Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H629_LEIDO

TriTrypDb:

LdBPK_080140.1 , LdCL_080006300 , LDHU3_08.0170

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H629

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H629

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.574
CLV_C14_Caspase3-7	412	416	PF00656	0.534
CLV_NRD_NRD_1	186	188	PF00675	0.542
CLV_NRD_NRD_1	19	21	PF00675	0.536
CLV_NRD_NRD_1	256	258	PF00675	0.614
CLV_NRD_NRD_1	364	366	PF00675	0.449
CLV_NRD_NRD_1	425	427	PF00675	0.543
CLV_NRD_NRD_1	536	538	PF00675	0.493
CLV_PCSK_FUR_1	253	257	PF00082	0.630
CLV_PCSK_KEX2_1	186	188	PF00082	0.492
CLV_PCSK_KEX2_1	19	21	PF00082	0.536
CLV_PCSK_KEX2_1	255	257	PF00082	0.616
CLV_PCSK_KEX2_1	364	366	PF00082	0.449
CLV_PCSK_KEX2_1	425	427	PF00082	0.543
CLV_PCSK_KEX2_1	536	538	PF00082	0.444
CLV_PCSK_KEX2_1	549	551	PF00082	0.366
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.465
CLV_PCSK_PC7_1	251	257	PF00082	0.631
CLV_PCSK_PC7_1	360	366	PF00082	0.413
CLV_PCSK_PC7_1	421	427	PF00082	0.554
CLV_PCSK_SKI1_1	202	206	PF00082	0.649
CLV_PCSK_SKI1_1	331	335	PF00082	0.709
CLV_PCSK_SKI1_1	398	402	PF00082	0.518
DEG_APCC_DBOX_1	330	338	PF00400	0.558
DEG_Nend_Nbox_1	1	3	PF02207	0.484
DEG_SCF_FBW7_1	292	299	PF00400	0.667
DEG_SPOP_SBC_1	21	25	PF00917	0.542
DEG_SPOP_SBC_1	222	226	PF00917	0.638
DOC_AGCK_PIF_2	571	576	PF00069	0.372
DOC_ANK_TNKS_1	388	395	PF00023	0.413
DOC_CDC14_PxL_1	483	491	PF14671	0.539
DOC_CKS1_1	93	98	PF01111	0.512
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.477
DOC_MAPK_FxFP_2	168	171	PF00069	0.574
DOC_MAPK_gen_1	255	264	PF00069	0.659
DOC_MAPK_MEF2A_6	438	445	PF00069	0.425
DOC_PP2B_LxvP_1	340	343	PF13499	0.527
DOC_PP2B_PxIxI_1	472	478	PF00149	0.416
DOC_PP4_FxxP_1	168	171	PF00568	0.574
DOC_PP4_FxxP_1	494	497	PF00568	0.453
DOC_PP4_FxxP_1	529	532	PF00568	0.461
DOC_USP7_MATH_1	21	25	PF00917	0.666
DOC_USP7_MATH_1	266	270	PF00917	0.688
DOC_USP7_MATH_1	296	300	PF00917	0.619
DOC_USP7_MATH_1	61	65	PF00917	0.596
DOC_USP7_UBL2_3	555	559	PF12436	0.503
DOC_WW_Pin1_4	162	167	PF00397	0.561
DOC_WW_Pin1_4	239	244	PF00397	0.784
DOC_WW_Pin1_4	292	297	PF00397	0.619
DOC_WW_Pin1_4	92	97	PF00397	0.460
LIG_14-3-3_CanoR_1	100	108	PF00244	0.697
LIG_14-3-3_CanoR_1	19	26	PF00244	0.496
LIG_14-3-3_CanoR_1	62	71	PF00244	0.601
LIG_APCC_ABBAyCdc20_2	398	404	PF00400	0.522
LIG_BIR_III_4	391	395	PF00653	0.471
LIG_BIR_III_4	415	419	PF00653	0.579
LIG_BRCT_BRCA1_1	119	123	PF00533	0.593
LIG_BRCT_BRCA1_1	164	168	PF00533	0.556
LIG_Clathr_ClatBox_1	474	478	PF01394	0.371
LIG_FHA_1	100	106	PF00498	0.588
LIG_FHA_1	175	181	PF00498	0.675
LIG_FHA_1	223	229	PF00498	0.641
LIG_FHA_1	343	349	PF00498	0.613
LIG_FHA_1	357	363	PF00498	0.408
LIG_FHA_1	383	389	PF00498	0.471
LIG_FHA_1	509	515	PF00498	0.462
LIG_FHA_2	334	340	PF00498	0.684
LIG_FHA_2	434	440	PF00498	0.474
LIG_LIR_Apic_2	165	171	PF02991	0.567
LIG_LIR_Apic_2	527	532	PF02991	0.470
LIG_LIR_Gen_1	570	579	PF02991	0.381
LIG_LIR_Nem_3	120	126	PF02991	0.549
LIG_LIR_Nem_3	141	147	PF02991	0.711
LIG_LIR_Nem_3	269	273	PF02991	0.619
LIG_LIR_Nem_3	305	309	PF02991	0.657
LIG_LIR_Nem_3	501	506	PF02991	0.470
LIG_LIR_Nem_3	525	529	PF02991	0.492
LIG_LIR_Nem_3	534	538	PF02991	0.358
LIG_LIR_Nem_3	570	574	PF02991	0.372
LIG_LIR_Nem_3	575	579	PF02991	0.365
LIG_LIR_Nem_3	87	93	PF02991	0.670
LIG_Pex14_2	522	526	PF04695	0.434
LIG_REV1ctd_RIR_1	202	211	PF16727	0.459
LIG_RPA_C_Fungi	15	27	PF08784	0.539
LIG_RPA_C_Fungi	57	69	PF08784	0.591
LIG_SH2_CRK	144	148	PF00017	0.569
LIG_SH2_CRK	285	289	PF00017	0.634
LIG_SH2_GRB2like	108	111	PF00017	0.519
LIG_SH2_PTP2	576	579	PF00017	0.416
LIG_SH2_SRC	108	111	PF00017	0.519
LIG_SH2_STAP1	386	390	PF00017	0.397
LIG_SH2_STAT3	149	152	PF00017	0.595
LIG_SH2_STAT5	108	111	PF00017	0.459
LIG_SH2_STAT5	158	161	PF00017	0.630
LIG_SH2_STAT5	386	389	PF00017	0.386
LIG_SH2_STAT5	576	579	PF00017	0.363
LIG_SH2_STAT5	92	95	PF00017	0.636
LIG_SH3_1	145	151	PF00018	0.540
LIG_SH3_1	285	291	PF00018	0.661
LIG_SH3_2	351	356	PF14604	0.454
LIG_SH3_3	144	150	PF00018	0.573
LIG_SH3_3	213	219	PF00018	0.614
LIG_SH3_3	244	250	PF00018	0.667
LIG_SH3_3	265	271	PF00018	0.637
LIG_SH3_3	273	279	PF00018	0.597
LIG_SH3_3	285	291	PF00018	0.787
LIG_SH3_3	295	301	PF00018	0.564
LIG_SH3_3	348	354	PF00018	0.514
LIG_SH3_3	442	448	PF00018	0.506
LIG_SH3_3	490	496	PF00018	0.486
LIG_SH3_3	50	56	PF00018	0.599
LIG_SH3_3	93	99	PF00018	0.495
LIG_SH3_CIN85_PxpxPR_1	284	289	PF14604	0.657
LIG_SUMO_SIM_anti_2	272	278	PF11976	0.582
LIG_SUMO_SIM_par_1	344	350	PF11976	0.615
LIG_SUMO_SIM_par_1	376	381	PF11976	0.429
LIG_SUMO_SIM_par_1	473	478	PF11976	0.379
LIG_TRAF2_1	291	294	PF00917	0.671
LIG_TRAF2_1	561	564	PF00917	0.442
LIG_TRFH_1	144	148	PF08558	0.528
LIG_UBA3_1	273	282	PF00899	0.583
MOD_CK1_1	136	142	PF00069	0.578
MOD_CK1_1	22	28	PF00069	0.436
MOD_CK1_1	4	10	PF00069	0.527
MOD_CK1_1	64	70	PF00069	0.641
MOD_CK2_1	266	272	PF00069	0.620
MOD_CK2_1	333	339	PF00069	0.675
MOD_GlcNHglycan	135	138	PF01048	0.595
MOD_GlcNHglycan	229	232	PF01048	0.623
MOD_GlcNHglycan	236	239	PF01048	0.649
MOD_GlcNHglycan	3	6	PF01048	0.518
MOD_GlcNHglycan	309	312	PF01048	0.683
MOD_GlcNHglycan	429	433	PF01048	0.520
MOD_GlcNHglycan	550	553	PF01048	0.514
MOD_GlcNHglycan	64	67	PF01048	0.682
MOD_GSK3_1	176	183	PF00069	0.579
MOD_GSK3_1	217	224	PF00069	0.623
MOD_GSK3_1	234	241	PF00069	0.595
MOD_GSK3_1	245	252	PF00069	0.698
MOD_GSK3_1	292	299	PF00069	0.791
MOD_GSK3_1	378	385	PF00069	0.459
MOD_GSK3_1	508	515	PF00069	0.477
MOD_LATS_1	18	24	PF00433	0.543
MOD_NEK2_1	1	6	PF00069	0.528
MOD_NEK2_1	234	239	PF00069	0.590
MOD_NEK2_1	245	250	PF00069	0.682
MOD_NEK2_1	333	338	PF00069	0.554
MOD_NEK2_1	382	387	PF00069	0.463
MOD_NEK2_1	506	511	PF00069	0.451
MOD_PIKK_1	99	105	PF00454	0.582
MOD_PKA_1	19	25	PF00069	0.504
MOD_PKA_1	256	262	PF00069	0.620
MOD_PKA_2	117	123	PF00069	0.442
MOD_PKA_2	127	133	PF00069	0.542
MOD_PKA_2	19	25	PF00069	0.471
MOD_PKA_2	217	223	PF00069	0.591
MOD_PKA_2	256	262	PF00069	0.708
MOD_PKA_2	61	67	PF00069	0.617
MOD_PKA_2	99	105	PF00069	0.684
MOD_PKB_1	187	195	PF00069	0.545
MOD_PKB_1	249	257	PF00069	0.630
MOD_PKB_1	426	434	PF00069	0.498
MOD_Plk_1	382	388	PF00069	0.403
MOD_Plk_2-3	433	439	PF00069	0.445
MOD_Plk_4	223	229	PF00069	0.665
MOD_Plk_4	272	278	PF00069	0.611
MOD_Plk_4	373	379	PF00069	0.419
MOD_Plk_4	498	504	PF00069	0.434
MOD_ProDKin_1	162	168	PF00069	0.563
MOD_ProDKin_1	239	245	PF00069	0.787
MOD_ProDKin_1	292	298	PF00069	0.615
MOD_ProDKin_1	92	98	PF00069	0.461
TRG_DiLeu_BaEn_1	329	334	PF01217	0.513
TRG_DiLeu_BaEn_4	564	570	PF01217	0.402
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.458
TRG_ENDOCYTIC_2	108	111	PF00928	0.519
TRG_ENDOCYTIC_2	144	147	PF00928	0.528
TRG_ENDOCYTIC_2	576	579	PF00928	0.363
TRG_ER_diArg_1	185	187	PF00400	0.592
TRG_ER_diArg_1	250	253	PF00400	0.595
TRG_ER_diArg_1	255	257	PF00400	0.599
TRG_ER_diArg_1	364	366	PF00400	0.449
TRG_ER_diArg_1	419	422	PF00400	0.639
TRG_ER_diArg_1	425	428	PF00400	0.585
TRG_ER_diArg_1	535	537	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I943	Leptomonas seymouri	49%	97%
A4HTG4	Leishmania infantum	99%	100%
E9AM92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%