Pre-rrna-processing_protein_tsr1_homolog/GeneDB:L mjF.07.0470

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-rrna-processing protein tsr1 homolog

Species:

Leishmania donovani

UniProt:

A0A3S5H5Y1_LEIDO

TriTrypDb:

LdBPK_070140.1 , LdCL_070010000 , LDHU3_07.0600

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S5H5Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5Y1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0022613	ribonucleoprotein complex biogenesis	4	10
GO:0042254	ribosome biogenesis	5	10
GO:0044085	cellular component biogenesis	3	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	1
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0005488	binding	1	1
GO:0005525	GTP binding	5	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017076	purine nucleotide binding	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0019001	guanyl nucleotide binding	5	1
GO:0030515	snoRNA binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032561	guanyl ribonucleotide binding	5	1
GO:0034511	U3 snoRNA binding	6	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	518	522	PF00656	0.420
CLV_NRD_NRD_1	115	117	PF00675	0.551
CLV_NRD_NRD_1	322	324	PF00675	0.593
CLV_NRD_NRD_1	595	597	PF00675	0.296
CLV_NRD_NRD_1	64	66	PF00675	0.535
CLV_NRD_NRD_1	719	721	PF00675	0.296
CLV_PCSK_FUR_1	53	57	PF00082	0.572
CLV_PCSK_KEX2_1	55	57	PF00082	0.465
CLV_PCSK_KEX2_1	64	66	PF00082	0.443
CLV_PCSK_KEX2_1	677	679	PF00082	0.292
CLV_PCSK_KEX2_1	719	721	PF00082	0.296
CLV_PCSK_KEX2_1	753	755	PF00082	0.283
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.477
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.292
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.283
CLV_PCSK_SKI1_1	117	121	PF00082	0.421
CLV_PCSK_SKI1_1	14	18	PF00082	0.547
CLV_PCSK_SKI1_1	164	168	PF00082	0.668
CLV_PCSK_SKI1_1	223	227	PF00082	0.379
CLV_PCSK_SKI1_1	264	268	PF00082	0.331
CLV_PCSK_SKI1_1	478	482	PF00082	0.294
CLV_PCSK_SKI1_1	483	487	PF00082	0.288
CLV_PCSK_SKI1_1	551	555	PF00082	0.442
CLV_PCSK_SKI1_1	58	62	PF00082	0.526
CLV_PCSK_SKI1_1	626	630	PF00082	0.442
CLV_PCSK_SKI1_1	678	682	PF00082	0.296
CLV_PCSK_SKI1_1	696	700	PF00082	0.296
CLV_PCSK_SKI1_1	734	738	PF00082	0.373
CLV_PCSK_SKI1_1	753	757	PF00082	0.147
DEG_APCC_DBOX_1	338	346	PF00400	0.497
DOC_CDC14_PxL_1	643	651	PF14671	0.296
DOC_CKS1_1	201	206	PF01111	0.406
DOC_CKS1_1	467	472	PF01111	0.296
DOC_CYCLIN_RxL_1	548	557	PF00134	0.398
DOC_MAPK_gen_1	219	227	PF00069	0.376
DOC_MAPK_gen_1	323	331	PF00069	0.624
DOC_MAPK_MEF2A_6	138	147	PF00069	0.341
DOC_PP1_RVXF_1	114	121	PF00149	0.297
DOC_PP1_RVXF_1	262	269	PF00149	0.296
DOC_PP4_FxxP_1	630	633	PF00568	0.327
DOC_PP4_FxxP_1	644	647	PF00568	0.296
DOC_USP7_MATH_1	137	141	PF00917	0.418
DOC_USP7_MATH_1	18	22	PF00917	0.652
DOC_USP7_MATH_1	197	201	PF00917	0.482
DOC_USP7_MATH_1	244	248	PF00917	0.517
DOC_USP7_MATH_1	35	39	PF00917	0.469
DOC_USP7_MATH_1	378	382	PF00917	0.542
DOC_USP7_MATH_1	582	586	PF00917	0.296
DOC_USP7_MATH_1	81	85	PF00917	0.419
DOC_USP7_UBL2_3	42	46	PF12436	0.617
DOC_WW_Pin1_4	200	205	PF00397	0.411
DOC_WW_Pin1_4	466	471	PF00397	0.296
DOC_WW_Pin1_4	584	589	PF00397	0.302
DOC_WW_Pin1_4	598	603	PF00397	0.239
LIG_14-3-3_CanoR_1	230	236	PF00244	0.406
LIG_14-3-3_CanoR_1	421	430	PF00244	0.602
LIG_14-3-3_CanoR_1	440	448	PF00244	0.465
LIG_14-3-3_CanoR_1	483	489	PF00244	0.290
LIG_14-3-3_CanoR_1	533	539	PF00244	0.428
LIG_14-3-3_CanoR_1	575	583	PF00244	0.334
LIG_14-3-3_CanoR_1	626	631	PF00244	0.322
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	600	604	PF00533	0.296
LIG_BRCT_BRCA1_1	615	619	PF00533	0.296
LIG_deltaCOP1_diTrp_1	563	571	PF00928	0.296
LIG_Dynein_DLC8_1	419	425	PF01221	0.670
LIG_eIF4E_1	636	642	PF01652	0.442
LIG_FHA_1	189	195	PF00498	0.401
LIG_FHA_1	201	207	PF00498	0.382
LIG_FHA_1	237	243	PF00498	0.436
LIG_FHA_1	250	256	PF00498	0.305
LIG_FHA_1	284	290	PF00498	0.411
LIG_FHA_1	301	307	PF00498	0.275
LIG_FHA_1	311	317	PF00498	0.283
LIG_FHA_1	369	375	PF00498	0.571
LIG_FHA_1	585	591	PF00498	0.314
LIG_FHA_1	671	677	PF00498	0.409
LIG_FHA_1	722	728	PF00498	0.308
LIG_FHA_1	85	91	PF00498	0.406
LIG_FHA_2	154	160	PF00498	0.457
LIG_FHA_2	165	171	PF00498	0.565
LIG_FHA_2	213	219	PF00498	0.408
LIG_FHA_2	348	354	PF00498	0.546
LIG_FHA_2	356	362	PF00498	0.506
LIG_FHA_2	404	410	PF00498	0.698
LIG_FHA_2	421	427	PF00498	0.439
LIG_FHA_2	440	446	PF00498	0.417
LIG_FHA_2	772	778	PF00498	0.636
LIG_FXI_DFP_1	99	103	PF00024	0.497
LIG_LIR_Apic_2	629	633	PF02991	0.296
LIG_LIR_Apic_2	704	710	PF02991	0.312
LIG_LIR_Gen_1	106	115	PF02991	0.533
LIG_LIR_Gen_1	140	147	PF02991	0.363
LIG_LIR_Gen_1	177	187	PF02991	0.534
LIG_LIR_Gen_1	249	258	PF02991	0.341
LIG_LIR_Gen_1	563	573	PF02991	0.292
LIG_LIR_Gen_1	601	611	PF02991	0.306
LIG_LIR_Gen_1	613	619	PF02991	0.273
LIG_LIR_Nem_3	106	112	PF02991	0.544
LIG_LIR_Nem_3	140	145	PF02991	0.362
LIG_LIR_Nem_3	177	183	PF02991	0.482
LIG_LIR_Nem_3	249	254	PF02991	0.336
LIG_LIR_Nem_3	563	569	PF02991	0.292
LIG_LIR_Nem_3	601	607	PF02991	0.306
LIG_LIR_Nem_3	613	618	PF02991	0.267
LIG_LIR_Nem_3	629	634	PF02991	0.244
LIG_LIR_Nem_3	712	717	PF02991	0.382
LIG_LIR_Nem_3	750	755	PF02991	0.283
LIG_LRP6_Inhibitor_1	152	158	PF00058	0.538
LIG_MLH1_MIPbox_1	615	619	PF16413	0.201
LIG_MYND_3	646	650	PF01753	0.296
LIG_PDZ_Class_3	775	780	PF00595	0.628
LIG_Pex14_2	615	619	PF04695	0.296
LIG_Pex14_2	752	756	PF04695	0.417
LIG_SH2_CRK	251	255	PF00017	0.331
LIG_SH2_CRK	503	507	PF00017	0.303
LIG_SH2_CRK	512	516	PF00017	0.285
LIG_SH2_GRB2like	231	234	PF00017	0.446
LIG_SH2_GRB2like	251	254	PF00017	0.201
LIG_SH2_PTP2	599	602	PF00017	0.296
LIG_SH2_SRC	503	506	PF00017	0.296
LIG_SH2_STAP1	190	194	PF00017	0.482
LIG_SH2_STAP1	251	255	PF00017	0.382
LIG_SH2_STAP1	503	507	PF00017	0.298
LIG_SH2_STAT3	507	510	PF00017	0.312
LIG_SH2_STAT5	190	193	PF00017	0.486
LIG_SH2_STAT5	231	234	PF00017	0.388
LIG_SH2_STAT5	251	254	PF00017	0.114
LIG_SH2_STAT5	505	508	PF00017	0.298
LIG_SH2_STAT5	599	602	PF00017	0.296
LIG_SH2_STAT5	714	717	PF00017	0.382
LIG_SH3_3	464	470	PF00018	0.296
LIG_SH3_3	536	542	PF00018	0.305
LIG_SH3_3	665	671	PF00018	0.298
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.342
LIG_SUMO_SIM_par_1	143	148	PF11976	0.349
LIG_SUMO_SIM_par_1	709	715	PF11976	0.312
LIG_TRAF2_1	276	279	PF00917	0.354
LIG_TRAF2_1	442	445	PF00917	0.502
LIG_TRAF2_1	457	460	PF00917	0.542
LIG_TRAF2_1	648	651	PF00917	0.296
LIG_UBA3_1	254	262	PF00899	0.331
LIG_UBA3_1	447	454	PF00899	0.597
LIG_UBA3_1	589	597	PF00899	0.312
LIG_WRC_WIRS_1	213	218	PF05994	0.401
LIG_WRC_WIRS_1	485	490	PF05994	0.312
LIG_WRC_WIRS_1	627	632	PF05994	0.296
LIG_WW_1	500	503	PF00397	0.354
MOD_CK1_1	110	116	PF00069	0.463
MOD_CK1_1	200	206	PF00069	0.435
MOD_CK1_1	234	240	PF00069	0.537
MOD_CK1_1	419	425	PF00069	0.584
MOD_CK1_1	487	493	PF00069	0.296
MOD_CK1_1	605	611	PF00069	0.300
MOD_CK1_1	613	619	PF00069	0.290
MOD_CK1_1	84	90	PF00069	0.398
MOD_CK2_1	153	159	PF00069	0.429
MOD_CK2_1	331	337	PF00069	0.514
MOD_CK2_1	346	352	PF00069	0.607
MOD_CK2_1	439	445	PF00069	0.502
MOD_CK2_1	454	460	PF00069	0.533
MOD_CK2_1	645	651	PF00069	0.296
MOD_CK2_1	771	777	PF00069	0.579
MOD_Cter_Amidation	717	720	PF01082	0.296
MOD_GlcNHglycan	300	303	PF01048	0.341
MOD_GlcNHglycan	37	40	PF01048	0.650
MOD_GlcNHglycan	517	520	PF01048	0.408
MOD_GlcNHglycan	556	559	PF01048	0.286
MOD_GlcNHglycan	608	611	PF01048	0.404
MOD_GlcNHglycan	67	70	PF01048	0.488
MOD_GlcNHglycan	681	684	PF01048	0.358
MOD_GlcNHglycan	83	86	PF01048	0.384
MOD_GSK3_1	143	150	PF00069	0.375
MOD_GSK3_1	160	167	PF00069	0.473
MOD_GSK3_1	171	178	PF00069	0.576
MOD_GSK3_1	258	265	PF00069	0.335
MOD_GSK3_1	283	290	PF00069	0.442
MOD_GSK3_1	306	313	PF00069	0.283
MOD_GSK3_1	416	423	PF00069	0.595
MOD_GSK3_1	598	605	PF00069	0.296
MOD_GSK3_1	606	613	PF00069	0.296
MOD_GSK3_1	758	765	PF00069	0.491
MOD_LATS_1	40	46	PF00433	0.540
MOD_N-GLC_1	347	352	PF02516	0.582
MOD_N-GLC_1	81	86	PF02516	0.412
MOD_N-GLC_2	547	549	PF02516	0.405
MOD_NEK2_1	147	152	PF00069	0.372
MOD_NEK2_1	160	165	PF00069	0.492
MOD_NEK2_1	236	241	PF00069	0.481
MOD_NEK2_1	258	263	PF00069	0.314
MOD_NEK2_1	289	294	PF00069	0.382
MOD_NEK2_1	300	305	PF00069	0.405
MOD_NEK2_1	554	559	PF00069	0.382
MOD_NEK2_1	663	668	PF00069	0.396
MOD_NEK2_1	94	99	PF00069	0.468
MOD_NEK2_2	484	489	PF00069	0.442
MOD_PIKK_1	147	153	PF00454	0.388
MOD_PIKK_1	197	203	PF00454	0.482
MOD_PIKK_1	244	250	PF00454	0.562
MOD_PIKK_1	283	289	PF00454	0.411
MOD_PIKK_1	300	306	PF00454	0.275
MOD_PIKK_1	420	426	PF00454	0.625
MOD_PKA_2	338	344	PF00069	0.554
MOD_PKA_2	420	426	PF00069	0.617
MOD_PKA_2	439	445	PF00069	0.346
MOD_PKA_2	515	521	PF00069	0.390
MOD_PKA_2	574	580	PF00069	0.331
MOD_PKB_1	624	632	PF00069	0.442
MOD_Plk_1	287	293	PF00069	0.433
MOD_Plk_1	347	353	PF00069	0.599
MOD_Plk_2-3	439	445	PF00069	0.502
MOD_Plk_4	175	181	PF00069	0.521
MOD_Plk_4	202	208	PF00069	0.385
MOD_Plk_4	231	237	PF00069	0.363
MOD_Plk_4	541	547	PF00069	0.338
MOD_Plk_4	626	632	PF00069	0.296
MOD_Plk_4	670	676	PF00069	0.404
MOD_ProDKin_1	200	206	PF00069	0.409
MOD_ProDKin_1	466	472	PF00069	0.296
MOD_ProDKin_1	584	590	PF00069	0.302
MOD_ProDKin_1	598	604	PF00069	0.239
MOD_SUMO_for_1	430	433	PF00179	0.549
MOD_SUMO_rev_2	110	119	PF00179	0.442
MOD_SUMO_rev_2	557	567	PF00179	0.296
MOD_SUMO_rev_2	702	708	PF00179	0.417
TRG_DiLeu_BaEn_1	550	555	PF01217	0.442
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.417
TRG_ENDOCYTIC_2	251	254	PF00928	0.312
TRG_ENDOCYTIC_2	274	277	PF00928	0.296
TRG_ENDOCYTIC_2	482	485	PF00928	0.296
TRG_ENDOCYTIC_2	503	506	PF00928	0.296
TRG_ENDOCYTIC_2	512	515	PF00928	0.296
TRG_ENDOCYTIC_2	697	700	PF00928	0.296
TRG_ENDOCYTIC_2	714	717	PF00928	0.296
TRG_ER_diArg_1	476	479	PF00400	0.312
TRG_ER_diArg_1	64	66	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	446	451	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD92	Leptomonas seymouri	83%	100%
A0A0S4JNZ2	Bodo saltans	54%	100%
A0A1X0NPB7	Trypanosomatidae	62%	100%
A0A422NAK8	Trypanosoma rangeli	61%	100%
A4H4Z3	Leishmania braziliensis	89%	100%
C9ZUQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AL58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13956	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q07381	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	99%
Q19329	Caenorhabditis elegans	31%	99%
Q2NL82	Homo sapiens	29%	97%
Q4QIP6	Leishmania major	97%	100%
Q5R434	Pongo abelii	29%	97%
Q5SWD9	Mus musculus	30%	97%
Q5XGY1	Xenopus laevis	29%	96%
Q61WR2	Caenorhabditis briggsae	31%	99%
Q9VP47	Drosophila melanogaster	29%	96%
V5BHC1	Trypanosoma cruzi	59%	100%