GPI-GlcNAc transferase complex, PIG-H component, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI-GlcNAc transferase complex, PIG-H component, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H631_LEIDO

TriTrypDb:

LdBPK_080160.1 , LdCL_080006500 , LDHU3_08.0190

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	3	7
GO:0016020	membrane	2	7
GO:0032991	protein-containing complex	1	7
GO:0098796	membrane protein complex	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0140534	endoplasmic reticulum protein-containing complex	2	7
GO:1902494	catalytic complex	2	7
GO:1990234	transferase complex	3	7

Expansion

Sequence features

A0A3S5H631

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H631

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	7
GO:0006505	GPI anchor metabolic process	6	7
GO:0006506	GPI anchor biosynthetic process	6	7
GO:0006629	lipid metabolic process	3	7
GO:0006643	membrane lipid metabolic process	4	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006661	phosphatidylinositol biosynthetic process	6	7
GO:0006664	glycolipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009247	glycolipid biosynthetic process	5	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019637	organophosphate metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	7
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0046474	glycerophospholipid biosynthetic process	5	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1903509	liposaccharide metabolic process	4	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	486	490	PF00656	0.621
CLV_MEL_PAP_1	249	255	PF00089	0.323
CLV_NRD_NRD_1	4	6	PF00675	0.453
CLV_NRD_NRD_1	62	64	PF00675	0.447
CLV_PCSK_KEX2_1	26	28	PF00082	0.486
CLV_PCSK_KEX2_1	366	368	PF00082	0.347
CLV_PCSK_KEX2_1	4	6	PF00082	0.453
CLV_PCSK_KEX2_1	62	64	PF00082	0.447
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.478
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.347
CLV_PCSK_SKI1_1	224	228	PF00082	0.410
CLV_PCSK_SKI1_1	332	336	PF00082	0.655
CLV_PCSK_SKI1_1	453	457	PF00082	0.328
CLV_PCSK_SKI1_1	460	464	PF00082	0.370
DEG_APCC_DBOX_1	452	460	PF00400	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.643
DEG_SPOP_SBC_1	315	319	PF00917	0.469
DOC_CKS1_1	170	175	PF01111	0.699
DOC_CKS1_1	503	508	PF01111	0.671
DOC_CYCLIN_RxL_1	62	73	PF00134	0.641
DOC_MAPK_gen_1	400	407	PF00069	0.469
DOC_MAPK_MEF2A_6	400	409	PF00069	0.469
DOC_MAPK_RevD_3	352	367	PF00069	0.303
DOC_PP1_RVXF_1	222	228	PF00149	0.646
DOC_PP1_RVXF_1	330	337	PF00149	0.455
DOC_PP1_RVXF_1	436	443	PF00149	0.469
DOC_PP2B_LxvP_1	174	177	PF13499	0.690
DOC_USP7_MATH_1	103	107	PF00917	0.652
DOC_USP7_MATH_1	281	285	PF00917	0.481
DOC_USP7_MATH_1	3	7	PF00917	0.665
DOC_USP7_MATH_1	315	319	PF00917	0.489
DOC_USP7_MATH_1	32	36	PF00917	0.709
DOC_USP7_MATH_1	45	49	PF00917	0.779
DOC_USP7_MATH_1	52	56	PF00917	0.732
DOC_USP7_MATH_2	467	473	PF00917	0.648
DOC_WW_Pin1_4	166	171	PF00397	0.757
DOC_WW_Pin1_4	177	182	PF00397	0.710
DOC_WW_Pin1_4	197	202	PF00397	0.663
DOC_WW_Pin1_4	27	32	PF00397	0.656
DOC_WW_Pin1_4	296	301	PF00397	0.502
DOC_WW_Pin1_4	342	347	PF00397	0.261
DOC_WW_Pin1_4	502	507	PF00397	0.685
DOC_WW_Pin1_4	92	97	PF00397	0.800
LIG_14-3-3_CanoR_1	115	119	PF00244	0.606
LIG_14-3-3_CanoR_1	18	23	PF00244	0.639
LIG_14-3-3_CanoR_1	204	208	PF00244	0.687
LIG_14-3-3_CanoR_1	252	256	PF00244	0.383
LIG_14-3-3_CanoR_1	479	487	PF00244	0.613
LIG_Actin_WH2_2	439	455	PF00022	0.513
LIG_AP_GAE_1	495	501	PF02883	0.695
LIG_APCC_ABBAyCdc20_2	460	466	PF00400	0.533
LIG_EH1_1	402	410	PF00400	0.516
LIG_eIF4E_1	376	382	PF01652	0.541
LIG_EVH1_1	28	32	PF00568	0.638
LIG_FHA_1	107	113	PF00498	0.661
LIG_FHA_1	114	120	PF00498	0.538
LIG_FHA_1	125	131	PF00498	0.503
LIG_FHA_1	18	24	PF00498	0.728
LIG_FHA_1	187	193	PF00498	0.685
LIG_FHA_1	232	238	PF00498	0.318
LIG_FHA_1	329	335	PF00498	0.440
LIG_FHA_1	343	349	PF00498	0.299
LIG_FHA_1	351	357	PF00498	0.313
LIG_FHA_1	359	365	PF00498	0.359
LIG_FHA_2	502	508	PF00498	0.702
LIG_FHA_2	513	519	PF00498	0.639
LIG_GBD_Chelix_1	364	372	PF00786	0.417
LIG_LIR_Gen_1	268	277	PF02991	0.453
LIG_LIR_Gen_1	360	368	PF02991	0.405
LIG_LIR_Nem_3	268	272	PF02991	0.466
LIG_LIR_Nem_3	360	365	PF02991	0.404
LIG_LIR_Nem_3	391	396	PF02991	0.469
LIG_LIR_Nem_3	398	404	PF02991	0.469
LIG_LIR_Nem_3	417	422	PF02991	0.469
LIG_MYND_1	78	82	PF01753	0.687
LIG_MYND_3	272	276	PF01753	0.359
LIG_NRBOX	353	359	PF00104	0.369
LIG_Pex14_1	223	227	PF04695	0.647
LIG_Pex14_2	227	231	PF04695	0.516
LIG_REV1ctd_RIR_1	417	423	PF16727	0.469
LIG_RPA_C_Fungi	58	70	PF08784	0.553
LIG_SH2_NCK_1	339	343	PF00017	0.506
LIG_SH2_STAP1	138	142	PF00017	0.415
LIG_SH2_STAP1	188	192	PF00017	0.521
LIG_SH2_STAT5	188	191	PF00017	0.565
LIG_SH2_STAT5	339	342	PF00017	0.510
LIG_SH2_STAT5	376	379	PF00017	0.361
LIG_SH2_STAT5	441	444	PF00017	0.477
LIG_SH3_1	26	32	PF00018	0.547
LIG_SH3_3	167	173	PF00018	0.749
LIG_SH3_3	26	32	PF00018	0.576
LIG_SH3_3	437	443	PF00018	0.304
LIG_SH3_3	448	454	PF00018	0.367
LIG_SH3_3	500	506	PF00018	0.580
LIG_SH3_3	6	12	PF00018	0.580
LIG_SH3_3	75	81	PF00018	0.671
LIG_SH3_3	90	96	PF00018	0.756
LIG_SUMO_SIM_anti_2	349	356	PF11976	0.349
LIG_SUMO_SIM_anti_2	378	384	PF11976	0.369
LIG_SUMO_SIM_par_1	116	122	PF11976	0.424
LIG_SUMO_SIM_par_1	234	240	PF11976	0.303
LIG_SUMO_SIM_par_1	246	251	PF11976	0.313
LIG_SUMO_SIM_par_1	353	361	PF11976	0.406
LIG_SUMO_SIM_par_1	406	412	PF11976	0.369
LIG_WRC_WIRS_1	192	197	PF05994	0.532
LIG_WRC_WIRS_1	359	364	PF05994	0.270
MOD_CDK_SPxxK_3	197	204	PF00069	0.618
MOD_CK1_1	106	112	PF00069	0.599
MOD_CK1_1	166	172	PF00069	0.627
MOD_CK1_1	186	192	PF00069	0.550
MOD_CK1_1	251	257	PF00069	0.501
MOD_CK1_1	265	271	PF00069	0.613
MOD_CK1_1	284	290	PF00069	0.477
MOD_CK1_1	296	302	PF00069	0.517
MOD_CK1_1	318	324	PF00069	0.663
MOD_CK1_1	35	41	PF00069	0.587
MOD_CK1_1	46	52	PF00069	0.580
MOD_CK1_1	485	491	PF00069	0.449
MOD_CK1_1	512	518	PF00069	0.642
MOD_CK2_1	284	290	PF00069	0.563
MOD_CK2_1	427	433	PF00069	0.304
MOD_CK2_1	469	475	PF00069	0.500
MOD_CK2_1	480	486	PF00069	0.477
MOD_CK2_1	494	500	PF00069	0.585
MOD_GlcNHglycan	105	108	PF01048	0.574
MOD_GlcNHglycan	166	169	PF01048	0.655
MOD_GlcNHglycan	195	198	PF01048	0.596
MOD_GlcNHglycan	264	267	PF01048	0.537
MOD_GlcNHglycan	283	286	PF01048	0.674
MOD_GlcNHglycan	295	298	PF01048	0.566
MOD_GlcNHglycan	301	304	PF01048	0.606
MOD_GlcNHglycan	34	37	PF01048	0.644
MOD_GlcNHglycan	368	371	PF01048	0.383
MOD_GlcNHglycan	38	41	PF01048	0.640
MOD_GlcNHglycan	390	393	PF01048	0.369
MOD_GlcNHglycan	45	48	PF01048	0.775
MOD_GlcNHglycan	482	485	PF01048	0.528
MOD_GlcNHglycan	63	66	PF01048	0.492
MOD_GSK3_1	102	109	PF00069	0.647
MOD_GSK3_1	183	190	PF00069	0.593
MOD_GSK3_1	191	198	PF00069	0.705
MOD_GSK3_1	258	265	PF00069	0.563
MOD_GSK3_1	280	287	PF00069	0.559
MOD_GSK3_1	314	321	PF00069	0.683
MOD_GSK3_1	32	39	PF00069	0.639
MOD_GSK3_1	324	331	PF00069	0.543
MOD_GSK3_1	337	344	PF00069	0.542
MOD_GSK3_1	366	373	PF00069	0.607
MOD_GSK3_1	46	53	PF00069	0.724
MOD_NEK2_1	195	200	PF00069	0.604
MOD_NEK2_1	267	272	PF00069	0.514
MOD_NEK2_1	335	340	PF00069	0.592
MOD_NEK2_1	348	353	PF00069	0.272
MOD_NEK2_1	357	362	PF00069	0.314
MOD_NEK2_1	388	393	PF00069	0.304
MOD_NEK2_1	409	414	PF00069	0.304
MOD_NEK2_1	426	431	PF00069	0.304
MOD_NEK2_1	70	75	PF00069	0.536
MOD_PIKK_1	337	343	PF00454	0.521
MOD_PKA_1	366	372	PF00069	0.476
MOD_PKA_2	114	120	PF00069	0.508
MOD_PKA_2	17	23	PF00069	0.476
MOD_PKA_2	203	209	PF00069	0.609
MOD_PKA_2	251	257	PF00069	0.519
MOD_PKA_2	3	9	PF00069	0.549
MOD_PKA_2	366	372	PF00069	0.476
MOD_PKA_2	61	67	PF00069	0.551
MOD_Plk_1	211	217	PF00069	0.583
MOD_Plk_1	348	354	PF00069	0.331
MOD_Plk_1	494	500	PF00069	0.615
MOD_Plk_2-3	469	475	PF00069	0.500
MOD_Plk_2-3	491	497	PF00069	0.493
MOD_Plk_4	114	120	PF00069	0.443
MOD_Plk_4	18	24	PF00069	0.617
MOD_Plk_4	251	257	PF00069	0.592
MOD_Plk_4	321	327	PF00069	0.581
MOD_Plk_4	350	356	PF00069	0.404
MOD_Plk_4	358	364	PF00069	0.369
MOD_ProDKin_1	166	172	PF00069	0.705
MOD_ProDKin_1	177	183	PF00069	0.639
MOD_ProDKin_1	197	203	PF00069	0.578
MOD_ProDKin_1	27	33	PF00069	0.569
MOD_ProDKin_1	296	302	PF00069	0.632
MOD_ProDKin_1	342	348	PF00069	0.292
MOD_ProDKin_1	502	508	PF00069	0.609
MOD_ProDKin_1	92	98	PF00069	0.763
MOD_SUMO_rev_2	429	436	PF00179	0.369
TRG_DiLeu_BaEn_4	468	474	PF01217	0.493
TRG_ENDOCYTIC_2	393	396	PF00928	0.304
TRG_ENDOCYTIC_2	401	404	PF00928	0.304
TRG_ENDOCYTIC_2	422	425	PF00928	0.304
TRG_ER_diArg_1	3	5	PF00400	0.593
TRG_NES_CRM1_1	406	417	PF08389	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I406	Leptomonas seymouri	50%	100%
A4H582	Leishmania braziliensis	68%	99%
A4HTG6	Leishmania infantum	99%	100%
E9AM94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
Q4QIF4	Leishmania major	89%	100%