RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H600_LEIDO

TriTrypDb:

LdBPK_070920.1 , LdCL_070014100 , LDHU3_07.1100

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H600

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H600

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003723	RNA binding	4	5
GO:0005488	binding	1	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.669
CLV_NRD_NRD_1	165	167	PF00675	0.667
CLV_NRD_NRD_1	369	371	PF00675	0.684
CLV_PCSK_KEX2_1	123	125	PF00082	0.688
CLV_PCSK_KEX2_1	369	371	PF00082	0.684
CLV_PCSK_KEX2_1	43	45	PF00082	0.469
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.688
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.469
CLV_PCSK_PC7_1	39	45	PF00082	0.457
DOC_CKS1_1	234	239	PF01111	0.663
DOC_CKS1_1	276	281	PF01111	0.667
DOC_MAPK_gen_1	43	51	PF00069	0.516
DOC_PP2B_LxvP_1	155	158	PF13499	0.628
DOC_PP2B_LxvP_1	280	283	PF13499	0.665
DOC_PP2B_LxvP_1	304	307	PF13499	0.604
DOC_PP2B_LxvP_1	323	326	PF13499	0.553
DOC_PP4_FxxP_1	360	363	PF00568	0.656
DOC_PP4_MxPP_1	282	285	PF00568	0.596
DOC_USP7_UBL2_3	163	167	PF12436	0.647
DOC_USP7_UBL2_3	86	90	PF12436	0.686
DOC_WW_Pin1_4	170	175	PF00397	0.720
DOC_WW_Pin1_4	187	192	PF00397	0.539
DOC_WW_Pin1_4	233	238	PF00397	0.646
DOC_WW_Pin1_4	272	277	PF00397	0.700
DOC_WW_Pin1_4	289	294	PF00397	0.515
DOC_WW_Pin1_4	353	358	PF00397	0.607
DOC_WW_Pin1_4	5	10	PF00397	0.583
DOC_WW_Pin1_4	73	78	PF00397	0.529
DOC_WW_Pin1_4	85	90	PF00397	0.674
LIG_14-3-3_CanoR_1	20	30	PF00244	0.408
LIG_14-3-3_CanoR_1	65	73	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_EVH1_1	360	364	PF00568	0.657
LIG_FHA_1	138	144	PF00498	0.722
LIG_FHA_1	173	179	PF00498	0.658
LIG_LIR_Apic_2	271	276	PF02991	0.613
LIG_LIR_Gen_1	264	273	PF02991	0.676
LIG_LIR_Gen_1	57	66	PF02991	0.609
LIG_LIR_Gen_1	8	19	PF02991	0.541
LIG_LIR_Nem_3	264	269	PF02991	0.710
LIG_LIR_Nem_3	28	34	PF02991	0.306
LIG_LIR_Nem_3	50	56	PF02991	0.545
LIG_LIR_Nem_3	57	61	PF02991	0.523
LIG_LIR_Nem_3	8	14	PF02991	0.609
LIG_PROFILIN_1	293	299	PF00235	0.648
LIG_PROFILIN_1	337	343	PF00235	0.633
LIG_PROFILIN_1	96	102	PF00235	0.622
LIG_SH2_CRK	266	270	PF00017	0.717
LIG_SH2_CRK	273	277	PF00017	0.630
LIG_SH2_NCK_1	273	277	PF00017	0.667
LIG_SH2_STAT3	118	121	PF00017	0.636
LIG_SH2_STAT5	273	276	PF00017	0.608
LIG_SH2_STAT5	30	33	PF00017	0.502
LIG_SH3_1	273	279	PF00018	0.609
LIG_SH3_1	90	96	PF00018	0.644
LIG_SH3_2	364	369	PF14604	0.652
LIG_SH3_3	146	152	PF00018	0.701
LIG_SH3_3	188	194	PF00018	0.728
LIG_SH3_3	198	204	PF00018	0.481
LIG_SH3_3	253	259	PF00018	0.677
LIG_SH3_3	273	279	PF00018	0.504
LIG_SH3_3	290	296	PF00018	0.529
LIG_SH3_3	309	315	PF00018	0.505
LIG_SH3_3	328	334	PF00018	0.625
LIG_SH3_3	335	341	PF00018	0.566
LIG_SH3_3	358	364	PF00018	0.668
LIG_SH3_3	90	96	PF00018	0.686
LIG_SH3_3	99	105	PF00018	0.609
LIG_SH3_CIN85_PxpxPR_1	364	369	PF14604	0.652
LIG_TYR_ITIM	51	56	PF00017	0.473
LIG_WW_3	366	370	PF00397	0.659
MOD_CDK_SPK_2	187	192	PF00069	0.621
MOD_CDK_SPK_2	5	10	PF00069	0.531
MOD_CDK_SPK_2	85	90	PF00069	0.674
MOD_CDK_SPxK_1	353	359	PF00069	0.609
MOD_CK1_1	268	274	PF00069	0.676
MOD_CK1_1	275	281	PF00069	0.610
MOD_CK1_1	353	359	PF00069	0.687
MOD_CK1_1	88	94	PF00069	0.704
MOD_CK2_1	187	193	PF00069	0.697
MOD_CK2_1	66	72	PF00069	0.566
MOD_GlcNHglycan	15	18	PF01048	0.478
MOD_GlcNHglycan	286	289	PF01048	0.700
MOD_GlcNHglycan	35	38	PF01048	0.353
MOD_GlcNHglycan	353	356	PF01048	0.697
MOD_GSK3_1	1	8	PF00069	0.626
MOD_GSK3_1	133	140	PF00069	0.672
MOD_GSK3_1	229	236	PF00069	0.575
MOD_GSK3_1	261	268	PF00069	0.701
MOD_GSK3_1	271	278	PF00069	0.606
MOD_GSK3_1	284	291	PF00069	0.553
MOD_GSK3_1	346	353	PF00069	0.684
MOD_N-GLC_1	350	355	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	13	18	PF00069	0.383
MOD_NEK2_1	177	182	PF00069	0.603
MOD_NEK2_1	308	313	PF00069	0.525
MOD_NEK2_1	327	332	PF00069	0.638
MOD_PIKK_1	100	106	PF00454	0.575
MOD_PIKK_1	107	113	PF00454	0.525
MOD_PIKK_1	116	122	PF00454	0.537
MOD_PIKK_1	135	141	PF00454	0.609
MOD_PIKK_1	66	72	PF00454	0.525
MOD_PIKK_1	88	94	PF00454	0.697
MOD_PKA_2	327	333	PF00069	0.651
MOD_PKB_1	124	132	PF00069	0.684
MOD_Plk_1	126	132	PF00069	0.693
MOD_Plk_4	229	235	PF00069	0.617
MOD_ProDKin_1	170	176	PF00069	0.720
MOD_ProDKin_1	187	193	PF00069	0.533
MOD_ProDKin_1	233	239	PF00069	0.653
MOD_ProDKin_1	272	278	PF00069	0.701
MOD_ProDKin_1	289	295	PF00069	0.511
MOD_ProDKin_1	353	359	PF00069	0.609
MOD_ProDKin_1	5	11	PF00069	0.570
MOD_ProDKin_1	73	79	PF00069	0.534
MOD_ProDKin_1	85	91	PF00069	0.677
MOD_SUMO_rev_2	160	168	PF00179	0.642
TRG_ENDOCYTIC_2	11	14	PF00928	0.591
TRG_ENDOCYTIC_2	266	269	PF00928	0.716
TRG_ENDOCYTIC_2	53	56	PF00928	0.547
TRG_ER_diArg_1	368	370	PF00400	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HTA7	Leishmania infantum	93%	99%
E9AL96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QIK8	Leishmania major	87%	100%