Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S5H608_LEIDO

TriTrypDb:

LdCL_070015900 , LDHU3_07.1320

Length:

1134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H608

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H608

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	345	349	PF00656	0.386
CLV_C14_Caspase3-7	706	710	PF00656	0.666
CLV_C14_Caspase3-7	777	781	PF00656	0.477
CLV_C14_Caspase3-7	912	916	PF00656	0.705
CLV_NRD_NRD_1	1129	1131	PF00675	0.728
CLV_NRD_NRD_1	117	119	PF00675	0.563
CLV_NRD_NRD_1	149	151	PF00675	0.454
CLV_NRD_NRD_1	158	160	PF00675	0.420
CLV_NRD_NRD_1	223	225	PF00675	0.519
CLV_NRD_NRD_1	341	343	PF00675	0.479
CLV_NRD_NRD_1	463	465	PF00675	0.474
CLV_NRD_NRD_1	521	523	PF00675	0.474
CLV_NRD_NRD_1	532	534	PF00675	0.405
CLV_NRD_NRD_1	616	618	PF00675	0.414
CLV_NRD_NRD_1	65	67	PF00675	0.402
CLV_NRD_NRD_1	680	682	PF00675	0.544
CLV_NRD_NRD_1	727	729	PF00675	0.521
CLV_NRD_NRD_1	93	95	PF00675	0.594
CLV_NRD_NRD_1	940	942	PF00675	0.565
CLV_PCSK_FUR_1	1127	1131	PF00082	0.501
CLV_PCSK_FUR_1	115	119	PF00082	0.397
CLV_PCSK_KEX2_1	1129	1131	PF00082	0.518
CLV_PCSK_KEX2_1	117	119	PF00082	0.446
CLV_PCSK_KEX2_1	148	150	PF00082	0.451
CLV_PCSK_KEX2_1	157	159	PF00082	0.423
CLV_PCSK_KEX2_1	223	225	PF00082	0.522
CLV_PCSK_KEX2_1	321	323	PF00082	0.467
CLV_PCSK_KEX2_1	341	343	PF00082	0.335
CLV_PCSK_KEX2_1	421	423	PF00082	0.436
CLV_PCSK_KEX2_1	463	465	PF00082	0.474
CLV_PCSK_KEX2_1	521	523	PF00082	0.473
CLV_PCSK_KEX2_1	546	548	PF00082	0.442
CLV_PCSK_KEX2_1	615	617	PF00082	0.465
CLV_PCSK_KEX2_1	65	67	PF00082	0.401
CLV_PCSK_KEX2_1	680	682	PF00082	0.527
CLV_PCSK_KEX2_1	726	728	PF00082	0.490
CLV_PCSK_KEX2_1	92	94	PF00082	0.586
CLV_PCSK_KEX2_1	940	942	PF00082	0.565
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.552
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.517
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.470
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.440
CLV_PCSK_PC7_1	459	465	PF00082	0.532
CLV_PCSK_PC7_1	612	618	PF00082	0.377
CLV_PCSK_PC7_1	89	95	PF00082	0.483
CLV_PCSK_SKI1_1	381	385	PF00082	0.530
CLV_PCSK_SKI1_1	453	457	PF00082	0.513
CLV_PCSK_SKI1_1	533	537	PF00082	0.467
CLV_PCSK_SKI1_1	595	599	PF00082	0.561
DEG_APCC_DBOX_1	206	214	PF00400	0.311
DEG_APCC_DBOX_1	21	29	PF00400	0.441
DEG_APCC_DBOX_1	267	275	PF00400	0.470
DEG_APCC_DBOX_1	633	641	PF00400	0.492
DEG_APCC_DBOX_1	725	733	PF00400	0.549
DEG_COP1_1	947	955	PF00400	0.629
DEG_SPOP_SBC_1	1075	1079	PF00917	0.573
DEG_SPOP_SBC_1	1103	1107	PF00917	0.474
DOC_ANK_TNKS_1	939	946	PF00023	0.587
DOC_CKS1_1	824	829	PF01111	0.678
DOC_CKS1_1	952	957	PF01111	0.620
DOC_CYCLIN_RxL_1	530	541	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	1004	1010	PF00134	0.756
DOC_CYCLIN_yCln2_LP_2	1095	1101	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	788	794	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	923	929	PF00134	0.607
DOC_MAPK_DCC_7	1065	1073	PF00069	0.580
DOC_MAPK_gen_1	742	751	PF00069	0.448
DOC_MAPK_gen_1	779	788	PF00069	0.675
DOC_MAPK_HePTP_8	938	950	PF00069	0.572
DOC_MAPK_MEF2A_6	1065	1073	PF00069	0.580
DOC_MAPK_MEF2A_6	895	903	PF00069	0.626
DOC_MAPK_MEF2A_6	941	950	PF00069	0.687
DOC_PP2B_LxvP_1	1004	1007	PF13499	0.753
DOC_PP2B_LxvP_1	1095	1098	PF13499	0.547
DOC_PP2B_LxvP_1	1101	1104	PF13499	0.654
DOC_PP2B_LxvP_1	501	504	PF13499	0.536
DOC_PP2B_LxvP_1	788	791	PF13499	0.578
DOC_PP2B_LxvP_1	923	926	PF13499	0.638
DOC_USP7_MATH_1	1031	1035	PF00917	0.576
DOC_USP7_MATH_1	1064	1068	PF00917	0.667
DOC_USP7_MATH_1	1074	1078	PF00917	0.586
DOC_USP7_MATH_1	1081	1085	PF00917	0.589
DOC_USP7_MATH_1	11	15	PF00917	0.533
DOC_USP7_MATH_1	1112	1116	PF00917	0.686
DOC_USP7_MATH_1	216	220	PF00917	0.451
DOC_USP7_MATH_1	257	261	PF00917	0.564
DOC_USP7_MATH_1	520	524	PF00917	0.490
DOC_USP7_MATH_1	55	59	PF00917	0.592
DOC_USP7_MATH_1	755	759	PF00917	0.594
DOC_USP7_MATH_1	840	844	PF00917	0.643
DOC_USP7_MATH_1	848	852	PF00917	0.606
DOC_USP7_MATH_2	870	876	PF00917	0.497
DOC_WW_Pin1_4	1020	1025	PF00397	0.700
DOC_WW_Pin1_4	1053	1058	PF00397	0.624
DOC_WW_Pin1_4	1077	1082	PF00397	0.768
DOC_WW_Pin1_4	794	799	PF00397	0.645
DOC_WW_Pin1_4	823	828	PF00397	0.655
DOC_WW_Pin1_4	842	847	PF00397	0.543
DOC_WW_Pin1_4	893	898	PF00397	0.555
DOC_WW_Pin1_4	918	923	PF00397	0.637
DOC_WW_Pin1_4	951	956	PF00397	0.623
DOC_WW_Pin1_4	961	966	PF00397	0.602
DOC_WW_Pin1_4	968	973	PF00397	0.537
DOC_WW_Pin1_4	978	983	PF00397	0.532
LIG_14-3-3_CanoR_1	239	246	PF00244	0.532
LIG_14-3-3_CanoR_1	256	264	PF00244	0.412
LIG_14-3-3_CanoR_1	407	416	PF00244	0.540
LIG_14-3-3_CanoR_1	521	528	PF00244	0.538
LIG_14-3-3_CanoR_1	687	691	PF00244	0.533
LIG_14-3-3_CanoR_1	703	711	PF00244	0.629
LIG_14-3-3_CterR_2	1130	1134	PF00244	0.595
LIG_Actin_WH2_2	412	430	PF00022	0.402
LIG_BRCT_BRCA1_1	652	656	PF00533	0.448
LIG_BRCT_BRCA1_2	652	658	PF00533	0.451
LIG_CtBP_PxDLS_1	870	874	PF00389	0.491
LIG_CtBP_PxDLS_1	928	932	PF00389	0.594
LIG_FHA_1	1034	1040	PF00498	0.581
LIG_FHA_1	245	251	PF00498	0.533
LIG_FHA_1	270	276	PF00498	0.494
LIG_FHA_1	49	55	PF00498	0.556
LIG_FHA_1	530	536	PF00498	0.414
LIG_FHA_1	664	670	PF00498	0.454
LIG_FHA_1	746	752	PF00498	0.583
LIG_FHA_1	824	830	PF00498	0.687
LIG_FHA_1	902	908	PF00498	0.756
LIG_FHA_1	947	953	PF00498	0.798
LIG_FHA_2	199	205	PF00498	0.512
LIG_FHA_2	220	226	PF00498	0.562
LIG_FHA_2	256	262	PF00498	0.565
LIG_FHA_2	385	391	PF00498	0.666
LIG_FHA_2	393	399	PF00498	0.573
LIG_FHA_2	694	700	PF00498	0.567
LIG_FHA_2	704	710	PF00498	0.629
LIG_FHA_2	910	916	PF00498	0.585
LIG_GBD_Chelix_1	899	907	PF00786	0.497
LIG_LIR_Apic_2	1085	1091	PF02991	0.494
LIG_LIR_Gen_1	1056	1066	PF02991	0.534
LIG_LIR_Gen_1	24	34	PF02991	0.464
LIG_LIR_Nem_3	1056	1061	PF02991	0.535
LIG_LIR_Nem_3	24	29	PF02991	0.663
LIG_LIR_Nem_3	696	700	PF02991	0.519
LIG_LIR_Nem_3	72	78	PF02991	0.440
LIG_MYND_1	1001	1005	PF01753	0.555
LIG_NRBOX	270	276	PF00104	0.505
LIG_Pex14_1	693	697	PF04695	0.507
LIG_PROFILIN_1	804	810	PF00235	0.540
LIG_PROFILIN_1	882	888	PF00235	0.478
LIG_PTAP_UEV_1	809	814	PF05743	0.557
LIG_Rb_pABgroove_1	311	319	PF01858	0.472
LIG_SH2_CRK	1058	1062	PF00017	0.659
LIG_SH2_CRK	1088	1092	PF00017	0.747
LIG_SH2_NCK_1	1058	1062	PF00017	0.536
LIG_SH2_NCK_1	1088	1092	PF00017	0.561
LIG_SH2_SRC	1019	1022	PF00017	0.498
LIG_SH2_SRC	968	971	PF00017	0.616
LIG_SH2_STAP1	480	484	PF00017	0.474
LIG_SH2_STAP1	619	623	PF00017	0.511
LIG_SH2_STAT5	1019	1022	PF00017	0.498
LIG_SH3_1	1088	1094	PF00018	0.552
LIG_SH3_3	1021	1027	PF00018	0.610
LIG_SH3_3	1045	1051	PF00018	0.560
LIG_SH3_3	1058	1064	PF00018	0.494
LIG_SH3_3	1068	1074	PF00018	0.602
LIG_SH3_3	1088	1094	PF00018	0.581
LIG_SH3_3	15	21	PF00018	0.458
LIG_SH3_3	7	13	PF00018	0.687
LIG_SH3_3	788	794	PF00018	0.614
LIG_SH3_3	801	807	PF00018	0.619
LIG_SH3_3	810	816	PF00018	0.582
LIG_SH3_3	851	857	PF00018	0.679
LIG_SH3_3	879	885	PF00018	0.555
LIG_SH3_3	947	953	PF00018	0.610
LIG_SH3_3	976	982	PF00018	0.767
LIG_SH3_3	992	998	PF00018	0.541
LIG_SH3_3	999	1005	PF00018	0.670
LIG_SUMO_SIM_par_1	1099	1110	PF11976	0.584
LIG_SUMO_SIM_par_1	927	932	PF11976	0.597
LIG_SUMO_SIM_par_1	947	954	PF11976	0.464
LIG_TRAF2_1	201	204	PF00917	0.545
LIG_TRAF2_1	493	496	PF00917	0.476
LIG_TRAF2_1	538	541	PF00917	0.465
LIG_WRC_WIRS_1	933	938	PF05994	0.566
LIG_WW_2	1093	1096	PF00397	0.533
MOD_CK1_1	1015	1021	PF00069	0.656
MOD_CK1_1	1067	1073	PF00069	0.780
MOD_CK1_1	1077	1083	PF00069	0.556
MOD_CK1_1	1105	1111	PF00069	0.693
MOD_CK1_1	219	225	PF00069	0.623
MOD_CK1_1	27	33	PF00069	0.576
MOD_CK1_1	545	551	PF00069	0.400
MOD_CK1_1	651	657	PF00069	0.650
MOD_CK1_1	686	692	PF00069	0.488
MOD_CK1_1	704	710	PF00069	0.476
MOD_CK1_1	932	938	PF00069	0.572
MOD_CK1_1	960	966	PF00069	0.662
MOD_CK2_1	1031	1037	PF00069	0.483
MOD_CK2_1	198	204	PF00069	0.432
MOD_CK2_1	219	225	PF00069	0.463
MOD_CK2_1	255	261	PF00069	0.555
MOD_CK2_1	305	311	PF00069	0.475
MOD_CK2_1	384	390	PF00069	0.608
MOD_CK2_1	392	398	PF00069	0.514
MOD_CK2_1	490	496	PF00069	0.518
MOD_CK2_1	693	699	PF00069	0.504
MOD_Cter_Amidation	938	941	PF01082	0.564
MOD_GlcNHglycan	1040	1043	PF01048	0.605
MOD_GlcNHglycan	1088	1091	PF01048	0.670
MOD_GlcNHglycan	1114	1117	PF01048	0.713
MOD_GlcNHglycan	18	21	PF01048	0.656
MOD_GlcNHglycan	287	290	PF01048	0.637
MOD_GlcNHglycan	29	32	PF01048	0.652
MOD_GlcNHglycan	307	310	PF01048	0.532
MOD_GlcNHglycan	387	390	PF01048	0.477
MOD_GlcNHglycan	449	452	PF01048	0.536
MOD_GlcNHglycan	45	48	PF01048	0.590
MOD_GlcNHglycan	492	495	PF01048	0.579
MOD_GlcNHglycan	522	525	PF01048	0.447
MOD_GlcNHglycan	547	550	PF01048	0.400
MOD_GlcNHglycan	571	576	PF01048	0.383
MOD_GlcNHglycan	649	653	PF01048	0.431
MOD_GlcNHglycan	751	754	PF01048	0.617
MOD_GlcNHglycan	788	791	PF01048	0.677
MOD_GlcNHglycan	801	804	PF01048	0.651
MOD_GlcNHglycan	810	813	PF01048	0.688
MOD_GlcNHglycan	846	849	PF01048	0.650
MOD_GlcNHglycan	941	944	PF01048	0.657
MOD_GlcNHglycan	985	988	PF01048	0.714
MOD_GSK3_1	1008	1015	PF00069	0.676
MOD_GSK3_1	1075	1082	PF00069	0.759
MOD_GSK3_1	1099	1106	PF00069	0.683
MOD_GSK3_1	285	292	PF00069	0.562
MOD_GSK3_1	443	450	PF00069	0.473
MOD_GSK3_1	464	471	PF00069	0.595
MOD_GSK3_1	541	548	PF00069	0.632
MOD_GSK3_1	701	708	PF00069	0.512
MOD_GSK3_1	745	752	PF00069	0.550
MOD_GSK3_1	830	837	PF00069	0.687
MOD_GSK3_1	840	847	PF00069	0.544
MOD_GSK3_1	873	880	PF00069	0.529
MOD_GSK3_1	914	921	PF00069	0.650
MOD_GSK3_1	927	934	PF00069	0.532
MOD_GSK3_1	957	964	PF00069	0.703
MOD_N-GLC_1	1012	1017	PF02516	0.563
MOD_N-GLC_1	237	242	PF02516	0.475
MOD_N-GLC_1	55	60	PF02516	0.671
MOD_N-GLC_1	586	591	PF02516	0.408
MOD_N-GLC_1	848	853	PF02516	0.708
MOD_NEK2_1	105	110	PF00069	0.458
MOD_NEK2_1	198	203	PF00069	0.516
MOD_NEK2_1	252	257	PF00069	0.495
MOD_NEK2_1	285	290	PF00069	0.524
MOD_NEK2_1	302	307	PF00069	0.413
MOD_NEK2_1	384	389	PF00069	0.653
MOD_NEK2_1	5	10	PF00069	0.628
MOD_NEK2_1	683	688	PF00069	0.543
MOD_NEK2_1	751	756	PF00069	0.496
MOD_NEK2_1	901	906	PF00069	0.649
MOD_NEK2_1	931	936	PF00069	0.661
MOD_NEK2_1	959	964	PF00069	0.693
MOD_NEK2_2	745	750	PF00069	0.456
MOD_PIKK_1	433	439	PF00454	0.496
MOD_PIKK_1	468	474	PF00454	0.470
MOD_PKA_2	238	244	PF00069	0.533
MOD_PKA_2	255	261	PF00069	0.408
MOD_PKA_2	385	391	PF00069	0.694
MOD_PKA_2	5	11	PF00069	0.717
MOD_PKA_2	520	526	PF00069	0.521
MOD_PKA_2	611	617	PF00069	0.487
MOD_PKA_2	663	669	PF00069	0.553
MOD_PKA_2	686	692	PF00069	0.482
MOD_PKA_2	749	755	PF00069	0.695
MOD_PKA_2	778	784	PF00069	0.631
MOD_PKA_2	864	870	PF00069	0.763
MOD_PKA_2	88	94	PF00069	0.566
MOD_PKA_2	939	945	PF00069	0.615
MOD_Plk_1	105	111	PF00069	0.410
MOD_Plk_1	191	197	PF00069	0.491
MOD_Plk_1	376	382	PF00069	0.615
MOD_Plk_1	55	61	PF00069	0.591
MOD_Plk_1	586	592	PF00069	0.530
MOD_Plk_1	745	751	PF00069	0.612
MOD_Plk_4	1015	1021	PF00069	0.487
MOD_Plk_4	49	55	PF00069	0.692
MOD_ProDKin_1	1020	1026	PF00069	0.700
MOD_ProDKin_1	1053	1059	PF00069	0.624
MOD_ProDKin_1	1077	1083	PF00069	0.766
MOD_ProDKin_1	794	800	PF00069	0.644
MOD_ProDKin_1	823	829	PF00069	0.655
MOD_ProDKin_1	842	848	PF00069	0.540
MOD_ProDKin_1	893	899	PF00069	0.556
MOD_ProDKin_1	918	924	PF00069	0.637
MOD_ProDKin_1	951	957	PF00069	0.624
MOD_ProDKin_1	961	967	PF00069	0.603
MOD_ProDKin_1	968	974	PF00069	0.532
MOD_ProDKin_1	978	984	PF00069	0.535
MOD_SUMO_for_1	170	173	PF00179	0.480
MOD_SUMO_for_1	335	338	PF00179	0.459
MOD_SUMO_for_1	402	405	PF00179	0.441
MOD_SUMO_for_1	412	415	PF00179	0.570
MOD_SUMO_for_1	568	571	PF00179	0.458
MOD_SUMO_rev_2	130	138	PF00179	0.476
MOD_SUMO_rev_2	318	323	PF00179	0.422
MOD_SUMO_rev_2	465	471	PF00179	0.406
TRG_DiLeu_BaEn_1	360	365	PF01217	0.491
TRG_DiLeu_BaEn_4	208	214	PF01217	0.468
TRG_DiLeu_BaEn_4	482	488	PF01217	0.486
TRG_DiLeu_BaEn_4	674	680	PF01217	0.529
TRG_DiLeu_BaEn_4	734	740	PF01217	0.468
TRG_DiLeu_BaEn_4	746	752	PF01217	0.483
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.437
TRG_DiLeu_BaLyEn_6	999	1004	PF01217	0.590
TRG_DiLeu_LyEn_5	360	365	PF01217	0.398
TRG_ENDOCYTIC_2	1058	1061	PF00928	0.622
TRG_ENDOCYTIC_2	697	700	PF00928	0.517
TRG_ENDOCYTIC_2	74	77	PF00928	0.468
TRG_ER_diArg_1	101	104	PF00400	0.579
TRG_ER_diArg_1	1127	1130	PF00400	0.505
TRG_ER_diArg_1	115	118	PF00400	0.517
TRG_ER_diArg_1	148	150	PF00400	0.449
TRG_ER_diArg_1	157	159	PF00400	0.425
TRG_ER_diArg_1	341	343	PF00400	0.476
TRG_ER_diArg_1	462	464	PF00400	0.487
TRG_ER_diArg_1	560	563	PF00400	0.494
TRG_ER_diArg_1	615	617	PF00400	0.491
TRG_ER_diArg_1	64	66	PF00400	0.412
TRG_ER_diArg_1	679	681	PF00400	0.544
TRG_ER_diArg_1	726	728	PF00400	0.579
TRG_NES_CRM1_1	242	253	PF08389	0.473
TRG_NLS_Bipartite_1	521	537	PF00514	0.551
TRG_NLS_MonoExtN_4	486	493	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	369	374	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	526	530	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	578	583	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	681	685	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	727	731	PF00026	0.637

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G2	Leptomonas seymouri	52%	97%
A0A0S4J512	Bodo saltans	27%	100%
A0A3R7M1Y7	Trypanosoma rangeli	30%	100%
A4H544	Leishmania braziliensis	72%	100%
C9ZUJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ALB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIJ1	Leishmania major	91%	100%
V5B8B7	Trypanosoma cruzi	28%	100%