WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H609_LEIDO

TriTrypDb:

LdCL_070016000 , LDHU3_07.1330

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H609

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H609

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	497	501	PF00656	0.528
CLV_MEL_PAP_1	588	594	PF00089	0.538
CLV_NRD_NRD_1	106	108	PF00675	0.696
CLV_NRD_NRD_1	116	118	PF00675	0.630
CLV_NRD_NRD_1	139	141	PF00675	0.548
CLV_NRD_NRD_1	229	231	PF00675	0.713
CLV_NRD_NRD_1	42	44	PF00675	0.728
CLV_NRD_NRD_1	557	559	PF00675	0.502
CLV_NRD_NRD_1	575	577	PF00675	0.340
CLV_NRD_NRD_1	629	631	PF00675	0.692
CLV_NRD_NRD_1	665	667	PF00675	0.619
CLV_NRD_NRD_1	690	692	PF00675	0.688
CLV_NRD_NRD_1	763	765	PF00675	0.798
CLV_PCSK_FUR_1	113	117	PF00082	0.648
CLV_PCSK_FUR_1	752	756	PF00082	0.805
CLV_PCSK_KEX2_1	106	108	PF00082	0.691
CLV_PCSK_KEX2_1	115	117	PF00082	0.633
CLV_PCSK_KEX2_1	139	141	PF00082	0.548
CLV_PCSK_KEX2_1	21	23	PF00082	0.628
CLV_PCSK_KEX2_1	229	231	PF00082	0.728
CLV_PCSK_KEX2_1	575	577	PF00082	0.600
CLV_PCSK_KEX2_1	628	630	PF00082	0.717
CLV_PCSK_KEX2_1	665	667	PF00082	0.619
CLV_PCSK_KEX2_1	690	692	PF00082	0.688
CLV_PCSK_KEX2_1	742	744	PF00082	0.752
CLV_PCSK_KEX2_1	754	756	PF00082	0.745
CLV_PCSK_KEX2_1	762	764	PF00082	0.500
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.675
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.752
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.745
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.500
CLV_PCSK_SKI1_1	101	105	PF00082	0.558
CLV_PCSK_SKI1_1	150	154	PF00082	0.648
CLV_PCSK_SKI1_1	174	178	PF00082	0.689
CLV_PCSK_SKI1_1	323	327	PF00082	0.591
CLV_PCSK_SKI1_1	356	360	PF00082	0.593
CLV_PCSK_SKI1_1	417	421	PF00082	0.445
CLV_PCSK_SKI1_1	558	562	PF00082	0.529
CLV_PCSK_SKI1_1	644	648	PF00082	0.610
CLV_PCSK_SKI1_1	694	698	PF00082	0.745
DEG_APCC_DBOX_1	149	157	PF00400	0.746
DEG_APCC_DBOX_1	841	849	PF00400	0.515
DEG_MDM2_SWIB_1	335	343	PF02201	0.469
DOC_CYCLIN_RxL_1	556	567	PF00134	0.504
DOC_CYCLIN_yClb3_PxF_3	236	244	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.623
DOC_MAPK_DCC_7	150	158	PF00069	0.751
DOC_MAPK_gen_1	115	127	PF00069	0.580
DOC_MAPK_gen_1	558	565	PF00069	0.473
DOC_MAPK_MEF2A_6	150	158	PF00069	0.751
DOC_MAPK_MEF2A_6	404	411	PF00069	0.473
DOC_MAPK_MEF2A_6	558	565	PF00069	0.573
DOC_MAPK_MEF2A_6	603	611	PF00069	0.621
DOC_MAPK_NFAT4_5	558	566	PF00069	0.488
DOC_PP1_RVXF_1	334	340	PF00149	0.448
DOC_PP2B_LxvP_1	253	256	PF13499	0.786
DOC_PP2B_LxvP_1	360	363	PF13499	0.538
DOC_PP4_FxxP_1	177	180	PF00568	0.729
DOC_PP4_FxxP_1	415	418	PF00568	0.478
DOC_PP4_FxxP_1	680	683	PF00568	0.506
DOC_PP4_MxPP_1	848	851	PF00568	0.535
DOC_USP7_MATH_1	224	228	PF00917	0.644
DOC_USP7_MATH_1	286	290	PF00917	0.813
DOC_USP7_MATH_1	302	306	PF00917	0.599
DOC_USP7_MATH_1	308	312	PF00917	0.635
DOC_USP7_MATH_1	375	379	PF00917	0.720
DOC_USP7_MATH_1	440	444	PF00917	0.462
DOC_USP7_MATH_1	494	498	PF00917	0.607
DOC_USP7_MATH_1	61	65	PF00917	0.585
DOC_USP7_MATH_1	638	642	PF00917	0.522
DOC_USP7_MATH_1	724	728	PF00917	0.644
DOC_USP7_MATH_1	748	752	PF00917	0.862
DOC_USP7_MATH_1	768	772	PF00917	0.626
DOC_WW_Pin1_4	143	148	PF00397	0.551
DOC_WW_Pin1_4	267	272	PF00397	0.701
DOC_WW_Pin1_4	303	308	PF00397	0.748
DOC_WW_Pin1_4	373	378	PF00397	0.762
DOC_WW_Pin1_4	384	389	PF00397	0.610
DOC_WW_Pin1_4	504	509	PF00397	0.450
DOC_WW_Pin1_4	590	595	PF00397	0.532
DOC_WW_Pin1_4	611	616	PF00397	0.436
DOC_WW_Pin1_4	63	68	PF00397	0.691
DOC_WW_Pin1_4	720	725	PF00397	0.704
DOC_WW_Pin1_4	731	736	PF00397	0.694
DOC_WW_Pin1_4	789	794	PF00397	0.735
LIG_14-3-3_CanoR_1	101	110	PF00244	0.549
LIG_14-3-3_CanoR_1	12	17	PF00244	0.696
LIG_14-3-3_CanoR_1	229	239	PF00244	0.737
LIG_14-3-3_CanoR_1	244	248	PF00244	0.600
LIG_14-3-3_CanoR_1	250	256	PF00244	0.606
LIG_14-3-3_CanoR_1	316	322	PF00244	0.596
LIG_14-3-3_CanoR_1	338	347	PF00244	0.542
LIG_14-3-3_CanoR_1	356	361	PF00244	0.478
LIG_14-3-3_CanoR_1	446	451	PF00244	0.476
LIG_14-3-3_CanoR_1	478	486	PF00244	0.592
LIG_14-3-3_CanoR_1	650	657	PF00244	0.474
LIG_Actin_WH2_2	549	566	PF00022	0.576
LIG_AP2alpha_2	130	132	PF02296	0.543
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BIR_III_1	1	5	PF00653	0.700
LIG_BIR_III_2	790	794	PF00653	0.825
LIG_BIR_III_3	1	5	PF00653	0.700
LIG_BRCT_BRCA1_1	12	16	PF00533	0.760
LIG_BRCT_BRCA1_1	128	132	PF00533	0.530
LIG_BRCT_BRCA1_1	411	415	PF00533	0.548
LIG_CaM_IQ_9	438	453	PF13499	0.595
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.638
LIG_EVH1_2	850	854	PF00568	0.577
LIG_FHA_1	120	126	PF00498	0.536
LIG_FHA_1	387	393	PF00498	0.791
LIG_FHA_1	436	442	PF00498	0.456
LIG_FHA_1	510	516	PF00498	0.590
LIG_FHA_1	575	581	PF00498	0.511
LIG_FHA_1	658	664	PF00498	0.677
LIG_FHA_1	676	682	PF00498	0.694
LIG_FHA_1	838	844	PF00498	0.633
LIG_FHA_2	535	541	PF00498	0.506
LIG_FHA_2	816	822	PF00498	0.517
LIG_FXI_DFP_1	479	483	PF00024	0.768
LIG_IRF3_LxIS_1	406	412	PF10401	0.481
LIG_LIR_Apic_2	13	17	PF02991	0.583
LIG_LIR_Apic_2	175	180	PF02991	0.629
LIG_LIR_Apic_2	194	200	PF02991	0.649
LIG_LIR_Apic_2	33	39	PF02991	0.644
LIG_LIR_Apic_2	399	403	PF02991	0.608
LIG_LIR_Apic_2	412	418	PF02991	0.466
LIG_LIR_Apic_2	678	683	PF02991	0.503
LIG_LIR_Gen_1	416	425	PF02991	0.455
LIG_LIR_Gen_1	527	535	PF02991	0.542
LIG_LIR_Gen_1	798	807	PF02991	0.729
LIG_LIR_LC3C_4	204	207	PF02991	0.473
LIG_LIR_Nem_3	327	333	PF02991	0.611
LIG_LIR_Nem_3	35	41	PF02991	0.676
LIG_LIR_Nem_3	416	422	PF02991	0.452
LIG_LIR_Nem_3	527	532	PF02991	0.526
LIG_LIR_Nem_3	798	802	PF02991	0.787
LIG_MYND_1	547	551	PF01753	0.492
LIG_Pex14_1	173	177	PF04695	0.639
LIG_Pex14_2	32	36	PF04695	0.629
LIG_Pex14_2	335	339	PF04695	0.464
LIG_Pex14_2	415	419	PF04695	0.471
LIG_PTAP_UEV_1	482	487	PF05743	0.559
LIG_Rb_LxCxE_1	350	368	PF01857	0.547
LIG_SH2_CRK	118	122	PF00017	0.613
LIG_SH2_CRK	14	18	PF00017	0.600
LIG_SH2_CRK	331	335	PF00017	0.556
LIG_SH2_CRK	400	404	PF00017	0.621
LIG_SH2_NCK_1	221	225	PF00017	0.502
LIG_SH2_NCK_1	331	335	PF00017	0.513
LIG_SH2_STAP1	509	513	PF00017	0.426
LIG_SH2_STAP1	631	635	PF00017	0.539
LIG_SH2_STAT5	14	17	PF00017	0.648
LIG_SH2_STAT5	201	204	PF00017	0.557
LIG_SH2_STAT5	331	334	PF00017	0.511
LIG_SH2_STAT5	625	628	PF00017	0.620
LIG_SH2_STAT5	631	634	PF00017	0.545
LIG_SH2_STAT5	655	658	PF00017	0.523
LIG_SH3_3	233	239	PF00018	0.563
LIG_SH3_3	268	274	PF00018	0.731
LIG_SH3_3	31	37	PF00018	0.631
LIG_SH3_3	346	352	PF00018	0.461
LIG_SH3_3	369	375	PF00018	0.776
LIG_SH3_3	480	486	PF00018	0.735
LIG_SH3_3	843	849	PF00018	0.602
LIG_SUMO_SIM_anti_2	834	840	PF11976	0.744
LIG_SUMO_SIM_par_1	122	130	PF11976	0.531
LIG_SUMO_SIM_par_1	407	413	PF11976	0.437
LIG_SUMO_SIM_par_1	536	542	PF11976	0.505
LIG_SUMO_SIM_par_1	644	649	PF11976	0.411
LIG_TRAF2_1	278	281	PF00917	0.565
LIG_TRAF2_1	352	355	PF00917	0.506
LIG_TRAF2_1	701	704	PF00917	0.704
LIG_TRAF2_1	778	781	PF00917	0.744
LIG_TRAF2_2	161	166	PF00917	0.675
LIG_WRC_WIRS_1	325	330	PF05994	0.604
LIG_WRC_WIRS_1	618	623	PF05994	0.607
LIG_WRC_WIRS_1	796	801	PF05994	0.706
LIG_WW_1	198	201	PF00397	0.513
MOD_CDC14_SPxK_1	270	273	PF00782	0.709
MOD_CDC14_SPxK_1	792	795	PF00782	0.822
MOD_CDK_SPxK_1	267	273	PF00069	0.708
MOD_CDK_SPxK_1	789	795	PF00069	0.827
MOD_CDK_SPxxK_3	143	150	PF00069	0.574
MOD_CDK_SPxxK_3	272	279	PF00069	0.705
MOD_CK1_1	186	192	PF00069	0.766
MOD_CK1_1	240	246	PF00069	0.709
MOD_CK1_1	289	295	PF00069	0.717
MOD_CK1_1	311	317	PF00069	0.713
MOD_CK1_1	51	57	PF00069	0.577
MOD_CK1_1	63	69	PF00069	0.824
MOD_CK1_1	727	733	PF00069	0.806
MOD_CK1_1	837	843	PF00069	0.571
MOD_CK1_1	856	862	PF00069	0.633
MOD_CK2_1	208	214	PF00069	0.463
MOD_CK2_1	289	295	PF00069	0.789
MOD_CK2_1	504	510	PF00069	0.440
MOD_CK2_1	565	571	PF00069	0.652
MOD_CK2_1	617	623	PF00069	0.696
MOD_CK2_1	815	821	PF00069	0.513
MOD_GlcNHglycan	193	196	PF01048	0.717
MOD_GlcNHglycan	209	213	PF01048	0.388
MOD_GlcNHglycan	253	256	PF01048	0.762
MOD_GlcNHglycan	291	294	PF01048	0.682
MOD_GlcNHglycan	317	320	PF01048	0.714
MOD_GlcNHglycan	367	372	PF01048	0.778
MOD_GlcNHglycan	384	387	PF01048	0.536
MOD_GlcNHglycan	483	486	PF01048	0.560
MOD_GlcNHglycan	50	53	PF01048	0.724
MOD_GlcNHglycan	540	544	PF01048	0.573
MOD_GlcNHglycan	567	570	PF01048	0.685
MOD_GlcNHglycan	585	588	PF01048	0.389
MOD_GlcNHglycan	667	670	PF01048	0.675
MOD_GlcNHglycan	684	687	PF01048	0.682
MOD_GlcNHglycan	729	732	PF01048	0.746
MOD_GlcNHglycan	758	761	PF01048	0.678
MOD_GlcNHglycan	812	815	PF01048	0.597
MOD_GlcNHglycan	855	858	PF01048	0.805
MOD_GlcNHglycan	864	867	PF01048	0.639
MOD_GSK3_1	183	190	PF00069	0.699
MOD_GSK3_1	20	27	PF00069	0.775
MOD_GSK3_1	311	318	PF00069	0.744
MOD_GSK3_1	382	389	PF00069	0.753
MOD_GSK3_1	392	399	PF00069	0.579
MOD_GSK3_1	477	484	PF00069	0.624
MOD_GSK3_1	590	597	PF00069	0.611
MOD_GSK3_1	720	727	PF00069	0.711
MOD_GSK3_1	852	859	PF00069	0.692
MOD_LATS_1	99	105	PF00433	0.561
MOD_N-GLC_1	230	235	PF02516	0.671
MOD_NEK2_1	172	177	PF00069	0.677
MOD_NEK2_1	187	192	PF00069	0.581
MOD_NEK2_1	32	37	PF00069	0.734
MOD_NEK2_1	329	334	PF00069	0.480
MOD_NEK2_1	434	439	PF00069	0.515
MOD_NEK2_1	503	508	PF00069	0.476
MOD_NEK2_1	539	544	PF00069	0.547
MOD_NEK2_1	552	557	PF00069	0.390
MOD_NEK2_1	648	653	PF00069	0.490
MOD_NEK2_1	853	858	PF00069	0.555
MOD_NEK2_2	453	458	PF00069	0.630
MOD_PIKK_1	248	254	PF00454	0.819
MOD_PIKK_1	311	317	PF00454	0.820
MOD_PIKK_1	338	344	PF00454	0.474
MOD_PIKK_1	392	398	PF00454	0.558
MOD_PIKK_1	650	656	PF00454	0.533
MOD_PKA_1	629	635	PF00069	0.423
MOD_PKA_1	665	671	PF00069	0.655
MOD_PKA_1	754	760	PF00069	0.842
MOD_PKA_2	119	125	PF00069	0.570
MOD_PKA_2	222	228	PF00069	0.623
MOD_PKA_2	237	243	PF00069	0.682
MOD_PKA_2	315	321	PF00069	0.734
MOD_PKA_2	477	483	PF00069	0.585
MOD_PKA_2	574	580	PF00069	0.633
MOD_PKA_2	61	67	PF00069	0.611
MOD_PKA_2	629	635	PF00069	0.560
MOD_PKA_2	665	671	PF00069	0.772
MOD_PKA_2	754	760	PF00069	0.781
MOD_PKB_1	336	344	PF00069	0.469
MOD_PKB_1	46	54	PF00069	0.725
MOD_Plk_1	32	38	PF00069	0.735
MOD_Plk_1	527	533	PF00069	0.537
MOD_Plk_1	648	654	PF00069	0.530
MOD_Plk_4	119	125	PF00069	0.695
MOD_Plk_4	183	189	PF00069	0.548
MOD_Plk_4	237	243	PF00069	0.767
MOD_Plk_4	321	327	PF00069	0.639
MOD_Plk_4	375	381	PF00069	0.738
MOD_Plk_4	453	459	PF00069	0.623
MOD_Plk_4	534	540	PF00069	0.480
MOD_ProDKin_1	143	149	PF00069	0.565
MOD_ProDKin_1	267	273	PF00069	0.703
MOD_ProDKin_1	303	309	PF00069	0.748
MOD_ProDKin_1	373	379	PF00069	0.763
MOD_ProDKin_1	384	390	PF00069	0.605
MOD_ProDKin_1	504	510	PF00069	0.452
MOD_ProDKin_1	590	596	PF00069	0.523
MOD_ProDKin_1	611	617	PF00069	0.440
MOD_ProDKin_1	63	69	PF00069	0.693
MOD_ProDKin_1	720	726	PF00069	0.707
MOD_ProDKin_1	731	737	PF00069	0.690
MOD_ProDKin_1	789	795	PF00069	0.735
MOD_SUMO_for_1	278	281	PF00179	0.762
MOD_SUMO_for_1	72	75	PF00179	0.748
MOD_SUMO_for_1	778	781	PF00179	0.740
TRG_DiLeu_BaEn_1	426	431	PF01217	0.472
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.612
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.519
TRG_ER_diArg_1	106	108	PF00400	0.691
TRG_ER_diArg_1	115	117	PF00400	0.633
TRG_ER_diArg_1	217	220	PF00400	0.586
TRG_ER_diArg_1	335	338	PF00400	0.432
TRG_ER_diArg_1	46	49	PF00400	0.761
TRG_ER_diArg_1	561	564	PF00400	0.565
TRG_ER_diArg_1	628	630	PF00400	0.477
TRG_ER_diArg_1	743	746	PF00400	0.849
TRG_NLS_MonoCore_2	741	746	PF00514	0.765
TRG_NLS_MonoExtC_3	42	47	PF00514	0.656
TRG_NLS_MonoExtC_3	741	746	PF00514	0.852
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN7	Leptomonas seymouri	43%	100%
A4H545	Leishmania braziliensis	71%	100%
A4HTC1	Leishmania infantum	99%	100%
E9ALB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QIJ0	Leishmania major	88%	100%