Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5U1_LEIDO

TriTrypDb:

LdBPK_061170.1 , LdCL_060016800 , LDHU3_06.1320

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A0A3S5H5U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5U1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.527
CLV_PCSK_SKI1_1	161	165	PF00082	0.401
DEG_Nend_UBRbox_3	1	3	PF02207	0.504
DEG_SCF_FBW7_2	5	10	PF00400	0.481
DOC_CDC14_PxL_1	13	21	PF14671	0.376
DOC_MAPK_HePTP_8	232	244	PF00069	0.373
DOC_MAPK_MEF2A_6	120	127	PF00069	0.410
DOC_MAPK_MEF2A_6	235	244	PF00069	0.396
DOC_PP1_RVXF_1	52	59	PF00149	0.308
DOC_PP4_FxxP_1	322	325	PF00568	0.417
DOC_USP7_MATH_1	145	149	PF00917	0.402
DOC_USP7_MATH_1	159	163	PF00917	0.262
DOC_USP7_MATH_1	31	35	PF00917	0.331
DOC_USP7_MATH_1	36	40	PF00917	0.419
DOC_WW_Pin1_4	3	8	PF00397	0.491
LIG_14-3-3_CanoR_1	138	142	PF00244	0.446
LIG_14-3-3_CanoR_1	161	168	PF00244	0.398
LIG_14-3-3_CanoR_1	213	218	PF00244	0.371
LIG_14-3-3_CanoR_1	45	53	PF00244	0.447
LIG_BIR_III_4	183	187	PF00653	0.351
LIG_FHA_1	150	156	PF00498	0.519
LIG_FHA_1	195	201	PF00498	0.515
LIG_FHA_1	204	210	PF00498	0.409
LIG_FHA_1	218	224	PF00498	0.370
LIG_FHA_1	239	245	PF00498	0.403
LIG_FHA_1	291	297	PF00498	0.397
LIG_FHA_2	162	168	PF00498	0.397
LIG_FHA_2	276	282	PF00498	0.440
LIG_GBD_Chelix_1	79	87	PF00786	0.340
LIG_Integrin_isoDGR_2	93	95	PF01839	0.376
LIG_LIR_Gen_1	313	322	PF02991	0.285
LIG_LIR_Nem_3	313	317	PF02991	0.295
LIG_NRP_CendR_1	327	329	PF00754	0.551
LIG_SH2_CRK	21	25	PF00017	0.326
LIG_SH2_CRK	314	318	PF00017	0.334
LIG_SH2_STAP1	42	46	PF00017	0.286
LIG_SH2_STAT5	32	35	PF00017	0.376
LIG_SH2_STAT5	42	45	PF00017	0.338
LIG_SH3_3	148	154	PF00018	0.470
LIG_SH3_3	8	14	PF00018	0.451
LIG_SUMO_SIM_par_1	213	218	PF11976	0.350
LIG_SUMO_SIM_par_1	78	84	PF11976	0.365
LIG_TRAF2_1	7	10	PF00917	0.354
LIG_TYR_ITIM	19	24	PF00017	0.338
MOD_CDK_SPK_2	3	8	PF00069	0.418
MOD_CK1_1	194	200	PF00069	0.486
MOD_CK1_1	34	40	PF00069	0.358
MOD_CK2_1	172	178	PF00069	0.483
MOD_CK2_1	262	268	PF00069	0.307
MOD_GlcNHglycan	147	150	PF01048	0.487
MOD_GlcNHglycan	180	183	PF01048	0.377
MOD_GlcNHglycan	236	239	PF01048	0.451
MOD_GlcNHglycan	256	259	PF01048	0.292
MOD_GlcNHglycan	264	267	PF01048	0.262
MOD_GlcNHglycan	288	291	PF01048	0.451
MOD_GlcNHglycan	38	41	PF01048	0.465
MOD_GlcNHglycan	83	86	PF01048	0.362
MOD_GSK3_1	145	152	PF00069	0.519
MOD_GSK3_1	203	210	PF00069	0.443
MOD_GSK3_1	213	220	PF00069	0.390
MOD_GSK3_1	234	241	PF00069	0.392
MOD_GSK3_1	286	293	PF00069	0.408
MOD_GSK3_1	36	43	PF00069	0.388
MOD_NEK2_1	254	259	PF00069	0.439
MOD_NEK2_2	40	45	PF00069	0.445
MOD_PK_1	213	219	PF00069	0.372
MOD_PKA_2	137	143	PF00069	0.451
MOD_PKA_2	234	240	PF00069	0.379
MOD_PKA_2	44	50	PF00069	0.420
MOD_Plk_1	275	281	PF00069	0.404
MOD_Plk_2-3	276	282	PF00069	0.417
MOD_ProDKin_1	3	9	PF00069	0.491
TRG_ENDOCYTIC_2	21	24	PF00928	0.360
TRG_ENDOCYTIC_2	314	317	PF00928	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR4	Leptomonas seymouri	48%	100%
A0A1X0NGN1	Trypanosomatidae	27%	99%
A0A422NM50	Trypanosoma rangeli	25%	99%
A4H4S4	Leishmania braziliensis	74%	100%
A4HT05	Leishmania infantum	100%	100%
C9ZTN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
E9AKZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QIW3	Leishmania major	93%	100%
Q9H977	Homo sapiens	26%	99%
V5BT69	Trypanosoma cruzi	25%	99%