Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H619_LEIDO

TriTrypDb:

LdBPK_071270.1 , LdCL_070017600 , LDHU3_07.1490

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H619

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H619

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.654
CLV_NRD_NRD_1	171	173	PF00675	0.671
CLV_NRD_NRD_1	181	183	PF00675	0.487
CLV_NRD_NRD_1	295	297	PF00675	0.580
CLV_NRD_NRD_1	69	71	PF00675	0.512
CLV_PCSK_FUR_1	67	71	PF00082	0.510
CLV_PCSK_KEX2_1	171	173	PF00082	0.669
CLV_PCSK_KEX2_1	183	185	PF00082	0.462
CLV_PCSK_KEX2_1	264	266	PF00082	0.614
CLV_PCSK_KEX2_1	291	293	PF00082	0.522
CLV_PCSK_KEX2_1	295	297	PF00082	0.566
CLV_PCSK_KEX2_1	69	71	PF00082	0.520
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.668
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.585
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.569
CLV_PCSK_SKI1_1	202	206	PF00082	0.764
CLV_PCSK_SKI1_1	288	292	PF00082	0.582
CLV_PCSK_SKI1_1	69	73	PF00082	0.507
DEG_SPOP_SBC_1	212	216	PF00917	0.550
DEG_SPOP_SBC_1	7	11	PF00917	0.579
DOC_USP7_MATH_1	160	164	PF00917	0.630
DOC_USP7_MATH_1	212	216	PF00917	0.647
DOC_USP7_MATH_1	42	46	PF00917	0.654
DOC_USP7_MATH_1	7	11	PF00917	0.709
DOC_WW_Pin1_4	174	179	PF00397	0.728
LIG_14-3-3_CanoR_1	218	226	PF00244	0.580
LIG_14-3-3_CanoR_1	255	261	PF00244	0.604
LIG_14-3-3_CanoR_1	69	77	PF00244	0.549
LIG_14-3-3_CanoR_1	92	102	PF00244	0.610
LIG_Actin_WH2_2	53	71	PF00022	0.586
LIG_CaM_NSCaTE_8	233	240	PF13499	0.570
LIG_FHA_1	175	181	PF00498	0.669
LIG_FHA_1	203	209	PF00498	0.779
LIG_FHA_1	236	242	PF00498	0.560
LIG_FHA_1	52	58	PF00498	0.656
LIG_FHA_1	98	104	PF00498	0.573
LIG_FHA_2	92	98	PF00498	0.661
LIG_GBD_Chelix_1	127	135	PF00786	0.606
LIG_LIR_Apic_2	145	149	PF02991	0.559
LIG_PTB_Apo_2	136	143	PF02174	0.450
LIG_SH2_CRK	146	150	PF00017	0.635
LIG_SH2_STAT5	104	107	PF00017	0.529
LIG_SH2_STAT5	143	146	PF00017	0.645
LIG_SH2_STAT5	260	263	PF00017	0.528
LIG_SH3_3	296	302	PF00018	0.500
LIG_SUMO_SIM_par_1	53	58	PF11976	0.609
LIG_TRAF2_1	271	274	PF00917	0.640
MOD_CK1_1	11	17	PF00069	0.657
MOD_CK1_1	19	25	PF00069	0.555
MOD_CK1_1	217	223	PF00069	0.602
MOD_CK1_1	229	235	PF00069	0.431
MOD_CK1_1	258	264	PF00069	0.619
MOD_CK2_1	160	166	PF00069	0.664
MOD_CK2_1	6	12	PF00069	0.649
MOD_CK2_1	91	97	PF00069	0.663
MOD_GlcNHglycan	154	157	PF01048	0.726
MOD_GlcNHglycan	19	22	PF01048	0.639
MOD_GlcNHglycan	202	205	PF01048	0.685
MOD_GlcNHglycan	219	222	PF01048	0.614
MOD_GlcNHglycan	46	49	PF01048	0.617
MOD_GSK3_1	15	22	PF00069	0.567
MOD_GSK3_1	196	203	PF00069	0.729
MOD_GSK3_1	213	220	PF00069	0.584
MOD_GSK3_1	235	242	PF00069	0.623
MOD_GSK3_1	251	258	PF00069	0.470
MOD_GSK3_1	44	51	PF00069	0.610
MOD_GSK3_1	7	14	PF00069	0.677
MOD_GSK3_1	93	100	PF00069	0.559
MOD_LATS_1	211	217	PF00433	0.552
MOD_LATS_1	253	259	PF00433	0.595
MOD_NEK2_1	142	147	PF00069	0.518
MOD_NEK2_1	15	20	PF00069	0.752
MOD_NEK2_1	219	224	PF00069	0.689
MOD_NEK2_1	237	242	PF00069	0.553
MOD_NEK2_1	251	256	PF00069	0.627
MOD_NEK2_1	88	93	PF00069	0.676
MOD_NEK2_2	160	165	PF00069	0.676
MOD_PIKK_1	70	76	PF00454	0.536
MOD_PKA_2	196	202	PF00069	0.777
MOD_PKA_2	217	223	PF00069	0.724
MOD_PKA_2	251	257	PF00069	0.695
MOD_PKA_2	91	97	PF00069	0.461
MOD_Plk_1	11	17	PF00069	0.762
MOD_Plk_1	97	103	PF00069	0.516
MOD_Plk_2-3	244	250	PF00069	0.563
MOD_Plk_4	130	136	PF00069	0.556
MOD_Plk_4	97	103	PF00069	0.502
MOD_ProDKin_1	174	180	PF00069	0.734
MOD_SUMO_rev_2	198	204	PF00179	0.624
MOD_SUMO_rev_2	258	266	PF00179	0.645
MOD_SUMO_rev_2	287	293	PF00179	0.531
TRG_ER_diArg_1	170	172	PF00400	0.692
TRG_ER_diArg_1	181	184	PF00400	0.475
TRG_ER_diArg_1	294	296	PF00400	0.539
TRG_ER_diArg_1	67	70	PF00400	0.516
TRG_NLS_Bipartite_1	171	186	PF00514	0.748
TRG_NLS_MonoExtN_4	179	186	PF00514	0.751
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.716
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L7	Leptomonas seymouri	54%	100%
A0A1X0NPM5	Trypanosomatidae	31%	91%
A0A3R7LS50	Trypanosoma rangeli	33%	99%
A4H559	Leishmania braziliensis	75%	100%
A4HTD6	Leishmania infantum	99%	100%
C9ZUH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ALC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QIH6	Leishmania major	91%	100%
V5BYD2	Trypanosoma cruzi	34%	90%