Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H617_LEIDO

TriTrypDb:

LdBPK_071250.1 , LdCL_070017400 , LDHU3_07.1470

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H617

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H617

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	214	220	PF00089	0.545
CLV_NRD_NRD_1	216	218	PF00675	0.438
CLV_NRD_NRD_1	367	369	PF00675	0.614
CLV_NRD_NRD_1	378	380	PF00675	0.630
CLV_NRD_NRD_1	381	383	PF00675	0.643
CLV_NRD_NRD_1	474	476	PF00675	0.705
CLV_NRD_NRD_1	511	513	PF00675	0.516
CLV_NRD_NRD_1	531	533	PF00675	0.338
CLV_NRD_NRD_1	608	610	PF00675	0.572
CLV_NRD_NRD_1	756	758	PF00675	0.517
CLV_NRD_NRD_1	798	800	PF00675	0.715
CLV_PCSK_KEX2_1	216	218	PF00082	0.438
CLV_PCSK_KEX2_1	241	243	PF00082	0.522
CLV_PCSK_KEX2_1	367	369	PF00082	0.610
CLV_PCSK_KEX2_1	474	476	PF00082	0.705
CLV_PCSK_KEX2_1	530	532	PF00082	0.541
CLV_PCSK_KEX2_1	756	758	PF00082	0.497
CLV_PCSK_KEX2_1	768	770	PF00082	0.420
CLV_PCSK_KEX2_1	798	800	PF00082	0.605
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.522
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.461
CLV_PCSK_SKI1_1	346	350	PF00082	0.657
CLV_PCSK_SKI1_1	360	364	PF00082	0.438
CLV_PCSK_SKI1_1	388	392	PF00082	0.537
CLV_PCSK_SKI1_1	394	398	PF00082	0.462
CLV_PCSK_SKI1_1	756	760	PF00082	0.517
DEG_APCC_DBOX_1	797	805	PF00400	0.554
DEG_Nend_UBRbox_2	1	3	PF02207	0.503
DEG_SPOP_SBC_1	786	790	PF00917	0.696
DOC_ANK_TNKS_1	216	223	PF00023	0.535
DOC_CYCLIN_RxL_1	753	762	PF00134	0.551
DOC_CYCLIN_yClb5_NLxxxL_5	554	563	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.648
DOC_MAPK_gen_1	97	104	PF00069	0.511
DOC_MAPK_MEF2A_6	589	596	PF00069	0.512
DOC_MAPK_MEF2A_6	97	106	PF00069	0.495
DOC_PP1_RVXF_1	73	79	PF00149	0.461
DOC_PP2B_LxvP_1	296	299	PF13499	0.637
DOC_USP7_MATH_1	114	118	PF00917	0.495
DOC_USP7_MATH_1	24	28	PF00917	0.559
DOC_USP7_MATH_1	313	317	PF00917	0.692
DOC_USP7_MATH_1	324	328	PF00917	0.665
DOC_USP7_MATH_1	479	483	PF00917	0.785
DOC_USP7_MATH_1	496	500	PF00917	0.645
DOC_USP7_MATH_1	521	525	PF00917	0.630
DOC_USP7_MATH_1	637	641	PF00917	0.595
DOC_USP7_MATH_1	689	693	PF00917	0.666
DOC_USP7_MATH_1	86	90	PF00917	0.560
DOC_USP7_UBL2_3	434	438	PF12436	0.528
DOC_WW_Pin1_4	136	141	PF00397	0.558
DOC_WW_Pin1_4	788	793	PF00397	0.669
DOC_WW_Pin1_4	82	87	PF00397	0.472
LIG_14-3-3_CanoR_1	340	344	PF00244	0.674
LIG_14-3-3_CanoR_1	553	557	PF00244	0.560
LIG_14-3-3_CanoR_1	601	605	PF00244	0.567
LIG_14-3-3_CanoR_1	769	777	PF00244	0.555
LIG_14-3-3_CanoR_1	798	802	PF00244	0.706
LIG_APCC_ABBA_1	359	364	PF00400	0.540
LIG_APCC_ABBA_1	61	66	PF00400	0.481
LIG_APCC_ABBAyCdc20_2	358	364	PF00400	0.543
LIG_APCC_Cbox_2	633	639	PF00515	0.577
LIG_BIR_III_4	155	159	PF00653	0.491
LIG_BIR_III_4	690	694	PF00653	0.690
LIG_Clathr_ClatBox_1	243	247	PF01394	0.319
LIG_FAT_LD_1	462	470	PF03623	0.454
LIG_FHA_1	140	146	PF00498	0.487
LIG_FHA_1	188	194	PF00498	0.469
LIG_FHA_1	223	229	PF00498	0.460
LIG_FHA_1	238	244	PF00498	0.334
LIG_FHA_1	248	254	PF00498	0.499
LIG_FHA_1	285	291	PF00498	0.433
LIG_FHA_1	313	319	PF00498	0.744
LIG_FHA_1	4	10	PF00498	0.552
LIG_FHA_1	487	493	PF00498	0.669
LIG_FHA_1	626	632	PF00498	0.529
LIG_FHA_1	659	665	PF00498	0.664
LIG_FHA_1	753	759	PF00498	0.573
LIG_FHA_1	817	823	PF00498	0.541
LIG_FHA_2	448	454	PF00498	0.613
LIG_FHA_2	580	586	PF00498	0.659
LIG_FHA_2	601	607	PF00498	0.563
LIG_FHA_2	715	721	PF00498	0.706
LIG_FHA_2	745	751	PF00498	0.555
LIG_FHA_2	83	89	PF00498	0.547
LIG_LIR_Gen_1	633	639	PF02991	0.561
LIG_LIR_Gen_1	747	753	PF02991	0.512
LIG_LIR_Nem_3	606	611	PF02991	0.507
LIG_LIR_Nem_3	633	638	PF02991	0.555
LIG_LIR_Nem_3	682	686	PF02991	0.648
LIG_LIR_Nem_3	747	752	PF02991	0.511
LIG_LIR_Nem_3	806	811	PF02991	0.557
LIG_LRP6_Inhibitor_1	737	743	PF00058	0.679
LIG_MYND_1	304	308	PF01753	0.727
LIG_NRBOX	538	544	PF00104	0.595
LIG_NRBOX	558	564	PF00104	0.304
LIG_PCNA_yPIPBox_3	629	641	PF02747	0.576
LIG_PCNA_yPIPBox_3	743	752	PF02747	0.622
LIG_Pex14_2	64	68	PF04695	0.475
LIG_PTB_Apo_2	100	107	PF02174	0.548
LIG_Rb_LxCxE_1	575	588	PF01857	0.680
LIG_RPA_C_Fungi	346	358	PF08784	0.531
LIG_RPA_C_Fungi	752	764	PF08784	0.614
LIG_SH2_CRK	148	152	PF00017	0.549
LIG_SH2_CRK	608	612	PF00017	0.603
LIG_SH2_NCK_1	79	83	PF00017	0.573
LIG_SH2_SRC	121	124	PF00017	0.549
LIG_SH2_STAP1	148	152	PF00017	0.549
LIG_SH2_STAT5	121	124	PF00017	0.516
LIG_SH2_STAT5	161	164	PF00017	0.490
LIG_SH2_STAT5	527	530	PF00017	0.534
LIG_SH2_STAT5	614	617	PF00017	0.525
LIG_SH2_STAT5	741	744	PF00017	0.538
LIG_SH2_STAT5	826	829	PF00017	0.477
LIG_SH3_3	119	125	PF00018	0.545
LIG_SH3_3	296	302	PF00018	0.654
LIG_SH3_3	551	557	PF00018	0.582
LIG_SH3_3	698	704	PF00018	0.787
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.543
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.628
LIG_SUMO_SIM_anti_2	761	767	PF11976	0.524
LIG_SUMO_SIM_par_1	225	231	PF11976	0.451
LIG_TRAF2_1	17	20	PF00917	0.572
LIG_TRAF2_1	350	353	PF00917	0.561
LIG_TRAF2_1	717	720	PF00917	0.684
LIG_UBA3_1	748	754	PF00899	0.614
LIG_WRC_WIRS_1	147	152	PF05994	0.546
MOD_CDK_SPxK_1	792	798	PF00069	0.759
MOD_CDK_SPxxK_3	792	799	PF00069	0.734
MOD_CK1_1	135	141	PF00069	0.559
MOD_CK1_1	339	345	PF00069	0.585
MOD_CK1_1	34	40	PF00069	0.544
MOD_CK1_1	674	680	PF00069	0.619
MOD_CK1_1	785	791	PF00069	0.593
MOD_CK1_1	797	803	PF00069	0.572
MOD_CK1_1	806	812	PF00069	0.480
MOD_CK2_1	174	180	PF00069	0.578
MOD_CK2_1	313	319	PF00069	0.724
MOD_CK2_1	436	442	PF00069	0.549
MOD_CK2_1	579	585	PF00069	0.597
MOD_CK2_1	600	606	PF00069	0.560
MOD_CK2_1	67	73	PF00069	0.525
MOD_CK2_1	714	720	PF00069	0.739
MOD_CK2_1	744	750	PF00069	0.587
MOD_CK2_1	825	831	PF00069	0.479
MOD_GlcNHglycan	116	119	PF01048	0.512
MOD_GlcNHglycan	155	159	PF01048	0.402
MOD_GlcNHglycan	218	221	PF01048	0.485
MOD_GlcNHglycan	230	233	PF01048	0.359
MOD_GlcNHglycan	26	29	PF01048	0.531
MOD_GlcNHglycan	315	318	PF01048	0.710
MOD_GlcNHglycan	33	36	PF01048	0.455
MOD_GlcNHglycan	481	484	PF01048	0.730
MOD_GlcNHglycan	504	507	PF01048	0.613
MOD_GlcNHglycan	519	522	PF01048	0.654
MOD_GlcNHglycan	559	562	PF01048	0.628
MOD_GlcNHglycan	644	648	PF01048	0.618
MOD_GlcNHglycan	673	676	PF01048	0.638
MOD_GlcNHglycan	690	694	PF01048	0.707
MOD_GlcNHglycan	771	774	PF01048	0.552
MOD_GlcNHglycan	784	787	PF01048	0.567
MOD_GlcNHglycan	808	811	PF01048	0.559
MOD_GlcNHglycan	827	830	PF01048	0.514
MOD_GSK3_1	112	119	PF00069	0.508
MOD_GSK3_1	130	137	PF00069	0.407
MOD_GSK3_1	189	196	PF00069	0.440
MOD_GSK3_1	230	237	PF00069	0.442
MOD_GSK3_1	247	254	PF00069	0.408
MOD_GSK3_1	394	401	PF00069	0.480
MOD_GSK3_1	422	429	PF00069	0.603
MOD_GSK3_1	433	440	PF00069	0.510
MOD_GSK3_1	443	450	PF00069	0.535
MOD_GSK3_1	487	494	PF00069	0.637
MOD_GSK3_1	517	524	PF00069	0.500
MOD_GSK3_1	596	603	PF00069	0.590
MOD_GSK3_1	671	678	PF00069	0.609
MOD_GSK3_1	781	788	PF00069	0.597
MOD_GSK3_1	82	89	PF00069	0.550
MOD_LATS_1	128	134	PF00433	0.572
MOD_LATS_1	767	773	PF00433	0.545
MOD_N-GLC_1	102	107	PF02516	0.546
MOD_N-GLC_1	557	562	PF02516	0.523
MOD_N-GLC_1	709	714	PF02516	0.649
MOD_N-GLC_1	782	787	PF02516	0.692
MOD_NEK2_1	134	139	PF00069	0.557
MOD_NEK2_1	422	427	PF00069	0.621
MOD_NEK2_1	465	470	PF00069	0.620
MOD_NEK2_1	517	522	PF00069	0.532
MOD_NEK2_1	525	530	PF00069	0.519
MOD_NEK2_1	563	568	PF00069	0.472
MOD_NEK2_1	596	601	PF00069	0.550
MOD_NEK2_1	653	658	PF00069	0.521
MOD_NEK2_1	660	665	PF00069	0.574
MOD_NEK2_1	759	764	PF00069	0.559
MOD_NEK2_2	116	121	PF00069	0.533
MOD_PIKK_1	415	421	PF00454	0.532
MOD_PIKK_1	625	631	PF00454	0.617
MOD_PKA_1	216	222	PF00069	0.468
MOD_PKA_1	451	457	PF00069	0.532
MOD_PKA_2	216	222	PF00069	0.455
MOD_PKA_2	339	345	PF00069	0.579
MOD_PKA_2	552	558	PF00069	0.559
MOD_PKA_2	600	606	PF00069	0.596
MOD_PKA_2	797	803	PF00069	0.642
MOD_Plk_1	102	108	PF00069	0.550
MOD_Plk_1	318	324	PF00069	0.614
MOD_Plk_1	415	421	PF00069	0.587
MOD_Plk_1	429	435	PF00069	0.619
MOD_Plk_1	436	442	PF00069	0.556
MOD_Plk_1	525	531	PF00069	0.532
MOD_Plk_1	557	563	PF00069	0.607
MOD_Plk_2-3	437	443	PF00069	0.594
MOD_Plk_2-3	744	750	PF00069	0.578
MOD_Plk_4	116	122	PF00069	0.482
MOD_Plk_4	146	152	PF00069	0.475
MOD_Plk_4	189	195	PF00069	0.429
MOD_Plk_4	230	236	PF00069	0.452
MOD_Plk_4	563	569	PF00069	0.481
MOD_Plk_4	744	750	PF00069	0.545
MOD_Plk_4	803	809	PF00069	0.567
MOD_Plk_4	86	92	PF00069	0.505
MOD_ProDKin_1	136	142	PF00069	0.550
MOD_ProDKin_1	788	794	PF00069	0.670
MOD_ProDKin_1	82	88	PF00069	0.474
MOD_SUMO_for_1	362	365	PF00179	0.622
MOD_SUMO_rev_2	339	348	PF00179	0.580
TRG_DiLeu_BaEn_1	180	185	PF01217	0.545
TRG_DiLeu_BaEn_1	365	370	PF01217	0.610
TRG_DiLeu_BaEn_1	535	540	PF01217	0.633
TRG_DiLeu_BaEn_3	365	371	PF01217	0.533
TRG_DiLeu_BaEn_4	352	358	PF01217	0.552
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.697
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.623
TRG_ENDOCYTIC_2	148	151	PF00928	0.562
TRG_ENDOCYTIC_2	608	611	PF00928	0.498
TRG_ER_diArg_1	216	218	PF00400	0.449
TRG_ER_diArg_1	357	360	PF00400	0.501
TRG_ER_diArg_1	367	369	PF00400	0.470
TRG_ER_diArg_1	474	476	PF00400	0.686
TRG_ER_diArg_1	529	532	PF00400	0.544
TRG_ER_diArg_1	546	549	PF00400	0.495
TRG_ER_diArg_1	756	758	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	729	734	PF00026	0.710
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	756	761	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV16	Leptomonas seymouri	56%	95%
A0A1X0NPL3	Trypanosomatidae	34%	91%
A0A3S5IQT7	Trypanosoma rangeli	38%	92%
A4H557	Leishmania braziliensis	76%	98%
A4HTD4	Leishmania infantum	100%	100%
C9ZUI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	95%
E9ALC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QIH8	Leishmania major	93%	100%
V5BTL6	Trypanosoma cruzi	34%	92%