NADH:flavin oxidoreductase / NADH oxidase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S5H5T4_LEIDO

TriTrypDb:

LdBPK_060960.1 , LdCL_060014700 , LDHU3_06.1100

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

A0A3S5H5T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5T4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0010181	FMN binding	4	19
GO:0016491	oxidoreductase activity	2	19
GO:0032553	ribonucleotide binding	3	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0097159	organic cyclic compound binding	2	19
GO:0097367	carbohydrate derivative binding	2	19
GO:1901265	nucleoside phosphate binding	3	19
GO:1901363	heterocyclic compound binding	2	19
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	5
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.565
CLV_C14_Caspase3-7	701	705	PF00656	0.268
CLV_NRD_NRD_1	131	133	PF00675	0.275
CLV_NRD_NRD_1	215	217	PF00675	0.275
CLV_NRD_NRD_1	406	408	PF00675	0.441
CLV_NRD_NRD_1	428	430	PF00675	0.299
CLV_NRD_NRD_1	506	508	PF00675	0.280
CLV_NRD_NRD_1	537	539	PF00675	0.294
CLV_NRD_NRD_1	650	652	PF00675	0.299
CLV_PCSK_KEX2_1	133	135	PF00082	0.237
CLV_PCSK_KEX2_1	215	217	PF00082	0.267
CLV_PCSK_KEX2_1	428	430	PF00082	0.299
CLV_PCSK_KEX2_1	450	452	PF00082	0.397
CLV_PCSK_KEX2_1	506	508	PF00082	0.280
CLV_PCSK_KEX2_1	537	539	PF00082	0.294
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.291
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.397
CLV_PCSK_PC7_1	129	135	PF00082	0.236
CLV_PCSK_SKI1_1	21	25	PF00082	0.356
CLV_PCSK_SKI1_1	346	350	PF00082	0.260
CLV_PCSK_SKI1_1	402	406	PF00082	0.554
CLV_PCSK_SKI1_1	594	598	PF00082	0.335
CLV_PCSK_SKI1_1	651	655	PF00082	0.308
CLV_PCSK_SKI1_1	92	96	PF00082	0.304
DEG_APCC_DBOX_1	241	249	PF00400	0.505
DEG_APCC_KENBOX_2	454	458	PF00400	0.262
DEG_SCF_FBW7_2	250	257	PF00400	0.476
DOC_CKS1_1	22	27	PF01111	0.467
DOC_CYCLIN_RxL_1	343	351	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.449
DOC_MAPK_gen_1	215	223	PF00069	0.491
DOC_MAPK_gen_1	428	435	PF00069	0.299
DOC_MAPK_gen_1	467	476	PF00069	0.362
DOC_MAPK_gen_1	560	569	PF00069	0.280
DOC_MAPK_gen_1	588	598	PF00069	0.290
DOC_MAPK_gen_1	89	97	PF00069	0.524
DOC_MAPK_MEF2A_6	215	223	PF00069	0.470
DOC_MAPK_MEF2A_6	470	478	PF00069	0.355
DOC_MAPK_MEF2A_6	560	569	PF00069	0.280
DOC_PP2B_LxvP_1	521	524	PF13499	0.334
DOC_PP4_FxxP_1	653	656	PF00568	0.336
DOC_USP7_MATH_1	112	116	PF00917	0.496
DOC_USP7_MATH_1	17	21	PF00917	0.425
DOC_USP7_MATH_1	360	364	PF00917	0.528
DOC_USP7_MATH_1	500	504	PF00917	0.280
DOC_USP7_MATH_1	514	518	PF00917	0.309
DOC_USP7_MATH_1	559	563	PF00917	0.333
DOC_USP7_UBL2_3	332	336	PF12436	0.513
DOC_USP7_UBL2_3	617	621	PF12436	0.376
DOC_USP7_UBL2_3	681	685	PF12436	0.322
DOC_WW_Pin1_4	139	144	PF00397	0.464
DOC_WW_Pin1_4	21	26	PF00397	0.286
DOC_WW_Pin1_4	250	255	PF00397	0.476
DOC_WW_Pin1_4	280	285	PF00397	0.436
DOC_WW_Pin1_4	581	586	PF00397	0.390
LIG_14-3-3_CanoR_1	134	143	PF00244	0.452
LIG_14-3-3_CanoR_1	150	154	PF00244	0.442
LIG_14-3-3_CanoR_1	384	392	PF00244	0.312
LIG_14-3-3_CanoR_1	402	407	PF00244	0.244
LIG_14-3-3_CanoR_1	470	478	PF00244	0.340
LIG_14-3-3_CanoR_1	506	513	PF00244	0.314
LIG_Actin_WH2_2	234	251	PF00022	0.449
LIG_APCC_ABBA_1	565	570	PF00400	0.280
LIG_BIR_II_1	1	5	PF00653	0.709
LIG_BIR_III_4	207	211	PF00653	0.436
LIG_BIR_III_4	637	641	PF00653	0.404
LIG_BRCT_BRCA1_1	19	23	PF00533	0.398
LIG_BRCT_BRCA1_1	649	653	PF00533	0.274
LIG_FHA_1	108	114	PF00498	0.460
LIG_FHA_1	218	224	PF00498	0.493
LIG_FHA_1	254	260	PF00498	0.453
LIG_FHA_1	324	330	PF00498	0.465
LIG_FHA_1	384	390	PF00498	0.334
LIG_FHA_1	419	425	PF00498	0.299
LIG_FHA_1	464	470	PF00498	0.307
LIG_FHA_1	82	88	PF00498	0.436
LIG_FHA_2	202	208	PF00498	0.491
LIG_FHA_2	432	438	PF00498	0.293
LIG_FHA_2	481	487	PF00498	0.326
LIG_HOMEOBOX	677	680	PF00046	0.299
LIG_LIR_Apic_2	152	158	PF02991	0.530
LIG_LIR_Apic_2	650	656	PF02991	0.388
LIG_LIR_Gen_1	167	176	PF02991	0.485
LIG_LIR_Gen_1	456	464	PF02991	0.270
LIG_LIR_Gen_1	674	684	PF02991	0.280
LIG_LIR_Nem_3	167	172	PF02991	0.491
LIG_LIR_Nem_3	178	184	PF02991	0.412
LIG_LIR_Nem_3	20	26	PF02991	0.314
LIG_LIR_Nem_3	693	697	PF02991	0.282
LIG_PCNA_PIPBox_1	59	68	PF02747	0.449
LIG_PCNA_yPIPBox_3	373	384	PF02747	0.346
LIG_PDZ_Class_2	725	730	PF00595	0.351
LIG_PTB_Apo_2	33	40	PF02174	0.524
LIG_PTB_Apo_2	666	673	PF02174	0.411
LIG_PTB_Phospho_1	33	39	PF10480	0.524
LIG_PTB_Phospho_1	666	672	PF10480	0.377
LIG_REV1ctd_RIR_1	63	73	PF16727	0.491
LIG_SH2_CRK	155	159	PF00017	0.438
LIG_SH2_CRK	39	43	PF00017	0.436
LIG_SH2_GRB2like	44	47	PF00017	0.436
LIG_SH2_SRC	291	294	PF00017	0.524
LIG_SH2_SRC	724	727	PF00017	0.360
LIG_SH2_STAP1	169	173	PF00017	0.491
LIG_SH2_STAT3	380	383	PF00017	0.374
LIG_SH2_STAT3	395	398	PF00017	0.375
LIG_SH2_STAT5	119	122	PF00017	0.527
LIG_SH2_STAT5	164	167	PF00017	0.452
LIG_SH2_STAT5	291	294	PF00017	0.468
LIG_SH2_STAT5	354	357	PF00017	0.524
LIG_SH2_STAT5	44	47	PF00017	0.436
LIG_SH2_STAT5	568	571	PF00017	0.301
LIG_SH2_STAT5	697	700	PF00017	0.296
LIG_SH2_STAT5	706	709	PF00017	0.520
LIG_SH3_2	145	150	PF14604	0.460
LIG_SH3_3	142	148	PF00018	0.428
LIG_SH3_3	181	187	PF00018	0.524
LIG_SH3_3	341	347	PF00018	0.527
LIG_SH3_3	584	590	PF00018	0.364
LIG_SUMO_SIM_anti_2	409	414	PF11976	0.325
LIG_SUMO_SIM_par_1	325	331	PF11976	0.410
LIG_TRAF2_1	483	486	PF00917	0.397
LIG_WRC_WIRS_1	551	556	PF05994	0.404
LIG_WRC_WIRS_1	97	102	PF05994	0.524
MOD_CDK_SPxK_1	21	27	PF00069	0.404
MOD_CDK_SPxxK_3	581	588	PF00069	0.280
MOD_CK1_1	107	113	PF00069	0.460
MOD_CK1_1	138	144	PF00069	0.443
MOD_CK1_1	189	195	PF00069	0.506
MOD_CK1_1	363	369	PF00069	0.421
MOD_CK1_1	4	10	PF00069	0.547
MOD_CK1_1	695	701	PF00069	0.356
MOD_CK2_1	164	170	PF00069	0.467
MOD_CK2_1	390	396	PF00069	0.337
MOD_CK2_1	431	437	PF00069	0.297
MOD_CK2_1	480	486	PF00069	0.368
MOD_Cter_Amidation	535	538	PF01082	0.297
MOD_GlcNHglycan	11	14	PF01048	0.640
MOD_GlcNHglycan	137	140	PF01048	0.300
MOD_GlcNHglycan	199	202	PF01048	0.291
MOD_GlcNHglycan	267	270	PF01048	0.278
MOD_GlcNHglycan	288	291	PF01048	0.314
MOD_GlcNHglycan	392	395	PF01048	0.289
MOD_GSK3_1	1	8	PF00069	0.543
MOD_GSK3_1	135	142	PF00069	0.420
MOD_GSK3_1	17	24	PF00069	0.270
MOD_GSK3_1	197	204	PF00069	0.526
MOD_GSK3_1	223	230	PF00069	0.470
MOD_GSK3_1	280	287	PF00069	0.445
MOD_GSK3_1	293	300	PF00069	0.429
MOD_GSK3_1	323	330	PF00069	0.517
MOD_GSK3_1	402	409	PF00069	0.464
MOD_GSK3_1	418	425	PF00069	0.321
MOD_GSK3_1	559	566	PF00069	0.407
MOD_GSK3_1	577	584	PF00069	0.433
MOD_GSK3_1	622	629	PF00069	0.352
MOD_GSK3_1	698	705	PF00069	0.286
MOD_N-GLC_1	274	279	PF02516	0.287
MOD_N-GLC_1	668	673	PF02516	0.280
MOD_N-GLC_2	373	375	PF02516	0.322
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	197	202	PF00069	0.449
MOD_NEK2_1	217	222	PF00069	0.324
MOD_NEK2_1	255	260	PF00069	0.515
MOD_NEK2_1	265	270	PF00069	0.424
MOD_NEK2_1	273	278	PF00069	0.396
MOD_NEK2_1	297	302	PF00069	0.457
MOD_NEK2_1	469	474	PF00069	0.282
MOD_NEK2_1	529	534	PF00069	0.280
MOD_NEK2_1	82	87	PF00069	0.439
MOD_NEK2_2	692	697	PF00069	0.420
MOD_PIKK_1	107	113	PF00454	0.410
MOD_PK_1	470	476	PF00069	0.404
MOD_PKA_1	506	512	PF00069	0.280
MOD_PKA_2	107	113	PF00069	0.467
MOD_PKA_2	149	155	PF00069	0.560
MOD_PKA_2	306	312	PF00069	0.554
MOD_PKA_2	383	389	PF00069	0.327
MOD_PKA_2	406	412	PF00069	0.404
MOD_PKA_2	469	475	PF00069	0.311
MOD_PKA_2	506	512	PF00069	0.280
MOD_PKA_2	559	565	PF00069	0.280
MOD_PKA_2	702	708	PF00069	0.448
MOD_Plk_1	217	223	PF00069	0.525
MOD_Plk_1	274	280	PF00069	0.517
MOD_Plk_1	363	369	PF00069	0.473
MOD_Plk_1	431	437	PF00069	0.268
MOD_Plk_1	563	569	PF00069	0.439
MOD_Plk_1	668	674	PF00069	0.311
MOD_Plk_1	692	698	PF00069	0.325
MOD_Plk_4	189	195	PF00069	0.529
MOD_Plk_4	422	428	PF00069	0.298
MOD_Plk_4	431	437	PF00069	0.296
MOD_Plk_4	550	556	PF00069	0.273
MOD_Plk_4	563	569	PF00069	0.425
MOD_Plk_4	577	583	PF00069	0.352
MOD_Plk_4	594	600	PF00069	0.355
MOD_Plk_4	623	629	PF00069	0.277
MOD_Plk_4	656	662	PF00069	0.325
MOD_Plk_4	671	677	PF00069	0.278
MOD_ProDKin_1	139	145	PF00069	0.464
MOD_ProDKin_1	21	27	PF00069	0.286
MOD_ProDKin_1	250	256	PF00069	0.476
MOD_ProDKin_1	280	286	PF00069	0.436
MOD_ProDKin_1	581	587	PF00069	0.390
TRG_DiLeu_BaEn_1	577	582	PF01217	0.404
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.433
TRG_DiLeu_BaLyEn_6	517	522	PF01217	0.388
TRG_ENDOCYTIC_2	169	172	PF00928	0.498
TRG_ENDOCYTIC_2	44	47	PF00928	0.436
TRG_ENDOCYTIC_2	458	461	PF00928	0.258
TRG_ENDOCYTIC_2	677	680	PF00928	0.320
TRG_ER_diArg_1	215	217	PF00400	0.468
TRG_ER_diArg_1	427	429	PF00400	0.299
TRG_ER_diArg_1	505	507	PF00400	0.280
TRG_ER_diArg_1	537	539	PF00400	0.294
TRG_NLS_MonoExtN_4	129	136	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	346	351	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	467	471	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	31%	100%
A0A0N0P5L6	Leptomonas seymouri	83%	100%
A0A0S4JCH5	Bodo saltans	55%	100%
A0A0S4JST7	Bodo saltans	32%	100%
A0A1X0NKW1	Trypanosomatidae	68%	100%
A0A1X0NU55	Trypanosomatidae	32%	100%
A0A3S7X6G9	Leishmania donovani	31%	100%
A4H4Q6	Leishmania braziliensis	91%	100%
A4HLD7	Leishmania braziliensis	31%	100%
A4HSY5	Leishmania infantum	100%	100%
A4I8U6	Leishmania infantum	32%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	28%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	29%	100%
P16099	Methylophilus methylotrophus	25%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	28%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	26%	100%
P32382	Thermoanaerobacter brockii	27%	100%
P42593	Escherichia coli (strain K12)	31%	100%
Q48303	Hyphomicrobium sp. (strain x)	26%	99%
Q4Q4A9	Leishmania major	32%	100%
Q4QIY4	Leishmania major	97%	100%
V5AR23	Trypanosoma cruzi	32%	100%
V5BNI9	Trypanosoma cruzi	70%	100%