Protein kinase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein kinase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5Z8_LEIDO

TriTrypDb:

LdCL_070013300 , LDHU3_07.1020

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Z8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.199
CLV_PCSK_KEX2_1	103	105	PF00082	0.199
CLV_Separin_Metazoa	109	113	PF03568	0.199
DEG_Nend_UBRbox_4	1	3	PF02207	0.489
DOC_CKS1_1	8	13	PF01111	0.464
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.199
DOC_MAPK_gen_1	103	110	PF00069	0.199
DOC_MAPK_gen_1	118	126	PF00069	0.330
DOC_MAPK_JIP1_4	104	110	PF00069	0.199
DOC_WW_Pin1_4	10	15	PF00397	0.465
DOC_WW_Pin1_4	4	9	PF00397	0.465
DOC_WW_Pin1_4	60	65	PF00397	0.199
LIG_14-3-3_CanoR_1	118	124	PF00244	0.316
LIG_BRCT_BRCA1_1	42	46	PF00533	0.199
LIG_LIR_Apic_2	78	82	PF02991	0.199
LIG_LIR_Nem_3	43	49	PF02991	0.199
LIG_PDZ_Class_2	121	126	PF00595	0.344
LIG_SH2_CRK	38	42	PF00017	0.199
LIG_SH2_CRK	79	83	PF00017	0.199
LIG_SH2_SRC	79	82	PF00017	0.199
LIG_SH3_3	42	48	PF00018	0.199
LIG_SH3_3	5	11	PF00018	0.468
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.199
LIG_TRAF2_2	64	69	PF00917	0.199
LIG_TYR_ITIM	35	40	PF00017	0.199
MOD_CK1_1	58	64	PF00069	0.199
MOD_CK1_1	7	13	PF00069	0.464
MOD_CK2_1	103	109	PF00069	0.199
MOD_GlcNHglycan	105	108	PF01048	0.199
MOD_GSK3_1	51	58	PF00069	0.199
MOD_N-GLC_1	58	63	PF02516	0.199
MOD_NEK2_1	21	26	PF00069	0.300
MOD_NEK2_1	40	45	PF00069	0.199
MOD_PIKK_1	13	19	PF00454	0.460
MOD_PIKK_1	21	27	PF00454	0.199
MOD_PKA_1	103	109	PF00069	0.199
MOD_PKA_2	103	109	PF00069	0.199
MOD_PKA_2	119	125	PF00069	0.321
MOD_PKA_2	19	25	PF00069	0.343
MOD_Plk_1	93	99	PF00069	0.199
MOD_Plk_4	119	125	PF00069	0.321
MOD_Plk_4	51	57	PF00069	0.199
MOD_Plk_4	83	89	PF00069	0.199
MOD_ProDKin_1	4	10	PF00069	0.465
MOD_ProDKin_1	60	66	PF00069	0.199
TRG_ENDOCYTIC_2	37	40	PF00928	0.199
TRG_ER_diArg_1	103	105	PF00400	0.199
TRG_ER_diArg_1	70	73	PF00400	0.199
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A2YNT8	ORYSI	29%	37%
A2ZAB5	ORYSI	31%	38%
A9TF79	PHYPA	32%	36%
O64812	ARATH	34%	37%
P0C5D6	ORYSJ	31%	38%
P43291	ARATH	31%	35%
P43292	ARATH	34%	36%
Q02066	WHEAT	30%	38%
Q0D4J7	ORYSJ	29%	37%
Q5N942	ORYSJ	35%	35%
Q6ZI44	ORYSJ	34%	35%
Q75H77	ORYSJ	35%	35%
Q75LR7	ORYSJ	32%	37%
Q75V57	ORYSJ	35%	35%
Q7XKA8	ORYSJ	35%	34%
Q7XQP4	ORYSJ	35%	35%
Q7Y0B9	ORYSJ	32%	34%
Q940H6	ARATH	34%	35%
Q96PN8	HUMAN	37%	47%
Q9C958	ARATH	31%	35%
Q9D2E1	MOUSE	36%	47%
Q9FFP9	ARATH	35%	35%
Q9SMQ4	ARATH	32%	36%