	0.416
DOC_WW_Pin1_4	50	55	PF00397	0.607
DOC_WW_Pin1_4	82	87	PF00397	0.571
DOC_WW_Pin1_4	95	100	PF00397	0.539
LIG_14-3-3_CanoR_1	10	14	PF00244	0.702
LIG_14-3-3_CanoR_1	117	123	PF00244	0.653
LIG_14-3-3_CanoR_1	207	216	PF00244	0.614
LIG_14-3-3_CanoR_1	228	232	PF00244	0.557
LIG_14-3-3_CanoR_1	287	292	PF00244	0.499
LIG_14-3-3_CanoR_1	307	313	PF00244	0.366
LIG_14-3-3_CanoR_1	413	421	PF00244	0.450
LIG_14-3-3_CanoR_1	468	472	PF00244	0.550
LIG_14-3-3_CanoR_1	484	490	PF00244	0.307
LIG_14-3-3_CanoR_1	70	80	PF00244	0.655
LIG_Actin_WH2_2	273	289	PF00022	0.525
LIG_Actin_WH2_2	293	309	PF00022	0.440
LIG_Actin_WH2_2	32	50	PF00022	0.585
LIG_Actin_WH2_2	73	90	PF00022	0.666
LIG_BRCT_BRCA1_1	255	259	PF00533	0.424
LIG_DLG_GKlike_1	253	261	PF00625	0.307
LIG_FHA_1	117	123	PF00498	0.583
LIG_FHA_1	201	207	PF00498	0.713
LIG_FHA_1	262	268	PF00498	0.559
LIG_FHA_1	485	491	PF00498	0.402
LIG_FHA_1	92	98	PF00498	0.540
LIG_FHA_2	119	125	PF00498	0.701
LIG_FHA_2	360	366	PF00498	0.439
LIG_FHA_2	422	428	PF00498	0.428
LIG_FHA_2	454	460	PF00498	0.535
LIG_LIR_Gen_1	309	320	PF02991	0.476
LIG_LIR_Gen_1	367	377	PF02991	0.465
LIG_LIR_Gen_1	454	465	PF02991	0.481
LIG_LIR_Nem_3	273	277	PF02991	0.410
LIG_LIR_Nem_3	309	315	PF02991	0.454
LIG_LIR_Nem_3	375	380	PF02991	0.480
LIG_LIR_Nem_3	454	460	PF02991	0.474
LIG_LIR_Nem_3	492	496	PF02991	0.449
LIG_MYND_1	148	152	PF01753	0.660
LIG_MYND_3	383	387	PF01753	0.451
LIG_PCNA_PIPBox_1	73	82	PF02747	0.581
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.609
LIG_PTB_Apo_2	245	252	PF02174	0.587
LIG_PTB_Phospho_1	245	251	PF10480	0.584
LIG_SH2_NCK_1	251	255	PF00017	0.603
LIG_SH2_SRC	457	460	PF00017	0.531
LIG_SH2_STAT5	114	117	PF00017	0.560
LIG_SH2_STAT5	312	315	PF00017	0.462
LIG_SH2_STAT5	457	460	PF00017	0.429
LIG_SH3_3	119	125	PF00018	0.701
LIG_SH3_3	378	384	PF00018	0.426
LIG_SH3_3	504	510	PF00018	0.464
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.439
LIG_SUMO_SIM_par_1	59	64	PF11976	0.659
LIG_TYR_ITIM	310	315	PF00017	0.467
LIG_TYR_ITIM	455	460	PF00017	0.430
LIG_Vh1_VBS_1	356	374	PF01044	0.485
LIG_WRC_WIRS_1	352	357	PF05994	0.451
MOD_CDC14_SPxK_1	85	88	PF00782	0.559
MOD_CDC14_SPxK_1	98	101	PF00782	0.522
MOD_CDK_SPK_2	403	408	PF00069	0.416
MOD_CDK_SPxK_1	82	88	PF00069	0.571
MOD_CDK_SPxK_1	95	101	PF00069	0.537
MOD_CDK_SPxxK_3	174	181	PF00069	0.688
MOD_CDK_SPxxK_3	50	57	PF00069	0.706
MOD_CK1_1	144	150	PF00069	0.737
MOD_CK1_1	16	22	PF00069	0.722
MOD_CK1_1	187	193	PF00069	0.742
MOD_CK1_1	200	206	PF00069	0.644
MOD_CK1_1	319	325	PF00069	0.534
MOD_CK1_1	345	351	PF00069	0.569
MOD_CK1_1	359	365	PF00069	0.334
MOD_CK1_1	375	381	PF00069	0.384
MOD_CK1_1	82	88	PF00069	0.571
MOD_CK2_1	334	340	PF00069	0.513
MOD_CK2_1	359	365	PF00069	0.488
MOD_CK2_1	467	473	PF00069	0.563
MOD_CK2_1	508	514	PF00069	0.470
MOD_Cter_Amidation	523	526	PF01082	0.565
MOD_GlcNHglycan	209	212	PF01048	0.690
MOD_GlcNHglycan	225	228	PF01048	0.518
MOD_GlcNHglycan	24	27	PF01048	0.696
MOD_GlcNHglycan	327	330	PF01048	0.636
MOD_GlcNHglycan	336	339	PF01048	0.389
MOD_GlcNHglycan	359	362	PF01048	0.457
MOD_GlcNHglycan	374	377	PF01048	0.504
MOD_GSK3_1	144	151	PF00069	0.715
MOD_GSK3_1	181	188	PF00069	0.751
MOD_GSK3_1	189	196	PF00069	0.654
MOD_GSK3_1	223	230	PF00069	0.637
MOD_GSK3_1	321	328	PF00069	0.607
MOD_GSK3_1	415	422	PF00069	0.527
MOD_GSK3_1	9	16	PF00069	0.717
MOD_GSK3_1	91	98	PF00069	0.638
MOD_N-GLC_1	144	149	PF02516	0.767
MOD_N-GLC_1	342	347	PF02516	0.543
MOD_N-GLC_1	484	489	PF02516	0.571
MOD_N-GLC_2	438	440	PF02516	0.546
MOD_NEK2_1	106	111	PF00069	0.461
MOD_NEK2_1	116	121	PF00069	0.537
MOD_NEK2_1	206	211	PF00069	0.715
MOD_NEK2_1	221	226	PF00069	0.500
MOD_NEK2_1	261	266	PF00069	0.450
MOD_NEK2_1	306	311	PF00069	0.540
MOD_NEK2_1	334	339	PF00069	0.538
MOD_NEK2_1	342	347	PF00069	0.339
MOD_NEK2_1	372	377	PF00069	0.498
MOD_NEK2_1	401	406	PF00069	0.393
MOD_NEK2_1	421	426	PF00069	0.384
MOD_NEK2_1	458	463	PF00069	0.530
MOD_NEK2_1	79	84	PF00069	0.611
MOD_PIKK_1	161	167	PF00454	0.696
MOD_PIKK_1	412	418	PF00454	0.462
MOD_PK_1	262	268	PF00069	0.481
MOD_PKA_1	117	123	PF00069	0.625
MOD_PKA_2	116	122	PF00069	0.570
MOD_PKA_2	200	206	PF00069	0.755
MOD_PKA_2	227	233	PF00069	0.570
MOD_PKA_2	306	312	PF00069	0.474
MOD_PKA_2	412	418	PF00069	0.484
MOD_PKA_2	467	473	PF00069	0.563
MOD_PKA_2	9	15	PF00069	0.710
MOD_PKB_1	205	213	PF00069	0.643
MOD_Plk_1	298	304	PF00069	0.586
MOD_Plk_1	342	348	PF00069	0.546
MOD_Plk_1	364	370	PF00069	0.433
MOD_Plk_1	484	490	PF00069	0.569
MOD_Plk_4	262	268	PF00069	0.559
MOD_Plk_4	270	276	PF00069	0.454
MOD_Plk_4	298	304	PF00069	0.557
MOD_Plk_4	308	314	PF00069	0.405
MOD_Plk_4	364	370	PF00069	0.408
MOD_Plk_4	453	459	PF00069	0.515
MOD_Plk_4	467	473	PF00069	0.359
MOD_Plk_4	485	491	PF00069	0.475
MOD_Plk_4	508	514	PF00069	0.449
MOD_Plk_4	9	15	PF00069	0.710
MOD_ProDKin_1	144	150	PF00069	0.787
MOD_ProDKin_1	16	22	PF00069	0.757
MOD_ProDKin_1	174	180	PF00069	0.682
MOD_ProDKin_1	181	187	PF00069	0.697
MOD_ProDKin_1	316	322	PF00069	0.525
MOD_ProDKin_1	403	409	PF00069	0.408
MOD_ProDKin_1	50	56	PF00069	0.600
MOD_ProDKin_1	82	88	PF00069	0.571
MOD_ProDKin_1	95	101	PF00069	0.537
TRG_DiLeu_BaEn_2	74	80	PF01217	0.527
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.523
TRG_ENDOCYTIC_2	251	254	PF00928	0.417
TRG_ENDOCYTIC_2	312	315	PF00928	0.462
TRG_ENDOCYTIC_2	457	460	PF00928	0.396
TRG_ER_diArg_1	116	118	PF00400	0.666
TRG_ER_diArg_1	199	202	PF00400	0.717
TRG_ER_diArg_1	204	207	PF00400	0.674
TRG_ER_diArg_1	29	32	PF00400	0.566
TRG_ER_diArg_1	304	307	PF00400	0.494
TRG_ER_diArg_1	520	522	PF00400	0.477
TRG_ER_diArg_1	56	58	PF00400	0.609
TRG_NES_CRM1_1	427	441	PF08389	0.546
TRG_NES_CRM1_1	51	64	PF08389	0.586
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P939	Leptomonas seymouri	45%	81%
A4H584	Leishmania braziliensis	74%	100%
A4HTG8	Leishmania infantum	100%	100%
E9AM96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIF2	Leishmania major	92%	100%