Lipoate-protein ligase-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipoate-protein ligase-like

Species:

Leishmania donovani

UniProt:

A0A3S5H615_LEIDO

TriTrypDb:

LdBPK_071230.1 , LdCL_070017200 , LDHU3_07.1450

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H615

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H615

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009249	protein lipoylation	5	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018205	peptidyl-lysine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016874	ligase activity	2	10
GO:0016740	transferase activity	2	5
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0017118	lipoyltransferase activity	5	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016979	lipoate-protein ligase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.375
CLV_NRD_NRD_1	108	110	PF00675	0.210
CLV_NRD_NRD_1	170	172	PF00675	0.367
CLV_NRD_NRD_1	310	312	PF00675	0.436
CLV_NRD_NRD_1	324	326	PF00675	0.356
CLV_NRD_NRD_1	352	354	PF00675	0.501
CLV_NRD_NRD_1	417	419	PF00675	0.465
CLV_NRD_NRD_1	97	99	PF00675	0.250
CLV_PCSK_KEX2_1	108	110	PF00082	0.210
CLV_PCSK_KEX2_1	245	247	PF00082	0.455
CLV_PCSK_KEX2_1	310	312	PF00082	0.491
CLV_PCSK_KEX2_1	351	353	PF00082	0.519
CLV_PCSK_KEX2_1	417	419	PF00082	0.468
CLV_PCSK_KEX2_1	97	99	PF00082	0.250
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.455
CLV_PCSK_SKI1_1	171	175	PF00082	0.270
CLV_PCSK_SKI1_1	352	356	PF00082	0.379
CLV_PCSK_SKI1_1	380	384	PF00082	0.499
CLV_PCSK_SKI1_1	409	413	PF00082	0.350
CLV_PCSK_SKI1_1	498	502	PF00082	0.347
CLV_PCSK_SKI1_1	507	511	PF00082	0.310
CLV_PCSK_SKI1_1	71	75	PF00082	0.330
DEG_APCC_DBOX_1	350	358	PF00400	0.378
DEG_APCC_DBOX_1	70	78	PF00400	0.334
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DEG_SPOP_SBC_1	419	423	PF00917	0.572
DOC_ANK_TNKS_1	97	104	PF00023	0.483
DOC_CYCLIN_RxL_1	495	502	PF00134	0.416
DOC_CYCLIN_RxL_1	59	68	PF00134	0.461
DOC_MAPK_gen_1	351	359	PF00069	0.467
DOC_MAPK_MEF2A_6	138	147	PF00069	0.464
DOC_MIT_MIM_1	349	357	PF04212	0.402
DOC_PP1_RVXF_1	69	76	PF00149	0.346
DOC_PP2B_LxvP_1	482	485	PF13499	0.343
DOC_USP7_MATH_1	198	202	PF00917	0.577
DOC_USP7_MATH_1	224	228	PF00917	0.417
DOC_USP7_MATH_1	33	37	PF00917	0.563
DOC_USP7_MATH_1	335	339	PF00917	0.347
DOC_USP7_MATH_1	424	428	PF00917	0.677
DOC_USP7_MATH_1	56	60	PF00917	0.501
DOC_USP7_UBL2_3	326	330	PF12436	0.418
DOC_WW_Pin1_4	220	225	PF00397	0.414
DOC_WW_Pin1_4	261	266	PF00397	0.425
LIG_14-3-3_CanoR_1	157	166	PF00244	0.478
LIG_14-3-3_CanoR_1	274	278	PF00244	0.369
LIG_14-3-3_CanoR_1	325	332	PF00244	0.318
LIG_14-3-3_CanoR_1	352	358	PF00244	0.454
LIG_14-3-3_CanoR_1	409	415	PF00244	0.340
LIG_14-3-3_CanoR_1	442	449	PF00244	0.458
LIG_14-3-3_CanoR_1	62	67	PF00244	0.464
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.433
LIG_Clathr_ClatBox_1	289	293	PF01394	0.409
LIG_deltaCOP1_diTrp_1	331	339	PF00928	0.406
LIG_deltaCOP1_diTrp_1	502	510	PF00928	0.418
LIG_eIF4E_1	186	192	PF01652	0.528
LIG_FHA_1	137	143	PF00498	0.488
LIG_FHA_1	188	194	PF00498	0.452
LIG_FHA_1	213	219	PF00498	0.390
LIG_FHA_1	29	35	PF00498	0.554
LIG_FHA_1	338	344	PF00498	0.398
LIG_FHA_1	354	360	PF00498	0.388
LIG_FHA_1	410	416	PF00498	0.465
LIG_FHA_1	43	49	PF00498	0.341
LIG_FHA_1	464	470	PF00498	0.473
LIG_FHA_1	495	501	PF00498	0.264
LIG_FHA_2	16	22	PF00498	0.463
LIG_FHA_2	262	268	PF00498	0.479
LIG_FHA_2	311	317	PF00498	0.525
LIG_FHA_2	402	408	PF00498	0.540
LIG_Integrin_RGD_1	314	316	PF01839	0.481
LIG_LIR_Apic_2	201	206	PF02991	0.430
LIG_LIR_Apic_2	331	337	PF02991	0.408
LIG_LIR_Gen_1	207	218	PF02991	0.425
LIG_LIR_Gen_1	358	366	PF02991	0.458
LIG_LIR_Gen_1	49	56	PF02991	0.361
LIG_LIR_LC3C_4	38	42	PF02991	0.412
LIG_LIR_Nem_3	207	213	PF02991	0.362
LIG_LIR_Nem_3	358	363	PF02991	0.479
LIG_LIR_Nem_3	49	54	PF02991	0.363
LIG_NRBOX	443	449	PF00104	0.452
LIG_SH2_CRK	334	338	PF00017	0.460
LIG_SH2_GRB2like	76	79	PF00017	0.305
LIG_SH2_NCK_1	334	338	PF00017	0.455
LIG_SH2_STAT3	9	12	PF00017	0.546
LIG_SH2_STAT5	203	206	PF00017	0.351
LIG_SH2_STAT5	210	213	PF00017	0.340
LIG_SH2_STAT5	76	79	PF00017	0.323
LIG_SH3_3	218	224	PF00018	0.401
LIG_SH3_3	23	29	PF00018	0.464
LIG_SH3_3	446	452	PF00018	0.551
LIG_SH3_3	74	80	PF00018	0.340
LIG_SH3_5	206	210	PF00018	0.468
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.370
LIG_SUMO_SIM_par_1	189	196	PF11976	0.433
LIG_SUMO_SIM_par_1	340	346	PF11976	0.319
LIG_SUMO_SIM_par_1	492	497	PF11976	0.506
LIG_TRAF2_1	370	373	PF00917	0.396
LIG_TRAF2_1	55	58	PF00917	0.285
LIG_TRFH_1	9	13	PF08558	0.535
LIG_UBA3_1	60	69	PF00899	0.365
LIG_WRC_WIRS_1	16	21	PF05994	0.403
LIG_WRC_WIRS_1	336	341	PF05994	0.320
MOD_CK1_1	126	132	PF00069	0.435
MOD_CK1_1	15	21	PF00069	0.382
MOD_CK1_1	217	223	PF00069	0.403
MOD_CK1_1	276	282	PF00069	0.416
MOD_CK1_1	338	344	PF00069	0.255
MOD_CK1_1	365	371	PF00069	0.438
MOD_CK1_1	432	438	PF00069	0.552
MOD_CK1_1	65	71	PF00069	0.344
MOD_CK2_1	15	21	PF00069	0.303
MOD_CK2_1	224	230	PF00069	0.422
MOD_CK2_1	261	267	PF00069	0.455
MOD_CK2_1	316	322	PF00069	0.382
MOD_CK2_1	343	349	PF00069	0.403
MOD_CK2_1	365	371	PF00069	0.478
MOD_CK2_1	401	407	PF00069	0.456
MOD_CK2_1	46	52	PF00069	0.433
MOD_Cter_Amidation	169	172	PF01082	0.320
MOD_Cter_Amidation	308	311	PF01082	0.477
MOD_GlcNHglycan	110	113	PF01048	0.242
MOD_GlcNHglycan	175	178	PF01048	0.233
MOD_GlcNHglycan	230	233	PF01048	0.444
MOD_GlcNHglycan	345	348	PF01048	0.542
MOD_GlcNHglycan	35	38	PF01048	0.516
MOD_GlcNHglycan	426	429	PF01048	0.733
MOD_GlcNHglycan	432	435	PF01048	0.683
MOD_GlcNHglycan	444	447	PF01048	0.304
MOD_GSK3_1	11	18	PF00069	0.575
MOD_GSK3_1	192	199	PF00069	0.530
MOD_GSK3_1	213	220	PF00069	0.413
MOD_GSK3_1	224	231	PF00069	0.438
MOD_GSK3_1	273	280	PF00069	0.447
MOD_GSK3_1	335	342	PF00069	0.408
MOD_GSK3_1	418	425	PF00069	0.603
MOD_GSK3_1	42	49	PF00069	0.372
MOD_GSK3_1	429	436	PF00069	0.562
MOD_GSK3_1	460	467	PF00069	0.445
MOD_N-GLC_2	122	124	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	123	128	PF00069	0.475
MOD_NEK2_1	147	152	PF00069	0.463
MOD_NEK2_1	158	163	PF00069	0.428
MOD_NEK2_1	19	24	PF00069	0.568
MOD_NEK2_1	192	197	PF00069	0.433
MOD_NEK2_1	213	218	PF00069	0.404
MOD_NEK2_1	228	233	PF00069	0.460
MOD_NEK2_1	273	278	PF00069	0.476
MOD_NEK2_1	339	344	PF00069	0.389
MOD_NEK2_1	410	415	PF00069	0.497
MOD_NEK2_1	494	499	PF00069	0.390
MOD_PK_1	355	361	PF00069	0.354
MOD_PKA_1	108	114	PF00069	0.440
MOD_PKA_1	171	177	PF00069	0.459
MOD_PKA_1	310	316	PF00069	0.493
MOD_PKA_2	108	114	PF00069	0.437
MOD_PKA_2	156	162	PF00069	0.456
MOD_PKA_2	273	279	PF00069	0.566
MOD_PKA_2	310	316	PF00069	0.390
MOD_PKA_2	324	330	PF00069	0.485
MOD_PKB_1	351	359	PF00069	0.360
MOD_Plk_1	136	142	PF00069	0.502
MOD_Plk_1	213	219	PF00069	0.311
MOD_Plk_1	464	470	PF00069	0.510
MOD_Plk_1	56	62	PF00069	0.342
MOD_Plk_1	92	98	PF00069	0.516
MOD_Plk_2-3	316	322	PF00069	0.522
MOD_Plk_4	1	7	PF00069	0.673
MOD_Plk_4	15	21	PF00069	0.406
MOD_Plk_4	187	193	PF00069	0.467
MOD_Plk_4	339	345	PF00069	0.378
MOD_Plk_4	355	361	PF00069	0.494
MOD_Plk_4	410	416	PF00069	0.441
MOD_Plk_4	46	52	PF00069	0.402
MOD_Plk_4	56	62	PF00069	0.407
MOD_ProDKin_1	220	226	PF00069	0.406
MOD_ProDKin_1	261	267	PF00069	0.430
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.365
TRG_ENDOCYTIC_2	210	213	PF00928	0.360
TRG_ER_diArg_1	310	312	PF00400	0.461
TRG_ER_diArg_1	350	353	PF00400	0.501
TRG_ER_diArg_1	416	418	PF00400	0.460
TRG_ER_diArg_1	96	98	PF00400	0.491
TRG_NES_CRM1_1	349	362	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I310	Leptomonas seymouri	58%	100%
A0A0S4IZJ4	Bodo saltans	34%	82%
A0A1X0NQ94	Trypanosomatidae	39%	100%
A0A3R7MGW3	Trypanosoma rangeli	40%	99%
A4H555	Leishmania braziliensis	78%	100%
C9ZUI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ALC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QII0	Leishmania major	91%	100%