ATP_synthase_subunit_C_putative/Pfam:PF00137

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase subunit 9, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H621_LEIDO

TriTrypDb:

LdBPK_240640.1 , LdCL_070017800 , LdCL_210013100 , LDHU3_07.1510 , LDHU3_21.0920

Length:

106

Annotations

LeishMANIAdb annotations

Hyperconserved component of the mitochondrial FoF1 synthase complex. Likely contains a transit signal as well.. Interestingly, this gene duplicated in parazitic kinetoplastids multiple times.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0032991	protein-containing complex	1	26
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain	3	26
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	4	26
GO:0098796	membrane protein complex	2	26
GO:0110165	cellular anatomical entity	1	26
GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	4	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S5H621

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H621

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	26
GO:0006163	purine nucleotide metabolic process	5	26
GO:0006164	purine nucleotide biosynthetic process	6	26
GO:0006725	cellular aromatic compound metabolic process	3	26
GO:0006753	nucleoside phosphate metabolic process	4	26
GO:0006754	ATP biosynthetic process	8	26
GO:0006793	phosphorus metabolic process	3	26
GO:0006796	phosphate-containing compound metabolic process	4	26
GO:0006807	nitrogen compound metabolic process	2	26
GO:0008152	metabolic process	1	26
GO:0009058	biosynthetic process	2	26
GO:0009117	nucleotide metabolic process	5	26
GO:0009141	nucleoside triphosphate metabolic process	5	26
GO:0009142	nucleoside triphosphate biosynthetic process	6	26
GO:0009144	purine nucleoside triphosphate metabolic process	6	26
GO:0009145	purine nucleoside triphosphate biosynthetic process	7	26
GO:0009150	purine ribonucleotide metabolic process	6	26
GO:0009152	purine ribonucleotide biosynthetic process	7	26
GO:0009165	nucleotide biosynthetic process	6	26
GO:0009199	ribonucleoside triphosphate metabolic process	6	26
GO:0009201	ribonucleoside triphosphate biosynthetic process	7	26
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	26
GO:0009206	purine ribonucleoside triphosphate biosynthetic process	8	26
GO:0009259	ribonucleotide metabolic process	5	26
GO:0009260	ribonucleotide biosynthetic process	6	26
GO:0009987	cellular process	1	26
GO:0015986	proton motive force-driven ATP synthesis	9	26
GO:0018130	heterocycle biosynthetic process	4	26
GO:0019438	aromatic compound biosynthetic process	4	26
GO:0019637	organophosphate metabolic process	3	26
GO:0019693	ribose phosphate metabolic process	4	26
GO:0034641	cellular nitrogen compound metabolic process	3	26
GO:0034654	nucleobase-containing compound biosynthetic process	4	26
GO:0044237	cellular metabolic process	2	26
GO:0044238	primary metabolic process	2	26
GO:0044249	cellular biosynthetic process	3	26
GO:0044271	cellular nitrogen compound biosynthetic process	4	26
GO:0044281	small molecule metabolic process	2	26
GO:0046034	ATP metabolic process	7	26
GO:0046390	ribose phosphate biosynthetic process	5	26
GO:0046483	heterocycle metabolic process	3	26
GO:0055086	nucleobase-containing small molecule metabolic process	3	26
GO:0071704	organic substance metabolic process	2	26
GO:0072521	purine-containing compound metabolic process	4	26
GO:0072522	purine-containing compound biosynthetic process	5	26
GO:0090407	organophosphate biosynthetic process	4	26
GO:1901135	carbohydrate derivative metabolic process	3	26
GO:1901137	carbohydrate derivative biosynthetic process	4	26
GO:1901293	nucleoside phosphate biosynthetic process	5	26
GO:1901360	organic cyclic compound metabolic process	3	26
GO:1901362	organic cyclic compound biosynthetic process	4	26
GO:1901564	organonitrogen compound metabolic process	3	26
GO:1901566	organonitrogen compound biosynthetic process	4	26
GO:1901576	organic substance biosynthetic process	3	26

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	26
GO:0005488	binding	1	26
GO:0008289	lipid binding	2	26
GO:0008324	monoatomic cation transmembrane transporter activity	4	26
GO:0015075	monoatomic ion transmembrane transporter activity	3	26
GO:0015078	proton transmembrane transporter activity	5	26
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	26
GO:0022857	transmembrane transporter activity	2	26
GO:0022890	inorganic cation transmembrane transporter activity	4	26
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.581
CLV_NRD_NRD_1	3	5	PF00675	0.578
CLV_PCSK_KEX2_1	12	14	PF00082	0.581
CLV_PCSK_KEX2_1	3	5	PF00082	0.578
CLV_PCSK_SKI1_1	76	80	PF00082	0.232
DOC_CYCLIN_yClb5_NLxxxL_5	70	78	PF00134	0.432
DOC_MAPK_MEF2A_6	26	35	PF00069	0.349
DOC_USP7_MATH_1	15	19	PF00917	0.443
LIG_14-3-3_CanoR_1	26	32	PF00244	0.356
LIG_FHA_1	28	34	PF00498	0.366
LIG_FHA_1	73	79	PF00498	0.432
LIG_FHA_1	87	93	PF00498	0.282
LIG_LIR_LC3C_4	18	23	PF02991	0.420
LIG_PCNA_yPIPBox_3	70	78	PF02747	0.432
LIG_Pex14_2	101	105	PF04695	0.237
LIG_SH2_CRK	81	85	PF00017	0.432
LIG_SH2_STAT5	40	43	PF00017	0.280
LIG_SH3_3	19	25	PF00018	0.414
LIG_SUMO_SIM_par_1	29	34	PF11976	0.342
MOD_GlcNHglycan	18	21	PF01048	0.584
MOD_GSK3_1	27	34	PF00069	0.361
MOD_N-GLC_1	72	77	PF02516	0.232
TRG_ENDOCYTIC_2	81	84	PF00928	0.432
TRG_ER_diArg_1	2	4	PF00400	0.380
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC53	Leptomonas seymouri	91%	100%
A0A0N1PD25	Leptomonas seymouri	91%	100%
A0A0S4JH41	Bodo saltans	75%	100%
A0A0S4JIC3	Bodo saltans	80%	100%
A0A1X0NII7	Trypanosomatidae	81%	97%
A0A1X0NQ50	Trypanosomatidae	82%	99%
A0A1X0NXV8	Trypanosomatidae	80%	100%
A0A381MIF8	Leishmania infantum	99%	100%
A0A3R7KS23	Trypanosoma rangeli	81%	99%
A0A3R7NDI3	Trypanosoma rangeli	83%	99%
A0A3S7WZM0	Leishmania donovani	99%	100%
A0A422NA05	Trypanosoma rangeli	80%	100%
A0A422NVI6	Trypanosoma rangeli	82%	97%
A1XQS5	Sus scrofa	47%	78%
A4HBS1	Leishmania braziliensis	89%	100%
A4HEQ2	Leishmania braziliensis	89%	100%
A4HZ75	Leishmania infantum	99%	100%
A8EX89	Rickettsia canadensis (strain McKiel)	41%	100%
B3CLG2	Wolbachia pipientis subsp. Culex pipiens (strain wPip)	36%	100%
C0R5U2	Wolbachia sp. subsp. Drosophila simulans (strain wRi)	36%	100%
C9ZS37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	91%
D0A1G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	90%
D0A727	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	70%
E9AV42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AWQ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P00842	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	54%	72%
P05496	Homo sapiens	46%	78%
P07926	Bos taurus	41%	74%
P15014	Rhodospirillum rubrum	39%	100%
P17605	Ovis aries	51%	78%
P21537	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P32876	Bos taurus	51%	78%
P48201	Homo sapiens	42%	75%
P48880	Chondrus crispus	55%	100%
P56383	Mus musculus	51%	73%
P56384	Mus musculus	51%	75%
Q01554	Trichophyton rubrum	58%	100%
Q03672	Podospora anserina	47%	74%
Q06055	Homo sapiens	51%	75%
Q06056	Ovis aries	41%	74%
Q06645	Rattus norvegicus	48%	78%
Q06646	Rattus norvegicus	51%	75%
Q0BQY6	Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1)	51%	100%
Q0C0X2	Hyphomonas neptunium (strain ATCC 15444)	39%	100%
Q12635	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	58%	100%
Q2GE12	Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama)	40%	100%
Q2LCR3	Dictyostelium citrinum	45%	100%
Q2RPA5	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	39%	100%
Q37315	Dictyostelium discoideum	45%	100%
Q37377	Acanthamoeba castellanii	56%	100%
Q4A8W4	Mesomycoplasma hyopneumoniae (strain 7448)	31%	100%
Q4AAW2	Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110)	33%	100%
Q4QAS0	Leishmania major	99%	100%
Q4QCD9	Leishmania major	98%	100%
Q5FRW6	Gluconobacter oxydans (strain 621H)	49%	100%
Q5RAP9	Pongo abelii	51%	75%
Q5RFL2	Pongo abelii	42%	75%
Q602A0	Mesomycoplasma hyopneumoniae (strain 232)	32%	100%
Q68XQ0	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	39%	100%
Q71S46	Rattus norvegicus	42%	75%
Q73HW2	Wolbachia pipientis wMel	36%	100%
Q9CR84	Mus musculus	48%	78%
Q9U505	Manduca sexta	51%	81%
Q9ZEC2	Rickettsia prowazekii (strain Madrid E)	38%	100%
V5B9K0	Trypanosoma cruzi	88%	97%