Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H624_LEIDO

TriTrypDb:

LdBPK_080020.1 , LdCL_080005100 , LDHU3_08.0030

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H624

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H624

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.629
CLV_PCSK_KEX2_1	240	242	PF00082	0.502
CLV_PCSK_KEX2_1	25	27	PF00082	0.597
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.502
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.615
DOC_MAPK_DCC_7	39	47	PF00069	0.673
DOC_MAPK_MEF2A_6	160	167	PF00069	0.558
DOC_MAPK_MEF2A_6	39	47	PF00069	0.686
DOC_PP2B_LxvP_1	181	184	PF13499	0.542
DOC_PP2B_LxvP_1	20	23	PF13499	0.717
DOC_PP2B_PxIxI_1	162	168	PF00149	0.552
DOC_PP4_FxxP_1	124	127	PF00568	0.621
DOC_PP4_FxxP_1	82	85	PF00568	0.550
DOC_WW_Pin1_4	147	152	PF00397	0.610
DOC_WW_Pin1_4	195	200	PF00397	0.650
LIG_14-3-3_CanoR_1	172	177	PF00244	0.534
LIG_14-3-3_CanoR_1	70	79	PF00244	0.664
LIG_APCC_ABBA_1	95	100	PF00400	0.649
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_2	35	39	PF00653	0.572
LIG_BIR_III_4	66	70	PF00653	0.680
LIG_BRCT_BRCA1_1	1	5	PF00533	0.645
LIG_BRCT_BRCA1_1	72	76	PF00533	0.720
LIG_EVH1_1	181	185	PF00568	0.621
LIG_EVH1_2	184	188	PF00568	0.622
LIG_FHA_1	104	110	PF00498	0.678
LIG_FHA_1	171	177	PF00498	0.523
LIG_FHA_1	53	59	PF00498	0.641
LIG_FHA_1	92	98	PF00498	0.621
LIG_FHA_2	257	263	PF00498	0.552
LIG_LIR_Apic_2	266	272	PF02991	0.500
LIG_LIR_Nem_3	187	191	PF02991	0.553
LIG_LIR_Nem_3	2	8	PF02991	0.704
LIG_LIR_Nem_3	73	79	PF02991	0.475
LIG_LYPXL_yS_3	162	165	PF13949	0.623
LIG_MLH1_MIPbox_1	1	5	PF16413	0.645
LIG_PTB_Apo_2	201	208	PF02174	0.531
LIG_SH2_CRK	269	273	PF00017	0.535
LIG_SH2_CRK	83	87	PF00017	0.673
LIG_SH2_STAP1	32	36	PF00017	0.753
LIG_SH2_STAT3	205	208	PF00017	0.499
LIG_SH2_STAT5	209	212	PF00017	0.575
LIG_SH2_STAT5	252	255	PF00017	0.564
LIG_SH3_3	176	182	PF00018	0.571
LIG_SUMO_SIM_anti_2	175	180	PF11976	0.607
MOD_CK1_1	198	204	PF00069	0.600
MOD_CK2_1	101	107	PF00069	0.629
MOD_CK2_1	256	262	PF00069	0.592
MOD_GlcNHglycan	226	229	PF01048	0.561
MOD_GlcNHglycan	72	75	PF01048	0.640
MOD_GlcNHglycan	91	94	PF01048	0.602
MOD_GSK3_1	166	173	PF00069	0.545
MOD_GSK3_1	194	201	PF00069	0.664
MOD_GSK3_1	52	59	PF00069	0.610
MOD_GSK3_1	89	96	PF00069	0.605
MOD_GSK3_1	99	106	PF00069	0.554
MOD_LATS_1	68	74	PF00433	0.597
MOD_N-GLC_1	100	105	PF02516	0.484
MOD_N-GLC_1	262	267	PF02516	0.553
MOD_N-GLC_1	52	57	PF02516	0.716
MOD_NEK2_1	99	104	PF00069	0.667
MOD_NEK2_2	93	98	PF00069	0.641
MOD_PIKK_1	166	172	PF00454	0.632
MOD_PK_1	172	178	PF00069	0.552
MOD_Plk_1	100	106	PF00069	0.585
MOD_Plk_1	152	158	PF00069	0.605
MOD_Plk_1	52	58	PF00069	0.679
MOD_Plk_4	174	180	PF00069	0.524
MOD_Plk_4	53	59	PF00069	0.591
MOD_ProDKin_1	147	153	PF00069	0.604
MOD_ProDKin_1	195	201	PF00069	0.641
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.684
TRG_ENDOCYTIC_2	162	165	PF00928	0.623
TRG_ENDOCYTIC_2	83	86	PF00928	0.679
TRG_ER_diArg_1	23	26	PF00400	0.657
TRG_NLS_MonoExtC_3	23	28	PF00514	0.685
TRG_NLS_MonoExtN_4	23	28	PF00514	0.683
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE07	Leptomonas seymouri	59%	98%
A0A1X0NNW9	Trypanosomatidae	27%	100%
A0A422N819	Trypanosoma rangeli	33%	100%
A4H569	Leishmania braziliensis	72%	100%
A4HTF2	Leishmania infantum	99%	100%
C9ZPM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AM80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIG7	Leishmania major	89%	100%
V5BLP6	Trypanosoma cruzi	33%	100%