Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H613_LEIDO

TriTrypDb:

LdBPK_071190.1 , LdCL_070016800 , LDHU3_07.1410

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H613

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H613

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.587
CLV_NRD_NRD_1	176	178	PF00675	0.523
CLV_NRD_NRD_1	94	96	PF00675	0.520
CLV_PCSK_FUR_1	154	158	PF00082	0.544
CLV_PCSK_FUR_1	174	178	PF00082	0.458
CLV_PCSK_KEX2_1	156	158	PF00082	0.587
CLV_PCSK_KEX2_1	176	178	PF00082	0.574
CLV_PCSK_SKI1_1	2	6	PF00082	0.643
CLV_PCSK_SKI1_1	9	13	PF00082	0.583
DEG_Nend_UBRbox_1	1	4	PF02207	0.634
DOC_CYCLIN_RxL_1	6	16	PF00134	0.606
DOC_MAPK_gen_1	154	164	PF00069	0.512
DOC_MAPK_MEF2A_6	142	150	PF00069	0.542
DOC_PP2B_LxvP_1	165	168	PF13499	0.583
DOC_PP2B_LxvP_1	82	85	PF13499	0.703
DOC_WW_Pin1_4	18	23	PF00397	0.591
LIG_14-3-3_CanoR_1	149	153	PF00244	0.567
LIG_14-3-3_CanoR_1	154	164	PF00244	0.535
LIG_14-3-3_CanoR_1	6	12	PF00244	0.603
LIG_BRCT_BRCA1_1	58	62	PF00533	0.583
LIG_FHA_1	145	151	PF00498	0.542
LIG_FHA_1	24	30	PF00498	0.601
LIG_FHA_1	40	46	PF00498	0.475
LIG_FHA_1	99	105	PF00498	0.496
LIG_LIR_Gen_1	151	159	PF02991	0.621
LIG_LIR_Nem_3	151	155	PF02991	0.612
LIG_LIR_Nem_3	58	64	PF02991	0.598
LIG_MLH1_MIPbox_1	58	62	PF16413	0.583
LIG_SH2_CRK	152	156	PF00017	0.610
LIG_SH2_CRK	179	183	PF00017	0.593
LIG_SH2_STAP1	100	104	PF00017	0.486
LIG_SH2_STAT5	100	103	PF00017	0.545
LIG_SH3_2	91	96	PF14604	0.517
LIG_SH3_3	101	107	PF00018	0.444
LIG_SH3_3	67	73	PF00018	0.633
LIG_SH3_3	85	91	PF00018	0.567
LIG_SUMO_SIM_par_1	41	46	PF11976	0.553
LIG_TYR_ITIM	150	155	PF00017	0.604
MOD_CDC14_SPxK_1	21	24	PF00782	0.552
MOD_CDK_SPxK_1	18	24	PF00069	0.550
MOD_CK1_1	57	63	PF00069	0.717
MOD_GlcNHglycan	139	142	PF01048	0.629
MOD_GlcNHglycan	48	51	PF01048	0.702
MOD_GSK3_1	144	151	PF00069	0.523
MOD_GSK3_1	39	46	PF00069	0.542
MOD_GSK3_1	52	59	PF00069	0.525
MOD_NEK2_1	183	188	PF00069	0.565
MOD_NEK2_1	43	48	PF00069	0.524
MOD_NEK2_1	52	57	PF00069	0.490
MOD_NEK2_2	98	103	PF00069	0.435
MOD_PIKK_1	183	189	PF00454	0.489
MOD_PK_1	24	30	PF00069	0.546
MOD_PKA_2	148	154	PF00069	0.602
MOD_PKA_2	155	161	PF00069	0.549
MOD_PKA_2	23	29	PF00069	0.500
MOD_PKA_2	5	11	PF00069	0.635
MOD_Plk_1	158	164	PF00069	0.602
MOD_Plk_1	168	174	PF00069	0.540
MOD_Plk_4	24	30	PF00069	0.601
MOD_Plk_4	57	63	PF00069	0.584
MOD_ProDKin_1	18	24	PF00069	0.595
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.628
TRG_ENDOCYTIC_2	152	155	PF00928	0.604
TRG_ENDOCYTIC_2	179	182	PF00928	0.558
TRG_ER_diArg_1	154	157	PF00400	0.594
TRG_ER_diArg_1	174	177	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSB8	Leptomonas seymouri	37%	100%
A4H552	Leishmania braziliensis	72%	100%
E9ACQ3	Leishmania major	89%	100%
E9AG77	Leishmania infantum	100%	100%
E9ALC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%