Exosome-associated protein 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S5H5S8_LEIDO

TriTrypDb:

LdBPK_060870.1 , LdCL_060013800 , LDHU3_06.1010

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S5H5S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.632
CLV_NRD_NRD_1	122	124	PF00675	0.554
CLV_NRD_NRD_1	150	152	PF00675	0.539
CLV_NRD_NRD_1	30	32	PF00675	0.404
CLV_PCSK_FUR_1	120	124	PF00082	0.465
CLV_PCSK_KEX2_1	122	124	PF00082	0.467
CLV_PCSK_KEX2_1	148	150	PF00082	0.593
CLV_PCSK_KEX2_1	16	18	PF00082	0.538
CLV_PCSK_KEX2_1	30	32	PF00082	0.550
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.593
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.513
CLV_PCSK_PC7_1	12	18	PF00082	0.515
CLV_PCSK_SKI1_1	215	219	PF00082	0.553
DEG_Nend_UBRbox_2	1	3	PF02207	0.537
DEG_SPOP_SBC_1	84	88	PF00917	0.616
DOC_MAPK_gen_1	110	118	PF00069	0.517
DOC_USP7_MATH_1	128	132	PF00917	0.542
DOC_USP7_MATH_1	147	151	PF00917	0.738
DOC_USP7_MATH_1	220	224	PF00917	0.674
DOC_USP7_MATH_1	78	82	PF00917	0.722
DOC_USP7_MATH_1	85	89	PF00917	0.684
DOC_USP7_UBL2_3	148	152	PF12436	0.543
DOC_WW_Pin1_4	141	146	PF00397	0.536
LIG_14-3-3_CanoR_1	104	112	PF00244	0.446
LIG_14-3-3_CanoR_1	151	161	PF00244	0.517
LIG_14-3-3_CanoR_1	48	57	PF00244	0.386
LIG_BIR_III_4	191	195	PF00653	0.524
LIG_BRCT_BRCA1_1	51	55	PF00533	0.494
LIG_CaM_IQ_9	109	125	PF13499	0.357
LIG_Clathr_ClatBox_1	115	119	PF01394	0.442
LIG_FHA_1	104	110	PF00498	0.480
LIG_FHA_1	156	162	PF00498	0.550
LIG_FHA_1	207	213	PF00498	0.512
LIG_FHA_1	54	60	PF00498	0.477
LIG_SH2_STAT5	108	111	PF00017	0.389
LIG_SH2_STAT5	50	53	PF00017	0.454
LIG_SUMO_SIM_par_1	55	60	PF11976	0.422
LIG_UBA3_1	10	16	PF00899	0.512
LIG_Vh1_VBS_1	198	216	PF01044	0.539
MOD_CDK_SPxxK_3	141	148	PF00069	0.538
MOD_CK1_1	124	130	PF00069	0.635
MOD_CK1_1	155	161	PF00069	0.653
MOD_CK1_1	180	186	PF00069	0.708
MOD_CK1_1	200	206	PF00069	0.525
MOD_CK1_1	39	45	PF00069	0.483
MOD_CK1_1	60	66	PF00069	0.461
MOD_CK1_1	88	94	PF00069	0.615
MOD_CK2_1	183	189	PF00069	0.718
MOD_CK2_1	2	8	PF00069	0.543
MOD_CK2_1	226	232	PF00069	0.622
MOD_CK2_1	39	45	PF00069	0.476
MOD_GlcNHglycan	123	126	PF01048	0.574
MOD_GlcNHglycan	130	133	PF01048	0.550
MOD_GlcNHglycan	154	157	PF01048	0.657
MOD_GlcNHglycan	223	226	PF01048	0.643
MOD_GlcNHglycan	51	54	PF01048	0.440
MOD_GlcNHglycan	73	76	PF01048	0.714
MOD_GlcNHglycan	80	83	PF01048	0.519
MOD_GlcNHglycan	90	93	PF01048	0.460
MOD_GSK3_1	124	131	PF00069	0.511
MOD_GSK3_1	49	56	PF00069	0.472
MOD_GSK3_1	83	90	PF00069	0.682
MOD_NEK2_1	226	231	PF00069	0.748
MOD_NEK2_1	49	54	PF00069	0.474
MOD_NEK2_1	55	60	PF00069	0.491
MOD_NEK2_1	83	88	PF00069	0.486
MOD_PIKK_1	93	99	PF00454	0.530
MOD_PKA_2	103	109	PF00069	0.402
MOD_PKA_2	121	127	PF00069	0.551
MOD_Plk_1	33	39	PF00069	0.483
MOD_Plk_2-3	2	8	PF00069	0.563
MOD_Plk_4	208	214	PF00069	0.505
MOD_Plk_4	33	39	PF00069	0.569
MOD_Plk_4	57	63	PF00069	0.500
MOD_ProDKin_1	141	147	PF00069	0.537
MOD_SUMO_for_1	100	103	PF00179	0.440
MOD_SUMO_for_1	116	119	PF00179	0.449
TRG_DiLeu_BaEn_1	208	213	PF01217	0.567
TRG_DiLeu_LyEn_5	6	11	PF01217	0.614
TRG_ER_diArg_1	120	123	PF00400	0.466
TRG_ER_diArg_1	29	31	PF00400	0.555
TRG_NES_CRM1_1	107	119	PF08389	0.427
TRG_NES_CRM1_1	8	24	PF08389	0.481
TRG_NLS_MonoExtC_3	147	152	PF00514	0.544
TRG_NLS_MonoExtC_3	170	176	PF00514	0.683
TRG_NLS_MonoExtN_4	145	152	PF00514	0.789
TRG_NLS_MonoExtN_4	169	175	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3M9	Leptomonas seymouri	60%	97%
A0A1X0NKL8	Trypanosomatidae	24%	99%
A0A3R7KNC7	Trypanosoma rangeli	31%	100%
A4H4P6	Leishmania braziliensis	67%	97%
A4HSX6	Leishmania infantum	99%	100%
C9ZTK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AKW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIZ3	Leishmania major	91%	100%
V5BNH6	Trypanosoma cruzi	31%	100%