Cysteine dioxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1637), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5U9_LEIDO

TriTrypDb:

LdBPK_061280.1 , LdCL_060018000 , LDHU3_06.1430

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	12
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	12
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051213	dioxygenase activity	3	12
GO:0047800	cysteamine dioxygenase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.539
CLV_PCSK_FUR_1	21	25	PF00082	0.385
CLV_PCSK_KEX2_1	23	25	PF00082	0.535
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.535
CLV_PCSK_PC7_1	19	25	PF00082	0.497
CLV_PCSK_SKI1_1	24	28	PF00082	0.363
DEG_APCC_DBOX_1	148	156	PF00400	0.457
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DOC_CYCLIN_RxL_1	126	135	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.440
DOC_PP1_RVXF_1	4	11	PF00149	0.476
DOC_PP4_FxxP_1	123	126	PF00568	0.448
DOC_USP7_MATH_1	98	102	PF00917	0.552
DOC_USP7_UBL2_3	23	27	PF12436	0.380
DOC_USP7_UBL2_3	268	272	PF12436	0.491
DOC_WW_Pin1_4	10	15	PF00397	0.632
DOC_WW_Pin1_4	195	200	PF00397	0.561
DOC_WW_Pin1_4	224	229	PF00397	0.473
DOC_WW_Pin1_4	92	97	PF00397	0.561
LIG_14-3-3_CanoR_1	12	22	PF00244	0.392
LIG_14-3-3_CanoR_1	24	30	PF00244	0.559
LIG_14-3-3_CanoR_1	86	96	PF00244	0.584
LIG_BIR_III_2	187	191	PF00653	0.457
LIG_FHA_1	167	173	PF00498	0.570
LIG_FHA_1	248	254	PF00498	0.591
LIG_FHA_1	89	95	PF00498	0.491
LIG_FHA_2	196	202	PF00498	0.532
LIG_FHA_2	33	39	PF00498	0.552
LIG_FHA_2	45	51	PF00498	0.361
LIG_LIR_Gen_1	41	51	PF02991	0.417
LIG_LIR_Nem_3	119	125	PF02991	0.510
LIG_LIR_Nem_3	50	54	PF02991	0.529
LIG_SH2_CRK	281	285	PF00017	0.480
LIG_SH2_NCK_1	230	234	PF00017	0.480
LIG_SH2_STAT5	242	245	PF00017	0.509
LIG_SH2_STAT5	54	57	PF00017	0.462
LIG_SH2_STAT5	63	66	PF00017	0.462
LIG_SH3_3	121	127	PF00018	0.493
LIG_TRFH_1	123	127	PF08558	0.400
LIG_WRC_WIRS_1	40	45	PF05994	0.480
MOD_CDC14_SPxK_1	3	6	PF00782	0.462
MOD_CK1_1	101	107	PF00069	0.396
MOD_CK1_1	33	39	PF00069	0.497
MOD_CK1_1	44	50	PF00069	0.306
MOD_CK1_1	88	94	PF00069	0.420
MOD_CK2_1	32	38	PF00069	0.453
MOD_GlcNHglycan	281	284	PF01048	0.362
MOD_GlcNHglycan	87	90	PF01048	0.418
MOD_GSK3_1	10	17	PF00069	0.649
MOD_GSK3_1	158	165	PF00069	0.388
MOD_GSK3_1	30	37	PF00069	0.454
MOD_GSK3_1	88	95	PF00069	0.398
MOD_GSK3_1	99	106	PF00069	0.308
MOD_N-GLC_1	172	177	PF02516	0.444
MOD_N-GLC_1	279	284	PF02516	0.350
MOD_NEK2_1	107	112	PF00069	0.335
MOD_NEK2_1	247	252	PF00069	0.386
MOD_NEK2_1	25	30	PF00069	0.487
MOD_NEK2_1	32	37	PF00069	0.432
MOD_NEK2_1	87	92	PF00069	0.381
MOD_NEK2_2	108	113	PF00069	0.289
MOD_NEK2_2	14	19	PF00069	0.476
MOD_PIKK_1	158	164	PF00454	0.356
MOD_PIKK_1	214	220	PF00454	0.302
MOD_PKA_2	85	91	PF00069	0.374
MOD_Plk_4	108	114	PF00069	0.289
MOD_Plk_4	137	143	PF00069	0.291
MOD_Plk_4	172	178	PF00069	0.370
MOD_Plk_4	249	255	PF00069	0.381
MOD_ProDKin_1	10	16	PF00069	0.630
MOD_ProDKin_1	195	201	PF00069	0.447
MOD_ProDKin_1	224	230	PF00069	0.324
MOD_ProDKin_1	92	98	PF00069	0.447
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.358
TRG_ER_diArg_1	19	22	PF00400	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C5	Leptomonas seymouri	57%	100%
A0A0S4IQ52	Bodo saltans	27%	100%
A0A1X0NH28	Trypanosomatidae	40%	100%
A0A422NM88	Trypanosoma rangeli	33%	100%
A4H4T5	Leishmania braziliensis	81%	100%
A4HT14	Leishmania infantum	99%	100%
C9ZTQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIV3	Leishmania major	92%	100%
V5BT74	Trypanosoma cruzi	38%	100%