Protoporphyrinogen oxidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoporphyrinogen oxidase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5V3_LEIDO

TriTrypDb:

LdBPK_061340.1 , LdCL_060018700 , LDHU3_06.1500

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S5H5V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5V3

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006778	porphyrin-containing compound metabolic process	5	7
GO:0006779	porphyrin-containing compound biosynthetic process	6	7
GO:0006782	protoporphyrinogen IX biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0033013	tetrapyrrole metabolic process	4	7
GO:0033014	tetrapyrrole biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046501	protoporphyrinogen IX metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006783	heme biosynthetic process	4	1
GO:0042168	heme metabolic process	3	1
GO:0042440	pigment metabolic process	2	1
GO:0046148	pigment biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	7
GO:0005488	binding	1	7
GO:0010181	FMN binding	4	7
GO:0016491	oxidoreductase activity	2	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	7
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	7
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	7
GO:0032553	ribonucleotide binding	3	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0070818	protoporphyrinogen oxidase activity	4	7
GO:0070819	menaquinone-dependent protoporphyrinogen oxidase activity	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.423
CLV_C14_Caspase3-7	194	198	PF00656	0.425
CLV_C14_Caspase3-7	42	46	PF00656	0.474
CLV_NRD_NRD_1	111	113	PF00675	0.223
CLV_NRD_NRD_1	97	99	PF00675	0.240
CLV_PCSK_KEX2_1	229	231	PF00082	0.415
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.363
CLV_PCSK_SKI1_1	112	116	PF00082	0.223
CLV_PCSK_SKI1_1	207	211	PF00082	0.240
CLV_PCSK_SKI1_1	56	60	PF00082	0.244
CLV_PCSK_SKI1_1	74	78	PF00082	0.216
DEG_APCC_DBOX_1	206	214	PF00400	0.233
DOC_CYCLIN_RxL_1	53	62	PF00134	0.474
DOC_MAPK_gen_1	35	43	PF00069	0.441
DOC_MAPK_RevD_3	217	230	PF00069	0.326
DOC_PP1_SILK_1	197	202	PF00149	0.412
DOC_PP2B_LxvP_1	182	185	PF13499	0.370
DOC_USP7_MATH_1	85	89	PF00917	0.419
DOC_USP7_MATH_1	97	101	PF00917	0.433
DOC_WW_Pin1_4	118	123	PF00397	0.309
DOC_WW_Pin1_4	2	7	PF00397	0.525
LIG_14-3-3_CanoR_1	171	181	PF00244	0.258
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.284
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BRCT_BRCA1_1	68	72	PF00533	0.474
LIG_BRCT_BRCA1_2	68	74	PF00533	0.416
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.266
LIG_FHA_1	104	110	PF00498	0.424
LIG_FHA_1	157	163	PF00498	0.306
LIG_FHA_1	17	23	PF00498	0.431
LIG_FHA_2	150	156	PF00498	0.223
LIG_FHA_2	19	25	PF00498	0.423
LIG_GBD_Chelix_1	22	30	PF00786	0.183
LIG_LIR_Gen_1	175	185	PF02991	0.313
LIG_LIR_Gen_1	5	12	PF02991	0.419
LIG_LIR_Gen_1	53	61	PF02991	0.456
LIG_LIR_Gen_1	88	97	PF02991	0.383
LIG_LIR_Nem_3	165	170	PF02991	0.293
LIG_LIR_Nem_3	175	180	PF02991	0.292
LIG_LIR_Nem_3	5	11	PF02991	0.420
LIG_LIR_Nem_3	53	57	PF02991	0.456
LIG_LIR_Nem_3	62	68	PF02991	0.437
LIG_LIR_Nem_3	69	75	PF02991	0.457
LIG_LIR_Nem_3	88	93	PF02991	0.354
LIG_Pex14_2	173	177	PF04695	0.247
LIG_Pex14_2	68	72	PF04695	0.443
LIG_REV1ctd_RIR_1	137	146	PF16727	0.251
LIG_SH2_STAP1	110	114	PF00017	0.423
LIG_SH2_STAP1	54	58	PF00017	0.423
LIG_SH2_STAT3	75	78	PF00017	0.474
LIG_SH2_STAT5	110	113	PF00017	0.429
LIG_SH2_STAT5	164	167	PF00017	0.276
LIG_SH2_STAT5	49	52	PF00017	0.424
LIG_SH2_STAT5	75	78	PF00017	0.453
LIG_SH2_STAT5	8	11	PF00017	0.415
LIG_SH3_3	182	188	PF00018	0.347
LIG_SUMO_SIM_par_1	39	45	PF11976	0.474
LIG_WW_3	184	188	PF00397	0.331
MOD_CDK_SPK_2	2	7	PF00069	0.525
MOD_CK1_1	118	124	PF00069	0.319
MOD_CK2_1	149	155	PF00069	0.223
MOD_GlcNHglycan	201	204	PF01048	0.644
MOD_GlcNHglycan	215	218	PF01048	0.192
MOD_GlcNHglycan	68	71	PF01048	0.311
MOD_GlcNHglycan	87	90	PF01048	0.178
MOD_GSK3_1	104	111	PF00069	0.361
MOD_GSK3_1	12	19	PF00069	0.435
MOD_GSK3_1	149	156	PF00069	0.223
MOD_GSK3_1	85	92	PF00069	0.559
MOD_GSK3_1	93	100	PF00069	0.422
MOD_N-GLC_1	115	120	PF02516	0.241
MOD_N-GLC_1	93	98	PF02516	0.244
MOD_NEK2_1	10	15	PF00069	0.451
MOD_NEK2_1	115	120	PF00069	0.430
MOD_NEK2_1	149	154	PF00069	0.246
MOD_NEK2_1	59	64	PF00069	0.427
MOD_PKA_2	97	103	PF00069	0.433
MOD_Plk_1	115	121	PF00069	0.424
MOD_Plk_4	18	24	PF00069	0.423
MOD_Plk_4	25	31	PF00069	0.423
MOD_Plk_4	45	51	PF00069	0.432
MOD_ProDKin_1	118	124	PF00069	0.309
MOD_ProDKin_1	2	8	PF00069	0.515
MOD_SUMO_rev_2	32	36	PF00179	0.441
TRG_ENDOCYTIC_2	137	140	PF00928	0.246
TRG_ENDOCYTIC_2	54	57	PF00928	0.453
TRG_ENDOCYTIC_2	65	68	PF00928	0.440
TRG_ENDOCYTIC_2	8	11	PF00928	0.415
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q7	Leptomonas seymouri	63%	100%
A4H4U0	Leishmania braziliensis	78%	100%
A4HT19	Leishmania infantum	100%	100%
E9AL08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P0ACB4	Escherichia coli (strain K12)	50%	100%
P0ACB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	50%	100%
P0ACB6	Escherichia coli O157:H7	50%	100%
Q4QIU7	Leishmania major	91%	100%
Q9L6L1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	50%	100%