Delta-5 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid desaturase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H618_LEIDO

TriTrypDb:

LdBPK_071260.1 , LdCL_070017500 , LDHU3_07.1480

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H618

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H618

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	110	116	PF00089	0.325
CLV_NRD_NRD_1	230	232	PF00675	0.451
CLV_NRD_NRD_1	379	381	PF00675	0.310
CLV_PCSK_FUR_1	222	226	PF00082	0.495
CLV_PCSK_KEX2_1	224	226	PF00082	0.467
CLV_PCSK_KEX2_1	230	232	PF00082	0.488
CLV_PCSK_KEX2_1	62	64	PF00082	0.476
CLV_PCSK_KEX2_1	81	83	PF00082	0.279
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.503
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.476
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.279
CLV_PCSK_SKI1_1	380	384	PF00082	0.297
CLV_PCSK_SKI1_1	401	405	PF00082	0.346
CLV_PCSK_SKI1_1	59	63	PF00082	0.329
CLV_PCSK_SKI1_1	82	86	PF00082	0.352
CLV_PCSK_SKI1_1	88	92	PF00082	0.319
DOC_CDC14_PxL_1	128	136	PF14671	0.314
DOC_CYCLIN_RxL_1	377	385	PF00134	0.493
DOC_MAPK_DCC_7	130	139	PF00069	0.326
DOC_MAPK_gen_1	200	207	PF00069	0.226
DOC_MAPK_gen_1	263	273	PF00069	0.422
DOC_MAPK_MEF2A_6	230	237	PF00069	0.267
DOC_MAPK_NFAT4_5	230	238	PF00069	0.267
DOC_PP1_SILK_1	31	36	PF00149	0.543
DOC_PP2B_LxvP_1	52	55	PF13499	0.529
DOC_PP4_FxxP_1	129	132	PF00568	0.314
DOC_PP4_FxxP_1	26	29	PF00568	0.502
DOC_USP7_MATH_1	29	33	PF00917	0.523
DOC_USP7_MATH_1	71	75	PF00917	0.599
DOC_USP7_UBL2_3	397	401	PF12436	0.449
DOC_USP7_UBL2_3	81	85	PF12436	0.543
DOC_WW_Pin1_4	194	199	PF00397	0.283
DOC_WW_Pin1_4	340	345	PF00397	0.483
LIG_14-3-3_CanoR_1	113	120	PF00244	0.495
LIG_14-3-3_CanoR_1	230	236	PF00244	0.248
LIG_14-3-3_CanoR_1	266	274	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	300	304	PF00533	0.337
LIG_BRCT_BRCA1_1	86	90	PF00533	0.480
LIG_eIF4E_1	112	118	PF01652	0.526
LIG_FHA_1	207	213	PF00498	0.258
LIG_FHA_1	242	248	PF00498	0.281
LIG_FHA_1	266	272	PF00498	0.391
LIG_FHA_1	337	343	PF00498	0.460
LIG_LIR_Apic_2	24	29	PF02991	0.495
LIG_LIR_Gen_1	305	315	PF02991	0.305
LIG_LIR_Gen_1	333	342	PF02991	0.483
LIG_LIR_Gen_1	44	55	PF02991	0.473
LIG_LIR_Nem_3	106	110	PF02991	0.477
LIG_LIR_Nem_3	290	295	PF02991	0.311
LIG_LIR_Nem_3	305	311	PF02991	0.220
LIG_LIR_Nem_3	333	337	PF02991	0.469
LIG_LIR_Nem_3	349	354	PF02991	0.391
LIG_LIR_Nem_3	402	406	PF02991	0.493
LIG_LIR_Nem_3	44	50	PF02991	0.480
LIG_LIR_Nem_3	87	93	PF02991	0.486
LIG_MYND_1	132	136	PF01753	0.314
LIG_PCNA_yPIPBox_3	222	233	PF02747	0.249
LIG_Pex14_1	350	354	PF04695	0.441
LIG_Pex14_2	103	107	PF04695	0.537
LIG_Pex14_2	300	304	PF04695	0.278
LIG_Pex14_2	347	351	PF04695	0.467
LIG_SH2_CRK	334	338	PF00017	0.483
LIG_SH2_GRB2like	354	357	PF00017	0.441
LIG_SH2_NCK_1	334	338	PF00017	0.483
LIG_SH2_PTP2	308	311	PF00017	0.278
LIG_SH2_STAP1	334	338	PF00017	0.447
LIG_SH2_STAT5	267	270	PF00017	0.462
LIG_SH2_STAT5	308	311	PF00017	0.302
LIG_SH2_STAT5	338	341	PF00017	0.441
LIG_SH2_STAT5	354	357	PF00017	0.441
LIG_SH2_STAT5	37	40	PF00017	0.545
LIG_SH2_STAT5	60	63	PF00017	0.570
LIG_SH3_1	62	68	PF00018	0.574
LIG_SH3_3	318	324	PF00018	0.506
LIG_SH3_3	362	368	PF00018	0.441
LIG_SH3_3	62	68	PF00018	0.574
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.483
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.391
LIG_TYR_ITIM	332	337	PF00017	0.483
LIG_UBA3_1	218	224	PF00899	0.200
MOD_CDK_SPxK_1	194	200	PF00069	0.283
MOD_Cter_Amidation	222	225	PF01082	0.483
MOD_GlcNHglycan	182	185	PF01048	0.442
MOD_GlcNHglycan	304	307	PF01048	0.480
MOD_GlcNHglycan	39	42	PF01048	0.329
MOD_GSK3_1	182	189	PF00069	0.381
MOD_GSK3_1	261	268	PF00069	0.447
MOD_GSK3_1	298	305	PF00069	0.351
MOD_GSK3_1	336	343	PF00069	0.483
MOD_GSK3_1	37	44	PF00069	0.496
MOD_GSK3_1	395	402	PF00069	0.574
MOD_N-GLC_1	103	108	PF02516	0.304
MOD_N-GLC_1	315	320	PF02516	0.283
MOD_N-GLC_1	340	345	PF02516	0.283
MOD_NEK2_1	103	108	PF00069	0.510
MOD_NEK2_1	182	187	PF00069	0.295
MOD_NEK2_1	287	292	PF00069	0.278
MOD_NEK2_1	315	320	PF00069	0.469
MOD_NEK2_1	399	404	PF00069	0.487
MOD_PIKK_1	186	192	PF00454	0.283
MOD_PIKK_1	261	267	PF00454	0.461
MOD_PIKK_1	298	304	PF00454	0.337
MOD_PKA_2	112	118	PF00069	0.526
MOD_PKA_2	265	271	PF00069	0.483
MOD_Plk_1	103	109	PF00069	0.501
MOD_Plk_1	315	321	PF00069	0.484
MOD_Plk_4	182	188	PF00069	0.381
MOD_Plk_4	243	249	PF00069	0.278
MOD_Plk_4	287	293	PF00069	0.471
MOD_Plk_4	29	35	PF00069	0.497
MOD_Plk_4	342	348	PF00069	0.456
MOD_ProDKin_1	194	200	PF00069	0.283
MOD_ProDKin_1	340	346	PF00069	0.483
MOD_SUMO_rev_2	74	83	PF00179	0.542
MOD_SUMO_rev_2	87	93	PF00179	0.527
TRG_DiLeu_BaEn_2	326	332	PF01217	0.461
TRG_ENDOCYTIC_2	126	129	PF00928	0.354
TRG_ENDOCYTIC_2	251	254	PF00928	0.278
TRG_ENDOCYTIC_2	308	311	PF00928	0.302
TRG_ENDOCYTIC_2	334	337	PF00928	0.483
TRG_ENDOCYTIC_2	47	50	PF00928	0.530
TRG_ER_diArg_1	229	231	PF00400	0.229
TRG_ER_diArg_1	377	380	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	Tachysurus fulvidraco	27%	94%
A0A0N1HZP4	Leptomonas seymouri	22%	100%
A0A0N1IMB2	Leptomonas seymouri	26%	100%
A0A0N1PAQ6	Leptomonas seymouri	80%	100%
A0A0S4KLP1	Bodo saltans	24%	100%
A0A1X0NMZ1	Trypanosomatidae	27%	100%
A0A1X0NPK3	Trypanosomatidae	59%	99%
A0A3Q8I9Z6	Leishmania donovani	23%	100%
A0A3Q8IK71	Leishmania donovani	24%	99%
A0A422NCE1	Trypanosoma rangeli	23%	98%
A4FV48	Bos taurus	28%	94%
A4H558	Leishmania braziliensis	88%	100%
A4H7V4	Leishmania braziliensis	22%	100%
A4HQL7	Leishmania braziliensis	25%	99%
A4HTD5	Leishmania infantum	99%	100%
A4HW80	Leishmania infantum	23%	100%
A4IFP3	Bos taurus	27%	94%
A4KDP0	Rebecca salina	48%	98%
A4KDP1	Rebecca salina	25%	98%
A4UVI1	Papio anubis	27%	94%
A8MWK0	Homo sapiens	24%	87%
B2KKL4	Siganus canaliculatus	27%	94%
B8R1K0	Papio anubis	26%	94%
C4QVU3	Komagataella phaffii (strain GS115 / ATCC 20864)	23%	77%
D0A3D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D8X2C5	Siganus canaliculatus	28%	94%
E9AI08	Leishmania infantum	24%	99%
E9ALC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9APY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AUD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	99%
G5EG11	Caenorhabditis elegans	25%	93%
O04353	Borago officinalis	24%	93%
O60427	Homo sapiens	27%	94%
O95864	Homo sapiens	26%	94%
O96099	Dictyostelium discoideum	24%	89%
Q0VAX3	Mus musculus	26%	86%
Q23221	Caenorhabditis elegans	26%	94%
Q3EBF7	Arabidopsis thaliana	27%	93%
Q43469	Helianthus annuus	25%	91%
Q4G2T3	Thalassiosira pseudonana	24%	81%
Q4Q058	Leishmania major	24%	100%
Q4QFK0	Leishmania major	25%	100%
Q4QIH7	Leishmania major	97%	100%
Q4R749	Macaca fascicularis	26%	94%
Q5AEK8	Candida albicans (strain SC5314 / ATCC MYA-2876)	22%	71%
Q5REA7	Pongo abelii	27%	94%
Q6CMK7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	73%
Q6DDK2	Xenopus laevis	27%	93%
Q8K1P9	Rattus norvegicus	28%	93%
Q8NKG8	Kluyveromyces lactis	24%	73%
Q8NKG9	Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651)	24%	73%
Q8S3C1	Thraustochytrium sp.	44%	95%
Q920L1	Mus musculus	26%	93%
Q920R3	Rattus norvegicus	28%	93%
Q9DEX7	Danio rerio	28%	94%
Q9FR82	Borago officinalis	25%	93%
Q9JJE7	Mus musculus	28%	93%
Q9LEM9	Ceratodon purpureus	25%	80%
Q9LEN0	Ceratodon purpureus	27%	86%
Q9SWQ9	Euglena gracilis	28%	100%
Q9Y5Q0	Homo sapiens	28%	94%
Q9Z0R9	Mus musculus	28%	94%
Q9Z122	Rattus norvegicus	28%	94%
Q9ZNW2	Physcomitrium patens	26%	79%
Q9ZRP7	Arabidopsis thaliana	23%	93%