Hemolysin-III related, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5S3_LEIDO

TriTrypDb:

LdBPK_060780.1 , LdCL_060012900 , LDHU3_06.0910

Length:

669

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S5H5S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5S3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	1
GO:0060089	molecular transducer activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.540
CLV_C14_Caspase3-7	243	247	PF00656	0.471
CLV_NRD_NRD_1	291	293	PF00675	0.534
CLV_NRD_NRD_1	38	40	PF00675	0.483
CLV_NRD_NRD_1	530	532	PF00675	0.437
CLV_NRD_NRD_1	537	539	PF00675	0.440
CLV_NRD_NRD_1	553	555	PF00675	0.427
CLV_NRD_NRD_1	58	60	PF00675	0.238
CLV_NRD_NRD_1	66	68	PF00675	0.414
CLV_PCSK_FUR_1	289	293	PF00082	0.534
CLV_PCSK_KEX2_1	291	293	PF00082	0.534
CLV_PCSK_KEX2_1	38	40	PF00082	0.483
CLV_PCSK_KEX2_1	530	532	PF00082	0.437
CLV_PCSK_KEX2_1	537	539	PF00082	0.440
CLV_PCSK_KEX2_1	553	555	PF00082	0.427
CLV_PCSK_KEX2_1	58	60	PF00082	0.238
CLV_PCSK_KEX2_1	68	70	PF00082	0.412
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.412
CLV_PCSK_PC7_1	64	70	PF00082	0.415
CLV_PCSK_SKI1_1	205	209	PF00082	0.322
CLV_PCSK_SKI1_1	32	36	PF00082	0.376
CLV_PCSK_SKI1_1	69	73	PF00082	0.467
DEG_APCC_DBOX_1	68	76	PF00400	0.672
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SPOP_SBC_1	215	219	PF00917	0.489
DEG_SPOP_SBC_1	569	573	PF00917	0.787
DEG_SPOP_SBC_1	598	602	PF00917	0.695
DOC_MAPK_DCC_7	259	269	PF00069	0.618
DOC_MAPK_DCC_7	614	622	PF00069	0.742
DOC_MAPK_gen_1	38	44	PF00069	0.589
DOC_MAPK_MEF2A_6	614	622	PF00069	0.742
DOC_PP2B_LxvP_1	101	104	PF13499	0.411
DOC_PP2B_LxvP_1	249	252	PF13499	0.549
DOC_PP2B_LxvP_1	411	414	PF13499	0.741
DOC_PP2B_LxvP_1	615	618	PF13499	0.738
DOC_USP7_MATH_1	108	112	PF00917	0.327
DOC_USP7_MATH_1	131	135	PF00917	0.446
DOC_USP7_MATH_1	176	180	PF00917	0.574
DOC_USP7_MATH_1	215	219	PF00917	0.548
DOC_USP7_MATH_1	233	237	PF00917	0.584
DOC_USP7_MATH_1	386	390	PF00917	0.666
DOC_USP7_MATH_1	451	455	PF00917	0.703
DOC_USP7_MATH_1	567	571	PF00917	0.792
DOC_USP7_MATH_1	71	75	PF00917	0.559
DOC_USP7_MATH_2	413	419	PF00917	0.662
DOC_WW_Pin1_4	13	18	PF00397	0.801
DOC_WW_Pin1_4	216	221	PF00397	0.618
DOC_WW_Pin1_4	234	239	PF00397	0.416
DOC_WW_Pin1_4	262	267	PF00397	0.409
DOC_WW_Pin1_4	580	585	PF00397	0.752
DOC_WW_Pin1_4	600	605	PF00397	0.562
LIG_14-3-3_CanoR_1	156	166	PF00244	0.537
LIG_14-3-3_CanoR_1	223	229	PF00244	0.545
LIG_14-3-3_CanoR_1	259	265	PF00244	0.546
LIG_14-3-3_CanoR_1	431	437	PF00244	0.709
LIG_14-3-3_CanoR_1	465	469	PF00244	0.545
LIG_14-3-3_CanoR_1	5	11	PF00244	0.705
LIG_APCC_ABBA_1	654	659	PF00400	0.568
LIG_BIR_III_4	562	566	PF00653	0.699
LIG_BRCT_BRCA1_1	218	222	PF00533	0.618
LIG_CSL_BTD_1	101	104	PF09270	0.411
LIG_deltaCOP1_diTrp_1	48	53	PF00928	0.602
LIG_eIF4E_1	478	484	PF01652	0.306
LIG_EVH1_1	249	253	PF00568	0.618
LIG_FHA_1	263	269	PF00498	0.374
LIG_FHA_1	330	336	PF00498	0.405
LIG_FHA_1	39	45	PF00498	0.613
LIG_FHA_1	534	540	PF00498	0.710
LIG_FHA_1	594	600	PF00498	0.667
LIG_FHA_1	606	612	PF00498	0.612
LIG_FHA_1	621	627	PF00498	0.663
LIG_FHA_1	81	87	PF00498	0.598
LIG_FHA_2	184	190	PF00498	0.544
LIG_FHA_2	451	457	PF00498	0.774
LIG_FHA_2	608	614	PF00498	0.765
LIG_GBD_Chelix_1	241	249	PF00786	0.345
LIG_GBD_Chelix_1	256	264	PF00786	0.334
LIG_GBD_Chelix_1	375	383	PF00786	0.512
LIG_IBAR_NPY_1	54	56	PF08397	0.666
LIG_LIR_Gen_1	25	34	PF02991	0.637
LIG_LIR_Gen_1	278	286	PF02991	0.411
LIG_LIR_Gen_1	312	322	PF02991	0.512
LIG_LIR_Gen_1	48	57	PF02991	0.596
LIG_LIR_Gen_1	505	515	PF02991	0.346
LIG_LIR_Gen_1	610	620	PF02991	0.751
LIG_LIR_Gen_1	82	92	PF02991	0.572
LIG_LIR_Nem_3	116	122	PF02991	0.319
LIG_LIR_Nem_3	219	225	PF02991	0.541
LIG_LIR_Nem_3	25	30	PF02991	0.640
LIG_LIR_Nem_3	278	284	PF02991	0.411
LIG_LIR_Nem_3	312	317	PF02991	0.512
LIG_LIR_Nem_3	48	53	PF02991	0.602
LIG_LIR_Nem_3	505	511	PF02991	0.398
LIG_LIR_Nem_3	610	615	PF02991	0.688
LIG_LIR_Nem_3	662	666	PF02991	0.598
LIG_LIR_Nem_3	82	87	PF02991	0.572
LIG_NRBOX	268	274	PF00104	0.372
LIG_NRBOX	94	100	PF00104	0.428
LIG_PCNA_yPIPBox_3	292	306	PF02747	0.346
LIG_PCNA_yPIPBox_3	419	427	PF02747	0.597
LIG_Pex14_2	271	275	PF04695	0.368
LIG_Pex14_2	61	65	PF04695	0.628
LIG_PTAP_UEV_1	387	392	PF05743	0.673
LIG_PTB_Apo_2	500	507	PF02174	0.384
LIG_PTB_Apo_2	78	85	PF02174	0.546
LIG_PTB_Phospho_1	500	506	PF10480	0.380
LIG_SH2_CRK	119	123	PF00017	0.271
LIG_SH2_CRK	294	298	PF00017	0.346
LIG_SH2_CRK	472	476	PF00017	0.411
LIG_SH2_CRK	663	667	PF00017	0.608
LIG_SH2_GRB2like	501	504	PF00017	0.378
LIG_SH2_NCK_1	129	133	PF00017	0.450
LIG_SH2_NCK_1	663	667	PF00017	0.680
LIG_SH2_PTP2	345	348	PF00017	0.512
LIG_SH2_PTP2	478	481	PF00017	0.399
LIG_SH2_PTP2	506	509	PF00017	0.450
LIG_SH2_STAP1	129	133	PF00017	0.450
LIG_SH2_STAP1	434	438	PF00017	0.609
LIG_SH2_STAT3	434	437	PF00017	0.603
LIG_SH2_STAT5	129	132	PF00017	0.450
LIG_SH2_STAT5	145	148	PF00017	0.545
LIG_SH2_STAT5	316	319	PF00017	0.411
LIG_SH2_STAT5	327	330	PF00017	0.546
LIG_SH2_STAT5	345	348	PF00017	0.308
LIG_SH2_STAT5	472	475	PF00017	0.411
LIG_SH2_STAT5	478	481	PF00017	0.411
LIG_SH2_STAT5	506	509	PF00017	0.394
LIG_SH2_STAT5	56	59	PF00017	0.671
LIG_SH2_STAT5	624	627	PF00017	0.652
LIG_SH2_STAT5	633	636	PF00017	0.595
LIG_SH2_STAT5	78	81	PF00017	0.546
LIG_SH3_1	385	391	PF00018	0.585
LIG_SH3_3	232	238	PF00018	0.589
LIG_SH3_3	247	253	PF00018	0.618
LIG_SH3_3	345	351	PF00018	0.411
LIG_SH3_3	385	391	PF00018	0.663
LIG_SH3_3	407	413	PF00018	0.835
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.613
LIG_SUMO_SIM_par_1	40	46	PF11976	0.608
LIG_WRC_WIRS_1	272	277	PF05994	0.411
LIG_WW_3	102	106	PF00397	0.418
MOD_CDK_SPxxK_3	216	223	PF00069	0.574
MOD_CK1_1	179	185	PF00069	0.547
MOD_CK1_1	218	224	PF00069	0.598
MOD_CK1_1	22	28	PF00069	0.709
MOD_CK1_1	229	235	PF00069	0.498
MOD_CK1_1	570	576	PF00069	0.788
MOD_CK1_1	597	603	PF00069	0.717
MOD_CK1_1	627	633	PF00069	0.601
MOD_CK1_1	648	654	PF00069	0.562
MOD_CK1_1	8	14	PF00069	0.801
MOD_CK2_1	194	200	PF00069	0.586
MOD_CK2_1	40	46	PF00069	0.680
MOD_GlcNHglycan	110	113	PF01048	0.545
MOD_GlcNHglycan	133	136	PF01048	0.384
MOD_GlcNHglycan	178	181	PF01048	0.374
MOD_GlcNHglycan	196	199	PF01048	0.338
MOD_GlcNHglycan	21	24	PF01048	0.536
MOD_GlcNHglycan	228	231	PF01048	0.410
MOD_GlcNHglycan	242	245	PF01048	0.245
MOD_GlcNHglycan	246	249	PF01048	0.271
MOD_GlcNHglycan	309	312	PF01048	0.419
MOD_GlcNHglycan	388	391	PF01048	0.553
MOD_GlcNHglycan	460	463	PF01048	0.427
MOD_GlcNHglycan	575	578	PF01048	0.609
MOD_GlcNHglycan	626	629	PF01048	0.422
MOD_GlcNHglycan	647	650	PF01048	0.368
MOD_GSK3_1	104	111	PF00069	0.408
MOD_GSK3_1	127	134	PF00069	0.475
MOD_GSK3_1	179	186	PF00069	0.530
MOD_GSK3_1	18	25	PF00069	0.619
MOD_GSK3_1	194	201	PF00069	0.471
MOD_GSK3_1	214	221	PF00069	0.545
MOD_GSK3_1	229	236	PF00069	0.503
MOD_GSK3_1	240	247	PF00069	0.498
MOD_GSK3_1	258	265	PF00069	0.506
MOD_GSK3_1	271	278	PF00069	0.349
MOD_GSK3_1	5	12	PF00069	0.784
MOD_GSK3_1	569	576	PF00069	0.800
MOD_GSK3_1	593	600	PF00069	0.779
MOD_GSK3_1	620	627	PF00069	0.702
MOD_N-GLC_1	451	456	PF02516	0.433
MOD_N-GLC_1	502	507	PF02516	0.581
MOD_N-GLC_1	80	85	PF02516	0.346
MOD_NEK2_1	224	229	PF00069	0.578
MOD_NEK2_1	260	265	PF00069	0.504
MOD_NEK2_1	271	276	PF00069	0.352
MOD_NEK2_1	463	468	PF00069	0.587
MOD_NEK2_1	526	531	PF00069	0.619
MOD_NEK2_1	568	573	PF00069	0.680
MOD_NEK2_1	599	604	PF00069	0.725
MOD_NEK2_1	620	625	PF00069	0.740
MOD_NEK2_2	40	45	PF00069	0.606
MOD_PIKK_1	188	194	PF00454	0.471
MOD_PIKK_1	403	409	PF00454	0.788
MOD_PIKK_1	493	499	PF00454	0.453
MOD_PKA_1	38	44	PF00069	0.619
MOD_PKA_2	104	110	PF00069	0.418
MOD_PKA_2	258	264	PF00069	0.552
MOD_PKA_2	38	44	PF00069	0.699
MOD_PKA_2	403	409	PF00069	0.691
MOD_PKA_2	464	470	PF00069	0.545
MOD_PKA_2	533	539	PF00069	0.665
MOD_PKA_2	573	579	PF00069	0.801
MOD_PKB_1	3	11	PF00069	0.677
MOD_Plk_1	198	204	PF00069	0.489
MOD_Plk_1	32	38	PF00069	0.577
MOD_Plk_1	451	457	PF00069	0.627
MOD_Plk_1	502	508	PF00069	0.382
MOD_Plk_1	80	86	PF00069	0.546
MOD_Plk_4	164	170	PF00069	0.546
MOD_Plk_4	22	28	PF00069	0.658
MOD_Plk_4	271	277	PF00069	0.396
MOD_Plk_4	337	343	PF00069	0.411
MOD_Plk_4	464	470	PF00069	0.552
MOD_Plk_4	502	508	PF00069	0.367
MOD_Plk_4	594	600	PF00069	0.753
MOD_Plk_4	607	613	PF00069	0.660
MOD_Plk_4	620	626	PF00069	0.664
MOD_Plk_4	71	77	PF00069	0.596
MOD_ProDKin_1	13	19	PF00069	0.799
MOD_ProDKin_1	216	222	PF00069	0.618
MOD_ProDKin_1	234	240	PF00069	0.416
MOD_ProDKin_1	262	268	PF00069	0.409
MOD_ProDKin_1	580	586	PF00069	0.749
MOD_ProDKin_1	600	606	PF00069	0.561
TRG_ENDOCYTIC_2	119	122	PF00928	0.271
TRG_ENDOCYTIC_2	281	284	PF00928	0.343
TRG_ENDOCYTIC_2	294	297	PF00928	0.279
TRG_ENDOCYTIC_2	314	317	PF00928	0.183
TRG_ENDOCYTIC_2	345	348	PF00928	0.411
TRG_ENDOCYTIC_2	472	475	PF00928	0.411
TRG_ENDOCYTIC_2	478	481	PF00928	0.411
TRG_ENDOCYTIC_2	506	509	PF00928	0.433
TRG_ENDOCYTIC_2	658	661	PF00928	0.571
TRG_ENDOCYTIC_2	663	666	PF00928	0.609
TRG_ER_diArg_1	289	292	PF00400	0.334
TRG_ER_diArg_1	37	39	PF00400	0.678
TRG_ER_diArg_1	537	539	PF00400	0.640
TRG_ER_diArg_1	552	554	PF00400	0.624
TRG_ER_diArg_1	57	59	PF00400	0.438
TRG_ER_diArg_1	61	64	PF00400	0.593
TRG_ER_diArg_1	66	69	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X6	Leptomonas seymouri	45%	87%
A4H4N9	Leishmania braziliensis	73%	100%
A4HSW7	Leishmania infantum	100%	100%
E9AKV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QJ02	Leishmania major	90%	100%