BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5U2_LEIDO

TriTrypDb:

LdBPK_061180.1 , LdCL_060016900 , LDHU3_06.1330

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.722
CLV_C14_Caspase3-7	539	543	PF00656	0.526
CLV_MEL_PAP_1	288	294	PF00089	0.606
CLV_NRD_NRD_1	265	267	PF00675	0.691
CLV_NRD_NRD_1	52	54	PF00675	0.662
CLV_NRD_NRD_1	561	563	PF00675	0.552
CLV_NRD_NRD_1	671	673	PF00675	0.506
CLV_NRD_NRD_1	693	695	PF00675	0.535
CLV_NRD_NRD_1	724	726	PF00675	0.738
CLV_NRD_NRD_1	730	732	PF00675	0.749
CLV_NRD_NRD_1	744	746	PF00675	0.513
CLV_PCSK_KEX2_1	265	267	PF00082	0.691
CLV_PCSK_KEX2_1	428	430	PF00082	0.670
CLV_PCSK_KEX2_1	51	53	PF00082	0.670
CLV_PCSK_KEX2_1	693	695	PF00082	0.535
CLV_PCSK_KEX2_1	724	726	PF00082	0.737
CLV_PCSK_KEX2_1	749	751	PF00082	0.839
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.691
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.725
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.759
CLV_PCSK_PC7_1	261	267	PF00082	0.672
CLV_PCSK_PC7_1	745	751	PF00082	0.700
CLV_PCSK_SKI1_1	105	109	PF00082	0.539
CLV_PCSK_SKI1_1	175	179	PF00082	0.476
CLV_PCSK_SKI1_1	285	289	PF00082	0.400
CLV_PCSK_SKI1_1	491	495	PF00082	0.619
CLV_PCSK_SKI1_1	521	525	PF00082	0.547
CLV_PCSK_SKI1_1	625	629	PF00082	0.552
CLV_PCSK_SKI1_1	687	691	PF00082	0.465
CLV_PCSK_SKI1_1	704	708	PF00082	0.593
DOC_CYCLIN_RxL_1	545	555	PF00134	0.566
DOC_CYCLIN_RxL_1	701	709	PF00134	0.611
DOC_MAPK_gen_1	505	514	PF00069	0.460
DOC_MAPK_gen_1	546	554	PF00069	0.562
DOC_MAPK_gen_1	672	680	PF00069	0.501
DOC_MAPK_MEF2A_6	285	292	PF00069	0.478
DOC_MAPK_MEF2A_6	546	554	PF00069	0.492
DOC_MAPK_NFAT4_5	285	293	PF00069	0.394
DOC_MAPK_RevD_3	254	268	PF00069	0.655
DOC_PP2B_LxvP_1	550	553	PF13499	0.504
DOC_PP2B_LxvP_1	633	636	PF13499	0.457
DOC_PP2B_PxIxI_1	318	324	PF00149	0.724
DOC_PP4_FxxP_1	679	682	PF00568	0.549
DOC_SPAK_OSR1_1	595	599	PF12202	0.455
DOC_USP7_MATH_1	152	156	PF00917	0.703
DOC_USP7_MATH_1	165	169	PF00917	0.482
DOC_USP7_MATH_1	197	201	PF00917	0.532
DOC_USP7_MATH_1	274	278	PF00917	0.629
DOC_USP7_MATH_1	309	313	PF00917	0.733
DOC_USP7_MATH_1	333	337	PF00917	0.663
DOC_USP7_MATH_1	35	39	PF00917	0.689
DOC_USP7_MATH_1	350	354	PF00917	0.741
DOC_USP7_MATH_1	384	388	PF00917	0.622
DOC_USP7_MATH_1	416	420	PF00917	0.815
DOC_USP7_MATH_1	463	467	PF00917	0.787
DOC_USP7_MATH_1	658	662	PF00917	0.793
DOC_USP7_MATH_1	734	738	PF00917	0.720
DOC_USP7_MATH_1	81	85	PF00917	0.715
DOC_WW_Pin1_4	107	112	PF00397	0.646
DOC_WW_Pin1_4	118	123	PF00397	0.515
DOC_WW_Pin1_4	182	187	PF00397	0.387
DOC_WW_Pin1_4	221	226	PF00397	0.700
DOC_WW_Pin1_4	243	248	PF00397	0.632
DOC_WW_Pin1_4	339	344	PF00397	0.763
DOC_WW_Pin1_4	469	474	PF00397	0.656
DOC_WW_Pin1_4	730	735	PF00397	0.725
DOC_WW_Pin1_4	739	744	PF00397	0.719
LIG_14-3-3_CanoR_1	105	111	PF00244	0.516
LIG_14-3-3_CanoR_1	210	216	PF00244	0.579
LIG_14-3-3_CanoR_1	335	345	PF00244	0.843
LIG_14-3-3_CanoR_1	347	355	PF00244	0.712
LIG_14-3-3_CanoR_1	368	375	PF00244	0.664
LIG_14-3-3_CanoR_1	51	56	PF00244	0.633
LIG_14-3-3_CanoR_1	546	551	PF00244	0.483
LIG_14-3-3_CanoR_1	693	702	PF00244	0.619
LIG_14-3-3_CanoR_1	735	743	PF00244	0.733
LIG_Actin_WH2_2	489	507	PF00022	0.504
LIG_Actin_WH2_2	561	579	PF00022	0.634
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BIR_III_4	283	287	PF00653	0.651
LIG_CSL_BTD_1	122	125	PF09270	0.493
LIG_FHA_1	119	125	PF00498	0.615
LIG_FHA_1	212	218	PF00498	0.581
LIG_FHA_1	246	252	PF00498	0.508
LIG_FHA_1	287	293	PF00498	0.522
LIG_FHA_1	369	375	PF00498	0.758
LIG_FHA_1	378	384	PF00498	0.783
LIG_FHA_1	422	428	PF00498	0.733
LIG_FHA_1	545	551	PF00498	0.487
LIG_FHA_1	622	628	PF00498	0.488
LIG_FHA_1	66	72	PF00498	0.460
LIG_FHA_1	9	15	PF00498	0.745
LIG_FHA_2	2	8	PF00498	0.712
LIG_FHA_2	274	280	PF00498	0.637
LIG_FHA_2	31	37	PF00498	0.819
LIG_FHA_2	383	389	PF00498	0.813
LIG_FHA_2	490	496	PF00498	0.404
LIG_FHA_2	52	58	PF00498	0.593
LIG_Integrin_isoDGR_2	327	329	PF01839	0.708
LIG_LIR_Gen_1	239	247	PF02991	0.626
LIG_LIR_Nem_3	120	126	PF02991	0.603
LIG_LIR_Nem_3	239	243	PF02991	0.494
LIG_LIR_Nem_3	643	648	PF02991	0.583
LIG_LIR_Nem_3	683	689	PF02991	0.460
LIG_LYPXL_SIV_4	294	302	PF13949	0.488
LIG_MYND_1	62	66	PF01753	0.625
LIG_SH2_CRK	126	130	PF00017	0.586
LIG_SH2_CRK	509	513	PF00017	0.582
LIG_SH2_STAP1	509	513	PF00017	0.582
LIG_SH2_STAT5	295	298	PF00017	0.508
LIG_SH2_STAT5	531	534	PF00017	0.571
LIG_SH3_2	726	731	PF14604	0.718
LIG_SH3_3	119	125	PF00018	0.494
LIG_SH3_3	166	172	PF00018	0.510
LIG_SH3_3	183	189	PF00018	0.382
LIG_SH3_3	222	228	PF00018	0.709
LIG_SH3_3	303	309	PF00018	0.708
LIG_SH3_3	601	607	PF00018	0.591
LIG_SH3_3	723	729	PF00018	0.716
LIG_SUMO_SIM_anti_2	10	19	PF11976	0.735
LIG_SUMO_SIM_anti_2	631	636	PF11976	0.563
LIG_SUMO_SIM_par_1	10	19	PF11976	0.735
LIG_TRAF2_1	45	48	PF00917	0.778
LIG_TRAF2_1	603	606	PF00917	0.704
MOD_CDC14_SPxK_1	742	745	PF00782	0.697
MOD_CDK_SPK_2	730	735	PF00069	0.719
MOD_CDK_SPxK_1	739	745	PF00069	0.705
MOD_CDK_SPxxK_3	739	746	PF00069	0.764
MOD_CK1_1	110	116	PF00069	0.710
MOD_CK1_1	117	123	PF00069	0.509
MOD_CK1_1	136	142	PF00069	0.447
MOD_CK1_1	146	152	PF00069	0.681
MOD_CK1_1	16	22	PF00069	0.788
MOD_CK1_1	200	206	PF00069	0.574
MOD_CK1_1	24	30	PF00069	0.720
MOD_CK1_1	246	252	PF00069	0.490
MOD_CK1_1	273	279	PF00069	0.721
MOD_CK1_1	314	320	PF00069	0.790
MOD_CK1_1	336	342	PF00069	0.844
MOD_CK1_1	370	376	PF00069	0.658
MOD_CK1_1	387	393	PF00069	0.679
MOD_CK1_1	396	402	PF00069	0.737
MOD_CK1_1	419	425	PF00069	0.708
MOD_CK1_1	468	474	PF00069	0.691
MOD_CK1_1	567	573	PF00069	0.614
MOD_CK1_1	659	665	PF00069	0.678
MOD_CK1_1	696	702	PF00069	0.622
MOD_CK1_1	727	733	PF00069	0.798
MOD_CK1_1	82	88	PF00069	0.659
MOD_CK2_1	1	7	PF00069	0.717
MOD_CK2_1	396	402	PF00069	0.732
MOD_CK2_1	483	489	PF00069	0.459
MOD_CK2_1	51	57	PF00069	0.637
MOD_CK2_1	81	87	PF00069	0.696
MOD_Cter_Amidation	722	725	PF01082	0.746
MOD_GlcNHglycan	154	157	PF01048	0.701
MOD_GlcNHglycan	159	162	PF01048	0.657
MOD_GlcNHglycan	193	196	PF01048	0.688
MOD_GlcNHglycan	23	26	PF01048	0.740
MOD_GlcNHglycan	272	275	PF01048	0.669
MOD_GlcNHglycan	311	314	PF01048	0.735
MOD_GlcNHglycan	335	338	PF01048	0.848
MOD_GlcNHglycan	348	351	PF01048	0.628
MOD_GlcNHglycan	352	355	PF01048	0.554
MOD_GlcNHglycan	397	401	PF01048	0.806
MOD_GlcNHglycan	473	476	PF01048	0.624
MOD_GlcNHglycan	600	603	PF01048	0.662
MOD_GlcNHglycan	618	621	PF01048	0.454
MOD_GlcNHglycan	658	661	PF01048	0.676
MOD_GlcNHglycan	663	666	PF01048	0.665
MOD_GlcNHglycan	695	698	PF01048	0.572
MOD_GlcNHglycan	72	76	PF01048	0.730
MOD_GlcNHglycan	81	84	PF01048	0.680
MOD_GSK3_1	106	113	PF00069	0.663
MOD_GSK3_1	114	121	PF00069	0.595
MOD_GSK3_1	143	150	PF00069	0.669
MOD_GSK3_1	152	159	PF00069	0.734
MOD_GSK3_1	19	26	PF00069	0.709
MOD_GSK3_1	200	207	PF00069	0.587
MOD_GSK3_1	270	277	PF00069	0.630
MOD_GSK3_1	30	37	PF00069	0.746
MOD_GSK3_1	346	353	PF00069	0.804
MOD_GSK3_1	369	376	PF00069	0.681
MOD_GSK3_1	419	426	PF00069	0.708
MOD_GSK3_1	465	472	PF00069	0.682
MOD_GSK3_1	578	585	PF00069	0.413
MOD_GSK3_1	652	659	PF00069	0.711
MOD_GSK3_1	661	668	PF00069	0.625
MOD_GSK3_1	710	717	PF00069	0.696
MOD_GSK3_1	730	737	PF00069	0.848
MOD_GSK3_1	744	751	PF00069	0.720
MOD_GSK3_1	79	86	PF00069	0.660
MOD_NEK2_1	133	138	PF00069	0.473
MOD_NEK2_1	173	178	PF00069	0.585
MOD_NEK2_1	23	28	PF00069	0.644
MOD_NEK2_1	478	483	PF00069	0.504
MOD_NEK2_1	519	524	PF00069	0.484
MOD_NEK2_1	576	581	PF00069	0.484
MOD_NEK2_1	652	657	PF00069	0.692
MOD_NEK2_1	695	700	PF00069	0.507
MOD_NEK2_1	71	76	PF00069	0.713
MOD_NEK2_2	211	216	PF00069	0.598
MOD_NEK2_2	286	291	PF00069	0.601
MOD_PIKK_1	24	30	PF00454	0.753
MOD_PIKK_1	336	342	PF00454	0.844
MOD_PIKK_1	361	367	PF00454	0.623
MOD_PIKK_1	408	414	PF00454	0.755
MOD_PIKK_1	724	730	PF00454	0.733
MOD_PIKK_1	736	742	PF00454	0.745
MOD_PKA_1	267	273	PF00069	0.688
MOD_PKA_1	51	57	PF00069	0.633
MOD_PKA_1	693	699	PF00069	0.543
MOD_PKA_1	724	730	PF00069	0.732
MOD_PKA_2	136	142	PF00069	0.557
MOD_PKA_2	267	273	PF00069	0.688
MOD_PKA_2	346	352	PF00069	0.805
MOD_PKA_2	367	373	PF00069	0.702
MOD_PKA_2	419	425	PF00069	0.612
MOD_PKA_2	430	436	PF00069	0.684
MOD_PKA_2	483	489	PF00069	0.522
MOD_PKA_2	51	57	PF00069	0.633
MOD_PKA_2	576	582	PF00069	0.632
MOD_PKA_2	693	699	PF00069	0.543
MOD_PKA_2	713	719	PF00069	0.625
MOD_PKA_2	724	730	PF00069	0.620
MOD_PKA_2	734	740	PF00069	0.742
MOD_PKA_2	744	750	PF00069	0.531
MOD_Plk_1	35	41	PF00069	0.784
MOD_Plk_1	377	383	PF00069	0.705
MOD_Plk_1	489	495	PF00069	0.617
MOD_Plk_1	570	576	PF00069	0.544
MOD_Plk_2-3	489	495	PF00069	0.617
MOD_Plk_2-3	8	14	PF00069	0.808
MOD_Plk_4	197	203	PF00069	0.630
MOD_Plk_4	370	376	PF00069	0.709
MOD_Plk_4	524	530	PF00069	0.395
MOD_Plk_4	536	542	PF00069	0.385
MOD_Plk_4	611	617	PF00069	0.511
MOD_ProDKin_1	107	113	PF00069	0.652
MOD_ProDKin_1	118	124	PF00069	0.506
MOD_ProDKin_1	182	188	PF00069	0.398
MOD_ProDKin_1	221	227	PF00069	0.707
MOD_ProDKin_1	243	249	PF00069	0.625
MOD_ProDKin_1	339	345	PF00069	0.762
MOD_ProDKin_1	469	475	PF00069	0.643
MOD_ProDKin_1	730	736	PF00069	0.724
MOD_ProDKin_1	739	745	PF00069	0.719
MOD_SUMO_rev_2	277	287	PF00179	0.464
MOD_SUMO_rev_2	486	493	PF00179	0.504
MOD_SUMO_rev_2	555	565	PF00179	0.499
MOD_SUMO_rev_2	606	615	PF00179	0.587
TRG_DiLeu_BaEn_1	10	15	PF01217	0.732
TRG_DiLeu_BaEn_1	495	500	PF01217	0.608
TRG_ENDOCYTIC_2	295	298	PF00928	0.494
TRG_ENDOCYTIC_2	509	512	PF00928	0.592
TRG_ER_diArg_1	231	234	PF00400	0.643
TRG_ER_diArg_1	50	53	PF00400	0.669
TRG_ER_diArg_1	545	548	PF00400	0.538
TRG_ER_diArg_1	587	590	PF00400	0.488
TRG_ER_diArg_1	693	695	PF00400	0.535
TRG_ER_diArg_1	724	726	PF00400	0.737
TRG_NLS_MonoCore_2	264	269	PF00514	0.667
TRG_NLS_MonoExtN_4	265	270	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	511	516	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	704	709	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD2	Leptomonas seymouri	40%	100%
A4H4S5	Leishmania braziliensis	72%	100%
A4HT06	Leishmania infantum	100%	100%
E9AKZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIW2	Leishmania major	90%	100%