Mitochondrial calcium uptake 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5W0_LEIDO

TriTrypDb:

LdBPK_070260.1 , LdCL_070006100 , LDHU3_07.0160

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	4
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1
GO:0016020	membrane	2	3

Expansion

Sequence features

A0A3S5H5W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5W0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006816	calcium ion transport	7	12
GO:0006851	mitochondrial calcium ion transmembrane transport	4	12
GO:0009987	cellular process	1	12
GO:0030001	metal ion transport	6	12
GO:0034220	monoatomic ion transmembrane transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0070588	calcium ion transmembrane transport	6	12
GO:0098655	monoatomic cation transmembrane transport	4	12
GO:0098660	inorganic ion transmembrane transport	4	12
GO:0098662	inorganic cation transmembrane transport	5	12
GO:1990542	mitochondrial transmembrane transport	3	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051560	mitochondrial calcium ion homeostasis	8	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.304
CLV_NRD_NRD_1	146	148	PF00675	0.444
CLV_NRD_NRD_1	162	164	PF00675	0.280
CLV_NRD_NRD_1	223	225	PF00675	0.413
CLV_NRD_NRD_1	270	272	PF00675	0.237
CLV_NRD_NRD_1	310	312	PF00675	0.376
CLV_NRD_NRD_1	324	326	PF00675	0.627
CLV_NRD_NRD_1	33	35	PF00675	0.363
CLV_NRD_NRD_1	330	332	PF00675	0.615
CLV_PCSK_KEX2_1	146	148	PF00082	0.429
CLV_PCSK_KEX2_1	162	164	PF00082	0.269
CLV_PCSK_KEX2_1	192	194	PF00082	0.421
CLV_PCSK_KEX2_1	223	225	PF00082	0.503
CLV_PCSK_KEX2_1	266	268	PF00082	0.285
CLV_PCSK_KEX2_1	270	272	PF00082	0.275
CLV_PCSK_KEX2_1	330	332	PF00082	0.615
CLV_PCSK_KEX2_1	35	37	PF00082	0.439
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.421
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.339
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.424
CLV_PCSK_SKI1_1	138	142	PF00082	0.462
CLV_PCSK_SKI1_1	152	156	PF00082	0.297
CLV_PCSK_SKI1_1	207	211	PF00082	0.489
CLV_PCSK_SKI1_1	312	316	PF00082	0.455
CLV_PCSK_SKI1_1	330	334	PF00082	0.624
DOC_CDC14_PxL_1	275	283	PF14671	0.266
DOC_CKS1_1	9	14	PF01111	0.407
DOC_CYCLIN_RxL_1	132	145	PF00134	0.491
DOC_CYCLIN_RxL_1	146	159	PF00134	0.312
DOC_USP7_MATH_2	322	328	PF00917	0.507
DOC_WW_Pin1_4	52	57	PF00397	0.464
DOC_WW_Pin1_4	8	13	PF00397	0.415
LIG_14-3-3_CanoR_1	162	167	PF00244	0.338
LIG_14-3-3_CanoR_1	193	201	PF00244	0.434
LIG_14-3-3_CanoR_1	270	276	PF00244	0.392
LIG_14-3-3_CanoR_1	325	329	PF00244	0.637
LIG_14-3-3_CanoR_1	90	96	PF00244	0.391
LIG_APCC_ABBA_1	243	248	PF00400	0.401
LIG_BIR_III_4	77	81	PF00653	0.260
LIG_deltaCOP1_diTrp_1	179	185	PF00928	0.292
LIG_DLG_GKlike_1	162	169	PF00625	0.479
LIG_FHA_1	11	17	PF00498	0.537
LIG_FHA_1	115	121	PF00498	0.404
LIG_FHA_1	283	289	PF00498	0.391
LIG_FHA_2	128	134	PF00498	0.514
LIG_FHA_2	195	201	PF00498	0.476
LIG_FHA_2	263	269	PF00498	0.422
LIG_FHA_2	42	48	PF00498	0.284
LIG_LIR_Apic_2	13	17	PF02991	0.344
LIG_LIR_Apic_2	8	12	PF02991	0.428
LIG_LIR_Gen_1	121	127	PF02991	0.360
LIG_LIR_Gen_1	199	209	PF02991	0.442
LIG_LIR_Gen_1	287	294	PF02991	0.351
LIG_LIR_Gen_1	304	314	PF02991	0.274
LIG_LIR_Gen_1	81	91	PF02991	0.259
LIG_LIR_Nem_3	104	110	PF02991	0.352
LIG_LIR_Nem_3	121	126	PF02991	0.154
LIG_LIR_Nem_3	165	169	PF02991	0.367
LIG_LIR_Nem_3	184	188	PF02991	0.284
LIG_LIR_Nem_3	199	204	PF02991	0.337
LIG_LIR_Nem_3	235	240	PF02991	0.343
LIG_LIR_Nem_3	25	30	PF02991	0.301
LIG_LIR_Nem_3	268	272	PF02991	0.339
LIG_LIR_Nem_3	287	293	PF02991	0.328
LIG_LIR_Nem_3	304	309	PF02991	0.256
LIG_LIR_Nem_3	81	86	PF02991	0.259
LIG_LIR_Nem_3	88	92	PF02991	0.230
LIG_NRBOX	91	97	PF00104	0.245
LIG_PCNA_yPIPBox_3	142	155	PF02747	0.447
LIG_Pex14_1	181	185	PF04695	0.289
LIG_SH2_CRK	30	34	PF00017	0.365
LIG_SH2_CRK	318	322	PF00017	0.621
LIG_SH2_NCK_1	318	322	PF00017	0.621
LIG_SH2_NCK_1	9	13	PF00017	0.479
LIG_SH2_SRC	14	17	PF00017	0.377
LIG_SH2_STAP1	246	250	PF00017	0.461
LIG_SH2_STAT3	246	249	PF00017	0.374
LIG_SH2_STAT5	108	111	PF00017	0.212
LIG_SH2_STAT5	14	17	PF00017	0.329
LIG_SH2_STAT5	19	22	PF00017	0.335
LIG_SH2_STAT5	217	220	PF00017	0.408
LIG_SH2_STAT5	83	86	PF00017	0.319
LIG_SH3_3	276	282	PF00018	0.372
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.237
LIG_SUMO_SIM_par_1	115	122	PF11976	0.391
LIG_SUMO_SIM_par_1	230	235	PF11976	0.349
LIG_TRAF2_1	119	122	PF00917	0.310
LIG_TRAF2_1	197	200	PF00917	0.481
LIG_TYR_ITIM	214	219	PF00017	0.501
LIG_TYR_ITIM	28	33	PF00017	0.371
LIG_UBA3_1	106	114	PF00899	0.277
LIG_UBA3_1	307	315	PF00899	0.329
MOD_CDC14_SPxK_1	55	58	PF00782	0.493
MOD_CDK_SPxK_1	52	58	PF00069	0.469
MOD_CK1_1	175	181	PF00069	0.485
MOD_CK1_1	260	266	PF00069	0.341
MOD_CK1_1	8	14	PF00069	0.592
MOD_CK1_1	94	100	PF00069	0.484
MOD_CK2_1	116	122	PF00069	0.334
MOD_CK2_1	128	134	PF00069	0.415
MOD_CK2_1	162	168	PF00069	0.383
MOD_CK2_1	194	200	PF00069	0.483
MOD_CK2_1	82	88	PF00069	0.260
MOD_GlcNHglycan	113	117	PF01048	0.401
MOD_GlcNHglycan	227	230	PF01048	0.466
MOD_GlcNHglycan	259	262	PF01048	0.395
MOD_GlcNHglycan	318	321	PF01048	0.572
MOD_GSK3_1	112	119	PF00069	0.356
MOD_GSK3_1	256	263	PF00069	0.512
MOD_GSK3_1	91	98	PF00069	0.378
MOD_NEK2_1	127	132	PF00069	0.531
MOD_NEK2_1	172	177	PF00069	0.466
MOD_NEK2_1	256	261	PF00069	0.425
MOD_NEK2_1	262	267	PF00069	0.261
MOD_NEK2_1	91	96	PF00069	0.327
MOD_PKA_1	162	168	PF00069	0.431
MOD_PKA_2	127	133	PF00069	0.343
MOD_PKA_2	162	168	PF00069	0.349
MOD_PKA_2	194	200	PF00069	0.480
MOD_PKA_2	324	330	PF00069	0.633
MOD_Plk_2-3	230	236	PF00069	0.342
MOD_Plk_4	10	16	PF00069	0.451
MOD_Plk_4	91	97	PF00069	0.332
MOD_ProDKin_1	52	58	PF00069	0.469
MOD_ProDKin_1	8	14	PF00069	0.409
MOD_SUMO_rev_2	319	328	PF00179	0.565
TRG_DiLeu_BaEn_1	168	173	PF01217	0.447
TRG_DiLeu_BaEn_1	200	205	PF01217	0.410
TRG_DiLeu_BaEn_1	88	93	PF01217	0.245
TRG_DiLeu_BaEn_2	301	307	PF01217	0.250
TRG_ENDOCYTIC_2	216	219	PF00928	0.539
TRG_ENDOCYTIC_2	30	33	PF00928	0.327
TRG_ENDOCYTIC_2	42	45	PF00928	0.241
TRG_ENDOCYTIC_2	83	86	PF00928	0.275
TRG_ER_diArg_1	161	163	PF00400	0.477
TRG_ER_diArg_1	193	196	PF00400	0.281
TRG_ER_diArg_1	222	224	PF00400	0.444
TRG_ER_diArg_1	23	26	PF00400	0.436
TRG_ER_diArg_1	269	271	PF00400	0.286
TRG_ER_diArg_1	329	331	PF00400	0.613
TRG_ER_diArg_1	33	36	PF00400	0.383
TRG_NES_CRM1_1	235	248	PF08389	0.424
TRG_NLS_MonoCore_2	33	38	PF00514	0.497
TRG_NLS_MonoExtC_3	310	315	PF00514	0.381
TRG_NLS_MonoExtN_4	311	316	PF00514	0.391
TRG_NLS_MonoExtN_4	34	39	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P773	Leptomonas seymouri	75%	79%
A0A0S4IPF8	Bodo saltans	43%	87%
A0A1X0NK53	Trypanosomatidae	49%	86%
A0A422NT64	Trypanosoma rangeli	47%	86%
A4H4V4	Leishmania braziliensis	87%	100%
A4HT58	Leishmania infantum	100%	100%
A4IG32	Danio rerio	22%	71%
C9ZUW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	72%
E9AL21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QIT3	Leishmania major	97%	100%
Q4R518	Macaca fascicularis	21%	72%
Q8CD10	Mus musculus	21%	80%
Q8IYU8	Homo sapiens	22%	79%
Q99P63	Rattus norvegicus	21%	80%
Q9BPX6	Homo sapiens	21%	72%
Q9SZ45	Arabidopsis thaliana	27%	69%
V5B8U7	Trypanosoma cruzi	49%	74%
V5BRA1	Trypanosoma cruzi	24%	74%