Separase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Separase

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5U4_LEIDO

TriTrypDb:

LdBPK_061200.1 , LdCL_060017100 , LDHU3_06.1350

Length:

1093

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.589
CLV_C14_Caspase3-7	241	245	PF00656	0.624
CLV_C14_Caspase3-7	523	527	PF00656	0.618
CLV_NRD_NRD_1	1089	1091	PF00675	0.649
CLV_NRD_NRD_1	122	124	PF00675	0.608
CLV_NRD_NRD_1	129	131	PF00675	0.547
CLV_NRD_NRD_1	355	357	PF00675	0.562
CLV_NRD_NRD_1	803	805	PF00675	0.722
CLV_NRD_NRD_1	847	849	PF00675	0.473
CLV_NRD_NRD_1	973	975	PF00675	0.667
CLV_PCSK_KEX2_1	1047	1049	PF00082	0.417
CLV_PCSK_KEX2_1	122	124	PF00082	0.608
CLV_PCSK_KEX2_1	129	131	PF00082	0.547
CLV_PCSK_KEX2_1	238	240	PF00082	0.730
CLV_PCSK_KEX2_1	355	357	PF00082	0.562
CLV_PCSK_KEX2_1	712	714	PF00082	0.460
CLV_PCSK_KEX2_1	803	805	PF00082	0.635
CLV_PCSK_KEX2_1	846	848	PF00082	0.475
CLV_PCSK_PC1ET2_1	1047	1049	PF00082	0.417
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.562
CLV_PCSK_PC1ET2_1	712	714	PF00082	0.460
CLV_PCSK_SKI1_1	1048	1052	PF00082	0.482
CLV_PCSK_SKI1_1	27	31	PF00082	0.488
CLV_PCSK_SKI1_1	372	376	PF00082	0.636
CLV_PCSK_SKI1_1	449	453	PF00082	0.532
CLV_PCSK_SKI1_1	553	557	PF00082	0.480
CLV_PCSK_SKI1_1	609	613	PF00082	0.414
CLV_PCSK_SKI1_1	663	667	PF00082	0.595
CLV_PCSK_SKI1_1	686	690	PF00082	0.557
CLV_PCSK_SKI1_1	866	870	PF00082	0.392
CLV_PCSK_SKI1_1	874	878	PF00082	0.390
CLV_PCSK_SKI1_1	910	914	PF00082	0.411
CLV_PCSK_SKI1_1	956	960	PF00082	0.580
CLV_Separin_Metazoa	691	695	PF03568	0.429
DEG_APCC_DBOX_1	371	379	PF00400	0.595
DEG_APCC_DBOX_1	637	645	PF00400	0.441
DEG_APCC_DBOX_1	662	670	PF00400	0.646
DEG_APCC_DBOX_1	685	693	PF00400	0.505
DEG_Nend_UBRbox_2	1	3	PF02207	0.654
DEG_SIAH_1	143	151	PF03145	0.716
DEG_SPOP_SBC_1	401	405	PF00917	0.488
DEG_SPOP_SBC_1	656	660	PF00917	0.663
DOC_CKS1_1	382	387	PF01111	0.620
DOC_CYCLIN_RxL_1	681	691	PF00134	0.530
DOC_CYCLIN_RxL_1	862	873	PF00134	0.351
DOC_MAPK_gen_1	1059	1069	PF00069	0.520
DOC_MAPK_gen_1	846	855	PF00069	0.383
DOC_MAPK_gen_1	863	871	PF00069	0.251
DOC_MAPK_MEF2A_6	1062	1069	PF00069	0.429
DOC_MAPK_MEF2A_6	13	21	PF00069	0.385
DOC_MAPK_MEF2A_6	372	380	PF00069	0.644
DOC_MAPK_MEF2A_6	445	454	PF00069	0.454
DOC_MAPK_MEF2A_6	987	994	PF00069	0.428
DOC_PP1_RVXF_1	115	122	PF00149	0.671
DOC_PP1_RVXF_1	48	54	PF00149	0.480
DOC_PP1_RVXF_1	684	691	PF00149	0.558
DOC_PP2B_LxvP_1	494	497	PF13499	0.443
DOC_PP2B_LxvP_1	620	623	PF13499	0.465
DOC_PP2B_PxIxI_1	256	262	PF00149	0.520
DOC_PP4_FxxP_1	707	710	PF00568	0.518
DOC_PP4_FxxP_1	832	835	PF00568	0.536
DOC_USP7_MATH_1	113	117	PF00917	0.641
DOC_USP7_MATH_1	161	165	PF00917	0.672
DOC_USP7_MATH_1	284	288	PF00917	0.517
DOC_USP7_MATH_1	297	301	PF00917	0.566
DOC_USP7_MATH_1	345	349	PF00917	0.672
DOC_USP7_MATH_1	402	406	PF00917	0.600
DOC_USP7_MATH_1	484	488	PF00917	0.499
DOC_USP7_MATH_1	497	501	PF00917	0.655
DOC_USP7_MATH_1	511	515	PF00917	0.511
DOC_USP7_MATH_1	551	555	PF00917	0.532
DOC_USP7_MATH_1	722	726	PF00917	0.505
DOC_USP7_MATH_1	744	748	PF00917	0.506
DOC_USP7_MATH_1	81	85	PF00917	0.789
DOC_USP7_MATH_1	814	818	PF00917	0.722
DOC_USP7_MATH_1	870	874	PF00917	0.453
DOC_USP7_MATH_1	92	96	PF00917	0.569
DOC_USP7_MATH_1	954	958	PF00917	0.406
DOC_WW_Pin1_4	1061	1066	PF00397	0.520
DOC_WW_Pin1_4	171	176	PF00397	0.694
DOC_WW_Pin1_4	194	199	PF00397	0.569
DOC_WW_Pin1_4	216	221	PF00397	0.422
DOC_WW_Pin1_4	253	258	PF00397	0.653
DOC_WW_Pin1_4	322	327	PF00397	0.671
DOC_WW_Pin1_4	381	386	PF00397	0.641
DOC_WW_Pin1_4	650	655	PF00397	0.581
DOC_WW_Pin1_4	674	679	PF00397	0.643
LIG_14-3-3_CanoR_1	1011	1019	PF00244	0.531
LIG_14-3-3_CanoR_1	1048	1057	PF00244	0.402
LIG_14-3-3_CanoR_1	303	311	PF00244	0.586
LIG_14-3-3_CanoR_1	336	346	PF00244	0.678
LIG_14-3-3_CanoR_1	874	880	PF00244	0.363
LIG_14-3-3_CanoR_1	897	903	PF00244	0.500
LIG_14-3-3_CanoR_1	949	958	PF00244	0.546
LIG_14-3-3_CanoR_1	974	982	PF00244	0.506
LIG_Actin_WH2_2	12	29	PF00022	0.426
LIG_Actin_WH2_2	198	213	PF00022	0.357
LIG_BIR_III_2	73	77	PF00653	0.548
LIG_BRCT_BRCA1_1	264	268	PF00533	0.488
LIG_BRCT_BRCA1_1	297	301	PF00533	0.553
LIG_BRCT_BRCA1_1	530	534	PF00533	0.473
LIG_CSL_BTD_1	328	331	PF09270	0.453
LIG_CSL_BTD_1	832	835	PF09270	0.536
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.482
LIG_eIF4E_1	14	20	PF01652	0.410
LIG_eIF4E_1	683	689	PF01652	0.497
LIG_FHA_1	102	108	PF00498	0.607
LIG_FHA_1	1040	1046	PF00498	0.585
LIG_FHA_1	1062	1068	PF00498	0.638
LIG_FHA_1	256	262	PF00498	0.553
LIG_FHA_1	310	316	PF00498	0.410
LIG_FHA_1	382	388	PF00498	0.618
LIG_FHA_1	415	421	PF00498	0.556
LIG_FHA_1	468	474	PF00498	0.476
LIG_FHA_1	6	12	PF00498	0.369
LIG_FHA_1	638	644	PF00498	0.512
LIG_FHA_1	657	663	PF00498	0.465
LIG_FHA_1	881	887	PF00498	0.451
LIG_FHA_1	963	969	PF00498	0.562
LIG_FHA_1	977	983	PF00498	0.495
LIG_FHA_2	1001	1007	PF00498	0.573
LIG_FHA_2	101	107	PF00498	0.594
LIG_FHA_2	1049	1055	PF00498	0.346
LIG_FHA_2	155	161	PF00498	0.630
LIG_FHA_2	195	201	PF00498	0.604
LIG_FHA_2	747	753	PF00498	0.523
LIG_GBD_Chelix_1	604	612	PF00786	0.487
LIG_LIR_Apic_2	705	710	PF02991	0.514
LIG_LIR_Gen_1	200	210	PF02991	0.422
LIG_LIR_Gen_1	687	697	PF02991	0.449
LIG_LIR_Gen_1	779	788	PF02991	0.402
LIG_LIR_Gen_1	856	864	PF02991	0.391
LIG_LIR_Gen_1	986	994	PF02991	0.463
LIG_LIR_Nem_3	200	206	PF02991	0.419
LIG_LIR_Nem_3	437	441	PF02991	0.536
LIG_LIR_Nem_3	626	632	PF02991	0.589
LIG_LIR_Nem_3	677	683	PF02991	0.614
LIG_LIR_Nem_3	687	693	PF02991	0.400
LIG_LIR_Nem_3	779	784	PF02991	0.402
LIG_LIR_Nem_3	856	860	PF02991	0.515
LIG_LIR_Nem_3	878	882	PF02991	0.440
LIG_LIR_Nem_3	986	992	PF02991	0.434
LIG_LYPXL_yS_3	917	920	PF13949	0.497
LIG_NRBOX	391	397	PF00104	0.603
LIG_NRBOX	661	667	PF00104	0.480
LIG_PCNA_yPIPBox_3	355	365	PF02747	0.476
LIG_Rb_pABgroove_1	262	270	PF01858	0.509
LIG_RPA_C_Fungi	1036	1048	PF08784	0.374
LIG_RPA_C_Fungi	118	130	PF08784	0.561
LIG_RPA_C_Fungi	440	452	PF08784	0.509
LIG_RPA_C_Insects	1026	1041	PF08784	0.385
LIG_SH2_CRK	1028	1032	PF00017	0.456
LIG_SH2_CRK	125	129	PF00017	0.597
LIG_SH2_CRK	648	652	PF00017	0.581
LIG_SH2_CRK	841	845	PF00017	0.529
LIG_SH2_GRB2like	932	935	PF00017	0.337
LIG_SH2_NCK_1	841	845	PF00017	0.452
LIG_SH2_PTP2	14	17	PF00017	0.412
LIG_SH2_PTP2	857	860	PF00017	0.413
LIG_SH2_SRC	769	772	PF00017	0.436
LIG_SH2_STAP1	431	435	PF00017	0.448
LIG_SH2_STAP1	44	48	PF00017	0.464
LIG_SH2_STAP1	469	473	PF00017	0.384
LIG_SH2_STAP1	7	11	PF00017	0.551
LIG_SH2_STAP1	875	879	PF00017	0.441
LIG_SH2_STAP1	964	968	PF00017	0.425
LIG_SH2_STAT5	14	17	PF00017	0.423
LIG_SH2_STAT5	435	438	PF00017	0.438
LIG_SH2_STAT5	469	472	PF00017	0.469
LIG_SH2_STAT5	7	10	PF00017	0.603
LIG_SH2_STAT5	762	765	PF00017	0.474
LIG_SH2_STAT5	773	776	PF00017	0.411
LIG_SH2_STAT5	857	860	PF00017	0.413
LIG_SH2_STAT5	964	967	PF00017	0.449
LIG_SH3_1	251	257	PF00018	0.549
LIG_SH3_3	169	175	PF00018	0.798
LIG_SH3_3	230	236	PF00018	0.522
LIG_SH3_3	251	257	PF00018	0.655
LIG_SH3_3	648	654	PF00018	0.587
LIG_SUMO_SIM_anti_2	639	645	PF11976	0.457
LIG_SUMO_SIM_anti_2	957	962	PF11976	0.328
LIG_SUMO_SIM_anti_2	988	994	PF11976	0.423
LIG_SUMO_SIM_par_1	652	661	PF11976	0.549
LIG_SUMO_SIM_par_1	867	873	PF11976	0.431
LIG_TRAF2_1	1072	1075	PF00917	0.521
LIG_TRAF2_1	702	705	PF00917	0.517
LIG_TYR_ITIM	839	844	PF00017	0.548
LIG_TYR_ITIM	855	860	PF00017	0.389
LIG_TYR_ITIM	915	920	PF00017	0.505
LIG_WRC_WIRS_1	435	440	PF05994	0.554
MOD_CDK_SPK_2	171	176	PF00069	0.625
MOD_CDK_SPxxK_3	674	681	PF00069	0.410
MOD_CK1_1	112	118	PF00069	0.781
MOD_CK1_1	231	237	PF00069	0.485
MOD_CK1_1	337	343	PF00069	0.771
MOD_CK1_1	410	416	PF00069	0.598
MOD_CK1_1	437	443	PF00069	0.458
MOD_CK1_1	501	507	PF00069	0.722
MOD_CK1_1	514	520	PF00069	0.778
MOD_CK1_1	554	560	PF00069	0.548
MOD_CK1_1	674	680	PF00069	0.579
MOD_CK1_1	733	739	PF00069	0.521
MOD_CK1_1	791	797	PF00069	0.618
MOD_CK1_1	84	90	PF00069	0.775
MOD_CK2_1	1048	1054	PF00069	0.416
MOD_CK2_1	1069	1075	PF00069	0.525
MOD_CK2_1	112	118	PF00069	0.643
MOD_CK2_1	171	177	PF00069	0.671
MOD_CK2_1	746	752	PF00069	0.528
MOD_CK2_1	916	922	PF00069	0.451
MOD_GlcNHglycan	1019	1022	PF01048	0.564
MOD_GlcNHglycan	1042	1045	PF01048	0.391
MOD_GlcNHglycan	1078	1081	PF01048	0.516
MOD_GlcNHglycan	111	114	PF01048	0.732
MOD_GlcNHglycan	194	197	PF01048	0.768
MOD_GlcNHglycan	240	243	PF01048	0.729
MOD_GlcNHglycan	274	280	PF01048	0.664
MOD_GlcNHglycan	297	300	PF01048	0.555
MOD_GlcNHglycan	336	339	PF01048	0.664
MOD_GlcNHglycan	347	350	PF01048	0.603
MOD_GlcNHglycan	425	428	PF01048	0.420
MOD_GlcNHglycan	503	506	PF01048	0.704
MOD_GlcNHglycan	522	525	PF01048	0.454
MOD_GlcNHglycan	595	598	PF01048	0.671
MOD_GlcNHglycan	732	735	PF01048	0.483
MOD_GlcNHglycan	744	747	PF01048	0.443
MOD_GlcNHglycan	790	793	PF01048	0.630
MOD_GlcNHglycan	820	823	PF01048	0.507
MOD_GlcNHglycan	83	86	PF01048	0.624
MOD_GlcNHglycan	898	901	PF01048	0.412
MOD_GlcNHglycan	90	93	PF01048	0.790
MOD_GlcNHglycan	934	937	PF01048	0.484
MOD_GSK3_1	1048	1055	PF00069	0.605
MOD_GSK3_1	109	116	PF00069	0.714
MOD_GSK3_1	192	199	PF00069	0.770
MOD_GSK3_1	234	241	PF00069	0.528
MOD_GSK3_1	253	260	PF00069	0.532
MOD_GSK3_1	334	341	PF00069	0.600
MOD_GSK3_1	381	388	PF00069	0.588
MOD_GSK3_1	410	417	PF00069	0.717
MOD_GSK3_1	497	504	PF00069	0.645
MOD_GSK3_1	514	521	PF00069	0.492
MOD_GSK3_1	551	558	PF00069	0.440
MOD_GSK3_1	582	589	PF00069	0.628
MOD_GSK3_1	593	600	PF00069	0.611
MOD_GSK3_1	670	677	PF00069	0.533
MOD_GSK3_1	742	749	PF00069	0.390
MOD_GSK3_1	814	821	PF00069	0.613
MOD_GSK3_1	84	91	PF00069	0.711
MOD_N-GLC_1	282	287	PF02516	0.568
MOD_N-GLC_1	497	502	PF02516	0.726
MOD_N-GLC_1	818	823	PF02516	0.597
MOD_NEK2_1	1017	1022	PF00069	0.603
MOD_NEK2_1	1027	1032	PF00069	0.373
MOD_NEK2_1	209	214	PF00069	0.531
MOD_NEK2_1	376	381	PF00069	0.544
MOD_NEK2_1	422	427	PF00069	0.430
MOD_NEK2_1	492	497	PF00069	0.554
MOD_NEK2_1	655	660	PF00069	0.690
MOD_NEK2_1	755	760	PF00069	0.407
MOD_NEK2_1	824	829	PF00069	0.583
MOD_NEK2_1	869	874	PF00069	0.435
MOD_NEK2_1	898	903	PF00069	0.505
MOD_NEK2_1	927	932	PF00069	0.385
MOD_NEK2_1	985	990	PF00069	0.457
MOD_NEK2_2	284	289	PF00069	0.544
MOD_NEK2_2	314	319	PF00069	0.330
MOD_NEK2_2	434	439	PF00069	0.563
MOD_OFUCOSY	1068	1073	PF10250	0.599
MOD_PIKK_1	161	167	PF00454	0.699
MOD_PIKK_1	302	308	PF00454	0.526
MOD_PIKK_1	378	384	PF00454	0.616
MOD_PIKK_1	414	420	PF00454	0.542
MOD_PKA_1	238	244	PF00069	0.575
MOD_PKA_2	1040	1046	PF00069	0.359
MOD_PKA_2	192	198	PF00069	0.709
MOD_PKA_2	234	240	PF00069	0.705
MOD_PKA_2	302	308	PF00069	0.467
MOD_PKA_2	414	420	PF00069	0.540
MOD_PKA_2	501	507	PF00069	0.635
MOD_PKA_2	637	643	PF00069	0.428
MOD_PKA_2	896	902	PF00069	0.515
MOD_PKA_2	948	954	PF00069	0.573
MOD_PKB_1	947	955	PF00069	0.439
MOD_Plk_1	100	106	PF00069	0.703
MOD_Plk_1	117	123	PF00069	0.579
MOD_Plk_1	376	382	PF00069	0.651
MOD_Plk_1	511	517	PF00069	0.614
MOD_Plk_1	814	820	PF00069	0.492
MOD_Plk_2-3	101	107	PF00069	0.582
MOD_Plk_2-3	582	588	PF00069	0.579
MOD_Plk_4	1052	1058	PF00069	0.622
MOD_Plk_4	133	139	PF00069	0.749
MOD_Plk_4	228	234	PF00069	0.499
MOD_Plk_4	402	408	PF00069	0.662
MOD_Plk_4	637	643	PF00069	0.482
MOD_Plk_4	755	761	PF00069	0.458
MOD_ProDKin_1	1061	1067	PF00069	0.517
MOD_ProDKin_1	171	177	PF00069	0.695
MOD_ProDKin_1	194	200	PF00069	0.551
MOD_ProDKin_1	216	222	PF00069	0.414
MOD_ProDKin_1	253	259	PF00069	0.634
MOD_ProDKin_1	322	328	PF00069	0.681
MOD_ProDKin_1	381	387	PF00069	0.641
MOD_ProDKin_1	650	656	PF00069	0.584
MOD_ProDKin_1	674	680	PF00069	0.642
MOD_SUMO_for_1	29	32	PF00179	0.480
MOD_SUMO_for_1	669	672	PF00179	0.613
MOD_SUMO_rev_2	802	812	PF00179	0.605
TRG_DiLeu_BaEn_1	24	29	PF01217	0.402
TRG_DiLeu_BaEn_1	587	592	PF01217	0.624
TRG_DiLeu_BaEn_1	639	644	PF01217	0.552
TRG_DiLeu_BaLyEn_6	967	972	PF01217	0.422
TRG_DiLeu_LyEn_5	24	29	PF01217	0.402
TRG_ENDOCYTIC_2	1028	1031	PF00928	0.396
TRG_ENDOCYTIC_2	125	128	PF00928	0.595
TRG_ENDOCYTIC_2	14	17	PF00928	0.395
TRG_ENDOCYTIC_2	435	438	PF00928	0.452
TRG_ENDOCYTIC_2	648	651	PF00928	0.581
TRG_ENDOCYTIC_2	841	844	PF00928	0.533
TRG_ENDOCYTIC_2	857	860	PF00928	0.392
TRG_ENDOCYTIC_2	917	920	PF00928	0.497
TRG_ER_diArg_1	121	123	PF00400	0.623
TRG_ER_diArg_1	128	130	PF00400	0.538
TRG_ER_diArg_1	354	356	PF00400	0.528
TRG_ER_diArg_1	803	806	PF00400	0.638
TRG_ER_diArg_1	846	848	PF00400	0.478
TRG_ER_diArg_1	947	950	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	663	667	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV03	Leptomonas seymouri	48%	100%
A0A3R7L2Z7	Trypanosoma rangeli	27%	100%
A4H4S7	Leishmania braziliensis	77%	100%
C9ZTP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AG70	Leishmania infantum	100%	100%
E9AKZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QIW0	Leishmania major	90%	100%
V5B820	Trypanosoma cruzi	26%	100%