Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Z0_LEIDO

TriTrypDb:

LdBPK_070740.1 , LdCL_070012200 , LDHU3_07.0890

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.500
CLV_C14_Caspase3-7	52	56	PF00656	0.770
CLV_NRD_NRD_1	214	216	PF00675	0.643
CLV_PCSK_KEX2_1	214	216	PF00082	0.643
CLV_PCSK_KEX2_1	370	372	PF00082	0.434
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.434
CLV_PCSK_PC7_1	210	216	PF00082	0.453
CLV_PCSK_SKI1_1	468	472	PF00082	0.550
CLV_PCSK_SKI1_1	75	79	PF00082	0.501
DEG_APCC_DBOX_1	463	471	PF00400	0.588
DEG_APCC_DBOX_1	74	82	PF00400	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.618
DEG_SPOP_SBC_1	56	60	PF00917	0.740
DOC_CDC14_PxL_1	147	155	PF14671	0.528
DOC_CYCLIN_RxL_1	464	475	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.606
DOC_MAPK_DCC_7	370	380	PF00069	0.528
DOC_MAPK_DCC_7	75	83	PF00069	0.579
DOC_MAPK_gen_1	484	491	PF00069	0.631
DOC_MAPK_HePTP_8	367	379	PF00069	0.583
DOC_MAPK_MEF2A_6	370	379	PF00069	0.555
DOC_MAPK_MEF2A_6	405	413	PF00069	0.529
DOC_MAPK_RevD_3	356	371	PF00069	0.397
DOC_PP1_RVXF_1	486	492	PF00149	0.629
DOC_PP2B_LxvP_1	41	44	PF13499	0.577
DOC_USP7_MATH_1	12	16	PF00917	0.538
DOC_USP7_MATH_1	229	233	PF00917	0.650
DOC_USP7_MATH_1	241	245	PF00917	0.658
DOC_USP7_MATH_1	307	311	PF00917	0.509
DOC_USP7_MATH_1	324	328	PF00917	0.568
DOC_USP7_MATH_1	33	37	PF00917	0.497
DOC_USP7_MATH_1	423	427	PF00917	0.706
DOC_USP7_MATH_1	56	60	PF00917	0.760
DOC_WW_Pin1_4	101	106	PF00397	0.612
DOC_WW_Pin1_4	119	124	PF00397	0.710
DOC_WW_Pin1_4	249	254	PF00397	0.719
DOC_WW_Pin1_4	27	32	PF00397	0.703
DOC_WW_Pin1_4	320	325	PF00397	0.508
DOC_WW_Pin1_4	361	366	PF00397	0.628
DOC_WW_Pin1_4	397	402	PF00397	0.649
LIG_14-3-3_CanoR_1	230	234	PF00244	0.709
LIG_14-3-3_CanoR_1	238	247	PF00244	0.707
LIG_14-3-3_CanoR_1	26	33	PF00244	0.664
LIG_14-3-3_CanoR_1	305	315	PF00244	0.522
LIG_APCC_ABBA_1	412	417	PF00400	0.538
LIG_BIR_III_4	434	438	PF00653	0.439
LIG_CAP-Gly_1	516	519	PF01302	0.562
LIG_eIF4E_1	147	153	PF01652	0.440
LIG_eIF4E_1	37	43	PF01652	0.500
LIG_FHA_1	137	143	PF00498	0.557
LIG_FHA_1	249	255	PF00498	0.642
LIG_FHA_1	460	466	PF00498	0.514
LIG_FHA_1	58	64	PF00498	0.725
LIG_FHA_2	185	191	PF00498	0.467
LIG_FHA_2	331	337	PF00498	0.518
LIG_FHA_2	361	367	PF00498	0.599
LIG_FHA_2	427	433	PF00498	0.639
LIG_FHA_2	480	486	PF00498	0.533
LIG_FHA_2	60	66	PF00498	0.737
LIG_HP1_1	259	263	PF01393	0.523
LIG_IRF3_LxIS_1	391	398	PF10401	0.347
LIG_LIR_Gen_1	144	154	PF02991	0.424
LIG_LIR_Gen_1	285	295	PF02991	0.431
LIG_LIR_Gen_1	35	45	PF02991	0.567
LIG_LIR_Nem_3	138	143	PF02991	0.449
LIG_LIR_Nem_3	144	150	PF02991	0.458
LIG_LIR_Nem_3	34	40	PF02991	0.586
LIG_LIR_Nem_3	445	450	PF02991	0.457
LIG_LIR_Nem_3	475	481	PF02991	0.625
LIG_MYND_1	119	123	PF01753	0.675
LIG_NRBOX	390	396	PF00104	0.407
LIG_Pex14_1	283	287	PF04695	0.388
LIG_SH2_CRK	143	147	PF00017	0.449
LIG_SH2_CRK	308	312	PF00017	0.450
LIG_SH2_CRK	38	42	PF00017	0.539
LIG_SH2_CRK	447	451	PF00017	0.521
LIG_SH2_NCK_1	147	151	PF00017	0.448
LIG_SH2_NCK_1	223	227	PF00017	0.662
LIG_SH2_NCK_1	308	312	PF00017	0.522
LIG_SH2_SRC	147	150	PF00017	0.454
LIG_SH2_STAP1	143	147	PF00017	0.430
LIG_SH2_STAP1	223	227	PF00017	0.654
LIG_SH2_STAP1	284	288	PF00017	0.484
LIG_SH2_STAP1	38	42	PF00017	0.570
LIG_SH2_STAT5	284	287	PF00017	0.492
LIG_SH2_STAT5	308	311	PF00017	0.492
LIG_SH2_STAT5	481	484	PF00017	0.645
LIG_SH3_3	148	154	PF00018	0.530
LIG_SH3_3	301	307	PF00018	0.354
LIG_SH3_3	460	466	PF00018	0.530
LIG_SUMO_SIM_anti_2	39	44	PF11976	0.574
LIG_SUMO_SIM_par_1	257	264	PF11976	0.411
LIG_SUMO_SIM_par_1	376	383	PF11976	0.484
LIG_TRFH_1	76	80	PF08558	0.590
LIG_TYR_ITIM	145	150	PF00017	0.439
LIG_TYR_ITIM	306	311	PF00017	0.445
LIG_TYR_ITSM	443	450	PF00017	0.347
LIG_UBA3_1	1	8	PF00899	0.710
MOD_CK1_1	181	187	PF00069	0.569
MOD_CK1_1	193	199	PF00069	0.499
MOD_CK1_1	249	255	PF00069	0.684
MOD_CK1_1	310	316	PF00069	0.534
MOD_CK1_1	323	329	PF00069	0.477
MOD_CK1_1	36	42	PF00069	0.517
MOD_CK1_1	426	432	PF00069	0.635
MOD_CK1_1	46	52	PF00069	0.627
MOD_CK1_1	59	65	PF00069	0.666
MOD_CK1_1	99	105	PF00069	0.701
MOD_CK2_1	101	107	PF00069	0.758
MOD_CK2_1	119	125	PF00069	0.558
MOD_CK2_1	184	190	PF00069	0.687
MOD_CK2_1	360	366	PF00069	0.545
MOD_CK2_1	426	432	PF00069	0.693
MOD_CK2_1	446	452	PF00069	0.320
MOD_CK2_1	474	480	PF00069	0.594
MOD_CK2_1	59	65	PF00069	0.742
MOD_GlcNHglycan	207	210	PF01048	0.529
MOD_GlcNHglycan	224	227	PF01048	0.591
MOD_GlcNHglycan	243	246	PF01048	0.665
MOD_GlcNHglycan	248	251	PF01048	0.680
MOD_GlcNHglycan	326	329	PF01048	0.696
MOD_GlcNHglycan	387	390	PF01048	0.460
MOD_GlcNHglycan	397	400	PF01048	0.543
MOD_GlcNHglycan	429	432	PF01048	0.687
MOD_GlcNHglycan	439	442	PF01048	0.583
MOD_GlcNHglycan	48	51	PF01048	0.664
MOD_GSK3_1	119	126	PF00069	0.602
MOD_GSK3_1	177	184	PF00069	0.527
MOD_GSK3_1	186	193	PF00069	0.529
MOD_GSK3_1	217	224	PF00069	0.559
MOD_GSK3_1	248	255	PF00069	0.727
MOD_GSK3_1	27	34	PF00069	0.679
MOD_GSK3_1	306	313	PF00069	0.475
MOD_GSK3_1	316	323	PF00069	0.471
MOD_GSK3_1	423	430	PF00069	0.723
MOD_GSK3_1	44	51	PF00069	0.540
MOD_GSK3_1	442	449	PF00069	0.294
MOD_GSK3_1	55	62	PF00069	0.695
MOD_GSK3_1	92	99	PF00069	0.692
MOD_N-GLC_2	490	492	PF02516	0.521
MOD_NEK2_1	205	210	PF00069	0.497
MOD_NEK2_1	25	30	PF00069	0.559
MOD_NEK2_1	360	365	PF00069	0.497
MOD_NEK2_1	395	400	PF00069	0.564
MOD_NEK2_2	459	464	PF00069	0.345
MOD_PIKK_1	12	18	PF00454	0.536
MOD_PIKK_1	442	448	PF00454	0.567
MOD_PKA_2	136	142	PF00069	0.603
MOD_PKA_2	229	235	PF00069	0.609
MOD_PKA_2	25	31	PF00069	0.568
MOD_PKA_2	65	71	PF00069	0.616
MOD_Plk_1	474	480	PF00069	0.672
MOD_Plk_2-3	474	480	PF00069	0.697
MOD_Plk_4	274	280	PF00069	0.478
MOD_Plk_4	291	297	PF00069	0.307
MOD_Plk_4	310	316	PF00069	0.216
MOD_Plk_4	33	39	PF00069	0.636
MOD_ProDKin_1	101	107	PF00069	0.614
MOD_ProDKin_1	119	125	PF00069	0.710
MOD_ProDKin_1	249	255	PF00069	0.715
MOD_ProDKin_1	27	33	PF00069	0.699
MOD_ProDKin_1	320	326	PF00069	0.512
MOD_ProDKin_1	361	367	PF00069	0.628
MOD_ProDKin_1	397	403	PF00069	0.647
TRG_DiLeu_BaEn_2	339	345	PF01217	0.384
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.534
TRG_ENDOCYTIC_2	143	146	PF00928	0.438
TRG_ENDOCYTIC_2	147	150	PF00928	0.435
TRG_ENDOCYTIC_2	284	287	PF00928	0.412
TRG_ENDOCYTIC_2	308	311	PF00928	0.453
TRG_ENDOCYTIC_2	353	356	PF00928	0.554
TRG_ENDOCYTIC_2	37	40	PF00928	0.510
TRG_ENDOCYTIC_2	447	450	PF00928	0.519
TRG_ER_diArg_1	214	216	PF00400	0.638
TRG_ER_diArg_1	3	6	PF00400	0.587
TRG_ER_diArg_1	486	489	PF00400	0.627
TRG_NES_CRM1_1	347	361	PF08389	0.521
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX1	Leptomonas seymouri	53%	100%
A0A1X0NPG1	Trypanosomatidae	26%	100%
A0A422N3S3	Trypanosoma rangeli	31%	100%
A4H517	Leishmania braziliensis	67%	99%
A4HT90	Leishmania infantum	100%	100%
C9ZUN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AL79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QIM5	Leishmania major	89%	100%
V5BTD2	Trypanosoma cruzi	28%	100%