Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5V0_LEIDO

TriTrypDb:

LdBPK_061310.1 , LdCL_060018300 , LDHU3_06.1460

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S5H5V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	111	117	PF00089	0.221
CLV_NRD_NRD_1	20	22	PF00675	0.415
CLV_NRD_NRD_1	24	26	PF00675	0.441
CLV_PCSK_KEX2_1	11	13	PF00082	0.456
CLV_PCSK_KEX2_1	167	169	PF00082	0.459
CLV_PCSK_KEX2_1	19	21	PF00082	0.412
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.419
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.513
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.452
DOC_MAPK_DCC_7	125	134	PF00069	0.411
DOC_MAPK_MEF2A_6	125	134	PF00069	0.451
DOC_MAPK_MEF2A_6	199	208	PF00069	0.494
DOC_MAPK_MEF2A_6	53	62	PF00069	0.467
DOC_MAPK_NFAT4_5	199	207	PF00069	0.510
DOC_PP1_RVXF_1	154	161	PF00149	0.611
DOC_PP2B_PxIxI_1	55	61	PF00149	0.300
DOC_PP4_FxxP_1	93	96	PF00568	0.686
DOC_USP7_MATH_2	96	102	PF00917	0.457
DOC_WW_Pin1_4	151	156	PF00397	0.509
DOC_WW_Pin1_4	47	52	PF00397	0.711
LIG_14-3-3_CanoR_1	114	123	PF00244	0.519
LIG_14-3-3_CanoR_1	159	165	PF00244	0.726
LIG_Actin_WH2_2	146	161	PF00022	0.506
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	153	157	PF00533	0.575
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.243
LIG_eIF4E_1	137	143	PF01652	0.341
LIG_FAT_LD_1	200	208	PF03623	0.525
LIG_FHA_1	103	109	PF00498	0.303
LIG_FHA_1	37	43	PF00498	0.746
LIG_FHA_1	50	56	PF00498	0.655
LIG_LIR_Apic_2	117	123	PF02991	0.474
LIG_LIR_Gen_1	154	164	PF02991	0.723
LIG_LIR_Gen_1	181	192	PF02991	0.620
LIG_LIR_Gen_1	31	42	PF02991	0.688
LIG_LIR_Gen_1	97	107	PF02991	0.519
LIG_LIR_Nem_3	154	160	PF02991	0.664
LIG_LIR_Nem_3	181	187	PF02991	0.631
LIG_LIR_Nem_3	31	37	PF02991	0.686
LIG_LIR_Nem_3	75	79	PF02991	0.349
LIG_LIR_Nem_3	97	102	PF02991	0.482
LIG_NRBOX	199	205	PF00104	0.525
LIG_NRBOX	58	64	PF00104	0.341
LIG_NRBOX	84	90	PF00104	0.365
LIG_SH2_CRK	120	124	PF00017	0.436
LIG_SH2_NCK_1	120	124	PF00017	0.477
LIG_SH2_PTP2	137	140	PF00017	0.375
LIG_SH2_PTP2	152	155	PF00017	0.432
LIG_SH2_SRC	34	37	PF00017	0.686
LIG_SH2_STAT5	137	140	PF00017	0.365
LIG_SH2_STAT5	149	152	PF00017	0.292
LIG_SH2_STAT5	217	220	PF00017	0.393
LIG_SH2_STAT5	34	37	PF00017	0.686
LIG_SH2_STAT5	77	80	PF00017	0.305
LIG_SH3_3	124	130	PF00018	0.442
LIG_SH3_3	62	68	PF00018	0.332
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.596
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.685
LIG_TYR_ITIM	135	140	PF00017	0.349
LIG_TYR_ITIM	215	220	PF00017	0.393
MOD_CDC14_SPxK_1	50	53	PF00782	0.668
MOD_CDK_SPK_2	151	156	PF00069	0.509
MOD_CDK_SPxK_1	47	53	PF00069	0.676
MOD_CK1_1	101	107	PF00069	0.372
MOD_CK1_1	2	8	PF00069	0.675
MOD_CK2_1	2	8	PF00069	0.621
MOD_Cter_Amidation	165	168	PF01082	0.436
MOD_GlcNHglycan	172	175	PF01048	0.461
MOD_GSK3_1	45	52	PF00069	0.697
MOD_GSK3_1	63	70	PF00069	0.194
MOD_GSK3_1	94	101	PF00069	0.658
MOD_NEK2_1	158	163	PF00069	0.716
MOD_NEK2_1	63	68	PF00069	0.407
MOD_NEK2_1	91	96	PF00069	0.468
MOD_PKA_2	113	119	PF00069	0.545
MOD_PKA_2	158	164	PF00069	0.625
MOD_PKA_2	169	175	PF00069	0.595
MOD_PKA_2	45	51	PF00069	0.694
MOD_PKB_1	168	176	PF00069	0.653
MOD_Plk_4	102	108	PF00069	0.299
MOD_Plk_4	54	60	PF00069	0.414
MOD_Plk_4	84	90	PF00069	0.342
MOD_ProDKin_1	151	157	PF00069	0.509
MOD_ProDKin_1	47	53	PF00069	0.711
TRG_DiLeu_BaEn_1	198	203	PF01217	0.640
TRG_DiLeu_BaEn_4	195	201	PF01217	0.709
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.514
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.448
TRG_ENDOCYTIC_2	137	140	PF00928	0.321
TRG_ENDOCYTIC_2	184	187	PF00928	0.610
TRG_ENDOCYTIC_2	217	220	PF00928	0.360
TRG_ENDOCYTIC_2	34	37	PF00928	0.686
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBC2	Leptomonas seymouri	68%	100%
A0A0S4JA41	Bodo saltans	29%	100%
A0A1X0NGU0	Trypanosomatidae	38%	100%
A4H4T7	Leishmania braziliensis	85%	100%
A4HT17	Leishmania infantum	100%	100%
C9ZTQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AL05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QIV0	Leishmania major	95%	100%