Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5Y8_LEIDO

TriTrypDb:

LdBPK_070680.1 , LdCL_070011700 , LDHU3_07.0820

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.539
CLV_PCSK_KEX2_1	145	147	PF00082	0.643
CLV_PCSK_KEX2_1	214	216	PF00082	0.789
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.643
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.789
DEG_SPOP_SBC_1	123	127	PF00917	0.698
DOC_CKS1_1	139	144	PF01111	0.699
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.460
DOC_MAPK_JIP1_4	2	8	PF00069	0.542
DOC_PP1_RVXF_1	179	185	PF00149	0.404
DOC_PP2B_LxvP_1	26	29	PF13499	0.533
DOC_PP4_FxxP_1	8	11	PF00568	0.485
DOC_USP7_MATH_1	117	121	PF00917	0.709
DOC_USP7_MATH_1	123	127	PF00917	0.559
DOC_USP7_MATH_1	133	137	PF00917	0.590
DOC_USP7_MATH_1	155	159	PF00917	0.583
DOC_USP7_MATH_1	224	228	PF00917	0.687
DOC_USP7_MATH_1	53	57	PF00917	0.720
DOC_WW_Pin1_4	138	143	PF00397	0.647
DOC_WW_Pin1_4	243	248	PF00397	0.370
LIG_14-3-3_CanoR_1	157	164	PF00244	0.532
LIG_14-3-3_CanoR_1	179	185	PF00244	0.487
LIG_FHA_1	23	29	PF00498	0.437
LIG_FHA_1	234	240	PF00498	0.492
LIG_FHA_1	34	40	PF00498	0.386
LIG_FHA_1	66	72	PF00498	0.617
LIG_FHA_1	80	86	PF00498	0.565
LIG_FHA_2	139	145	PF00498	0.646
LIG_FHA_2	173	179	PF00498	0.520
LIG_LIR_Gen_1	166	173	PF02991	0.406
LIG_LIR_Nem_3	166	171	PF02991	0.407
LIG_Pex14_2	164	168	PF04695	0.530
LIG_RPA_C_Fungi	196	208	PF08784	0.620
LIG_SH2_STAP1	143	147	PF00017	0.643
LIG_SH2_STAT5	102	105	PF00017	0.507
LIG_SH3_3	136	142	PF00018	0.724
LIG_SH3_3	25	31	PF00018	0.427
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.437
LIG_SUMO_SIM_par_1	234	240	PF11976	0.485
MOD_CDK_SPxxK_3	138	145	PF00069	0.527
MOD_CK1_1	122	128	PF00069	0.687
MOD_CK1_1	70	76	PF00069	0.652
MOD_CK2_1	172	178	PF00069	0.518
MOD_Cter_Amidation	212	215	PF01082	0.785
MOD_GlcNHglycan	119	122	PF01048	0.727
MOD_GlcNHglycan	126	129	PF01048	0.714
MOD_GlcNHglycan	157	160	PF01048	0.603
MOD_GlcNHglycan	165	168	PF01048	0.508
MOD_GlcNHglycan	18	22	PF01048	0.555
MOD_GlcNHglycan	228	231	PF01048	0.588
MOD_GlcNHglycan	39	42	PF01048	0.512
MOD_GlcNHglycan	51	54	PF01048	0.520
MOD_GlcNHglycan	96	99	PF01048	0.525
MOD_GSK3_1	119	126	PF00069	0.691
MOD_GSK3_1	133	140	PF00069	0.548
MOD_GSK3_1	233	240	PF00069	0.433
MOD_GSK3_1	33	40	PF00069	0.387
MOD_GSK3_1	49	56	PF00069	0.682
MOD_GSK3_1	67	74	PF00069	0.662
MOD_GSK3_1	9	16	PF00069	0.546
MOD_GSK3_1	94	101	PF00069	0.447
MOD_N-GLC_1	199	204	PF02516	0.692
MOD_NEK2_1	111	116	PF00069	0.601
MOD_NEK2_1	182	187	PF00069	0.498
MOD_NEK2_1	37	42	PF00069	0.374
MOD_PIKK_1	172	178	PF00454	0.518
MOD_PKA_2	13	19	PF00069	0.537
MOD_PKA_2	180	186	PF00069	0.453
MOD_Plk_1	199	205	PF00069	0.657
MOD_Plk_1	233	239	PF00069	0.432
MOD_Plk_4	237	243	PF00069	0.432
MOD_Plk_4	71	77	PF00069	0.580
MOD_ProDKin_1	138	144	PF00069	0.642
MOD_ProDKin_1	243	249	PF00069	0.386
MOD_SUMO_rev_2	225	230	PF00179	0.625
TRG_ER_diArg_1	179	182	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.744

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P403	Leptomonas seymouri	45%	96%
A0A1X0NPF9	Trypanosomatidae	27%	100%
A0A3R7K387	Trypanosoma rangeli	28%	100%
A4H512	Leishmania braziliensis	66%	98%
A4HT86	Leishmania infantum	98%	100%
C9ZUN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AL74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QIN0	Leishmania major	83%	100%