Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5X7_LEIDO

TriTrypDb:

LdBPK_070080.1 , LdCL_070009200 , LDHU3_07.0500

Length:

928

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.533
CLV_C14_Caspase3-7	481	485	PF00656	0.698
CLV_NRD_NRD_1	258	260	PF00675	0.458
CLV_NRD_NRD_1	38	40	PF00675	0.625
CLV_NRD_NRD_1	499	501	PF00675	0.598
CLV_NRD_NRD_1	562	564	PF00675	0.650
CLV_NRD_NRD_1	815	817	PF00675	0.661
CLV_NRD_NRD_1	887	889	PF00675	0.646
CLV_PCSK_FUR_1	560	564	PF00082	0.542
CLV_PCSK_KEX2_1	258	260	PF00082	0.570
CLV_PCSK_KEX2_1	38	40	PF00082	0.625
CLV_PCSK_KEX2_1	499	501	PF00082	0.598
CLV_PCSK_KEX2_1	562	564	PF00082	0.650
CLV_PCSK_KEX2_1	639	641	PF00082	0.693
CLV_PCSK_KEX2_1	815	817	PF00082	0.759
CLV_PCSK_KEX2_1	820	822	PF00082	0.702
CLV_PCSK_KEX2_1	887	889	PF00082	0.646
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.693
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.707
CLV_PCSK_PC7_1	816	822	PF00082	0.697
CLV_PCSK_SKI1_1	11	15	PF00082	0.604
CLV_PCSK_SKI1_1	233	237	PF00082	0.457
CLV_PCSK_SKI1_1	258	262	PF00082	0.558
CLV_PCSK_SKI1_1	506	510	PF00082	0.598
CLV_PCSK_SKI1_1	604	608	PF00082	0.539
CLV_PCSK_SKI1_1	640	644	PF00082	0.676
CLV_PCSK_SKI1_1	698	702	PF00082	0.563
CLV_PCSK_SKI1_1	72	76	PF00082	0.759
CLV_PCSK_SKI1_1	794	798	PF00082	0.763
CLV_PCSK_SKI1_1	858	862	PF00082	0.526
DEG_APCC_DBOX_1	232	240	PF00400	0.602
DEG_APCC_DBOX_1	257	265	PF00400	0.448
DEG_APCC_DBOX_1	505	513	PF00400	0.594
DEG_Kelch_Keap1_1	530	535	PF01344	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.574
DEG_SCF_FBW7_2	267	274	PF00400	0.680
DEG_SPOP_SBC_1	207	211	PF00917	0.706
DOC_CKS1_1	19	24	PF01111	0.553
DOC_CKS1_1	268	273	PF01111	0.574
DOC_MAPK_DCC_7	670	680	PF00069	0.662
DOC_MAPK_gen_1	695	703	PF00069	0.577
DOC_MAPK_MEF2A_6	269	277	PF00069	0.508
DOC_MAPK_MEF2A_6	695	703	PF00069	0.577
DOC_MAPK_RevD_3	547	563	PF00069	0.632
DOC_PP1_RVXF_1	9	15	PF00149	0.508
DOC_PP2B_LxvP_1	116	119	PF13499	0.525
DOC_PP2B_LxvP_1	549	552	PF13499	0.735
DOC_PP2B_LxvP_1	609	612	PF13499	0.520
DOC_PP2B_LxvP_1	678	681	PF13499	0.617
DOC_PP2B_LxvP_1	701	704	PF13499	0.574
DOC_PP4_FxxP_1	15	18	PF00568	0.623
DOC_USP7_MATH_1	119	123	PF00917	0.665
DOC_USP7_MATH_1	129	133	PF00917	0.685
DOC_USP7_MATH_1	173	177	PF00917	0.728
DOC_USP7_MATH_1	197	201	PF00917	0.749
DOC_USP7_MATH_1	208	212	PF00917	0.637
DOC_USP7_MATH_1	220	224	PF00917	0.568
DOC_USP7_MATH_1	285	289	PF00917	0.654
DOC_USP7_MATH_1	292	296	PF00917	0.612
DOC_USP7_MATH_1	331	335	PF00917	0.627
DOC_USP7_MATH_1	354	358	PF00917	0.621
DOC_USP7_MATH_1	374	378	PF00917	0.709
DOC_USP7_MATH_1	435	439	PF00917	0.575
DOC_USP7_MATH_1	441	445	PF00917	0.602
DOC_USP7_MATH_1	573	577	PF00917	0.772
DOC_USP7_MATH_1	632	636	PF00917	0.716
DOC_USP7_MATH_1	717	721	PF00917	0.576
DOC_USP7_MATH_1	74	78	PF00917	0.692
DOC_USP7_MATH_1	744	748	PF00917	0.628
DOC_USP7_MATH_1	828	832	PF00917	0.738
DOC_USP7_MATH_1	874	878	PF00917	0.578
DOC_WW_Pin1_4	14	19	PF00397	0.618
DOC_WW_Pin1_4	155	160	PF00397	0.729
DOC_WW_Pin1_4	165	170	PF00397	0.608
DOC_WW_Pin1_4	195	200	PF00397	0.632
DOC_WW_Pin1_4	215	220	PF00397	0.503
DOC_WW_Pin1_4	267	272	PF00397	0.583
DOC_WW_Pin1_4	296	301	PF00397	0.685
DOC_WW_Pin1_4	386	391	PF00397	0.560
DOC_WW_Pin1_4	585	590	PF00397	0.834
DOC_WW_Pin1_4	733	738	PF00397	0.710
LIG_14-3-3_CanoR_1	144	150	PF00244	0.675
LIG_14-3-3_CanoR_1	378	384	PF00244	0.608
LIG_14-3-3_CanoR_1	499	509	PF00244	0.688
LIG_14-3-3_CanoR_1	53	57	PF00244	0.582
LIG_14-3-3_CanoR_1	553	558	PF00244	0.528
LIG_14-3-3_CanoR_1	613	622	PF00244	0.656
LIG_14-3-3_CanoR_1	821	830	PF00244	0.757
LIG_14-3-3_CanoR_1	858	864	PF00244	0.632
LIG_APCC_ABBA_1	232	237	PF00400	0.497
LIG_APCC_ABBA_1	879	884	PF00400	0.677
LIG_BIR_III_2	289	293	PF00653	0.671
LIG_BIR_III_2	440	444	PF00653	0.539
LIG_BIR_III_2	88	92	PF00653	0.646
LIG_BIR_III_4	133	137	PF00653	0.791
LIG_BIR_III_4	743	747	PF00653	0.731
LIG_BRCT_BRCA1_1	719	723	PF00533	0.728
LIG_BRCT_BRCA1_1	750	754	PF00533	0.567
LIG_CaM_NSCaTE_8	336	343	PF13499	0.667
LIG_CSL_BTD_1	678	681	PF09270	0.617
LIG_deltaCOP1_diTrp_1	3	9	PF00928	0.623
LIG_deltaCOP1_diTrp_1	453	463	PF00928	0.637
LIG_deltaCOP1_diTrp_1	912	918	PF00928	0.493
LIG_eIF4E_1	380	386	PF01652	0.573
LIG_FHA_1	108	114	PF00498	0.498
LIG_FHA_1	244	250	PF00498	0.639
LIG_FHA_1	268	274	PF00498	0.575
LIG_FHA_1	327	333	PF00498	0.741
LIG_FHA_1	43	49	PF00498	0.585
LIG_FHA_1	471	477	PF00498	0.699
LIG_FHA_1	53	59	PF00498	0.595
LIG_FHA_1	553	559	PF00498	0.527
LIG_FHA_1	615	621	PF00498	0.591
LIG_FHA_1	626	632	PF00498	0.507
LIG_FHA_1	747	753	PF00498	0.620
LIG_FHA_1	761	767	PF00498	0.599
LIG_FHA_1	854	860	PF00498	0.593
LIG_FHA_1	881	887	PF00498	0.642
LIG_FHA_1	895	901	PF00498	0.632
LIG_FHA_2	208	214	PF00498	0.679
LIG_FHA_2	250	256	PF00498	0.575
LIG_FHA_2	26	32	PF00498	0.626
LIG_FHA_2	479	485	PF00498	0.704
LIG_FHA_2	490	496	PF00498	0.527
LIG_FHA_2	593	599	PF00498	0.710
LIG_FHA_2	781	787	PF00498	0.672
LIG_Integrin_RGD_1	86	88	PF01839	0.686
LIG_LIR_Apic_2	265	271	PF02991	0.583
LIG_LIR_Apic_2	444	450	PF02991	0.706
LIG_LIR_Gen_1	7	15	PF02991	0.606
LIG_LIR_Gen_1	720	731	PF02991	0.623
LIG_LIR_Gen_1	848	855	PF02991	0.656
LIG_LIR_Gen_1	98	109	PF02991	0.593
LIG_LIR_LC3C_4	617	622	PF02991	0.626
LIG_LIR_Nem_3	276	281	PF02991	0.586
LIG_LIR_Nem_3	377	383	PF02991	0.662
LIG_LIR_Nem_3	448	452	PF02991	0.511
LIG_LIR_Nem_3	7	12	PF02991	0.652
LIG_LIR_Nem_3	707	713	PF02991	0.571
LIG_LIR_Nem_3	720	726	PF02991	0.630
LIG_LIR_Nem_3	848	853	PF02991	0.532
LIG_NRP_CendR_1	927	928	PF00754	0.800
LIG_Pex14_1	5	9	PF04695	0.611
LIG_Pex14_1	914	918	PF04695	0.495
LIG_SH2_CRK	268	272	PF00017	0.580
LIG_SH2_CRK	447	451	PF00017	0.684
LIG_SH2_CRK	710	714	PF00017	0.619
LIG_SH2_NCK_1	341	345	PF00017	0.598
LIG_SH2_SRC	674	677	PF00017	0.712
LIG_SH2_STAP1	407	411	PF00017	0.436
LIG_SH2_STAT3	407	410	PF00017	0.411
LIG_SH2_STAT3	605	608	PF00017	0.509
LIG_SH2_STAT5	112	115	PF00017	0.539
LIG_SH2_STAT5	384	387	PF00017	0.699
LIG_SH2_STAT5	557	560	PF00017	0.599
LIG_SH2_STAT5	605	608	PF00017	0.462
LIG_SH2_STAT5	67	70	PF00017	0.542
LIG_SH2_STAT5	674	677	PF00017	0.600
LIG_SH2_STAT5	779	782	PF00017	0.563
LIG_SH3_1	670	676	PF00018	0.610
LIG_SH3_3	315	321	PF00018	0.660
LIG_SH3_3	357	363	PF00018	0.750
LIG_SH3_3	523	529	PF00018	0.744
LIG_SH3_3	542	548	PF00018	0.423
LIG_SH3_3	670	676	PF00018	0.610
LIG_SH3_3	796	802	PF00018	0.672
LIG_SUMO_SIM_par_1	189	194	PF11976	0.637
LIG_SUMO_SIM_par_1	270	276	PF11976	0.488
LIG_SUMO_SIM_par_1	384	389	PF11976	0.780
LIG_SUMO_SIM_par_1	54	60	PF11976	0.693
LIG_TRAF2_1	28	31	PF00917	0.636
LIG_TRAF2_1	842	845	PF00917	0.610
LIG_TRAF2_1	910	913	PF00917	0.573
LIG_TRAF2_2	159	164	PF00917	0.702
MOD_CDK_SPxxK_3	386	393	PF00069	0.562
MOD_CDK_SPxxK_3	733	740	PF00069	0.717
MOD_CK1_1	132	138	PF00069	0.690
MOD_CK1_1	165	171	PF00069	0.666
MOD_CK1_1	198	204	PF00069	0.793
MOD_CK1_1	247	253	PF00069	0.649
MOD_CK1_1	299	305	PF00069	0.689
MOD_CK1_1	339	345	PF00069	0.569
MOD_CK1_1	355	361	PF00069	0.603
MOD_CK1_1	379	385	PF00069	0.773
MOD_CK1_1	445	451	PF00069	0.586
MOD_CK1_1	502	508	PF00069	0.713
MOD_CK1_1	530	536	PF00069	0.681
MOD_CK1_1	733	739	PF00069	0.687
MOD_CK1_1	747	753	PF00069	0.766
MOD_CK1_1	95	101	PF00069	0.635
MOD_CK2_1	100	106	PF00069	0.705
MOD_CK2_1	25	31	PF00069	0.636
MOD_CK2_1	4	10	PF00069	0.738
MOD_CK2_1	489	495	PF00069	0.649
MOD_CK2_1	529	535	PF00069	0.590
MOD_CK2_1	596	602	PF00069	0.669
MOD_CK2_1	780	786	PF00069	0.669
MOD_CK2_1	800	806	PF00069	0.469
MOD_CK2_1	901	907	PF00069	0.651
MOD_GlcNHglycan	133	137	PF01048	0.711
MOD_GlcNHglycan	140	143	PF01048	0.613
MOD_GlcNHglycan	164	167	PF01048	0.787
MOD_GlcNHglycan	175	178	PF01048	0.588
MOD_GlcNHglycan	210	213	PF01048	0.763
MOD_GlcNHglycan	246	249	PF01048	0.662
MOD_GlcNHglycan	283	286	PF01048	0.576
MOD_GlcNHglycan	294	297	PF01048	0.650
MOD_GlcNHglycan	333	336	PF01048	0.705
MOD_GlcNHglycan	341	344	PF01048	0.645
MOD_GlcNHglycan	368	371	PF01048	0.765
MOD_GlcNHglycan	398	401	PF01048	0.576
MOD_GlcNHglycan	437	440	PF01048	0.641
MOD_GlcNHglycan	532	535	PF01048	0.646
MOD_GlcNHglycan	6	9	PF01048	0.603
MOD_GlcNHglycan	652	655	PF01048	0.583
MOD_GlcNHglycan	665	668	PF01048	0.536
MOD_GlcNHglycan	689	692	PF01048	0.616
MOD_GlcNHglycan	695	698	PF01048	0.586
MOD_GlcNHglycan	732	735	PF01048	0.680
MOD_GlcNHglycan	76	79	PF01048	0.797
MOD_GlcNHglycan	826	829	PF01048	0.703
MOD_GlcNHglycan	830	833	PF01048	0.699
MOD_GlcNHglycan	847	850	PF01048	0.333
MOD_GSK3_1	100	107	PF00069	0.549
MOD_GSK3_1	14	21	PF00069	0.597
MOD_GSK3_1	151	158	PF00069	0.602
MOD_GSK3_1	191	198	PF00069	0.648
MOD_GSK3_1	214	221	PF00069	0.636
MOD_GSK3_1	243	250	PF00069	0.656
MOD_GSK3_1	263	270	PF00069	0.340
MOD_GSK3_1	281	288	PF00069	0.431
MOD_GSK3_1	292	299	PF00069	0.677
MOD_GSK3_1	326	333	PF00069	0.611
MOD_GSK3_1	441	448	PF00069	0.560
MOD_GSK3_1	478	485	PF00069	0.737
MOD_GSK3_1	530	537	PF00069	0.660
MOD_GSK3_1	57	64	PF00069	0.712
MOD_GSK3_1	585	592	PF00069	0.726
MOD_GSK3_1	687	694	PF00069	0.664
MOD_GSK3_1	717	724	PF00069	0.728
MOD_GSK3_1	744	751	PF00069	0.707
MOD_GSK3_1	756	763	PF00069	0.703
MOD_GSK3_1	788	795	PF00069	0.626
MOD_GSK3_1	820	827	PF00069	0.647
MOD_GSK3_1	91	98	PF00069	0.671
MOD_N-GLC_1	138	143	PF02516	0.479
MOD_N-GLC_1	573	578	PF02516	0.693
MOD_N-GLC_1	632	637	PF02516	0.564
MOD_N-GLC_1	81	86	PF02516	0.756
MOD_N-GLC_1	834	839	PF02516	0.613
MOD_N-GLC_2	762	764	PF02516	0.621
MOD_NEK2_1	104	109	PF00069	0.512
MOD_NEK2_1	145	150	PF00069	0.673
MOD_NEK2_1	281	286	PF00069	0.620
MOD_NEK2_1	416	421	PF00069	0.515
MOD_NEK2_1	501	506	PF00069	0.664
MOD_NEK2_1	583	588	PF00069	0.804
MOD_NEK2_1	63	68	PF00069	0.675
MOD_NEK2_1	760	765	PF00069	0.629
MOD_NEK2_1	780	785	PF00069	0.489
MOD_NEK2_1	788	793	PF00069	0.571
MOD_NEK2_1	859	864	PF00069	0.632
MOD_NEK2_1	92	97	PF00069	0.709
MOD_NEK2_2	336	341	PF00069	0.709
MOD_NEK2_2	534	539	PF00069	0.677
MOD_NEK2_2	81	86	PF00069	0.720
MOD_OFUCOSY	757	764	PF10250	0.642
MOD_PIKK_1	157	163	PF00454	0.619
MOD_PIKK_1	462	468	PF00454	0.610
MOD_PIKK_1	583	589	PF00454	0.731
MOD_PIKK_1	800	806	PF00454	0.646
MOD_PKA_1	499	505	PF00069	0.714
MOD_PKA_1	820	826	PF00069	0.773
MOD_PKA_2	145	151	PF00069	0.682
MOD_PKA_2	162	168	PF00069	0.628
MOD_PKA_2	499	505	PF00069	0.714
MOD_PKA_2	52	58	PF00069	0.658
MOD_PKA_2	552	558	PF00069	0.537
MOD_PKA_2	820	826	PF00069	0.785
MOD_Plk_1	191	197	PF00069	0.579
MOD_Plk_1	534	540	PF00069	0.656
MOD_Plk_1	747	753	PF00069	0.629
MOD_Plk_1	780	786	PF00069	0.595
MOD_Plk_1	81	87	PF00069	0.713
MOD_Plk_4	107	113	PF00069	0.557
MOD_Plk_4	145	151	PF00069	0.682
MOD_Plk_4	21	27	PF00069	0.645
MOD_Plk_4	263	269	PF00069	0.671
MOD_Plk_4	307	313	PF00069	0.681
MOD_Plk_4	336	342	PF00069	0.617
MOD_Plk_4	424	430	PF00069	0.591
MOD_Plk_4	442	448	PF00069	0.631
MOD_Plk_4	553	559	PF00069	0.511
MOD_Plk_4	626	632	PF00069	0.570
MOD_Plk_4	63	69	PF00069	0.479
MOD_Plk_4	674	680	PF00069	0.552
MOD_Plk_4	725	731	PF00069	0.637
MOD_Plk_4	748	754	PF00069	0.685
MOD_Plk_4	792	798	PF00069	0.765
MOD_Plk_4	874	880	PF00069	0.550
MOD_ProDKin_1	14	20	PF00069	0.620
MOD_ProDKin_1	155	161	PF00069	0.732
MOD_ProDKin_1	165	171	PF00069	0.606
MOD_ProDKin_1	195	201	PF00069	0.636
MOD_ProDKin_1	215	221	PF00069	0.500
MOD_ProDKin_1	267	273	PF00069	0.578
MOD_ProDKin_1	296	302	PF00069	0.683
MOD_ProDKin_1	386	392	PF00069	0.560
MOD_ProDKin_1	585	591	PF00069	0.835
MOD_ProDKin_1	733	739	PF00069	0.713
MOD_SUMO_rev_2	884	892	PF00179	0.585
TRG_DiLeu_BaEn_4	30	36	PF01217	0.600
TRG_DiLeu_BaEn_4	602	608	PF01217	0.632
TRG_DiLeu_BaLyEn_6	695	700	PF01217	0.682
TRG_ENDOCYTIC_2	380	383	PF00928	0.646
TRG_ENDOCYTIC_2	710	713	PF00928	0.608
TRG_ER_diArg_1	257	259	PF00400	0.455
TRG_ER_diArg_1	37	39	PF00400	0.613
TRG_ER_diArg_1	498	500	PF00400	0.599
TRG_ER_diArg_1	559	562	PF00400	0.577
TRG_ER_diArg_1	814	816	PF00400	0.684
TRG_ER_diArg_1	886	888	PF00400	0.644
TRG_NLS_MonoCore_2	815	820	PF00514	0.593
TRG_NLS_MonoExtC_3	815	820	PF00514	0.648
TRG_NLS_MonoExtN_4	815	820	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF8	Leptomonas seymouri	40%	100%
A4H4Y5	Leishmania braziliensis	73%	97%
A4HT29	Leishmania infantum	100%	100%
E9AL50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIQ4	Leishmania major	89%	100%