Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Z9_LEIDO

TriTrypDb:

LdBPK_070860.1 , LdCL_070013400 , LDHU3_07.1030

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H5Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.604
CLV_C14_Caspase3-7	147	151	PF00656	0.546
CLV_NRD_NRD_1	116	118	PF00675	0.601
CLV_NRD_NRD_1	12	14	PF00675	0.700
CLV_NRD_NRD_1	285	287	PF00675	0.467
CLV_NRD_NRD_1	68	70	PF00675	0.782
CLV_NRD_NRD_1	99	101	PF00675	0.707
CLV_PCSK_FUR_1	64	68	PF00082	0.770
CLV_PCSK_KEX2_1	115	117	PF00082	0.598
CLV_PCSK_KEX2_1	12	14	PF00082	0.700
CLV_PCSK_KEX2_1	284	286	PF00082	0.465
CLV_PCSK_KEX2_1	66	68	PF00082	0.774
CLV_PCSK_KEX2_1	98	100	PF00082	0.715
CLV_PCSK_PC7_1	64	70	PF00082	0.731
CLV_PCSK_SKI1_1	248	252	PF00082	0.552
DEG_APCC_DBOX_1	247	255	PF00400	0.356
DEG_Nend_UBRbox_1	1	4	PF02207	0.502
DEG_SPOP_SBC_1	181	185	PF00917	0.428
DOC_MAPK_HePTP_8	241	253	PF00069	0.448
DOC_MAPK_JIP1_4	248	254	PF00069	0.313
DOC_MAPK_MEF2A_6	169	178	PF00069	0.553
DOC_MAPK_MEF2A_6	244	253	PF00069	0.437
DOC_PP4_FxxP_1	38	41	PF00568	0.513
DOC_USP7_MATH_1	144	148	PF00917	0.598
DOC_WW_Pin1_4	202	207	PF00397	0.426
LIG_Actin_WH2_2	174	189	PF00022	0.489
LIG_FHA_1	169	175	PF00498	0.507
LIG_FHA_1	181	187	PF00498	0.391
LIG_FHA_2	135	141	PF00498	0.536
LIG_FHA_2	47	53	PF00498	0.540
LIG_LIR_Apic_2	205	210	PF02991	0.555
LIG_LIR_Gen_1	5	16	PF02991	0.517
LIG_LIR_Gen_1	51	60	PF02991	0.540
LIG_LIR_Nem_3	5	11	PF02991	0.516
LIG_LIR_Nem_3	51	56	PF02991	0.533
LIG_NRBOX	250	256	PF00104	0.358
LIG_SH2_CRK	207	211	PF00017	0.557
LIG_SH2_CRK	53	57	PF00017	0.536
LIG_SH2_CRK	8	12	PF00017	0.516
LIG_SH2_GRB2like	129	132	PF00017	0.502
LIG_SH2_GRB2like	207	210	PF00017	0.510
LIG_SH2_NCK_1	53	57	PF00017	0.536
LIG_SH2_SRC	207	210	PF00017	0.510
LIG_SH2_STAT5	229	232	PF00017	0.512
LIG_SH3_3	243	249	PF00018	0.451
LIG_SUMO_SIM_par_1	253	258	PF11976	0.355
LIG_TRAF2_1	49	52	PF00917	0.540
MOD_CK1_1	143	149	PF00069	0.604
MOD_CK2_1	182	188	PF00069	0.454
MOD_CK2_1	46	52	PF00069	0.542
MOD_Cter_Amidation	96	99	PF01082	0.708
MOD_GlcNHglycan	142	145	PF01048	0.838
MOD_GlcNHglycan	146	149	PF01048	0.823
MOD_GlcNHglycan	211	214	PF01048	0.749
MOD_GlcNHglycan	259	262	PF01048	0.390
MOD_GlcNHglycan	75	79	PF01048	0.760
MOD_GSK3_1	134	141	PF00069	0.645
MOD_N-GLC_1	179	184	PF02516	0.716
MOD_N-GLC_1	44	49	PF02516	0.705
MOD_NEK2_1	179	184	PF00069	0.515
MOD_NEK2_1	192	197	PF00069	0.431
MOD_NEK2_1	231	236	PF00069	0.501
MOD_NEK2_1	255	260	PF00069	0.419
MOD_NEK2_1	266	271	PF00069	0.296
MOD_PKA_2	168	174	PF00069	0.514
MOD_Plk_1	44	50	PF00069	0.505
MOD_Plk_2-3	91	97	PF00069	0.507
MOD_ProDKin_1	202	208	PF00069	0.423
TRG_DiLeu_BaEn_1	6	11	PF01217	0.514
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.434
TRG_ENDOCYTIC_2	229	232	PF00928	0.521
TRG_ENDOCYTIC_2	53	56	PF00928	0.535
TRG_ENDOCYTIC_2	8	11	PF00928	0.513
TRG_ER_diArg_1	11	13	PF00400	0.496
TRG_ER_diArg_1	114	117	PF00400	0.403
TRG_ER_diArg_1	193	196	PF00400	0.529
TRG_ER_diArg_1	273	276	PF00400	0.642
TRG_ER_diArg_1	283	286	PF00400	0.606
TRG_ER_diArg_1	34	37	PF00400	0.521
TRG_ER_diArg_1	64	67	PF00400	0.569
TRG_ER_diArg_1	68	71	PF00400	0.557
TRG_ER_diArg_1	98	100	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H527	Leishmania braziliensis	68%	100%
A4HTA1	Leishmania infantum	99%	100%
E9AL90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QIL4	Leishmania major	94%	100%