LeishMANIAdb
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CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Gene product:
phosphatidylglycerolphosphate synthase, mitochondrial, putative
Species:
Leishmania donovani
UniProt:
A0A3S5H5W5_LEIDO
TriTrypDb:
LdBPK_070360.1 * , LdCL_070007100 , LDHU3_07.0270
Length:
755

Annotations

LeishMANIAdb annotations

Overall very similar to animal mitochondrial PGS1 enzymes, with one key difference: instead a a transit signal, the Kinetoplastid variant has membrane anchor.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 8
GO:0043226 organelle 2 8
GO:0043227 membrane-bounded organelle 3 8
GO:0043229 intracellular organelle 3 8
GO:0043231 intracellular membrane-bounded organelle 4 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A0A3S5H5W5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5W5

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 8
GO:0006644 phospholipid metabolic process 4 8
GO:0006650 glycerophospholipid metabolic process 5 8
GO:0006655 phosphatidylglycerol biosynthetic process 6 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0008152 metabolic process 1 8
GO:0008610 lipid biosynthetic process 4 8
GO:0008654 phospholipid biosynthetic process 5 8
GO:0009058 biosynthetic process 2 8
GO:0009987 cellular process 1 8
GO:0019637 organophosphate metabolic process 3 8
GO:0032048 cardiolipin metabolic process 7 8
GO:0032049 cardiolipin biosynthetic process 7 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0044249 cellular biosynthetic process 3 8
GO:0044255 cellular lipid metabolic process 3 8
GO:0045017 glycerolipid biosynthetic process 4 8
GO:0046471 phosphatidylglycerol metabolic process 6 8
GO:0046474 glycerophospholipid biosynthetic process 5 8
GO:0046486 glycerolipid metabolic process 4 8
GO:0071704 organic substance metabolic process 2 8
GO:0090407 organophosphate biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 8
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 8
GO:0003824 catalytic activity 1 8
GO:0005488 binding 1 8
GO:0005524 ATP binding 5 8
GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity 6 8
GO:0016740 transferase activity 2 8
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 8
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 8
GO:0017076 purine nucleotide binding 4 8
GO:0017169 CDP-alcohol phosphatidyltransferase activity 5 8
GO:0030554 adenyl nucleotide binding 5 8
GO:0032553 ribonucleotide binding 3 8
GO:0032555 purine ribonucleotide binding 4 8
GO:0032559 adenyl ribonucleotide binding 5 8
GO:0035639 purine ribonucleoside triphosphate binding 4 8
GO:0036094 small molecule binding 2 8
GO:0043167 ion binding 2 8
GO:0043168 anion binding 3 8
GO:0097159 organic cyclic compound binding 2 8
GO:0097367 carbohydrate derivative binding 2 8
GO:1901265 nucleoside phosphate binding 3 8
GO:1901363 heterocyclic compound binding 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 240 244 PF00656 0.614
CLV_C14_Caspase3-7 257 261 PF00656 0.671
CLV_C14_Caspase3-7 704 708 PF00656 0.598
CLV_NRD_NRD_1 190 192 PF00675 0.428
CLV_NRD_NRD_1 367 369 PF00675 0.435
CLV_NRD_NRD_1 451 453 PF00675 0.454
CLV_NRD_NRD_1 490 492 PF00675 0.414
CLV_NRD_NRD_1 606 608 PF00675 0.442
CLV_NRD_NRD_1 630 632 PF00675 0.494
CLV_NRD_NRD_1 69 71 PF00675 0.545
CLV_PCSK_KEX2_1 134 136 PF00082 0.363
CLV_PCSK_KEX2_1 490 492 PF00082 0.395
CLV_PCSK_KEX2_1 606 608 PF00082 0.442
CLV_PCSK_KEX2_1 630 632 PF00082 0.497
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.363
CLV_PCSK_SKI1_1 141 145 PF00082 0.367
CLV_PCSK_SKI1_1 280 284 PF00082 0.414
CLV_PCSK_SKI1_1 301 305 PF00082 0.387
CLV_PCSK_SKI1_1 349 353 PF00082 0.395
CLV_PCSK_SKI1_1 526 530 PF00082 0.355
CLV_PCSK_SKI1_1 616 620 PF00082 0.417
DEG_APCC_DBOX_1 190 198 PF00400 0.630
DEG_APCC_DBOX_1 582 590 PF00400 0.598
DEG_APCC_DBOX_1 713 721 PF00400 0.552
DEG_SPOP_SBC_1 264 268 PF00917 0.794
DOC_CYCLIN_RxL_1 520 533 PF00134 0.579
DOC_CYCLIN_yCln2_LP_2 122 128 PF00134 0.588
DOC_MAPK_FxFP_2 506 509 PF00069 0.562
DOC_MAPK_gen_1 191 197 PF00069 0.589
DOC_MAPK_gen_1 299 306 PF00069 0.594
DOC_MAPK_gen_1 452 459 PF00069 0.620
DOC_MAPK_MEF2A_6 739 746 PF00069 0.620
DOC_PP1_RVXF_1 164 170 PF00149 0.598
DOC_PP1_RVXF_1 495 501 PF00149 0.550
DOC_PP1_RVXF_1 614 621 PF00149 0.618
DOC_PP4_FxxP_1 506 509 PF00568 0.562
DOC_USP7_MATH_1 113 117 PF00917 0.544
DOC_USP7_MATH_1 139 143 PF00917 0.598
DOC_USP7_MATH_1 220 224 PF00917 0.736
DOC_USP7_MATH_1 271 275 PF00917 0.760
DOC_USP7_MATH_1 387 391 PF00917 0.733
DOC_USP7_MATH_1 410 414 PF00917 0.758
DOC_USP7_MATH_1 436 440 PF00917 0.756
DOC_USP7_MATH_1 44 48 PF00917 0.783
DOC_USP7_MATH_1 681 685 PF00917 0.525
DOC_USP7_MATH_1 69 73 PF00917 0.774
DOC_USP7_MATH_2 670 676 PF00917 0.630
DOC_WW_Pin1_4 223 228 PF00397 0.763
DOC_WW_Pin1_4 383 388 PF00397 0.791
DOC_WW_Pin1_4 40 45 PF00397 0.719
DOC_WW_Pin1_4 417 422 PF00397 0.760
DOC_WW_Pin1_4 431 436 PF00397 0.668
DOC_WW_Pin1_4 444 449 PF00397 0.602
DOC_WW_Pin1_4 539 544 PF00397 0.532
DOC_WW_Pin1_4 639 644 PF00397 0.768
LIG_14-3-3_CanoR_1 141 146 PF00244 0.530
LIG_14-3-3_CanoR_1 230 236 PF00244 0.794
LIG_14-3-3_CanoR_1 360 364 PF00244 0.619
LIG_14-3-3_CanoR_1 452 459 PF00244 0.577
LIG_14-3-3_CanoR_1 530 539 PF00244 0.546
LIG_14-3-3_CanoR_1 70 76 PF00244 0.732
LIG_Actin_WH2_2 591 608 PF00022 0.644
LIG_APCC_ABBA_1 19 24 PF00400 0.634
LIG_APCC_ABBAyCdc20_2 515 521 PF00400 0.540
LIG_BRCT_BRCA1_1 155 159 PF00533 0.534
LIG_BRCT_BRCA1_1 237 241 PF00533 0.756
LIG_BRCT_BRCA1_1 396 400 PF00533 0.649
LIG_CaM_NSCaTE_8 488 495 PF13499 0.525
LIG_deltaCOP1_diTrp_1 499 506 PF00928 0.593
LIG_EH1_1 176 184 PF00400 0.589
LIG_FHA_1 1 7 PF00498 0.344
LIG_FHA_1 116 122 PF00498 0.572
LIG_FHA_1 16 22 PF00498 0.356
LIG_FHA_1 178 184 PF00498 0.532
LIG_FHA_1 208 214 PF00498 0.752
LIG_FHA_1 350 356 PF00498 0.608
LIG_FHA_1 436 442 PF00498 0.787
LIG_FHA_1 49 55 PF00498 0.719
LIG_FHA_1 557 563 PF00498 0.578
LIG_FHA_1 564 570 PF00498 0.551
LIG_FHA_2 197 203 PF00498 0.602
LIG_FHA_2 238 244 PF00498 0.627
LIG_FHA_2 331 337 PF00498 0.590
LIG_FHA_2 531 537 PF00498 0.587
LIG_FHA_2 60 66 PF00498 0.816
LIG_FHA_2 702 708 PF00498 0.599
LIG_Integrin_RGD_1 255 257 PF01839 0.492
LIG_LIR_Apic_2 504 509 PF02991 0.566
LIG_LIR_Gen_1 18 25 PF02991 0.564
LIG_LIR_Gen_1 184 190 PF02991 0.571
LIG_LIR_Gen_1 336 346 PF02991 0.544
LIG_LIR_Gen_1 542 552 PF02991 0.529
LIG_LIR_Nem_3 18 22 PF02991 0.432
LIG_LIR_Nem_3 288 293 PF02991 0.612
LIG_LIR_Nem_3 336 341 PF02991 0.517
LIG_LIR_Nem_3 499 503 PF02991 0.576
LIG_LIR_Nem_3 505 511 PF02991 0.510
LIG_LIR_Nem_3 592 598 PF02991 0.550
LIG_NRBOX 716 722 PF00104 0.557
LIG_OCRL_FandH_1 313 325 PF00620 0.556
LIG_PALB2_WD40_1 346 354 PF16756 0.582
LIG_PCNA_PIPBox_1 98 107 PF02747 0.591
LIG_PCNA_yPIPBox_3 337 351 PF02747 0.556
LIG_PCNA_yPIPBox_3 91 105 PF02747 0.642
LIG_PDZ_Class_3 750 755 PF00595 0.664
LIG_Pex14_1 290 294 PF04695 0.641
LIG_RPA_C_Fungi 486 498 PF08784 0.387
LIG_RPA_C_Fungi 626 638 PF08784 0.431
LIG_SH2_CRK 284 288 PF00017 0.468
LIG_SH2_CRK 602 606 PF00017 0.499
LIG_SH2_CRK 689 693 PF00017 0.483
LIG_SH2_GRB2like 284 287 PF00017 0.466
LIG_SH2_GRB2like 544 547 PF00017 0.418
LIG_SH2_SRC 284 287 PF00017 0.466
LIG_SH2_STAP1 503 507 PF00017 0.453
LIG_SH2_STAT5 149 152 PF00017 0.405
LIG_SH2_STAT5 330 333 PF00017 0.434
LIG_SH2_STAT5 544 547 PF00017 0.418
LIG_SH2_STAT5 561 564 PF00017 0.405
LIG_SH2_STAT5 588 591 PF00017 0.420
LIG_SH2_STAT5 597 600 PF00017 0.431
LIG_SH2_STAT5 678 681 PF00017 0.455
LIG_SH2_STAT5 7 10 PF00017 0.515
LIG_SH3_3 290 296 PF00018 0.426
LIG_SH3_3 430 436 PF00018 0.598
LIG_SH3_3 665 671 PF00018 0.624
LIG_SUMO_SIM_anti_2 178 184 PF11976 0.416
LIG_SUMO_SIM_anti_2 454 460 PF11976 0.412
LIG_SUMO_SIM_par_1 178 184 PF11976 0.469
LIG_SUMO_SIM_par_1 193 199 PF11976 0.515
LIG_TYR_ITIM 127 132 PF00017 0.457
LIG_TYR_ITIM 5 10 PF00017 0.501
LIG_TYR_ITIM 586 591 PF00017 0.472
LIG_UBA3_1 200 206 PF00899 0.349
LIG_WRC_WIRS_1 101 106 PF05994 0.464
LIG_WRC_WIRS_1 503 508 PF05994 0.450
MOD_CDC14_SPxK_1 420 423 PF00782 0.623
MOD_CDK_SPxK_1 383 389 PF00069 0.778
MOD_CDK_SPxK_1 417 423 PF00069 0.634
MOD_CDK_SPxxK_3 223 230 PF00069 0.625
MOD_CDK_SPxxK_3 639 646 PF00069 0.664
MOD_CK1_1 196 202 PF00069 0.559
MOD_CK1_1 223 229 PF00069 0.760
MOD_CK1_1 231 237 PF00069 0.759
MOD_CK1_1 263 269 PF00069 0.808
MOD_CK1_1 439 445 PF00069 0.662
MOD_CK1_1 468 474 PF00069 0.521
MOD_CK1_1 47 53 PF00069 0.754
MOD_CK1_1 568 574 PF00069 0.471
MOD_CK2_1 196 202 PF00069 0.500
MOD_CK2_1 410 416 PF00069 0.714
MOD_CK2_1 439 445 PF00069 0.696
MOD_CK2_1 529 535 PF00069 0.432
MOD_Cter_Amidation 628 631 PF01082 0.576
MOD_DYRK1A_RPxSP_1 431 435 PF00069 0.742
MOD_GlcNHglycan 145 148 PF01048 0.383
MOD_GlcNHglycan 222 225 PF01048 0.716
MOD_GlcNHglycan 257 260 PF01048 0.821
MOD_GlcNHglycan 262 265 PF01048 0.780
MOD_GlcNHglycan 376 379 PF01048 0.498
MOD_GlcNHglycan 389 392 PF01048 0.608
MOD_GlcNHglycan 396 399 PF01048 0.621
MOD_GlcNHglycan 412 415 PF01048 0.548
MOD_GlcNHglycan 46 49 PF01048 0.667
MOD_GlcNHglycan 633 636 PF01048 0.644
MOD_GlcNHglycan 674 677 PF01048 0.460
MOD_GlcNHglycan 78 82 PF01048 0.627
MOD_GSK3_1 139 146 PF00069 0.478
MOD_GSK3_1 222 229 PF00069 0.804
MOD_GSK3_1 230 237 PF00069 0.770
MOD_GSK3_1 260 267 PF00069 0.765
MOD_GSK3_1 374 381 PF00069 0.544
MOD_GSK3_1 38 45 PF00069 0.596
MOD_GSK3_1 383 390 PF00069 0.621
MOD_GSK3_1 406 413 PF00069 0.705
MOD_GSK3_1 427 434 PF00069 0.660
MOD_GSK3_1 435 442 PF00069 0.680
MOD_GSK3_1 50 57 PF00069 0.740
MOD_GSK3_1 721 728 PF00069 0.426
MOD_LATS_1 609 615 PF00433 0.415
MOD_N-GLC_1 324 329 PF02516 0.376
MOD_N-GLC_1 387 392 PF02516 0.583
MOD_N-GLC_1 410 415 PF02516 0.725
MOD_NEK2_1 177 182 PF00069 0.414
MOD_NEK2_1 235 240 PF00069 0.788
MOD_NEK2_1 354 359 PF00069 0.469
MOD_NEK2_1 38 43 PF00069 0.518
MOD_NEK2_1 393 398 PF00069 0.702
MOD_NEK2_1 400 405 PF00069 0.613
MOD_NEK2_1 529 534 PF00069 0.468
MOD_NEK2_1 547 552 PF00069 0.266
MOD_NEK2_1 556 561 PF00069 0.382
MOD_NEK2_1 591 596 PF00069 0.411
MOD_NEK2_1 701 706 PF00069 0.425
MOD_NEK2_1 709 714 PF00069 0.428
MOD_NEK2_1 721 726 PF00069 0.245
MOD_NEK2_2 688 693 PF00069 0.428
MOD_PIKK_1 349 355 PF00454 0.487
MOD_PIKK_1 439 445 PF00454 0.696
MOD_PK_1 611 617 PF00069 0.494
MOD_PKA_2 316 322 PF00069 0.430
MOD_PKA_2 359 365 PF00069 0.493
MOD_PKA_2 451 457 PF00069 0.530
MOD_PKA_2 529 535 PF00069 0.441
MOD_PKA_2 69 75 PF00069 0.680
MOD_PKA_2 709 715 PF00069 0.520
MOD_Plk_1 591 597 PF00069 0.417
MOD_Plk_1 611 617 PF00069 0.235
MOD_Plk_4 196 202 PF00069 0.497
MOD_Plk_4 316 322 PF00069 0.430
MOD_Plk_4 436 442 PF00069 0.745
MOD_Plk_4 502 508 PF00069 0.404
MOD_Plk_4 519 525 PF00069 0.398
MOD_Plk_4 547 553 PF00069 0.475
MOD_Plk_4 557 563 PF00069 0.479
MOD_Plk_4 84 90 PF00069 0.501
MOD_ProDKin_1 223 229 PF00069 0.720
MOD_ProDKin_1 383 389 PF00069 0.760
MOD_ProDKin_1 40 46 PF00069 0.667
MOD_ProDKin_1 417 423 PF00069 0.717
MOD_ProDKin_1 431 437 PF00069 0.591
MOD_ProDKin_1 444 450 PF00069 0.486
MOD_ProDKin_1 539 545 PF00069 0.399
MOD_ProDKin_1 639 645 PF00069 0.731
MOD_SUMO_rev_2 184 194 PF00179 0.517
MOD_SUMO_rev_2 53 62 PF00179 0.619
TRG_DiLeu_BaEn_1 342 347 PF01217 0.413
TRG_DiLeu_BaEn_1 716 721 PF01217 0.422
TRG_DiLeu_BaEn_2 534 540 PF01217 0.461
TRG_DiLeu_BaEn_2 696 702 PF01217 0.412
TRG_DiLeu_BaEn_2 99 105 PF01217 0.475
TRG_ENDOCYTIC_2 129 132 PF00928 0.426
TRG_ENDOCYTIC_2 185 188 PF00928 0.433
TRG_ENDOCYTIC_2 338 341 PF00928 0.395
TRG_ENDOCYTIC_2 503 506 PF00928 0.456
TRG_ENDOCYTIC_2 544 547 PF00928 0.383
TRG_ENDOCYTIC_2 588 591 PF00928 0.420
TRG_ENDOCYTIC_2 596 599 PF00928 0.422
TRG_ENDOCYTIC_2 602 605 PF00928 0.438
TRG_ENDOCYTIC_2 689 692 PF00928 0.485
TRG_ENDOCYTIC_2 7 10 PF00928 0.447
TRG_ER_diArg_1 166 169 PF00400 0.575
TRG_ER_diArg_1 277 280 PF00400 0.542
TRG_ER_diArg_1 490 492 PF00400 0.484
TRG_ER_diArg_1 605 607 PF00400 0.563
TRG_NES_CRM1_1 455 466 PF08389 0.440
TRG_NES_CRM1_1 715 729 PF08389 0.477
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILX1 Leptomonas seymouri 62% 100%
A0A0S4JQL9 Bodo saltans 35% 100%
A4H4W4 Leishmania braziliensis 79% 99%
A4HT38 Leishmania infantum 99% 100%
E9AL30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
Q4QIS4 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS