Succinate dehydrogenase assembly factor 4, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1674), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5X5_LEIDO

TriTrypDb:

LdCL_070008900 , LDHU3_07.0470

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 1
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5X5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0034552	respiratory chain complex II assembly	6	1
GO:0034553	mitochondrial respiratory chain complex II assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	75	77	PF00675	0.702
CLV_PCSK_KEX2_1	124	126	PF00082	0.438
CLV_PCSK_KEX2_1	75	77	PF00082	0.702
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.438
CLV_PCSK_SKI1_1	124	128	PF00082	0.443
DOC_MAPK_gen_1	48	56	PF00069	0.462
DOC_MAPK_gen_1	75	82	PF00069	0.471
DOC_MAPK_HePTP_8	72	84	PF00069	0.469
DOC_MAPK_MEF2A_6	35	43	PF00069	0.524
DOC_MAPK_MEF2A_6	75	84	PF00069	0.471
DOC_PP2B_LxvP_1	43	46	PF13499	0.537
DOC_PP4_FxxP_1	64	67	PF00568	0.470
DOC_USP7_MATH_1	39	43	PF00917	0.724
DOC_WW_Pin1_4	12	17	PF00397	0.488
DOC_WW_Pin1_4	35	40	PF00397	0.472
DOC_WW_Pin1_4	63	68	PF00397	0.473
LIG_14-3-3_CanoR_1	117	123	PF00244	0.402
LIG_14-3-3_CanoR_1	125	131	PF00244	0.447
LIG_14-3-3_CanoR_1	40	44	PF00244	0.540
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	57	61	PF00533	0.505
LIG_Clathr_ClatBox_1	81	85	PF01394	0.479
LIG_FHA_1	125	131	PF00498	0.689
LIG_FHA_1	144	150	PF00498	0.410
LIG_FHA_1	151	157	PF00498	0.432
LIG_FHA_1	36	42	PF00498	0.548
LIG_FHA_1	45	51	PF00498	0.611
LIG_FHA_2	158	164	PF00498	0.449
LIG_HP1_1	39	43	PF01393	0.538
LIG_Integrin_isoDGR_2	173	175	PF01839	0.250
LIG_LIR_Gen_1	58	68	PF02991	0.485
LIG_LIR_Gen_1	69	78	PF02991	0.397
LIG_LIR_Nem_3	58	64	PF02991	0.496
LIG_LIR_Nem_3	66	71	PF02991	0.401
LIG_PDZ_Class_2	174	179	PF00595	0.449
LIG_Pex14_2	64	68	PF04695	0.469
LIG_SH2_STAT5	21	24	PF00017	0.489
LIG_SH2_STAT5	98	101	PF00017	0.622
MOD_CDK_SPK_2	35	40	PF00069	0.472
MOD_CK1_1	129	135	PF00069	0.461
MOD_CK1_1	33	39	PF00069	0.510
MOD_CK2_1	63	69	PF00069	0.469
MOD_DYRK1A_RPxSP_1	35	39	PF00069	0.466
MOD_GlcNHglycan	131	134	PF01048	0.459
MOD_GlcNHglycan	90	93	PF01048	0.430
MOD_GSK3_1	125	132	PF00069	0.455
MOD_GSK3_1	35	42	PF00069	0.475
MOD_NEK2_1	126	131	PF00069	0.458
MOD_NEK2_1	55	60	PF00069	0.458
MOD_NEK2_2	39	44	PF00069	0.540
MOD_OFUCOSY	8	14	PF10250	0.495
MOD_PIKK_1	157	163	PF00454	0.449
MOD_PKA_1	124	130	PF00069	0.451
MOD_PKA_2	10	16	PF00069	0.447
MOD_PKA_2	116	122	PF00069	0.411
MOD_PKA_2	124	130	PF00069	0.442
MOD_PKA_2	39	45	PF00069	0.539
MOD_Plk_4	132	138	PF00069	0.458
MOD_Plk_4	85	91	PF00069	0.462
MOD_ProDKin_1	12	18	PF00069	0.487
MOD_ProDKin_1	35	41	PF00069	0.474
MOD_ProDKin_1	63	69	PF00069	0.469
MOD_SUMO_rev_2	119	126	PF00179	0.422
TRG_DiLeu_BaEn_2	84	90	PF01217	0.467
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.469
TRG_ER_diArg_1	74	76	PF00400	0.688
TRG_NLS_MonoExtC_3	47	53	PF00514	0.463
TRG_NLS_MonoExtN_4	46	52	PF00514	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4QIQ7	Leishmania major	92%	100%