Nucleolar RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H611_LEIDO

TriTrypDb:

LdCL_070016200 , LDHU3_07.1350

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H611

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H611

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.699
CLV_PCSK_KEX2_1	331	333	PF00082	0.670
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.670
CLV_PCSK_SKI1_1	13	17	PF00082	0.520
CLV_PCSK_SKI1_1	49	53	PF00082	0.375
DEG_Kelch_Keap1_1	173	178	PF01344	0.538
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.375
DOC_PP2B_LxvP_1	30	33	PF13499	0.375
DOC_USP7_MATH_1	107	111	PF00917	0.679
DOC_USP7_MATH_1	143	147	PF00917	0.708
DOC_WW_Pin1_4	132	137	PF00397	0.649
LIG_14-3-3_CanoR_1	26	33	PF00244	0.375
LIG_Actin_WH2_2	12	28	PF00022	0.375
LIG_FHA_1	65	71	PF00498	0.389
LIG_FHA_1	88	94	PF00498	0.476
LIG_FHA_2	174	180	PF00498	0.542
LIG_Integrin_RGD_1	243	245	PF01839	0.693
LIG_LIR_Apic_2	90	95	PF02991	0.375
LIG_LIR_LC3C_4	41	44	PF02991	0.375
LIG_LIR_Nem_3	2	7	PF02991	0.375
LIG_SH2_PTP2	92	95	PF00017	0.514
LIG_SH2_STAT5	92	95	PF00017	0.660
LIG_TRAF2_1	110	113	PF00917	0.733
LIG_TRAF2_1	146	149	PF00917	0.700
LIG_TRAF2_1	176	179	PF00917	0.546
LIG_WRC_WIRS_1	43	48	PF05994	0.375
MOD_CK2_1	107	113	PF00069	0.682
MOD_CK2_1	122	128	PF00069	0.553
MOD_CK2_1	143	149	PF00069	0.707
MOD_CK2_1	173	179	PF00069	0.541
MOD_Cter_Amidation	329	332	PF01082	0.672
MOD_GlcNHglycan	109	112	PF01048	0.688
MOD_GlcNHglycan	137	140	PF01048	0.647
MOD_GlcNHglycan	79	82	PF01048	0.462
MOD_GSK3_1	122	129	PF00069	0.701
MOD_GSK3_1	38	45	PF00069	0.491
MOD_NEK2_1	25	30	PF00069	0.520
MOD_PIKK_1	25	31	PF00454	0.520
MOD_PKA_2	25	31	PF00069	0.375
MOD_Plk_1	75	81	PF00069	0.375
MOD_Plk_2-3	113	119	PF00069	0.701
MOD_Plk_2-3	122	128	PF00069	0.605
MOD_Plk_4	38	44	PF00069	0.455
MOD_ProDKin_1	132	138	PF00069	0.650
MOD_SUMO_rev_2	41	51	PF00179	0.375
TRG_ER_diArg_1	332	335	PF00400	0.672
TRG_NLS_MonoExtN_4	328	335	PF00514	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9ALB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QII8	Leishmania major	83%	100%