Zinc finger motif, C2HC5-type/ASCH domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative zinc finger motif, C2HC5-type/ASCH domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H626_LEIDO

TriTrypDb:

LdBPK_080070.1 , LdCL_080005600 , LDHU3_08.0090

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S5H626

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H626

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	1
GO:0003713	transcription coactivator activity	3	1
GO:0140110	transcription regulator activity	1	1
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.640
CLV_NRD_NRD_1	222	224	PF00675	0.452
CLV_NRD_NRD_1	260	262	PF00675	0.553
CLV_NRD_NRD_1	301	303	PF00675	0.722
CLV_NRD_NRD_1	397	399	PF00675	0.610
CLV_NRD_NRD_1	404	406	PF00675	0.523
CLV_NRD_NRD_1	621	623	PF00675	0.335
CLV_NRD_NRD_1	82	84	PF00675	0.430
CLV_PCSK_FUR_1	126	130	PF00082	0.728
CLV_PCSK_FUR_1	233	237	PF00082	0.482
CLV_PCSK_KEX2_1	118	120	PF00082	0.618
CLV_PCSK_KEX2_1	125	127	PF00082	0.593
CLV_PCSK_KEX2_1	128	130	PF00082	0.599
CLV_PCSK_KEX2_1	222	224	PF00082	0.410
CLV_PCSK_KEX2_1	235	237	PF00082	0.476
CLV_PCSK_KEX2_1	260	262	PF00082	0.560
CLV_PCSK_KEX2_1	366	368	PF00082	0.678
CLV_PCSK_KEX2_1	397	399	PF00082	0.624
CLV_PCSK_KEX2_1	4	6	PF00082	0.638
CLV_PCSK_KEX2_1	404	406	PF00082	0.535
CLV_PCSK_KEX2_1	505	507	PF00082	0.411
CLV_PCSK_KEX2_1	81	83	PF00082	0.424
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.646
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.615
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.620
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.501
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.695
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.638
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.411
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.433
CLV_PCSK_PC7_1	393	399	PF00082	0.605
CLV_PCSK_SKI1_1	556	560	PF00082	0.439
CLV_PCSK_SKI1_1	596	600	PF00082	0.398
DEG_APCC_DBOX_1	621	629	PF00400	0.368
DEG_APCC_KENBOX_2	302	306	PF00400	0.726
DEG_SPOP_SBC_1	98	102	PF00917	0.566
DOC_CYCLIN_yCln2_LP_2	598	604	PF00134	0.337
DOC_MAPK_DCC_7	596	604	PF00069	0.337
DOC_MAPK_gen_1	427	435	PF00069	0.558
DOC_MAPK_MEF2A_6	371	380	PF00069	0.566
DOC_PP1_RVXF_1	594	601	PF00149	0.430
DOC_PP2B_LxvP_1	378	381	PF13499	0.571
DOC_PP2B_LxvP_1	96	99	PF13499	0.538
DOC_PP4_FxxP_1	542	545	PF00568	0.281
DOC_PP4_FxxP_1	600	603	PF00568	0.360
DOC_SPAK_OSR1_1	474	478	PF12202	0.438
DOC_USP7_MATH_1	137	141	PF00917	0.622
DOC_USP7_MATH_1	263	267	PF00917	0.598
DOC_USP7_MATH_1	339	343	PF00917	0.629
DOC_USP7_MATH_1	389	393	PF00917	0.738
DOC_USP7_MATH_1	455	459	PF00917	0.730
DOC_USP7_MATH_1	470	474	PF00917	0.599
DOC_USP7_MATH_1	476	480	PF00917	0.524
DOC_USP7_MATH_1	495	499	PF00917	0.251
DOC_USP7_MATH_1	524	528	PF00917	0.366
DOC_USP7_MATH_1	60	64	PF00917	0.417
DOC_USP7_MATH_1	7	11	PF00917	0.560
DOC_USP7_MATH_1	99	103	PF00917	0.556
DOC_USP7_UBL2_3	427	431	PF12436	0.469
DOC_WW_Pin1_4	246	251	PF00397	0.519
DOC_WW_Pin1_4	253	258	PF00397	0.494
DOC_WW_Pin1_4	347	352	PF00397	0.720
DOC_WW_Pin1_4	457	462	PF00397	0.659
DOC_WW_Pin1_4	583	588	PF00397	0.355
LIG_14-3-3_CanoR_1	236	240	PF00244	0.630
LIG_14-3-3_CanoR_1	405	411	PF00244	0.649
LIG_14-3-3_CanoR_1	482	490	PF00244	0.481
LIG_APCC_ABBA_1	415	420	PF00400	0.575
LIG_BH_BH3_1	18	34	PF00452	0.430
LIG_BRCT_BRCA1_1	71	75	PF00533	0.467
LIG_Clathr_ClatBox_1	610	614	PF01394	0.346
LIG_EH1_1	474	482	PF00400	0.439
LIG_eIF4E_1	20	26	PF01652	0.443
LIG_eIF4E_1	553	559	PF01652	0.266
LIG_FHA_1	111	117	PF00498	0.707
LIG_FHA_1	20	26	PF00498	0.536
LIG_FHA_1	215	221	PF00498	0.462
LIG_FHA_1	235	241	PF00498	0.401
LIG_FHA_1	553	559	PF00498	0.266
LIG_FHA_1	563	569	PF00498	0.266
LIG_FHA_1	66	72	PF00498	0.404
LIG_FHA_2	236	242	PF00498	0.607
LIG_FHA_2	333	339	PF00498	0.635
LIG_FHA_2	352	358	PF00498	0.746
LIG_FHA_2	56	62	PF00498	0.498
LIG_LIR_Apic_2	252	257	PF02991	0.502
LIG_LIR_Apic_2	540	545	PF02991	0.360
LIG_LIR_Gen_1	536	545	PF02991	0.281
LIG_LIR_Gen_1	585	595	PF02991	0.344
LIG_LIR_Nem_3	536	542	PF02991	0.266
LIG_LIR_Nem_3	585	591	PF02991	0.336
LIG_MAD2	331	339	PF02301	0.577
LIG_Pex14_1	512	516	PF04695	0.266
LIG_SH2_CRK	588	592	PF00017	0.452
LIG_SH2_NCK_1	20	24	PF00017	0.462
LIG_SH2_NCK_1	573	577	PF00017	0.276
LIG_SH2_PTP2	561	564	PF00017	0.266
LIG_SH2_SRC	195	198	PF00017	0.593
LIG_SH2_SRC	561	564	PF00017	0.295
LIG_SH2_SRC	573	576	PF00017	0.295
LIG_SH2_STAP1	195	199	PF00017	0.452
LIG_SH2_STAP1	20	24	PF00017	0.462
LIG_SH2_STAP1	216	220	PF00017	0.416
LIG_SH2_STAP1	539	543	PF00017	0.300
LIG_SH2_STAP1	573	577	PF00017	0.387
LIG_SH2_STAT5	20	23	PF00017	0.480
LIG_SH2_STAT5	216	219	PF00017	0.465
LIG_SH2_STAT5	410	413	PF00017	0.564
LIG_SH2_STAT5	561	564	PF00017	0.266
LIG_SH3_3	466	472	PF00018	0.612
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.663
LIG_SUMO_SIM_par_1	430	436	PF11976	0.453
LIG_SUMO_SIM_par_1	67	73	PF11976	0.430
LIG_TRAF2_1	198	201	PF00917	0.582
LIG_TRAF2_1	256	259	PF00917	0.570
LIG_TRAF2_1	381	384	PF00917	0.722
LIG_TRAF2_1	42	45	PF00917	0.576
LIG_TYR_ITIM	559	564	PF00017	0.266
MOD_CDK_SPxxK_3	253	260	PF00069	0.467
MOD_CK1_1	100	106	PF00069	0.673
MOD_CK1_1	249	255	PF00069	0.614
MOD_CK1_1	358	364	PF00069	0.699
MOD_CK1_1	392	398	PF00069	0.729
MOD_CK1_1	586	592	PF00069	0.354
MOD_CK2_1	195	201	PF00069	0.607
MOD_CK2_1	215	221	PF00069	0.320
MOD_CK2_1	253	259	PF00069	0.464
MOD_CK2_1	263	269	PF00069	0.488
MOD_CK2_1	332	338	PF00069	0.645
MOD_CK2_1	351	357	PF00069	0.738
MOD_CK2_1	39	45	PF00069	0.550
MOD_CK2_1	406	412	PF00069	0.638
MOD_CK2_1	55	61	PF00069	0.335
MOD_Cter_Amidation	126	129	PF01082	0.690
MOD_Cter_Amidation	361	364	PF01082	0.642
MOD_GlcNHglycan	104	107	PF01048	0.456
MOD_GlcNHglycan	139	142	PF01048	0.596
MOD_GlcNHglycan	14	17	PF01048	0.589
MOD_GlcNHglycan	217	220	PF01048	0.637
MOD_GlcNHglycan	241	246	PF01048	0.578
MOD_GlcNHglycan	251	254	PF01048	0.572
MOD_GlcNHglycan	264	268	PF01048	0.587
MOD_GlcNHglycan	304	308	PF01048	0.705
MOD_GlcNHglycan	357	360	PF01048	0.642
MOD_GlcNHglycan	465	469	PF01048	0.656
MOD_GlcNHglycan	84	88	PF01048	0.557
MOD_GSK3_1	110	117	PF00069	0.698
MOD_GSK3_1	249	256	PF00069	0.590
MOD_GSK3_1	263	270	PF00069	0.480
MOD_GSK3_1	347	354	PF00069	0.582
MOD_GSK3_1	384	391	PF00069	0.703
MOD_GSK3_1	65	72	PF00069	0.588
MOD_GSK3_1	98	105	PF00069	0.572
MOD_N-GLC_1	114	119	PF02516	0.654
MOD_N-GLC_2	36	38	PF02516	0.578
MOD_NEK2_1	114	119	PF00069	0.632
MOD_NEK2_1	162	167	PF00069	0.470
MOD_NEK2_1	475	480	PF00069	0.493
MOD_NEK2_2	155	160	PF00069	0.497
MOD_PIKK_1	291	297	PF00454	0.589
MOD_PIKK_1	392	398	PF00454	0.778
MOD_PIKK_1	433	439	PF00454	0.551
MOD_PIKK_1	524	530	PF00454	0.335
MOD_PIKK_1	7	13	PF00454	0.757
MOD_PKA_1	235	241	PF00069	0.629
MOD_PKA_2	162	168	PF00069	0.540
MOD_PKA_2	235	241	PF00069	0.629
MOD_PKA_2	392	398	PF00069	0.746
MOD_PKA_2	481	487	PF00069	0.488
MOD_PKA_2	7	13	PF00069	0.470
MOD_Plk_1	195	201	PF00069	0.581
MOD_Plk_4	235	241	PF00069	0.629
MOD_Plk_4	243	249	PF00069	0.627
MOD_Plk_4	339	345	PF00069	0.575
MOD_Plk_4	406	412	PF00069	0.504
MOD_Plk_4	476	482	PF00069	0.589
MOD_Plk_4	495	501	PF00069	0.171
MOD_Plk_4	586	592	PF00069	0.465
MOD_Plk_4	65	71	PF00069	0.397
MOD_Plk_4	91	97	PF00069	0.537
MOD_ProDKin_1	246	252	PF00069	0.509
MOD_ProDKin_1	253	259	PF00069	0.493
MOD_ProDKin_1	347	353	PF00069	0.718
MOD_ProDKin_1	457	463	PF00069	0.658
MOD_ProDKin_1	583	589	PF00069	0.347
MOD_SUMO_for_1	577	580	PF00179	0.287
MOD_SUMO_rev_2	196	205	PF00179	0.538
MOD_SUMO_rev_2	589	598	PF00179	0.457
TRG_DiLeu_BaEn_1	594	599	PF01217	0.427
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.482
TRG_ENDOCYTIC_2	539	542	PF00928	0.266
TRG_ENDOCYTIC_2	561	564	PF00928	0.266
TRG_ENDOCYTIC_2	588	591	PF00928	0.433
TRG_ER_diArg_1	397	399	PF00400	0.611
TRG_ER_diArg_1	404	406	PF00400	0.524
TRG_ER_diArg_1	516	519	PF00400	0.281
TRG_ER_FFAT_2	213	221	PF00635	0.446
TRG_NLS_MonoExtC_3	124	129	PF00514	0.724
TRG_NLS_MonoExtC_3	362	367	PF00514	0.481
TRG_NLS_MonoExtN_4	360	367	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGL1	Leptomonas seymouri	69%	100%
A0A0S4IUQ4	Bodo saltans	38%	98%
A0A1X0NNW7	Trypanosomatidae	43%	98%
A0A3S5IQP6	Trypanosoma rangeli	49%	100%
A4H574	Leishmania braziliensis	79%	100%
A4HTF7	Leishmania infantum	100%	100%
C9ZPN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AM85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIG2	Leishmania major	93%	100%
V5BH64	Trypanosoma cruzi	47%	100%