Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5T7_LEIDO

TriTrypDb:

LdBPK_061050.1 , LdCL_060015600 , LDHU3_06.1190

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.679
CLV_C14_Caspase3-7	242	246	PF00656	0.332
CLV_C14_Caspase3-7	34	38	PF00656	0.430
CLV_C14_Caspase3-7	459	463	PF00656	0.498
CLV_C14_Caspase3-7	591	595	PF00656	0.637
CLV_NRD_NRD_1	128	130	PF00675	0.689
CLV_NRD_NRD_1	163	165	PF00675	0.639
CLV_NRD_NRD_1	170	172	PF00675	0.576
CLV_NRD_NRD_1	296	298	PF00675	0.645
CLV_NRD_NRD_1	499	501	PF00675	0.511
CLV_NRD_NRD_1	51	53	PF00675	0.705
CLV_NRD_NRD_1	659	661	PF00675	0.375
CLV_NRD_NRD_1	761	763	PF00675	0.591
CLV_NRD_NRD_1	8	10	PF00675	0.669
CLV_PCSK_KEX2_1	128	130	PF00082	0.693
CLV_PCSK_KEX2_1	163	165	PF00082	0.639
CLV_PCSK_KEX2_1	170	172	PF00082	0.576
CLV_PCSK_KEX2_1	296	298	PF00082	0.614
CLV_PCSK_KEX2_1	499	501	PF00082	0.511
CLV_PCSK_KEX2_1	659	661	PF00082	0.375
CLV_PCSK_KEX2_1	761	763	PF00082	0.594
CLV_PCSK_KEX2_1	8	10	PF00082	0.669
CLV_PCSK_SKI1_1	100	104	PF00082	0.463
CLV_PCSK_SKI1_1	114	118	PF00082	0.435
CLV_PCSK_SKI1_1	214	218	PF00082	0.444
CLV_PCSK_SKI1_1	347	351	PF00082	0.483
CLV_PCSK_SKI1_1	382	386	PF00082	0.463
CLV_PCSK_SKI1_1	499	503	PF00082	0.518
CLV_PCSK_SKI1_1	651	655	PF00082	0.431
CLV_PCSK_SKI1_1	702	706	PF00082	0.457
CLV_PCSK_SKI1_1	738	742	PF00082	0.557
CLV_PCSK_SKI1_1	83	87	PF00082	0.430
DEG_APCC_DBOX_1	346	354	PF00400	0.420
DEG_APCC_DBOX_1	498	506	PF00400	0.512
DEG_APCC_DBOX_1	701	709	PF00400	0.449
DEG_COP1_1	27	35	PF00400	0.472
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_CYCLIN_RxL_1	100	109	PF00134	0.457
DOC_CYCLIN_RxL_1	379	388	PF00134	0.461
DOC_CYCLIN_RxL_1	521	532	PF00134	0.524
DOC_CYCLIN_RxL_1	735	745	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	262	268	PF00134	0.563
DOC_MAPK_gen_1	700	707	PF00069	0.481
DOC_MAPK_HePTP_8	656	673	PF00069	0.393
DOC_MAPK_MEF2A_6	664	673	PF00069	0.394
DOC_PP1_SILK_1	79	84	PF00149	0.334
DOC_PP2B_LxvP_1	262	265	PF13499	0.526
DOC_PP2B_LxvP_1	733	736	PF13499	0.524
DOC_USP7_MATH_1	123	127	PF00917	0.674
DOC_USP7_MATH_1	133	137	PF00917	0.698
DOC_USP7_MATH_1	26	30	PF00917	0.560
DOC_USP7_MATH_1	31	35	PF00917	0.561
DOC_USP7_MATH_1	318	322	PF00917	0.686
DOC_USP7_MATH_1	575	579	PF00917	0.664
DOC_WW_Pin1_4	313	318	PF00397	0.799
DOC_WW_Pin1_4	397	402	PF00397	0.564
DOC_WW_Pin1_4	414	419	PF00397	0.662
DOC_WW_Pin1_4	51	56	PF00397	0.619
DOC_WW_Pin1_4	578	583	PF00397	0.594
LIG_14-3-3_CanoR_1	134	139	PF00244	0.634
LIG_14-3-3_CanoR_1	382	388	PF00244	0.432
LIG_14-3-3_CanoR_1	426	430	PF00244	0.604
LIG_14-3-3_CanoR_1	457	465	PF00244	0.454
LIG_14-3-3_CanoR_1	507	513	PF00244	0.451
LIG_14-3-3_CanoR_1	664	669	PF00244	0.443
LIG_14-3-3_CanoR_1	700	705	PF00244	0.376
LIG_14-3-3_CanoR_1	8	15	PF00244	0.552
LIG_APCC_ABBAyCdc20_2	538	544	PF00400	0.493
LIG_BRCT_BRCA1_1	353	357	PF00533	0.380
LIG_Clathr_ClatBox_1	525	529	PF01394	0.531
LIG_DLG_GKlike_1	134	141	PF00625	0.616
LIG_DLG_GKlike_1	664	671	PF00625	0.434
LIG_FHA_1	185	191	PF00498	0.547
LIG_FHA_1	215	221	PF00498	0.373
LIG_FHA_1	231	237	PF00498	0.574
LIG_FHA_1	246	252	PF00498	0.377
LIG_FHA_1	322	328	PF00498	0.547
LIG_FHA_1	34	40	PF00498	0.611
LIG_FHA_1	402	408	PF00498	0.552
LIG_FHA_1	430	436	PF00498	0.546
LIG_FHA_1	478	484	PF00498	0.452
LIG_FHA_1	602	608	PF00498	0.502
LIG_FHA_1	644	650	PF00498	0.403
LIG_FHA_1	682	688	PF00498	0.448
LIG_FHA_1	73	79	PF00498	0.430
LIG_FHA_2	148	154	PF00498	0.671
LIG_FHA_2	301	307	PF00498	0.646
LIG_FHA_2	369	375	PF00498	0.624
LIG_FHA_2	457	463	PF00498	0.484
LIG_FHA_2	466	472	PF00498	0.371
LIG_FHA_2	530	536	PF00498	0.562
LIG_FHA_2	579	585	PF00498	0.627
LIG_FHA_2	742	748	PF00498	0.563
LIG_Integrin_RGD_1	660	662	PF01839	0.361
LIG_LIR_Gen_1	269	277	PF02991	0.558
LIG_LIR_Gen_1	354	364	PF02991	0.499
LIG_LIR_Gen_1	630	640	PF02991	0.493
LIG_LIR_Gen_1	703	712	PF02991	0.383
LIG_LIR_Gen_1	76	87	PF02991	0.463
LIG_LIR_Nem_3	269	273	PF02991	0.556
LIG_LIR_Nem_3	354	360	PF02991	0.485
LIG_LIR_Nem_3	630	635	PF02991	0.436
LIG_LIR_Nem_3	703	707	PF02991	0.378
LIG_LIR_Nem_3	76	82	PF02991	0.477
LIG_NRBOX	81	87	PF00104	0.480
LIG_PCNA_PIPBox_1	392	401	PF02747	0.503
LIG_PCNA_yPIPBox_3	702	716	PF02747	0.417
LIG_Pex14_2	212	216	PF04695	0.444
LIG_Rb_pABgroove_1	442	450	PF01858	0.470
LIG_SH2_CRK	632	636	PF00017	0.366
LIG_SH2_CRK	640	644	PF00017	0.394
LIG_SH2_GRB2like	675	678	PF00017	0.501
LIG_SH2_NCK_1	399	403	PF00017	0.517
LIG_SH2_NCK_1	448	452	PF00017	0.465
LIG_SH2_SRC	448	451	PF00017	0.474
LIG_SH2_STAP1	542	546	PF00017	0.408
LIG_SH2_STAT3	377	380	PF00017	0.492
LIG_SH2_STAT5	352	355	PF00017	0.485
LIG_SH2_STAT5	383	386	PF00017	0.472
LIG_SH2_STAT5	399	402	PF00017	0.572
LIG_SH2_STAT5	497	500	PF00017	0.514
LIG_SH3_3	117	123	PF00018	0.534
LIG_SH3_3	714	720	PF00018	0.472
LIG_SUMO_SIM_anti_2	449	455	PF11976	0.469
LIG_SUMO_SIM_anti_2	684	689	PF11976	0.434
LIG_SUMO_SIM_par_1	186	191	PF11976	0.603
LIG_SUMO_SIM_par_1	275	281	PF11976	0.441
LIG_SUMO_SIM_par_1	383	388	PF11976	0.466
LIG_SUMO_SIM_par_1	524	532	PF11976	0.524
LIG_SUMO_SIM_par_1	652	658	PF11976	0.436
LIG_TRAF2_1	468	471	PF00917	0.541
LIG_TRAF2_1	726	729	PF00917	0.428
LIG_TRFH_1	179	183	PF08558	0.624
LIG_TYR_ITIM	106	111	PF00017	0.533
LIG_TYR_ITIM	268	273	PF00017	0.475
LIG_UBA3_1	81	88	PF00899	0.462
LIG_WW_3	316	320	PF00397	0.654
LIG_WW_3	735	739	PF00397	0.583
MOD_CDC14_SPxK_1	316	319	PF00782	0.659
MOD_CDK_SPxK_1	313	319	PF00069	0.661
MOD_CK1_1	142	148	PF00069	0.745
MOD_CK1_1	184	190	PF00069	0.619
MOD_CK1_1	20	26	PF00069	0.484
MOD_CK1_1	321	327	PF00069	0.638
MOD_CK1_1	413	419	PF00069	0.775
MOD_CK1_1	548	554	PF00069	0.483
MOD_CK1_1	578	584	PF00069	0.669
MOD_CK2_1	106	112	PF00069	0.424
MOD_CK2_1	465	471	PF00069	0.527
MOD_CK2_1	529	535	PF00069	0.568
MOD_CK2_1	548	554	PF00069	0.489
MOD_CK2_1	719	725	PF00069	0.420
MOD_GlcNHglycan	10	13	PF01048	0.573
MOD_GlcNHglycan	108	111	PF01048	0.593
MOD_GlcNHglycan	190	193	PF01048	0.561
MOD_GlcNHglycan	197	200	PF01048	0.456
MOD_GlcNHglycan	306	312	PF01048	0.571
MOD_GlcNHglycan	33	36	PF01048	0.588
MOD_GlcNHglycan	407	410	PF01048	0.762
MOD_GlcNHglycan	577	580	PF01048	0.699
MOD_GlcNHglycan	750	753	PF01048	0.614
MOD_GSK3_1	16	23	PF00069	0.468
MOD_GSK3_1	177	184	PF00069	0.586
MOD_GSK3_1	227	234	PF00069	0.627
MOD_GSK3_1	241	248	PF00069	0.549
MOD_GSK3_1	278	285	PF00069	0.433
MOD_GSK3_1	313	320	PF00069	0.707
MOD_GSK3_1	393	400	PF00069	0.517
MOD_GSK3_1	401	408	PF00069	0.649
MOD_GSK3_1	410	417	PF00069	0.638
MOD_GSK3_1	425	432	PF00069	0.628
MOD_GSK3_1	544	551	PF00069	0.567
MOD_GSK3_1	719	726	PF00069	0.493
MOD_LATS_1	132	138	PF00433	0.569
MOD_LATS_1	698	704	PF00433	0.461
MOD_N-GLC_1	139	144	PF02516	0.623
MOD_NEK2_1	188	193	PF00069	0.530
MOD_NEK2_1	385	390	PF00069	0.484
MOD_NEK2_1	425	430	PF00069	0.659
MOD_NEK2_1	434	439	PF00069	0.624
MOD_NEK2_1	545	550	PF00069	0.370
MOD_NEK2_1	688	693	PF00069	0.459
MOD_NEK2_1	748	753	PF00069	0.526
MOD_PIKK_1	227	233	PF00454	0.544
MOD_PIKK_1	393	399	PF00454	0.451
MOD_PIKK_1	601	607	PF00454	0.519
MOD_PKA_1	8	14	PF00069	0.597
MOD_PKA_2	133	139	PF00069	0.615
MOD_PKA_2	184	190	PF00069	0.557
MOD_PKA_2	318	324	PF00069	0.617
MOD_PKA_2	425	431	PF00069	0.652
MOD_PKA_2	456	462	PF00069	0.569
MOD_PKA_2	557	563	PF00069	0.605
MOD_PKA_2	72	78	PF00069	0.519
MOD_PKA_2	8	14	PF00069	0.552
MOD_Plk_1	123	129	PF00069	0.665
MOD_Plk_1	26	32	PF00069	0.465
MOD_Plk_2-3	529	535	PF00069	0.568
MOD_Plk_4	17	23	PF00069	0.378
MOD_Plk_4	177	183	PF00069	0.643
MOD_Plk_4	184	190	PF00069	0.548
MOD_Plk_4	74	80	PF00069	0.439
MOD_ProDKin_1	313	319	PF00069	0.799
MOD_ProDKin_1	397	403	PF00069	0.573
MOD_ProDKin_1	414	420	PF00069	0.663
MOD_ProDKin_1	51	57	PF00069	0.614
MOD_ProDKin_1	578	584	PF00069	0.599
MOD_SUMO_for_1	292	295	PF00179	0.514
MOD_SUMO_rev_2	725	733	PF00179	0.405
TRG_DiLeu_BaEn_4	470	476	PF01217	0.495
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.471
TRG_ENDOCYTIC_2	108	111	PF00928	0.423
TRG_ENDOCYTIC_2	270	273	PF00928	0.465
TRG_ENDOCYTIC_2	4	7	PF00928	0.570
TRG_ENDOCYTIC_2	448	451	PF00928	0.465
TRG_ENDOCYTIC_2	542	545	PF00928	0.380
TRG_ENDOCYTIC_2	632	635	PF00928	0.361
TRG_ENDOCYTIC_2	640	643	PF00928	0.391
TRG_ER_diArg_1	127	129	PF00400	0.693
TRG_ER_diArg_1	498	500	PF00400	0.530
TRG_ER_diArg_1	555	558	PF00400	0.451
TRG_ER_diArg_1	699	702	PF00400	0.404
TRG_ER_diArg_1	7	9	PF00400	0.638
TRG_ER_diArg_1	760	762	PF00400	0.618
TRG_NES_CRM1_1	517	531	PF08389	0.521
TRG_NES_CRM1_1	76	90	PF08389	0.419
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXP3	Leptomonas seymouri	54%	100%
A0A3R7K270	Trypanosoma rangeli	34%	100%
A4H4R4	Leishmania braziliensis	81%	98%
A4HSZ3	Leishmania infantum	100%	100%
C9ZTM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QIX5	Leishmania major	93%	100%