Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5W8_LEIDO

TriTrypDb:

LdBPK_070400.1 , LdCL_070007500 , LDHU3_07.0310

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A0A3S5H5W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.396
CLV_NRD_NRD_1	231	233	PF00675	0.698
CLV_NRD_NRD_1	236	238	PF00675	0.669
CLV_NRD_NRD_1	271	273	PF00675	0.607
CLV_NRD_NRD_1	290	292	PF00675	0.599
CLV_NRD_NRD_1	303	305	PF00675	0.632
CLV_NRD_NRD_1	315	317	PF00675	0.566
CLV_NRD_NRD_1	33	35	PF00675	0.402
CLV_NRD_NRD_1	365	367	PF00675	0.707
CLV_NRD_NRD_1	394	396	PF00675	0.713
CLV_NRD_NRD_1	40	42	PF00675	0.512
CLV_NRD_NRD_1	427	429	PF00675	0.819
CLV_NRD_NRD_1	447	449	PF00675	0.577
CLV_NRD_NRD_1	6	8	PF00675	0.458
CLV_PCSK_FUR_1	301	305	PF00082	0.705
CLV_PCSK_FUR_1	445	449	PF00082	0.708
CLV_PCSK_KEX2_1	231	233	PF00082	0.701
CLV_PCSK_KEX2_1	236	238	PF00082	0.673
CLV_PCSK_KEX2_1	271	273	PF00082	0.607
CLV_PCSK_KEX2_1	290	292	PF00082	0.484
CLV_PCSK_KEX2_1	303	305	PF00082	0.551
CLV_PCSK_KEX2_1	315	317	PF00082	0.566
CLV_PCSK_KEX2_1	33	35	PF00082	0.398
CLV_PCSK_KEX2_1	364	366	PF00082	0.695
CLV_PCSK_KEX2_1	39	41	PF00082	0.517
CLV_PCSK_KEX2_1	394	396	PF00082	0.713
CLV_PCSK_KEX2_1	427	429	PF00082	0.819
CLV_PCSK_KEX2_1	447	449	PF00082	0.577
CLV_PCSK_KEX2_1	6	8	PF00082	0.484
CLV_PCSK_PC7_1	232	238	PF00082	0.683
CLV_PCSK_SKI1_1	271	275	PF00082	0.613
CLV_PCSK_SKI1_1	455	459	PF00082	0.708
CLV_PCSK_SKI1_1	46	50	PF00082	0.409
CLV_PCSK_SKI1_1	503	507	PF00082	0.731
DEG_Nend_Nbox_1	1	3	PF02207	0.726
DOC_CKS1_1	178	183	PF01111	0.526
DOC_CKS1_1	411	416	PF01111	0.539
DOC_CYCLIN_RxL_1	268	277	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.446
DOC_MAPK_gen_1	236	242	PF00069	0.418
DOC_MAPK_gen_1	364	372	PF00069	0.445
DOC_MAPK_gen_1	424	434	PF00069	0.599
DOC_MAPK_MEF2A_6	132	140	PF00069	0.368
DOC_MAPK_RevD_3	352	366	PF00069	0.466
DOC_PP2B_LxvP_1	79	82	PF13499	0.541
DOC_PP4_FxxP_1	125	128	PF00568	0.428
DOC_PP4_FxxP_1	327	330	PF00568	0.533
DOC_USP7_MATH_1	205	209	PF00917	0.498
DOC_USP7_MATH_1	459	463	PF00917	0.487
DOC_USP7_MATH_1	572	576	PF00917	0.522
DOC_USP7_MATH_1	581	585	PF00917	0.400
DOC_WW_Pin1_4	168	173	PF00397	0.569
DOC_WW_Pin1_4	17	22	PF00397	0.701
DOC_WW_Pin1_4	177	182	PF00397	0.563
DOC_WW_Pin1_4	210	215	PF00397	0.513
DOC_WW_Pin1_4	274	279	PF00397	0.435
DOC_WW_Pin1_4	295	300	PF00397	0.437
DOC_WW_Pin1_4	410	415	PF00397	0.514
LIG_14-3-3_CanoR_1	132	140	PF00244	0.336
LIG_14-3-3_CanoR_1	271	277	PF00244	0.419
LIG_14-3-3_CanoR_1	331	339	PF00244	0.498
LIG_14-3-3_CanoR_1	427	433	PF00244	0.538
LIG_14-3-3_CanoR_1	476	484	PF00244	0.473
LIG_Actin_WH2_2	116	134	PF00022	0.410
LIG_Actin_WH2_2	524	539	PF00022	0.567
LIG_APCC_ABBA_1	354	359	PF00400	0.388
LIG_BRCT_BRCA1_1	188	192	PF00533	0.526
LIG_BRCT_BRCA1_1	26	30	PF00533	0.671
LIG_DLG_GKlike_1	40	47	PF00625	0.626
LIG_EH1_1	60	68	PF00400	0.299
LIG_eIF4E_1	61	67	PF01652	0.402
LIG_FHA_1	107	113	PF00498	0.426
LIG_FHA_1	213	219	PF00498	0.491
LIG_FHA_1	261	267	PF00498	0.424
LIG_FHA_1	3	9	PF00498	0.776
LIG_FHA_1	342	348	PF00498	0.477
LIG_FHA_1	386	392	PF00498	0.533
LIG_FHA_1	459	465	PF00498	0.537
LIG_FHA_1	62	68	PF00498	0.389
LIG_FHA_2	417	423	PF00498	0.556
LIG_FHA_2	85	91	PF00498	0.466
LIG_Integrin_isoDGR_2	407	409	PF01839	0.744
LIG_LIR_Apic_2	124	128	PF02991	0.421
LIG_LIR_Gen_1	249	255	PF02991	0.405
LIG_LIR_Gen_1	355	363	PF02991	0.388
LIG_LIR_Gen_1	487	494	PF02991	0.464
LIG_LIR_LC3C_4	64	68	PF02991	0.375
LIG_LIR_Nem_3	249	253	PF02991	0.412
LIG_LIR_Nem_3	355	360	PF02991	0.387
LIG_LIR_Nem_3	43	47	PF02991	0.536
LIG_LIR_Nem_3	436	442	PF02991	0.531
LIG_LIR_Nem_3	487	491	PF02991	0.462
LIG_LIR_Nem_3	89	94	PF02991	0.403
LIG_MLH1_MIPbox_1	26	30	PF16413	0.601
LIG_MYND_1	96	100	PF01753	0.419
LIG_PCNA_PIPBox_1	494	503	PF02747	0.397
LIG_PCNA_PIPBox_1	73	82	PF02747	0.456
LIG_PCNA_yPIPBox_3	69	80	PF02747	0.448
LIG_Pex14_2	121	125	PF04695	0.409
LIG_PTB_Apo_2	244	251	PF02174	0.421
LIG_PTB_Phospho_1	244	250	PF10480	0.416
LIG_REV1ctd_RIR_1	123	127	PF16727	0.411
LIG_REV1ctd_RIR_1	27	38	PF16727	0.659
LIG_SH2_NCK_1	133	137	PF00017	0.365
LIG_SH2_NCK_1	250	254	PF00017	0.426
LIG_SH2_SRC	435	438	PF00017	0.538
LIG_SH2_SRC	556	559	PF00017	0.514
LIG_SH2_STAP1	133	137	PF00017	0.365
LIG_SH2_STAP1	435	439	PF00017	0.503
LIG_SH2_STAT3	550	553	PF00017	0.435
LIG_SH2_STAT5	286	289	PF00017	0.389
LIG_SH2_STAT5	61	64	PF00017	0.411
LIG_SH2_STAT5	86	89	PF00017	0.469
LIG_SH3_1	368	374	PF00018	0.516
LIG_SH3_1	453	459	PF00018	0.550
LIG_SH3_2	211	216	PF14604	0.490
LIG_SH3_3	136	142	PF00018	0.377
LIG_SH3_3	15	21	PF00018	0.788
LIG_SH3_3	208	214	PF00018	0.530
LIG_SH3_3	368	374	PF00018	0.484
LIG_SH3_3	376	382	PF00018	0.589
LIG_SH3_3	408	414	PF00018	0.603
LIG_SH3_3	453	459	PF00018	0.550
LIG_SH3_5	82	86	PF00018	0.577
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.375
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.357
LIG_SUMO_SIM_par_1	272	277	PF11976	0.431
LIG_TRAF2_1	603	606	PF00917	0.619
LIG_TYR_ITIM	131	136	PF00017	0.449
LIG_UBA3_1	241	248	PF00899	0.454
LIG_ULM_U2AF65_1	364	370	PF00076	0.639
LIG_WRC_WIRS_1	122	127	PF05994	0.516
MOD_CDC14_SPxK_1	171	174	PF00782	0.700
MOD_CDC14_SPxK_1	213	216	PF00782	0.680
MOD_CDK_SPxK_1	168	174	PF00069	0.702
MOD_CDK_SPxK_1	210	216	PF00069	0.691
MOD_CDK_SPxK_1	295	301	PF00069	0.537
MOD_CDK_SPxxK_3	17	24	PF00069	0.674
MOD_CDK_SPxxK_3	177	184	PF00069	0.667
MOD_CK1_1	176	182	PF00069	0.634
MOD_CK1_1	385	391	PF00069	0.641
MOD_CK1_1	560	566	PF00069	0.502
MOD_CK2_1	345	351	PF00069	0.488
MOD_CK2_1	459	465	PF00069	0.651
MOD_Cter_Amidation	313	316	PF01082	0.524
MOD_GlcNHglycan	14	17	PF01048	0.650
MOD_GlcNHglycan	175	178	PF01048	0.736
MOD_GlcNHglycan	200	203	PF01048	0.735
MOD_GlcNHglycan	278	281	PF01048	0.660
MOD_GlcNHglycan	384	387	PF01048	0.720
MOD_GlcNHglycan	399	402	PF01048	0.718
MOD_GlcNHglycan	56	59	PF01048	0.371
MOD_GSK3_1	106	113	PF00069	0.503
MOD_GSK3_1	173	180	PF00069	0.737
MOD_GSK3_1	272	279	PF00069	0.634
MOD_GSK3_1	341	348	PF00069	0.613
MOD_GSK3_1	381	388	PF00069	0.777
MOD_GSK3_1	556	563	PF00069	0.631
MOD_N-GLC_1	186	191	PF02516	0.568
MOD_N-GLC_1	257	262	PF02516	0.635
MOD_N-GLC_1	581	586	PF02516	0.548
MOD_NEK2_1	106	111	PF00069	0.457
MOD_NEK2_1	121	126	PF00069	0.367
MOD_NEK2_1	131	136	PF00069	0.427
MOD_NEK2_1	173	178	PF00069	0.743
MOD_NEK2_1	2	7	PF00069	0.642
MOD_NEK2_1	317	322	PF00069	0.550
MOD_NEK2_1	477	482	PF00069	0.628
MOD_PIKK_1	331	337	PF00454	0.614
MOD_PK_1	272	278	PF00069	0.569
MOD_PKA_1	24	30	PF00069	0.503
MOD_PKA_1	40	46	PF00069	0.522
MOD_PKA_2	106	112	PF00069	0.453
MOD_PKA_2	131	137	PF00069	0.446
MOD_PKA_2	193	199	PF00069	0.704
MOD_PKA_2	2	8	PF00069	0.638
MOD_PKA_2	40	46	PF00069	0.522
MOD_PKA_2	426	432	PF00069	0.777
MOD_PKA_2	477	483	PF00069	0.627
MOD_PKB_1	184	192	PF00069	0.601
MOD_Plk_1	317	323	PF00069	0.647
MOD_Plk_1	459	465	PF00069	0.651
MOD_Plk_1	556	562	PF00069	0.539
MOD_Plk_1	581	587	PF00069	0.553
MOD_Plk_1	84	90	PF00069	0.603
MOD_Plk_4	121	127	PF00069	0.531
MOD_Plk_4	317	323	PF00069	0.545
MOD_Plk_4	459	465	PF00069	0.651
MOD_Plk_4	572	578	PF00069	0.647
MOD_ProDKin_1	168	174	PF00069	0.724
MOD_ProDKin_1	17	23	PF00069	0.628
MOD_ProDKin_1	177	183	PF00069	0.704
MOD_ProDKin_1	210	216	PF00069	0.645
MOD_ProDKin_1	274	280	PF00069	0.538
MOD_ProDKin_1	295	301	PF00069	0.537
MOD_ProDKin_1	410	416	PF00069	0.647
MOD_SUMO_rev_2	85	94	PF00179	0.615
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.605
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.765
TRG_ENDOCYTIC_2	133	136	PF00928	0.440
TRG_ENDOCYTIC_2	250	253	PF00928	0.498
TRG_ENDOCYTIC_2	284	287	PF00928	0.498
TRG_ENDOCYTIC_2	357	360	PF00928	0.471
TRG_ENDOCYTIC_2	439	442	PF00928	0.677
TRG_ER_diArg_1	183	186	PF00400	0.692
TRG_ER_diArg_1	231	233	PF00400	0.633
TRG_ER_diArg_1	235	237	PF00400	0.626
TRG_ER_diArg_1	271	273	PF00400	0.496
TRG_ER_diArg_1	289	291	PF00400	0.480
TRG_ER_diArg_1	303	305	PF00400	0.532
TRG_ER_diArg_1	315	317	PF00400	0.416
TRG_ER_diArg_1	33	35	PF00400	0.511
TRG_ER_diArg_1	363	366	PF00400	0.602
TRG_ER_diArg_1	38	41	PF00400	0.643
TRG_ER_diArg_1	427	430	PF00400	0.800
TRG_ER_diArg_1	445	448	PF00400	0.639
TRG_ER_diArg_1	475	478	PF00400	0.650
TRG_ER_diArg_1	481	484	PF00400	0.641
TRG_ER_diArg_1	6	8	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.791
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.625
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE68	Leptomonas seymouri	54%	100%
A4H4W9	Leishmania braziliensis	80%	98%
A4HT42	Leishmania infantum	100%	100%
E9AL34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QIS0	Leishmania major	94%	100%