LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H622_LEIDO
TriTrypDb:
LdBPK_071310.1 , LdCL_070018100 , LDHU3_07.1550
Length:
576

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial outer membrane GTPases.. The lone C-terminal TM segment has a high positive charge at both ends, characteristic of mitochondrial outer membrane anchored proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1
GO:0005856 cytoskeleton 5 1
GO:0005886 plasma membrane 3 1
GO:0005938 cell cortex 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A0A3S5H622
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H622

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007015 actin filament organization 5 1
GO:0007163 establishment or maintenance of cell polarity 2 1
GO:0008360 regulation of cell shape 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022603 regulation of anatomical structure morphogenesis 4 1
GO:0022604 regulation of cell morphogenesis 5 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0050789 regulation of biological process 2 1
GO:0050793 regulation of developmental process 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0003924 GTPase activity 7 1
GO:0005488 binding 1 4
GO:0005515 protein binding 2 1
GO:0005525 GTP binding 5 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1
GO:0019001 guanyl nucleotide binding 5 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032561 guanyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 4
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1
GO:0005509 calcium ion binding 5 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 457 461 PF00656 0.437
CLV_C14_Caspase3-7 472 476 PF00656 0.339
CLV_C14_Caspase3-7 93 97 PF00656 0.398
CLV_NRD_NRD_1 163 165 PF00675 0.585
CLV_NRD_NRD_1 309 311 PF00675 0.568
CLV_NRD_NRD_1 332 334 PF00675 0.574
CLV_NRD_NRD_1 361 363 PF00675 0.524
CLV_NRD_NRD_1 548 550 PF00675 0.461
CLV_NRD_NRD_1 572 574 PF00675 0.375
CLV_PCSK_KEX2_1 265 267 PF00082 0.506
CLV_PCSK_KEX2_1 309 311 PF00082 0.530
CLV_PCSK_KEX2_1 332 334 PF00082 0.574
CLV_PCSK_KEX2_1 361 363 PF00082 0.524
CLV_PCSK_KEX2_1 51 53 PF00082 0.573
CLV_PCSK_KEX2_1 548 550 PF00082 0.461
CLV_PCSK_KEX2_1 572 574 PF00082 0.436
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.572
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.611
CLV_PCSK_SKI1_1 112 116 PF00082 0.568
CLV_PCSK_SKI1_1 137 141 PF00082 0.526
CLV_PCSK_SKI1_1 51 55 PF00082 0.597
CLV_PCSK_SKI1_1 548 552 PF00082 0.527
CLV_PCSK_SKI1_1 78 82 PF00082 0.564
DEG_MDM2_SWIB_1 181 189 PF02201 0.392
DEG_SPOP_SBC_1 387 391 PF00917 0.310
DEG_SPOP_SBC_1 506 510 PF00917 0.424
DOC_CDC14_PxL_1 154 162 PF14671 0.365
DOC_MAPK_gen_1 110 118 PF00069 0.376
DOC_MAPK_gen_1 48 56 PF00069 0.392
DOC_MAPK_gen_1 545 555 PF00069 0.261
DOC_MAPK_MEF2A_6 110 118 PF00069 0.327
DOC_PP2B_LxvP_1 118 121 PF13499 0.316
DOC_PP2B_LxvP_1 155 158 PF13499 0.391
DOC_PP2B_LxvP_1 502 505 PF13499 0.320
DOC_PP2B_LxvP_1 81 84 PF13499 0.371
DOC_USP7_MATH_1 281 285 PF00917 0.349
DOC_USP7_MATH_1 513 517 PF00917 0.431
DOC_USP7_MATH_1 527 531 PF00917 0.340
DOC_USP7_MATH_1 70 74 PF00917 0.383
DOC_USP7_MATH_1 86 90 PF00917 0.271
DOC_WW_Pin1_4 130 135 PF00397 0.361
DOC_WW_Pin1_4 274 279 PF00397 0.296
DOC_WW_Pin1_4 65 70 PF00397 0.309
LIG_14-3-3_CanoR_1 244 250 PF00244 0.338
LIG_14-3-3_CanoR_1 361 365 PF00244 0.316
LIG_14-3-3_CanoR_1 37 46 PF00244 0.380
LIG_14-3-3_CanoR_1 388 393 PF00244 0.339
LIG_14-3-3_CanoR_1 548 553 PF00244 0.340
LIG_14-3-3_CanoR_1 562 568 PF00244 0.425
LIG_APCC_ABBA_1 201 206 PF00400 0.392
LIG_BIR_II_1 1 5 PF00653 0.395
LIG_BIR_III_4 150 154 PF00653 0.378
LIG_BRCT_BRCA1_1 326 330 PF00533 0.304
LIG_BRCT_BRCA1_1 34 38 PF00533 0.413
LIG_BRCT_BRCA1_1 372 376 PF00533 0.419
LIG_BRCT_BRCA1_1 96 100 PF00533 0.338
LIG_CSL_BTD_1 502 505 PF09270 0.320
LIG_DLG_GKlike_1 95 103 PF00625 0.258
LIG_FHA_1 101 107 PF00498 0.407
LIG_FHA_1 113 119 PF00498 0.384
LIG_FHA_1 268 274 PF00498 0.421
LIG_FHA_1 294 300 PF00498 0.307
LIG_FHA_1 346 352 PF00498 0.296
LIG_FHA_1 39 45 PF00498 0.366
LIG_FHA_1 427 433 PF00498 0.383
LIG_FHA_2 438 444 PF00498 0.390
LIG_FHA_2 470 476 PF00498 0.316
LIG_FHA_2 506 512 PF00498 0.360
LIG_LIR_Gen_1 215 225 PF02991 0.390
LIG_LIR_Gen_1 451 461 PF02991 0.344
LIG_LIR_Gen_1 542 550 PF02991 0.468
LIG_LIR_Gen_1 551 560 PF02991 0.347
LIG_LIR_Nem_3 141 147 PF02991 0.375
LIG_LIR_Nem_3 215 220 PF02991 0.378
LIG_LIR_Nem_3 233 237 PF02991 0.199
LIG_LIR_Nem_3 296 301 PF02991 0.275
LIG_LIR_Nem_3 451 456 PF02991 0.390
LIG_LIR_Nem_3 542 546 PF02991 0.449
LIG_LIR_Nem_3 551 555 PF02991 0.291
LIG_MAD2 112 120 PF02301 0.391
LIG_MLH1_MIPbox_1 96 100 PF16413 0.338
LIG_NRBOX 4 10 PF00104 0.327
LIG_NRP_CendR_1 573 576 PF00754 0.465
LIG_Pex14_1 32 36 PF04695 0.334
LIG_Pex14_2 140 144 PF04695 0.325
LIG_Pex14_2 181 185 PF04695 0.391
LIG_Pex14_2 298 302 PF04695 0.285
LIG_REV1ctd_RIR_1 390 400 PF16727 0.399
LIG_SH2_CRK 304 308 PF00017 0.307
LIG_SH2_CRK 338 342 PF00017 0.419
LIG_SH2_NCK_1 409 413 PF00017 0.289
LIG_SH2_NCK_1 526 530 PF00017 0.407
LIG_SH2_PTP2 543 546 PF00017 0.492
LIG_SH2_STAP1 212 216 PF00017 0.400
LIG_SH2_STAP1 316 320 PF00017 0.275
LIG_SH2_STAP1 448 452 PF00017 0.418
LIG_SH2_STAP1 75 79 PF00017 0.417
LIG_SH2_STAT5 212 215 PF00017 0.379
LIG_SH2_STAT5 249 252 PF00017 0.289
LIG_SH2_STAT5 328 331 PF00017 0.387
LIG_SH2_STAT5 386 389 PF00017 0.317
LIG_SH2_STAT5 543 546 PF00017 0.504
LIG_SH3_3 275 281 PF00018 0.301
LIG_SH3_3 533 539 PF00018 0.362
LIG_SUMO_SIM_anti_2 429 434 PF11976 0.284
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.425
LIG_SUMO_SIM_par_1 6 13 PF11976 0.364
LIG_SUMO_SIM_par_1 79 85 PF11976 0.313
LIG_TRAF2_1 105 108 PF00917 0.416
LIG_TRAF2_1 173 176 PF00917 0.461
LIG_TYR_ITIM 541 546 PF00017 0.495
LIG_UBA3_1 420 428 PF00899 0.261
MOD_CDK_SPxxK_3 130 137 PF00069 0.402
MOD_CDK_SPxxK_3 65 72 PF00069 0.382
MOD_CK1_1 379 385 PF00069 0.439
MOD_CK1_1 39 45 PF00069 0.353
MOD_CK1_1 410 416 PF00069 0.409
MOD_CK1_1 68 74 PF00069 0.321
MOD_CK2_1 170 176 PF00069 0.446
MOD_CK2_1 368 374 PF00069 0.364
MOD_CK2_1 419 425 PF00069 0.363
MOD_CK2_1 448 454 PF00069 0.366
MOD_CK2_1 505 511 PF00069 0.348
MOD_CK2_1 517 523 PF00069 0.356
MOD_CK2_1 86 92 PF00069 0.345
MOD_Cter_Amidation 359 362 PF01082 0.503
MOD_GlcNHglycan 1 4 PF01048 0.659
MOD_GlcNHglycan 172 175 PF01048 0.575
MOD_GlcNHglycan 370 373 PF01048 0.699
MOD_GlcNHglycan 41 44 PF01048 0.516
MOD_GlcNHglycan 412 415 PF01048 0.600
MOD_GlcNHglycan 443 447 PF01048 0.584
MOD_GlcNHglycan 456 459 PF01048 0.598
MOD_GSK3_1 216 223 PF00069 0.284
MOD_GSK3_1 245 252 PF00069 0.368
MOD_GSK3_1 32 39 PF00069 0.352
MOD_GSK3_1 324 331 PF00069 0.373
MOD_GSK3_1 341 348 PF00069 0.371
MOD_GSK3_1 366 373 PF00069 0.359
MOD_GSK3_1 376 383 PF00069 0.488
MOD_GSK3_1 388 395 PF00069 0.359
MOD_GSK3_1 403 410 PF00069 0.338
MOD_GSK3_1 513 520 PF00069 0.418
MOD_N-GLC_1 32 37 PF02516 0.626
MOD_NEK2_1 1 6 PF00069 0.396
MOD_NEK2_1 100 105 PF00069 0.378
MOD_NEK2_1 21 26 PF00069 0.194
MOD_NEK2_1 220 225 PF00069 0.304
MOD_NEK2_1 368 373 PF00069 0.374
MOD_NEK2_1 38 43 PF00069 0.231
MOD_NEK2_1 392 397 PF00069 0.426
MOD_NEK2_1 407 412 PF00069 0.398
MOD_NEK2_1 424 429 PF00069 0.373
MOD_NEK2_1 94 99 PF00069 0.383
MOD_NEK2_2 216 221 PF00069 0.364
MOD_NEK2_2 448 453 PF00069 0.407
MOD_PKA_1 548 554 PF00069 0.340
MOD_PKA_2 243 249 PF00069 0.306
MOD_PKA_2 36 42 PF00069 0.255
MOD_PKA_2 360 366 PF00069 0.314
MOD_PKA_2 387 393 PF00069 0.335
MOD_PKA_2 548 554 PF00069 0.340
MOD_PKA_2 94 100 PF00069 0.337
MOD_Plk_1 32 38 PF00069 0.408
MOD_Plk_1 324 330 PF00069 0.340
MOD_Plk_1 95 101 PF00069 0.257
MOD_Plk_2-3 517 523 PF00069 0.436
MOD_Plk_4 230 236 PF00069 0.349
MOD_Plk_4 245 251 PF00069 0.212
MOD_Plk_4 382 388 PF00069 0.394
MOD_Plk_4 403 409 PF00069 0.353
MOD_Plk_4 448 454 PF00069 0.402
MOD_Plk_4 539 545 PF00069 0.468
MOD_Plk_4 548 554 PF00069 0.262
MOD_Plk_4 563 569 PF00069 0.329
MOD_Plk_4 95 101 PF00069 0.328
MOD_ProDKin_1 130 136 PF00069 0.356
MOD_ProDKin_1 274 280 PF00069 0.294
MOD_ProDKin_1 65 71 PF00069 0.311
MOD_SUMO_rev_2 107 111 PF00179 0.414
MOD_SUMO_rev_2 483 488 PF00179 0.321
TRG_DiLeu_BaEn_1 403 408 PF01217 0.386
TRG_DiLeu_BaEn_2 462 468 PF01217 0.388
TRG_DiLeu_BaLyEn_6 49 54 PF01217 0.329
TRG_ENDOCYTIC_2 304 307 PF00928 0.284
TRG_ENDOCYTIC_2 543 546 PF00928 0.492
TRG_ER_diArg_1 308 310 PF00400 0.368
TRG_ER_diArg_1 547 549 PF00400 0.382
TRG_ER_diArg_1 571 573 PF00400 0.630
TRG_NES_CRM1_1 425 438 PF08389 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCT6 Leptomonas seymouri 69% 100%
A0A1X0NPJ9 Trypanosomatidae 46% 100%
A0A3R7KVN9 Trypanosoma rangeli 47% 100%
A4H562 Leishmania braziliensis 85% 100%
A4HTD9 Leishmania infantum 100% 100%
C9ZUH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9ALD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q2HJF8 Bos taurus 22% 91%
Q2UM43 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 24% 91%
Q4QIH3 Leishmania major 93% 100%
Q4WN24 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 91%
Q5B5L3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 91%
Q5ZM73 Gallus gallus 22% 93%
Q8IXI1 Homo sapiens 23% 93%
Q8RXF8 Arabidopsis thaliana 22% 89%
V5BTM0 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS