FeS_assembly_P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF59, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H612_LEIDO

TriTrypDb:

LdBPK_071160.1 , LdCL_070016400 , LDHU3_07.1370

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H612

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H612

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	10
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:0006790	sulfur compound metabolic process	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.332
CLV_PCSK_KEX2_1	49	51	PF00082	0.332
CLV_PCSK_KEX2_1	77	79	PF00082	0.385
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.385
CLV_PCSK_SKI1_1	81	85	PF00082	0.395
DOC_CKS1_1	118	123	PF01111	0.501
DOC_CKS1_1	83	88	PF01111	0.298
DOC_CYCLIN_RxL_1	76	87	PF00134	0.382
DOC_MAPK_gen_1	76	84	PF00069	0.360
DOC_MAPK_MEF2A_6	76	84	PF00069	0.301
DOC_MAPK_RevD_3	63	77	PF00069	0.382
DOC_PP1_RVXF_1	79	85	PF00149	0.273
DOC_USP7_MATH_1	89	93	PF00917	0.273
DOC_WW_Pin1_4	117	122	PF00397	0.408
DOC_WW_Pin1_4	82	87	PF00397	0.273
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_Clathr_ClatBox_1	70	74	PF01394	0.289
LIG_deltaCOP1_diTrp_1	40	45	PF00928	0.502
LIG_FHA_1	83	89	PF00498	0.292
LIG_FHA_1	92	98	PF00498	0.317
LIG_FHA_2	111	117	PF00498	0.298
LIG_FHA_2	21	27	PF00498	0.521
LIG_FHA_2	8	14	PF00498	0.643
LIG_LIR_Apic_2	116	121	PF02991	0.484
LIG_LIR_Gen_1	111	119	PF02991	0.382
LIG_LIR_Gen_1	40	48	PF02991	0.283
LIG_LIR_Nem_3	111	115	PF02991	0.382
LIG_LIR_Nem_3	40	45	PF02991	0.376
LIG_MAD2	81	89	PF02301	0.382
LIG_PCNA_yPIPBox_3	139	153	PF02747	0.366
LIG_SH2_NCK_1	112	116	PF00017	0.382
LIG_SH2_PTP2	118	121	PF00017	0.495
LIG_SH2_STAT5	112	115	PF00017	0.387
LIG_SH2_STAT5	118	121	PF00017	0.497
LIG_SH3_3	51	57	PF00018	0.328
LIG_SH3_3	62	68	PF00018	0.273
LIG_SH3_3	8	14	PF00018	0.601
LIG_SH3_3	83	89	PF00018	0.273
LIG_SUMO_SIM_par_1	69	74	PF11976	0.365
MOD_CK1_1	69	75	PF00069	0.365
MOD_CK1_1	92	98	PF00069	0.273
MOD_CK2_1	105	111	PF00069	0.382
MOD_CK2_1	20	26	PF00069	0.465
MOD_CK2_1	7	13	PF00069	0.591
MOD_NEK2_1	105	110	PF00069	0.350
MOD_Plk_1	105	111	PF00069	0.388
MOD_Plk_4	66	72	PF00069	0.382
MOD_Plk_4	7	13	PF00069	0.480
MOD_Plk_4	92	98	PF00069	0.273
MOD_ProDKin_1	117	123	PF00069	0.409
MOD_ProDKin_1	82	88	PF00069	0.273
TRG_DiLeu_BaEn_1	145	150	PF01217	0.374
TRG_ENDOCYTIC_2	112	115	PF00928	0.382
TRG_ER_diArg_1	48	50	PF00400	0.332
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA31	Leptomonas seymouri	85%	100%
A0A0S4IN86	Bodo saltans	53%	100%
A0A0S4JKU2	Bodo saltans	34%	97%
A0A1X0NPI3	Trypanosomatidae	68%	100%
A0A1X0P633	Trypanosomatidae	35%	100%
A0A3R7MWC2	Trypanosoma rangeli	34%	100%
A0A422NPZ2	Trypanosoma rangeli	66%	100%
A4H549	Leishmania braziliensis	92%	100%
A4HTC5	Leishmania infantum	99%	100%
A8MR89	Arabidopsis thaliana	48%	100%
C9ZUJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZYM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ALB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O62252	Caenorhabditis elegans	52%	100%
P38829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	70%
Q3T0U7	Bos taurus	54%	100%
Q4QII6	Leishmania major	98%	100%
Q54QK1	Dictyostelium discoideum	46%	99%
Q9C9G6	Arabidopsis thaliana	50%	100%
Q9D187	Mus musculus	52%	99%
Q9DCL2	Mus musculus	54%	100%
Q9GPR0	Dictyostelium discoideum	43%	100%
Q9H5X1	Homo sapiens	54%	100%
Q9SR25	Arabidopsis thaliana	44%	100%
Q9UTL0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	91%
Q9V968	Drosophila melanogaster	52%	74%
Q9VTC4	Drosophila melanogaster	52%	100%
Q9Y3D0	Homo sapiens	54%	99%