Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5X2_LEIDO

TriTrypDb:

LdBPK_070480.1 , LdCL_070008300 , LDHU3_07.0400

Length:

1045

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A0A3S5H5X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.628
CLV_C14_Caspase3-7	616	620	PF00656	0.672
CLV_C14_Caspase3-7	709	713	PF00656	0.636
CLV_C14_Caspase3-7	771	775	PF00656	0.736
CLV_C14_Caspase3-7	853	857	PF00656	0.648
CLV_C14_Caspase3-7	972	976	PF00656	0.472
CLV_MEL_PAP_1	1014	1020	PF00089	0.298
CLV_NRD_NRD_1	1016	1018	PF00675	0.471
CLV_NRD_NRD_1	1043	1045	PF00675	0.582
CLV_NRD_NRD_1	2	4	PF00675	0.498
CLV_NRD_NRD_1	257	259	PF00675	0.570
CLV_NRD_NRD_1	593	595	PF00675	0.648
CLV_NRD_NRD_1	785	787	PF00675	0.565
CLV_NRD_NRD_1	920	922	PF00675	0.424
CLV_PCSK_KEX2_1	1016	1018	PF00082	0.476
CLV_PCSK_KEX2_1	1043	1045	PF00082	0.631
CLV_PCSK_KEX2_1	125	127	PF00082	0.543
CLV_PCSK_KEX2_1	2	4	PF00082	0.500
CLV_PCSK_KEX2_1	593	595	PF00082	0.688
CLV_PCSK_KEX2_1	784	786	PF00082	0.580
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.543
CLV_PCSK_SKI1_1	1006	1010	PF00082	0.355
CLV_PCSK_SKI1_1	258	262	PF00082	0.407
CLV_PCSK_SKI1_1	423	427	PF00082	0.362
CLV_PCSK_SKI1_1	6	10	PF00082	0.552
DEG_APCC_DBOX_1	257	265	PF00400	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.541
DEG_SCF_FBW7_2	284	290	PF00400	0.496
DEG_SPOP_SBC_1	684	688	PF00917	0.605
DOC_CDC14_PxL_1	955	963	PF14671	0.383
DOC_CKS1_1	284	289	PF01111	0.510
DOC_CKS1_1	309	314	PF01111	0.450
DOC_CYCLIN_RxL_1	558	567	PF00134	0.605
DOC_MAPK_DCC_7	360	368	PF00069	0.464
DOC_MAPK_gen_1	1013	1023	PF00069	0.426
DOC_MAPK_gen_1	2	11	PF00069	0.517
DOC_MAPK_gen_1	258	264	PF00069	0.395
DOC_MAPK_gen_1	360	368	PF00069	0.356
DOC_MAPK_gen_1	418	427	PF00069	0.388
DOC_MAPK_gen_1	493	501	PF00069	0.648
DOC_MAPK_gen_1	559	568	PF00069	0.623
DOC_MAPK_gen_1	784	793	PF00069	0.500
DOC_MAPK_MEF2A_6	1013	1022	PF00069	0.411
DOC_MAPK_MEF2A_6	362	370	PF00069	0.360
DOC_PP1_RVXF_1	268	274	PF00149	0.405
DOC_PP1_RVXF_1	559	566	PF00149	0.605
DOC_PP1_RVXF_1	960	967	PF00149	0.436
DOC_PP2B_LxvP_1	157	160	PF13499	0.426
DOC_PP4_FxxP_1	309	312	PF00568	0.386
DOC_PP4_FxxP_1	665	668	PF00568	0.582
DOC_USP7_MATH_1	489	493	PF00917	0.689
DOC_USP7_MATH_1	629	633	PF00917	0.775
DOC_USP7_MATH_1	657	661	PF00917	0.557
DOC_USP7_MATH_1	684	688	PF00917	0.610
DOC_USP7_MATH_1	746	750	PF00917	0.565
DOC_USP7_MATH_1	769	773	PF00917	0.705
DOC_USP7_MATH_1	84	88	PF00917	0.638
DOC_USP7_MATH_1	91	95	PF00917	0.744
DOC_USP7_UBL2_3	165	169	PF12436	0.446
DOC_WW_Pin1_4	1026	1031	PF00397	0.493
DOC_WW_Pin1_4	20	25	PF00397	0.430
DOC_WW_Pin1_4	264	269	PF00397	0.454
DOC_WW_Pin1_4	283	288	PF00397	0.380
DOC_WW_Pin1_4	308	313	PF00397	0.437
DOC_WW_Pin1_4	320	325	PF00397	0.435
DOC_WW_Pin1_4	361	366	PF00397	0.458
DOC_WW_Pin1_4	50	55	PF00397	0.632
DOC_WW_Pin1_4	525	530	PF00397	0.745
DOC_WW_Pin1_4	538	543	PF00397	0.629
DOC_WW_Pin1_4	580	585	PF00397	0.630
DOC_WW_Pin1_4	67	72	PF00397	0.648
DOC_WW_Pin1_4	78	83	PF00397	0.530
DOC_WW_Pin1_4	836	841	PF00397	0.684
DOC_WW_Pin1_4	98	103	PF00397	0.623
LIG_14-3-3_CanoR_1	1006	1014	PF00244	0.456
LIG_14-3-3_CanoR_1	200	204	PF00244	0.460
LIG_14-3-3_CanoR_1	208	213	PF00244	0.350
LIG_14-3-3_CanoR_1	215	219	PF00244	0.335
LIG_14-3-3_CanoR_1	244	253	PF00244	0.444
LIG_14-3-3_CanoR_1	421	426	PF00244	0.391
LIG_14-3-3_CanoR_1	593	601	PF00244	0.708
LIG_14-3-3_CanoR_1	630	634	PF00244	0.582
LIG_14-3-3_CanoR_1	689	693	PF00244	0.597
LIG_14-3-3_CanoR_1	845	855	PF00244	0.574
LIG_14-3-3_CanoR_1	914	919	PF00244	0.482
LIG_Actin_WH2_2	186	202	PF00022	0.494
LIG_Actin_WH2_2	326	341	PF00022	0.485
LIG_Actin_WH2_2	947	964	PF00022	0.427
LIG_APCC_ABBAyCdc20_2	673	679	PF00400	0.537
LIG_BIR_III_2	518	522	PF00653	0.620
LIG_BIR_III_2	743	747	PF00653	0.503
LIG_BIR_III_4	834	838	PF00653	0.646
LIG_BRCT_BRCA1_1	410	414	PF00533	0.432
LIG_BRCT_BRCA1_1	52	56	PF00533	0.448
LIG_deltaCOP1_diTrp_1	4	11	PF00928	0.414
LIG_EH1_1	229	237	PF00400	0.337
LIG_eIF4E_1	256	262	PF01652	0.449
LIG_eIF4E_1	468	474	PF01652	0.417
LIG_FHA_1	1007	1013	PF00498	0.391
LIG_FHA_1	102	108	PF00498	0.562
LIG_FHA_1	200	206	PF00498	0.555
LIG_FHA_1	283	289	PF00498	0.571
LIG_FHA_1	325	331	PF00498	0.496
LIG_FHA_1	335	341	PF00498	0.497
LIG_FHA_1	417	423	PF00498	0.548
LIG_FHA_1	629	635	PF00498	0.570
LIG_FHA_1	638	644	PF00498	0.597
LIG_FHA_1	648	654	PF00498	0.608
LIG_FHA_1	737	743	PF00498	0.595
LIG_FHA_1	810	816	PF00498	0.643
LIG_FHA_1	821	827	PF00498	0.512
LIG_FHA_1	928	934	PF00498	0.434
LIG_FHA_2	130	136	PF00498	0.605
LIG_FHA_2	215	221	PF00498	0.488
LIG_FHA_2	246	252	PF00498	0.402
LIG_FHA_2	46	52	PF00498	0.554
LIG_FHA_2	972	978	PF00498	0.395
LIG_FHA_2	986	992	PF00498	0.544
LIG_GBD_Chelix_1	440	448	PF00786	0.445
LIG_LIR_Apic_2	152	158	PF02991	0.447
LIG_LIR_Apic_2	662	668	PF02991	0.582
LIG_LIR_Gen_1	27	38	PF02991	0.530
LIG_LIR_Gen_1	276	287	PF02991	0.475
LIG_LIR_Gen_1	341	351	PF02991	0.426
LIG_LIR_Gen_1	386	397	PF02991	0.375
LIG_LIR_Gen_1	53	61	PF02991	0.469
LIG_LIR_Nem_3	152	157	PF02991	0.374
LIG_LIR_Nem_3	27	33	PF02991	0.504
LIG_LIR_Nem_3	276	282	PF02991	0.517
LIG_LIR_Nem_3	293	298	PF02991	0.406
LIG_LIR_Nem_3	341	346	PF02991	0.410
LIG_LIR_Nem_3	386	392	PF02991	0.436
LIG_LIR_Nem_3	426	432	PF02991	0.414
LIG_LIR_Nem_3	53	59	PF02991	0.475
LIG_LYPXL_yS_3	380	383	PF13949	0.446
LIG_PCNA_yPIPBox_3	447	457	PF02747	0.450
LIG_Pex14_1	26	30	PF04695	0.398
LIG_Pex14_2	7	11	PF04695	0.382
LIG_Rb_LxCxE_1	364	376	PF01857	0.443
LIG_RPA_C_Fungi	488	500	PF08784	0.651
LIG_RPA_C_Fungi	780	792	PF08784	0.506
LIG_SH2_CRK	155	159	PF00017	0.396
LIG_SH2_CRK	265	269	PF00017	0.472
LIG_SH2_CRK	279	283	PF00017	0.540
LIG_SH2_GRB2like	279	282	PF00017	0.492
LIG_SH2_GRB2like	965	968	PF00017	0.390
LIG_SH2_NCK_1	265	269	PF00017	0.401
LIG_SH2_NCK_1	981	985	PF00017	0.381
LIG_SH2_SRC	109	112	PF00017	0.610
LIG_SH2_SRC	230	233	PF00017	0.322
LIG_SH2_SRC	300	303	PF00017	0.472
LIG_SH2_STAP1	343	347	PF00017	0.469
LIG_SH2_STAP1	61	65	PF00017	0.430
LIG_SH2_STAP1	736	740	PF00017	0.525
LIG_SH2_STAP1	872	876	PF00017	0.557
LIG_SH2_STAT3	468	471	PF00017	0.385
LIG_SH2_STAT3	479	482	PF00017	0.461
LIG_SH2_STAT5	155	158	PF00017	0.406
LIG_SH2_STAT5	216	219	PF00017	0.399
LIG_SH2_STAT5	241	244	PF00017	0.347
LIG_SH2_STAT5	256	259	PF00017	0.366
LIG_SH2_STAT5	300	303	PF00017	0.412
LIG_SH2_STAT5	454	457	PF00017	0.455
LIG_SH2_STAT5	468	471	PF00017	0.350
LIG_SH2_STAT5	479	482	PF00017	0.495
LIG_SH2_STAT5	61	64	PF00017	0.483
LIG_SH2_STAT5	796	799	PF00017	0.511
LIG_SH2_STAT5	918	921	PF00017	0.375
LIG_SH2_STAT5	942	945	PF00017	0.365
LIG_SH2_STAT5	965	968	PF00017	0.390
LIG_SH3_1	921	927	PF00018	0.371
LIG_SH3_2	312	317	PF14604	0.390
LIG_SH3_3	257	263	PF00018	0.438
LIG_SH3_3	281	287	PF00018	0.484
LIG_SH3_3	309	315	PF00018	0.400
LIG_SH3_3	404	410	PF00018	0.477
LIG_SH3_3	517	523	PF00018	0.716
LIG_SH3_3	526	532	PF00018	0.617
LIG_SH3_3	578	584	PF00018	0.698
LIG_SH3_3	65	71	PF00018	0.677
LIG_SH3_3	921	927	PF00018	0.403
LIG_TRAF2_1	583	586	PF00917	0.658
LIG_TRAF2_1	731	734	PF00917	0.626
LIG_TRAF2_1	932	935	PF00917	0.448
LIG_TYR_ITIM	277	282	PF00017	0.530
MOD_CDC14_SPxK_1	267	270	PF00782	0.479
MOD_CDC14_SPxK_1	323	326	PF00782	0.578
MOD_CDK_SPxK_1	264	270	PF00069	0.475
MOD_CDK_SPxK_1	320	326	PF00069	0.551
MOD_CK1_1	1001	1007	PF00069	0.434
MOD_CK1_1	101	107	PF00069	0.714
MOD_CK1_1	116	122	PF00069	0.664
MOD_CK1_1	531	537	PF00069	0.717
MOD_CK1_1	632	638	PF00069	0.616
MOD_CK1_1	642	648	PF00069	0.559
MOD_CK1_1	683	689	PF00069	0.540
MOD_CK1_1	755	761	PF00069	0.637
MOD_CK1_1	767	773	PF00069	0.782
MOD_CK1_1	795	801	PF00069	0.724
MOD_CK1_1	94	100	PF00069	0.700
MOD_CK2_1	245	251	PF00069	0.359
MOD_CK2_1	338	344	PF00069	0.455
MOD_CK2_1	45	51	PF00069	0.668
MOD_CK2_1	580	586	PF00069	0.691
MOD_CK2_1	728	734	PF00069	0.705
MOD_CK2_1	929	935	PF00069	0.491
MOD_CK2_1	971	977	PF00069	0.348
MOD_CK2_1	985	991	PF00069	0.372
MOD_Cter_Amidation	123	126	PF01082	0.542
MOD_GlcNHglycan	458	461	PF01048	0.493
MOD_GlcNHglycan	486	490	PF01048	0.716
MOD_GlcNHglycan	535	538	PF01048	0.504
MOD_GlcNHglycan	596	599	PF01048	0.726
MOD_GlcNHglycan	621	624	PF01048	0.692
MOD_GlcNHglycan	634	637	PF01048	0.686
MOD_GlcNHglycan	655	658	PF01048	0.693
MOD_GlcNHglycan	659	662	PF01048	0.709
MOD_GlcNHglycan	665	668	PF01048	0.749
MOD_GlcNHglycan	682	685	PF01048	0.522
MOD_GlcNHglycan	700	703	PF01048	0.651
MOD_GlcNHglycan	717	720	PF01048	0.653
MOD_GlcNHglycan	748	751	PF01048	0.632
MOD_GlcNHglycan	754	757	PF01048	0.629
MOD_GlcNHglycan	771	774	PF01048	0.711
MOD_GlcNHglycan	787	790	PF01048	0.734
MOD_GlcNHglycan	798	801	PF01048	0.611
MOD_GlcNHglycan	816	819	PF01048	0.516
MOD_GlcNHglycan	828	832	PF01048	0.609
MOD_GlcNHglycan	937	941	PF01048	0.418
MOD_GlcNHglycan	98	101	PF01048	0.721
MOD_GSK3_1	113	120	PF00069	0.583
MOD_GSK3_1	282	289	PF00069	0.536
MOD_GSK3_1	320	327	PF00069	0.513
MOD_GSK3_1	334	341	PF00069	0.542
MOD_GSK3_1	383	390	PF00069	0.393
MOD_GSK3_1	421	428	PF00069	0.421
MOD_GSK3_1	435	442	PF00069	0.408
MOD_GSK3_1	485	492	PF00069	0.648
MOD_GSK3_1	538	545	PF00069	0.663
MOD_GSK3_1	619	626	PF00069	0.588
MOD_GSK3_1	628	635	PF00069	0.777
MOD_GSK3_1	637	644	PF00069	0.668
MOD_GSK3_1	649	656	PF00069	0.750
MOD_GSK3_1	679	686	PF00069	0.612
MOD_GSK3_1	698	705	PF00069	0.644
MOD_GSK3_1	748	755	PF00069	0.564
MOD_GSK3_1	792	799	PF00069	0.689
MOD_GSK3_1	816	823	PF00069	0.676
MOD_GSK3_1	846	853	PF00069	0.726
MOD_GSK3_1	94	101	PF00069	0.684
MOD_GSK3_1	967	974	PF00069	0.382
MOD_N-GLC_1	684	689	PF02516	0.512
MOD_N-GLC_1	693	698	PF02516	0.536
MOD_N-GLC_1	967	972	PF02516	0.429
MOD_N-GLC_1	985	990	PF02516	0.353
MOD_NEK2_1	1023	1028	PF00069	0.383
MOD_NEK2_1	199	204	PF00069	0.589
MOD_NEK2_1	214	219	PF00069	0.389
MOD_NEK2_1	224	229	PF00069	0.381
MOD_NEK2_1	33	38	PF00069	0.493
MOD_NEK2_1	338	343	PF00069	0.456
MOD_NEK2_1	414	419	PF00069	0.575
MOD_NEK2_1	439	444	PF00069	0.345
MOD_NEK2_1	448	453	PF00069	0.348
MOD_NEK2_1	485	490	PF00069	0.592
MOD_NEK2_1	639	644	PF00069	0.773
MOD_NEK2_1	672	677	PF00069	0.643
MOD_NEK2_1	680	685	PF00069	0.590
MOD_NEK2_1	698	703	PF00069	0.660
MOD_NEK2_1	759	764	PF00069	0.619
MOD_NEK2_1	792	797	PF00069	0.638
MOD_NEK2_1	846	851	PF00069	0.735
MOD_NEK2_2	84	89	PF00069	0.623
MOD_PIKK_1	1038	1044	PF00454	0.384
MOD_PIKK_1	45	51	PF00454	0.650
MOD_PIKK_1	809	815	PF00454	0.593
MOD_PKA_1	785	791	PF00069	0.498
MOD_PKA_2	199	205	PF00069	0.519
MOD_PKA_2	214	220	PF00069	0.407
MOD_PKA_2	245	251	PF00069	0.483
MOD_PKA_2	489	495	PF00069	0.685
MOD_PKA_2	592	598	PF00069	0.703
MOD_PKA_2	629	635	PF00069	0.593
MOD_PKA_2	672	678	PF00069	0.793
MOD_PKA_2	688	694	PF00069	0.576
MOD_PKA_2	698	704	PF00069	0.670
MOD_PKA_2	785	791	PF00069	0.583
MOD_PKA_2	94	100	PF00069	0.676
MOD_PKB_1	421	429	PF00069	0.368
MOD_PKB_1	43	51	PF00069	0.542
MOD_Plk_1	275	281	PF00069	0.543
MOD_Plk_1	33	39	PF00069	0.534
MOD_Plk_1	373	379	PF00069	0.490
MOD_Plk_1	693	699	PF00069	0.704
MOD_Plk_1	927	933	PF00069	0.471
MOD_Plk_1	967	973	PF00069	0.333
MOD_Plk_1	985	991	PF00069	0.511
MOD_Plk_4	1028	1034	PF00069	0.375
MOD_Plk_4	231	237	PF00069	0.351
MOD_Plk_4	338	344	PF00069	0.394
MOD_Plk_4	435	441	PF00069	0.419
MOD_Plk_4	542	548	PF00069	0.661
MOD_Plk_4	629	635	PF00069	0.658
MOD_Plk_4	787	793	PF00069	0.555
MOD_Plk_4	850	856	PF00069	0.620
MOD_Plk_4	891	897	PF00069	0.588
MOD_Plk_4	914	920	PF00069	0.369
MOD_ProDKin_1	1026	1032	PF00069	0.492
MOD_ProDKin_1	20	26	PF00069	0.424
MOD_ProDKin_1	264	270	PF00069	0.459
MOD_ProDKin_1	283	289	PF00069	0.379
MOD_ProDKin_1	308	314	PF00069	0.440
MOD_ProDKin_1	320	326	PF00069	0.439
MOD_ProDKin_1	361	367	PF00069	0.461
MOD_ProDKin_1	50	56	PF00069	0.625
MOD_ProDKin_1	525	531	PF00069	0.745
MOD_ProDKin_1	538	544	PF00069	0.624
MOD_ProDKin_1	580	586	PF00069	0.630
MOD_ProDKin_1	67	73	PF00069	0.656
MOD_ProDKin_1	78	84	PF00069	0.531
MOD_ProDKin_1	836	842	PF00069	0.684
MOD_ProDKin_1	98	104	PF00069	0.623
MOD_SUMO_rev_2	385	395	PF00179	0.450
MOD_SUMO_rev_2	399	407	PF00179	0.374
MOD_SUMO_rev_2	511	516	PF00179	0.566
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.475
TRG_ENDOCYTIC_2	279	282	PF00928	0.465
TRG_ENDOCYTIC_2	28	31	PF00928	0.493
TRG_ENDOCYTIC_2	343	346	PF00928	0.468
TRG_ENDOCYTIC_2	380	383	PF00928	0.446
TRG_ENDOCYTIC_2	389	392	PF00928	0.370
TRG_ENDOCYTIC_2	429	432	PF00928	0.429
TRG_ENDOCYTIC_2	872	875	PF00928	0.582
TRG_ER_diArg_1	1	3	PF00400	0.565
TRG_ER_diArg_1	1016	1018	PF00400	0.492
TRG_ER_diArg_1	243	246	PF00400	0.421
TRG_ER_diArg_1	494	497	PF00400	0.702
TRG_ER_diArg_1	783	786	PF00400	0.627
TRG_ER_diArg_1	959	962	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	869	873	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	921	926	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D4	Leptomonas seymouri	56%	91%
A0A3R7MCX5	Trypanosoma rangeli	40%	100%
A4H4X7	Leishmania braziliensis	75%	100%
A4HT50	Leishmania infantum	100%	100%
C9ZUS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AL42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4QIR2	Leishmania major	93%	99%