Thioredoxin, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5U6_LEIDO

TriTrypDb:

LdBPK_061240.1 , LdCL_060017400 , LDHU3_06.1380

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	169	171	PF00082	0.576
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.576
CLV_PCSK_SKI1_1	151	155	PF00082	0.579
CLV_PCSK_SKI1_1	35	39	PF00082	0.449
DEG_SCF_FBW7_1	180	187	PF00400	0.347
DOC_CKS1_1	181	186	PF01111	0.435
DOC_MAPK_DCC_7	70	79	PF00069	0.546
DOC_MAPK_gen_1	129	137	PF00069	0.376
DOC_MAPK_gen_1	42	50	PF00069	0.592
DOC_MAPK_MEF2A_6	42	50	PF00069	0.592
DOC_MAPK_MEF2A_6	70	79	PF00069	0.548
DOC_PP4_FxxP_1	181	184	PF00568	0.435
DOC_USP7_MATH_1	195	199	PF00917	0.376
DOC_USP7_MATH_1	56	60	PF00917	0.629
DOC_USP7_MATH_1	95	99	PF00917	0.510
DOC_WW_Pin1_4	180	185	PF00397	0.435
LIG_14-3-3_CanoR_1	129	138	PF00244	0.435
LIG_14-3-3_CanoR_1	140	150	PF00244	0.305
LIG_14-3-3_CanoR_1	54	63	PF00244	0.762
LIG_14-3-3_CanoR_1	9	17	PF00244	0.601
LIG_BRCT_BRCA1_1	202	206	PF00533	0.435
LIG_BRCT_BRCA1_1	33	37	PF00533	0.657
LIG_FHA_1	117	123	PF00498	0.435
LIG_FHA_1	185	191	PF00498	0.375
LIG_FHA_1	69	75	PF00498	0.556
LIG_GBD_Chelix_1	77	85	PF00786	0.446
LIG_IRF3_LxIS_1	137	144	PF10401	0.347
LIG_LIR_Apic_2	178	184	PF02991	0.435
LIG_LIR_Apic_2	191	195	PF02991	0.282
LIG_LIR_Gen_1	116	125	PF02991	0.432
LIG_LIR_Nem_3	106	111	PF02991	0.408
LIG_LIR_Nem_3	116	121	PF02991	0.398
LIG_LIR_Nem_3	162	167	PF02991	0.343
LIG_LYPXL_yS_3	164	167	PF13949	0.435
LIG_NRBOX	80	86	PF00104	0.446
LIG_PCNA_yPIPBox_3	140	154	PF02747	0.376
LIG_Pex14_2	204	208	PF04695	0.482
LIG_SH2_CRK	118	122	PF00017	0.435
LIG_SH2_CRK	182	186	PF00017	0.435
LIG_SH2_CRK	192	196	PF00017	0.317
LIG_SH2_SRC	158	161	PF00017	0.435
LIG_SH2_STAP1	118	122	PF00017	0.435
LIG_SH2_STAT5	111	114	PF00017	0.337
LIG_SH2_STAT5	118	121	PF00017	0.305
LIG_SH2_STAT5	123	126	PF00017	0.253
LIG_SH2_STAT5	158	161	PF00017	0.331
LIG_SH2_STAT5	182	185	PF00017	0.435
LIG_SH2_STAT5	199	202	PF00017	0.343
LIG_SH3_3	109	115	PF00018	0.303
LIG_SH3_3	18	24	PF00018	0.605
LIG_SUMO_SIM_par_1	98	104	PF11976	0.435
LIG_TYR_ITIM	180	185	PF00017	0.435
LIG_WRC_WIRS_1	201	206	PF05994	0.435
MOD_CK1_1	31	37	PF00069	0.736
MOD_CK2_1	143	149	PF00069	0.435
MOD_GlcNHglycan	51	54	PF01048	0.385
MOD_GSK3_1	139	146	PF00069	0.435
MOD_GSK3_1	180	187	PF00069	0.347
MOD_GSK3_1	31	38	PF00069	0.658
MOD_GSK3_1	54	61	PF00069	0.620
MOD_GSK3_1	8	15	PF00069	0.597
MOD_NEK2_1	12	17	PF00069	0.603
MOD_NEK2_1	141	146	PF00069	0.435
MOD_NEK2_1	200	205	PF00069	0.389
MOD_NEK2_1	37	42	PF00069	0.643
MOD_NEK2_1	63	68	PF00069	0.760
MOD_PIKK_1	10	16	PF00454	0.599
MOD_PIKK_1	141	147	PF00454	0.408
MOD_PK_1	28	34	PF00069	0.665
MOD_PKA_1	28	34	PF00069	0.621
MOD_PKA_2	104	110	PF00069	0.435
MOD_PKA_2	139	145	PF00069	0.435
MOD_PKA_2	195	201	PF00069	0.340
MOD_PKA_2	63	69	PF00069	0.675
MOD_PKA_2	8	14	PF00069	0.599
MOD_Plk_1	95	101	PF00069	0.542
MOD_Plk_4	116	122	PF00069	0.357
MOD_Plk_4	175	181	PF00069	0.425
MOD_Plk_4	195	201	PF00069	0.339
MOD_Plk_4	28	34	PF00069	0.621
MOD_ProDKin_1	180	186	PF00069	0.435
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.405
TRG_ENDOCYTIC_2	118	121	PF00928	0.435
TRG_ENDOCYTIC_2	164	167	PF00928	0.435
TRG_ENDOCYTIC_2	182	185	PF00928	0.435
TRG_ER_diArg_1	45	48	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H4T0	Leishmania braziliensis	83%	100%
A4HT10	Leishmania infantum	100%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QIV7	Leishmania major	86%	100%