Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5W6_LEIDO

TriTrypDb:

LdBPK_070370.1 , LdCL_070007200 , LDHU3_07.0280

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.578
CLV_NRD_NRD_1	23	25	PF00675	0.660
CLV_PCSK_KEX2_1	159	161	PF00082	0.578
CLV_PCSK_KEX2_1	23	25	PF00082	0.661
CLV_Separin_Metazoa	183	187	PF03568	0.411
DEG_SCF_FBW7_1	84	91	PF00400	0.671
DOC_CKS1_1	85	90	PF01111	0.670
DOC_MAPK_MEF2A_6	137	145	PF00069	0.483
DOC_PP2B_LxvP_1	185	188	PF13499	0.528
DOC_PP4_FxxP_1	4	7	PF00568	0.695
DOC_USP7_MATH_1	129	133	PF00917	0.605
DOC_USP7_MATH_1	198	202	PF00917	0.660
DOC_USP7_MATH_1	240	244	PF00917	0.516
DOC_USP7_MATH_1	78	82	PF00917	0.635
DOC_USP7_MATH_1	88	92	PF00917	0.657
DOC_WW_Pin1_4	10	15	PF00397	0.742
DOC_WW_Pin1_4	135	140	PF00397	0.542
DOC_WW_Pin1_4	200	205	PF00397	0.646
DOC_WW_Pin1_4	213	218	PF00397	0.693
DOC_WW_Pin1_4	72	77	PF00397	0.650
DOC_WW_Pin1_4	84	89	PF00397	0.694
LIG_14-3-3_CanoR_1	176	182	PF00244	0.529
LIG_14-3-3_CanoR_1	23	31	PF00244	0.608
LIG_14-3-3_CanoR_1	36	43	PF00244	0.493
LIG_APCC_ABBA_1	114	119	PF00400	0.530
LIG_FHA_1	136	142	PF00498	0.560
LIG_FHA_1	60	66	PF00498	0.456
LIG_FHA_2	11	17	PF00498	0.650
LIG_FHA_2	178	184	PF00498	0.438
LIG_FHA_2	36	42	PF00498	0.504
LIG_LIR_Gen_1	112	122	PF02991	0.556
LIG_LIR_Gen_1	49	58	PF02991	0.523
LIG_LIR_Nem_3	112	118	PF02991	0.523
LIG_LIR_Nem_3	223	229	PF02991	0.632
LIG_LIR_Nem_3	49	54	PF02991	0.523
LIG_PCNA_yPIPBox_3	176	185	PF02747	0.481
LIG_PDZ_Class_1	248	253	PF00595	0.592
LIG_Pex14_2	54	58	PF04695	0.525
LIG_SH2_NCK_1	161	165	PF00017	0.554
LIG_SH2_STAP1	161	165	PF00017	0.474
LIG_SH2_STAP1	241	245	PF00017	0.475
LIG_SH3_3	11	17	PF00018	0.680
LIG_SH3_3	70	76	PF00018	0.586
LIG_SH3_3	82	88	PF00018	0.665
LIG_TRAF2_1	39	42	PF00917	0.503
MOD_CK1_1	216	222	PF00069	0.703
MOD_CK1_1	224	230	PF00069	0.584
MOD_CK2_1	10	16	PF00069	0.615
MOD_CK2_1	129	135	PF00069	0.538
MOD_CK2_1	160	166	PF00069	0.486
MOD_CK2_1	177	183	PF00069	0.503
MOD_CK2_1	224	230	PF00069	0.549
MOD_CK2_1	35	41	PF00069	0.574
MOD_CK2_1	53	59	PF00069	0.522
MOD_CK2_1	88	94	PF00069	0.717
MOD_GlcNHglycan	162	165	PF01048	0.614
MOD_GlcNHglycan	207	210	PF01048	0.713
MOD_GlcNHglycan	223	226	PF01048	0.594
MOD_GlcNHglycan	80	83	PF01048	0.678
MOD_GlcNHglycan	99	102	PF01048	0.682
MOD_GSK3_1	105	112	PF00069	0.531
MOD_GSK3_1	19	26	PF00069	0.557
MOD_GSK3_1	198	205	PF00069	0.620
MOD_GSK3_1	212	219	PF00069	0.651
MOD_GSK3_1	220	227	PF00069	0.569
MOD_GSK3_1	49	56	PF00069	0.512
MOD_GSK3_1	84	91	PF00069	0.674
MOD_LATS_1	210	216	PF00433	0.637
MOD_N-GLC_1	177	182	PF02516	0.517
MOD_N-GLC_1	213	218	PF02516	0.657
MOD_NEK2_1	105	110	PF00069	0.503
MOD_NEK2_1	248	253	PF00069	0.590
MOD_NEK2_1	53	58	PF00069	0.500
MOD_PKA_1	23	29	PF00069	0.590
MOD_PKA_2	23	29	PF00069	0.642
MOD_PKA_2	35	41	PF00069	0.483
MOD_Plk_1	105	111	PF00069	0.513
MOD_Plk_1	177	183	PF00069	0.514
MOD_Plk_1	198	204	PF00069	0.611
MOD_Plk_1	230	236	PF00069	0.620
MOD_Plk_1	58	64	PF00069	0.504
MOD_Plk_4	109	115	PF00069	0.454
MOD_Plk_4	240	246	PF00069	0.489
MOD_ProDKin_1	10	16	PF00069	0.742
MOD_ProDKin_1	135	141	PF00069	0.531
MOD_ProDKin_1	200	206	PF00069	0.646
MOD_ProDKin_1	213	219	PF00069	0.691
MOD_ProDKin_1	72	78	PF00069	0.658
MOD_ProDKin_1	84	90	PF00069	0.694
MOD_SUMO_rev_2	132	139	PF00179	0.571
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.521
TRG_ENDOCYTIC_2	241	244	PF00928	0.484
TRG_ER_diArg_1	159	161	PF00400	0.590
TRG_NES_CRM1_1	106	120	PF08389	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I988	Leptomonas seymouri	38%	100%
A4H4W5	Leishmania braziliensis	62%	97%
A4HT39	Leishmania infantum	98%	100%
E9AL31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIS3	Leishmania major	89%	100%