DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5U3_LEIDO

TriTrypDb:

LdBPK_061190.1 , LdCL_060017000 , LDHU3_06.1340

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.687
CLV_C14_Caspase3-7	183	187	PF00656	0.591
CLV_NRD_NRD_1	14	16	PF00675	0.648
CLV_NRD_NRD_1	309	311	PF00675	0.546
CLV_NRD_NRD_1	324	326	PF00675	0.514
CLV_NRD_NRD_1	486	488	PF00675	0.494
CLV_PCSK_FUR_1	483	487	PF00082	0.511
CLV_PCSK_KEX2_1	14	16	PF00082	0.648
CLV_PCSK_KEX2_1	309	311	PF00082	0.529
CLV_PCSK_KEX2_1	324	326	PF00082	0.432
CLV_PCSK_KEX2_1	485	487	PF00082	0.515
CLV_PCSK_SKI1_1	416	420	PF00082	0.363
CLV_PCSK_SKI1_1	456	460	PF00082	0.411
DEG_APCC_DBOX_1	411	419	PF00400	0.425
DEG_ODPH_VHL_1	8	21	PF01847	0.500
DEG_SPOP_SBC_1	237	241	PF00917	0.326
DEG_SPOP_SBC_1	48	52	PF00917	0.482
DOC_CKS1_1	127	132	PF01111	0.331
DOC_CKS1_1	179	184	PF01111	0.806
DOC_CYCLIN_RxL_1	11	23	PF00134	0.473
DOC_CYCLIN_RxL_1	485	498	PF00134	0.544
DOC_MAPK_gen_1	387	396	PF00069	0.462
DOC_MAPK_gen_1	412	420	PF00069	0.418
DOC_MAPK_gen_1	485	495	PF00069	0.546
DOC_PP1_RVXF_1	13	20	PF00149	0.474
DOC_PP4_FxxP_1	124	127	PF00568	0.413
DOC_USP7_MATH_1	149	153	PF00917	0.340
DOC_USP7_MATH_1	191	195	PF00917	0.767
DOC_USP7_MATH_1	312	316	PF00917	0.641
DOC_USP7_MATH_1	382	386	PF00917	0.390
DOC_USP7_MATH_1	452	456	PF00917	0.433
DOC_USP7_MATH_1	57	61	PF00917	0.692
DOC_USP7_MATH_1	66	70	PF00917	0.712
DOC_WW_Pin1_4	126	131	PF00397	0.367
DOC_WW_Pin1_4	175	180	PF00397	0.646
DOC_WW_Pin1_4	181	186	PF00397	0.686
DOC_WW_Pin1_4	251	256	PF00397	0.407
DOC_WW_Pin1_4	285	290	PF00397	0.763
DOC_WW_Pin1_4	316	321	PF00397	0.544
DOC_WW_Pin1_4	73	78	PF00397	0.573
LIG_14-3-3_CanoR_1	139	147	PF00244	0.391
LIG_14-3-3_CanoR_1	14	20	PF00244	0.640
LIG_14-3-3_CanoR_1	196	204	PF00244	0.700
LIG_14-3-3_CanoR_1	238	247	PF00244	0.477
LIG_14-3-3_CanoR_1	273	277	PF00244	0.513
LIG_14-3-3_CanoR_1	309	318	PF00244	0.582
LIG_14-3-3_CanoR_1	347	356	PF00244	0.411
LIG_14-3-3_CanoR_1	359	367	PF00244	0.257
LIG_14-3-3_CanoR_1	387	392	PF00244	0.440
LIG_14-3-3_CanoR_1	4	9	PF00244	0.714
LIG_14-3-3_CanoR_1	504	510	PF00244	0.602
LIG_14-3-3_CanoR_1	68	78	PF00244	0.510
LIG_Actin_WH2_2	403	418	PF00022	0.518
LIG_APCC_ABBA_1	339	344	PF00400	0.492
LIG_APCC_ABBA_1	418	423	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_BRCT_BRCA1_1	209	213	PF00533	0.312
LIG_BRCT_BRCA1_1	361	365	PF00533	0.326
LIG_BRCT_BRCA1_1	454	458	PF00533	0.482
LIG_BRCT_BRCA1_1	75	79	PF00533	0.417
LIG_Clathr_ClatBox_1	78	82	PF01394	0.477
LIG_DLG_GKlike_1	387	394	PF00625	0.477
LIG_FHA_1	28	34	PF00498	0.648
LIG_FHA_2	112	118	PF00498	0.658
LIG_FHA_2	181	187	PF00498	0.707
LIG_FHA_2	417	423	PF00498	0.345
LIG_FHA_2	506	512	PF00498	0.569
LIG_LIR_Nem_3	209	214	PF02991	0.393
LIG_LIR_Nem_3	432	437	PF02991	0.463
LIG_LYPXL_yS_3	211	214	PF13949	0.441
LIG_PCNA_PIPBox_1	100	109	PF02747	0.450
LIG_PCNA_yPIPBox_3	100	111	PF02747	0.566
LIG_SH2_PTP2	417	420	PF00017	0.474
LIG_SH2_STAP1	367	371	PF00017	0.390
LIG_SH2_STAT3	169	172	PF00017	0.503
LIG_SH2_STAT5	417	420	PF00017	0.474
LIG_SH3_2	320	325	PF14604	0.458
LIG_SH3_3	124	130	PF00018	0.400
LIG_SH3_3	176	182	PF00018	0.719
LIG_SH3_3	274	280	PF00018	0.737
LIG_SH3_3	290	296	PF00018	0.551
LIG_SH3_3	317	323	PF00018	0.616
LIG_SH3_3	394	400	PF00018	0.541
LIG_SH3_3	421	427	PF00018	0.417
LIG_SH3_3	43	49	PF00018	0.720
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.407
LIG_TYR_ITIM	415	420	PF00017	0.486
MOD_CDC14_SPxK_1	322	325	PF00782	0.481
MOD_CDK_SPK_2	319	324	PF00069	0.526
MOD_CDK_SPxK_1	319	325	PF00069	0.516
MOD_CK1_1	145	151	PF00069	0.406
MOD_CK1_1	152	158	PF00069	0.390
MOD_CK1_1	178	184	PF00069	0.692
MOD_CK1_1	195	201	PF00069	0.554
MOD_CK1_1	240	246	PF00069	0.421
MOD_CK1_1	259	265	PF00069	0.355
MOD_CK1_1	275	281	PF00069	0.661
MOD_CK1_1	319	325	PF00069	0.616
MOD_CK1_1	349	355	PF00069	0.432
MOD_CK1_1	385	391	PF00069	0.469
MOD_CK1_1	51	57	PF00069	0.704
MOD_CK1_1	67	73	PF00069	0.626
MOD_CK2_1	230	236	PF00069	0.414
MOD_CK2_1	505	511	PF00069	0.566
MOD_GlcNHglycan	119	122	PF01048	0.682
MOD_GlcNHglycan	147	150	PF01048	0.304
MOD_GlcNHglycan	240	243	PF01048	0.372
MOD_GlcNHglycan	314	317	PF01048	0.589
MOD_GlcNHglycan	384	387	PF01048	0.463
MOD_GlcNHglycan	480	483	PF01048	0.530
MOD_GlcNHglycan	59	62	PF01048	0.676
MOD_GSK3_1	107	114	PF00069	0.582
MOD_GSK3_1	138	145	PF00069	0.404
MOD_GSK3_1	191	198	PF00069	0.747
MOD_GSK3_1	23	30	PF00069	0.721
MOD_GSK3_1	232	239	PF00069	0.390
MOD_GSK3_1	278	285	PF00069	0.774
MOD_GSK3_1	312	319	PF00069	0.447
MOD_GSK3_1	404	411	PF00069	0.453
MOD_GSK3_1	459	466	PF00069	0.547
MOD_GSK3_1	47	54	PF00069	0.686
MOD_GSK3_1	64	71	PF00069	0.639
MOD_NEK2_1	207	212	PF00069	0.420
MOD_NEK2_1	21	26	PF00069	0.693
MOD_NEK2_1	27	32	PF00069	0.658
MOD_NEK2_1	282	287	PF00069	0.593
MOD_NEK2_1	458	463	PF00069	0.483
MOD_NEK2_1	493	498	PF00069	0.577
MOD_NEK2_1	505	510	PF00069	0.581
MOD_NEK2_2	29	34	PF00069	0.694
MOD_PIKK_1	142	148	PF00454	0.335
MOD_PIKK_1	459	465	PF00454	0.420
MOD_PKA_2	107	113	PF00069	0.531
MOD_PKA_2	138	144	PF00069	0.351
MOD_PKA_2	149	155	PF00069	0.304
MOD_PKA_2	195	201	PF00069	0.743
MOD_PKA_2	237	243	PF00069	0.457
MOD_PKA_2	272	278	PF00069	0.671
MOD_PKA_2	346	352	PF00069	0.466
MOD_PKA_2	437	443	PF00069	0.417
MOD_PKA_2	67	73	PF00069	0.659
MOD_PKB_1	414	422	PF00069	0.420
MOD_Plk_4	240	246	PF00069	0.302
MOD_Plk_4	351	357	PF00069	0.278
MOD_ProDKin_1	126	132	PF00069	0.367
MOD_ProDKin_1	175	181	PF00069	0.651
MOD_ProDKin_1	251	257	PF00069	0.407
MOD_ProDKin_1	285	291	PF00069	0.762
MOD_ProDKin_1	316	322	PF00069	0.538
MOD_ProDKin_1	73	79	PF00069	0.556
TRG_ENDOCYTIC_2	211	214	PF00928	0.441
TRG_ENDOCYTIC_2	417	420	PF00928	0.474
TRG_ER_diArg_1	13	15	PF00400	0.714
TRG_ER_diArg_1	323	325	PF00400	0.556
TRG_ER_diArg_1	358	361	PF00400	0.286
TRG_ER_diArg_1	412	415	PF00400	0.540
TRG_ER_diArg_1	483	486	PF00400	0.554
TRG_ER_diArg_1	488	491	PF00400	0.553
TRG_NES_CRM1_1	84	97	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ62	Leptomonas seymouri	62%	100%
A0A0S4KFW8	Bodo saltans	29%	100%
A0A1X0NIH3	Trypanosomatidae	37%	100%
A0A3R7NRE8	Trypanosoma rangeli	38%	100%
A4H4S6	Leishmania braziliensis	74%	100%
A4HT07	Leishmania infantum	100%	100%
C9ZTN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	92%
E9AKZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIW1	Leishmania major	93%	100%
V5BNK9	Trypanosoma cruzi	37%	100%