RNA-editing complex protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H616_LEIDO

TriTrypDb:

LdBPK_071240.1 , LdCL_070017300 , LDHU3_07.1460

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S5H616

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H616

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.726
CLV_NRD_NRD_1	49	51	PF00675	0.606
CLV_NRD_NRD_1	58	60	PF00675	0.586
CLV_PCSK_FUR_1	260	264	PF00082	0.525
CLV_PCSK_KEX2_1	262	264	PF00082	0.569
CLV_PCSK_KEX2_1	49	51	PF00082	0.584
CLV_PCSK_KEX2_1	58	60	PF00082	0.568
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.568
CLV_PCSK_SKI1_1	262	266	PF00082	0.484
DEG_SPOP_SBC_1	163	167	PF00917	0.700
DEG_SPOP_SBC_1	169	173	PF00917	0.646
DEG_SPOP_SBC_1	182	186	PF00917	0.739
DEG_SPOP_SBC_1	214	218	PF00917	0.739
DOC_CKS1_1	316	321	PF01111	0.694
DOC_CKS1_1	424	429	PF01111	0.495
DOC_MAPK_gen_1	142	150	PF00069	0.579
DOC_MAPK_MEF2A_6	391	399	PF00069	0.521
DOC_MAPK_MEF2A_6	478	487	PF00069	0.354
DOC_PP2B_PxIxI_1	482	488	PF00149	0.354
DOC_PP4_FxxP_1	200	203	PF00568	0.622
DOC_PP4_FxxP_1	424	427	PF00568	0.431
DOC_PP4_FxxP_1	446	449	PF00568	0.498
DOC_SPAK_OSR1_1	459	463	PF12202	0.385
DOC_USP7_MATH_1	164	168	PF00917	0.633
DOC_USP7_MATH_1	169	173	PF00917	0.600
DOC_USP7_MATH_1	181	185	PF00917	0.591
DOC_USP7_MATH_1	207	211	PF00917	0.696
DOC_USP7_MATH_1	215	219	PF00917	0.700
DOC_USP7_MATH_1	314	318	PF00917	0.724
DOC_USP7_MATH_1	330	334	PF00917	0.602
DOC_USP7_MATH_1	348	352	PF00917	0.572
DOC_USP7_UBL2_3	138	142	PF12436	0.529
DOC_WW_Pin1_4	172	177	PF00397	0.645
DOC_WW_Pin1_4	183	188	PF00397	0.634
DOC_WW_Pin1_4	191	196	PF00397	0.503
DOC_WW_Pin1_4	216	221	PF00397	0.687
DOC_WW_Pin1_4	230	235	PF00397	0.603
DOC_WW_Pin1_4	305	310	PF00397	0.682
DOC_WW_Pin1_4	315	320	PF00397	0.748
DOC_WW_Pin1_4	33	38	PF00397	0.472
DOC_WW_Pin1_4	423	428	PF00397	0.417
DOC_WW_Pin1_4	71	76	PF00397	0.635
LIG_14-3-3_CanoR_1	59	67	PF00244	0.676
LIG_14-3-3_CanoR_1	97	105	PF00244	0.588
LIG_CaM_IQ_9	267	283	PF13499	0.410
LIG_Clathr_ClatBox_1	147	151	PF01394	0.564
LIG_EVH1_2	38	42	PF00568	0.474
LIG_FHA_1	116	122	PF00498	0.486
LIG_FHA_1	150	156	PF00498	0.637
LIG_FHA_1	271	277	PF00498	0.421
LIG_FHA_1	436	442	PF00498	0.360
LIG_FHA_1	461	467	PF00498	0.371
LIG_FHA_1	88	94	PF00498	0.586
LIG_FHA_2	29	35	PF00498	0.467
LIG_FHA_2	316	322	PF00498	0.672
LIG_LIR_Apic_2	422	427	PF02991	0.435
LIG_LIR_Apic_2	445	449	PF02991	0.497
LIG_LIR_Gen_1	433	442	PF02991	0.372
LIG_LIR_Nem_3	118	122	PF02991	0.451
LIG_LIR_Nem_3	433	439	PF02991	0.400
LIG_LIR_Nem_3	445	450	PF02991	0.397
LIG_LYPXL_yS_3	482	485	PF13949	0.357
LIG_MYND_1	39	43	PF01753	0.474
LIG_PDZ_Class_2	492	497	PF00595	0.380
LIG_Pex14_2	196	200	PF04695	0.660
LIG_SH2_CRK	480	484	PF00017	0.377
LIG_SH2_STAT3	358	361	PF00017	0.682
LIG_SH2_STAT5	358	361	PF00017	0.548
LIG_SH2_STAT5	409	412	PF00017	0.470
LIG_SH3_3	313	319	PF00018	0.776
LIG_SH3_3	364	370	PF00018	0.479
LIG_SH3_3	375	381	PF00018	0.465
LIG_SH3_3	426	432	PF00018	0.437
LIG_TRAF2_1	256	259	PF00917	0.686
LIG_TRAF2_1	380	383	PF00917	0.448
MOD_CK1_1	165	171	PF00069	0.638
MOD_CK1_1	172	178	PF00069	0.643
MOD_CK1_1	186	192	PF00069	0.759
MOD_CK1_1	216	222	PF00069	0.717
MOD_CK1_1	295	301	PF00069	0.572
MOD_CK1_1	315	321	PF00069	0.764
MOD_CK1_1	77	83	PF00069	0.690
MOD_CK1_1	88	94	PF00069	0.727
MOD_CK2_1	242	248	PF00069	0.691
MOD_CK2_1	28	34	PF00069	0.471
MOD_CK2_1	315	321	PF00069	0.787
MOD_GlcNHglycan	172	175	PF01048	0.646
MOD_GlcNHglycan	188	191	PF01048	0.730
MOD_GlcNHglycan	230	233	PF01048	0.628
MOD_GlcNHglycan	250	253	PF01048	0.639
MOD_GlcNHglycan	294	297	PF01048	0.562
MOD_GlcNHglycan	299	302	PF01048	0.583
MOD_GlcNHglycan	328	331	PF01048	0.739
MOD_GlcNHglycan	332	335	PF01048	0.667
MOD_GlcNHglycan	44	47	PF01048	0.515
MOD_GlcNHglycan	455	458	PF01048	0.503
MOD_GlcNHglycan	490	493	PF01048	0.474
MOD_GlcNHglycan	62	65	PF01048	0.526
MOD_GlcNHglycan	76	79	PF01048	0.696
MOD_GSK3_1	163	170	PF00069	0.624
MOD_GSK3_1	18	25	PF00069	0.517
MOD_GSK3_1	182	189	PF00069	0.672
MOD_GSK3_1	216	223	PF00069	0.623
MOD_GSK3_1	28	35	PF00069	0.501
MOD_GSK3_1	291	298	PF00069	0.499
MOD_GSK3_1	326	333	PF00069	0.606
MOD_GSK3_1	37	44	PF00069	0.663
MOD_GSK3_1	419	426	PF00069	0.474
MOD_N-GLC_1	248	253	PF02516	0.636
MOD_N-GLC_1	348	353	PF02516	0.598
MOD_N-GLC_2	394	396	PF02516	0.371
MOD_NEK2_1	228	233	PF00069	0.635
MOD_NEK2_1	265	270	PF00069	0.419
MOD_NEK2_1	416	421	PF00069	0.431
MOD_NEK2_1	460	465	PF00069	0.432
MOD_NEK2_2	115	120	PF00069	0.483
MOD_NEK2_2	270	275	PF00069	0.406
MOD_PIKK_1	471	477	PF00454	0.507
MOD_PKA_2	96	102	PF00069	0.676
MOD_Plk_1	348	354	PF00069	0.594
MOD_Plk_4	37	43	PF00069	0.551
MOD_Plk_4	77	83	PF00069	0.624
MOD_ProDKin_1	172	178	PF00069	0.647
MOD_ProDKin_1	183	189	PF00069	0.634
MOD_ProDKin_1	191	197	PF00069	0.499
MOD_ProDKin_1	216	222	PF00069	0.688
MOD_ProDKin_1	230	236	PF00069	0.604
MOD_ProDKin_1	305	311	PF00069	0.685
MOD_ProDKin_1	315	321	PF00069	0.749
MOD_ProDKin_1	33	39	PF00069	0.470
MOD_ProDKin_1	423	429	PF00069	0.421
MOD_ProDKin_1	71	77	PF00069	0.635
TRG_DiLeu_BaEn_2	260	266	PF01217	0.636
TRG_ENDOCYTIC_2	482	485	PF00928	0.357
TRG_ER_diArg_1	48	50	PF00400	0.611
TRG_ER_diArg_1	58	60	PF00400	0.581
TRG_ER_diArg_1	9	12	PF00400	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P1	Leptomonas seymouri	57%	100%
A0A0S4IKI2	Bodo saltans	44%	100%
A0A1X0NPK8	Trypanosomatidae	47%	100%
A0A422N9Y4	Trypanosoma rangeli	45%	100%
A4H556	Leishmania braziliensis	72%	96%
A4HTD3	Leishmania infantum	100%	100%
C9ZUI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ALC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIH9	Leishmania major	90%	99%
V5DQ35	Trypanosoma cruzi	48%	100%