Snare region anchored in the vesicle membrane C-terminus family protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qa-SNARE protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5Z1_LEIDO

TriTrypDb:

LdBPK_070750.1 , LdCL_070012300 , LDHU3_07.0900

Length:

168

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, Qa-SNARE

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Phosphorylation

Amastigote: 15

Expansion

Sequence features

A0A3S5H5Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Z1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.657
DEG_Nend_UBRbox_1	1	4	PF02207	0.768
DEG_SIAH_1	57	65	PF03145	0.701
DEG_SPOP_SBC_1	69	73	PF00917	0.715
DOC_USP7_MATH_1	64	68	PF00917	0.713
DOC_USP7_UBL2_3	164	168	PF12436	0.423
LIG_APCC_ABBA_1	137	142	PF00400	0.613
LIG_APCC_ABBAyCdc20_2	136	142	PF00400	0.615
LIG_EH1_1	151	159	PF00400	0.398
LIG_FHA_2	14	20	PF00498	0.692
LIG_LIR_Gen_1	96	104	PF02991	0.490
LIG_LIR_Nem_3	49	54	PF02991	0.744
LIG_LIR_Nem_3	96	101	PF02991	0.504
LIG_SH2_CRK	51	55	PF00017	0.766
LIG_SH2_CRK	98	102	PF00017	0.501
LIG_SH2_STAP1	162	166	PF00017	0.413
LIG_SUMO_SIM_par_1	157	163	PF11976	0.449
LIG_UBA3_1	156	164	PF00899	0.367
LIG_UBA3_1	17	22	PF00899	0.759
MOD_CK1_1	114	120	PF00069	0.562
MOD_CK1_1	49	55	PF00069	0.709
MOD_CK1_1	56	62	PF00069	0.527
MOD_CK1_1	71	77	PF00069	0.689
MOD_CK2_1	13	19	PF00069	0.690
MOD_GlcNHglycan	48	51	PF01048	0.494
MOD_GlcNHglycan	55	58	PF01048	0.442
MOD_GlcNHglycan	66	69	PF01048	0.496
MOD_GlcNHglycan	95	98	PF01048	0.339
MOD_GSK3_1	114	121	PF00069	0.528
MOD_GSK3_1	21	28	PF00069	0.762
MOD_GSK3_1	49	56	PF00069	0.697
MOD_GSK3_1	64	71	PF00069	0.661
MOD_GSK3_1	72	79	PF00069	0.620
MOD_GSK3_1	93	100	PF00069	0.476
MOD_N-GLC_1	12	17	PF02516	0.514
MOD_N-GLC_1	93	98	PF02516	0.288
MOD_NEK2_1	125	130	PF00069	0.537
MOD_NEK2_1	21	26	PF00069	0.707
MOD_PIKK_1	32	38	PF00454	0.634
MOD_Plk_1	12	18	PF00069	0.688
MOD_Plk_4	13	19	PF00069	0.690
TRG_ENDOCYTIC_2	162	165	PF00928	0.361
TRG_ENDOCYTIC_2	51	54	PF00928	0.747
TRG_ENDOCYTIC_2	98	101	PF00928	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y0	Leptomonas seymouri	70%	100%
A0A0S4J4H4	Bodo saltans	37%	100%
A0A1X0NPE1	Trypanosomatidae	38%	92%
A0A3R7K1F7	Trypanosoma rangeli	45%	100%
A4H518	Leishmania braziliensis	79%	99%
A4HT91	Leishmania infantum	100%	100%
C9ZUN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AL80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIM4	Leishmania major	90%	99%
V5B8I6	Trypanosoma cruzi	46%	100%