LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S5H5R7_LEIDO
TriTrypDb:
LdBPK_060680.1 * , LdCL_060011900 , LDHU3_06.0800
Length:
679

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S5H5R7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5R7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.657
CLV_C14_Caspase3-7 201 205 PF00656 0.706
CLV_C14_Caspase3-7 610 614 PF00656 0.685
CLV_NRD_NRD_1 11 13 PF00675 0.636
CLV_NRD_NRD_1 252 254 PF00675 0.736
CLV_NRD_NRD_1 255 257 PF00675 0.699
CLV_NRD_NRD_1 272 274 PF00675 0.649
CLV_NRD_NRD_1 401 403 PF00675 0.657
CLV_NRD_NRD_1 411 413 PF00675 0.611
CLV_NRD_NRD_1 58 60 PF00675 0.725
CLV_PCSK_KEX2_1 11 13 PF00082 0.705
CLV_PCSK_KEX2_1 222 224 PF00082 0.806
CLV_PCSK_KEX2_1 252 254 PF00082 0.736
CLV_PCSK_KEX2_1 272 274 PF00082 0.728
CLV_PCSK_KEX2_1 401 403 PF00082 0.657
CLV_PCSK_KEX2_1 411 413 PF00082 0.611
CLV_PCSK_KEX2_1 58 60 PF00082 0.724
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.637
CLV_PCSK_PC1ET2_1 222 224 PF00082 0.699
CLV_PCSK_SKI1_1 277 281 PF00082 0.791
CLV_PCSK_SKI1_1 339 343 PF00082 0.687
CLV_PCSK_SKI1_1 402 406 PF00082 0.642
CLV_PCSK_SKI1_1 450 454 PF00082 0.606
DEG_APCC_DBOX_1 401 409 PF00400 0.572
DEG_COP1_1 519 529 PF00400 0.525
DEG_SPOP_SBC_1 261 265 PF00917 0.614
DEG_SPOP_SBC_1 543 547 PF00917 0.658
DOC_CKS1_1 384 389 PF01111 0.656
DOC_CYCLIN_RxL_1 447 457 PF00134 0.604
DOC_CYCLIN_yClb1_LxF_4 448 453 PF00134 0.592
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.588
DOC_MAPK_FxFP_2 676 679 PF00069 0.622
DOC_MAPK_gen_1 339 345 PF00069 0.578
DOC_MAPK_MEF2A_6 554 563 PF00069 0.675
DOC_PP1_RVXF_1 448 454 PF00149 0.593
DOC_PP2B_LxvP_1 244 247 PF13499 0.594
DOC_PP2B_LxvP_1 308 311 PF13499 0.713
DOC_PP2B_LxvP_1 561 564 PF13499 0.721
DOC_PP4_FxxP_1 404 407 PF00568 0.691
DOC_PP4_FxxP_1 504 507 PF00568 0.555
DOC_PP4_FxxP_1 676 679 PF00568 0.709
DOC_PP4_MxPP_1 433 436 PF00568 0.671
DOC_USP7_MATH_1 104 108 PF00917 0.512
DOC_USP7_MATH_1 117 121 PF00917 0.560
DOC_USP7_MATH_1 18 22 PF00917 0.815
DOC_USP7_MATH_1 212 216 PF00917 0.674
DOC_USP7_MATH_1 240 244 PF00917 0.740
DOC_USP7_MATH_1 261 265 PF00917 0.650
DOC_USP7_MATH_1 325 329 PF00917 0.826
DOC_USP7_MATH_1 33 37 PF00917 0.619
DOC_USP7_MATH_1 330 334 PF00917 0.761
DOC_USP7_MATH_1 41 45 PF00917 0.621
DOC_USP7_MATH_1 507 511 PF00917 0.654
DOC_USP7_MATH_1 51 55 PF00917 0.628
DOC_USP7_MATH_1 512 516 PF00917 0.608
DOC_USP7_MATH_1 525 529 PF00917 0.638
DOC_USP7_MATH_1 534 538 PF00917 0.666
DOC_USP7_MATH_1 548 552 PF00917 0.696
DOC_USP7_MATH_1 581 585 PF00917 0.611
DOC_USP7_MATH_1 617 621 PF00917 0.762
DOC_USP7_MATH_1 90 94 PF00917 0.758
DOC_USP7_UBL2_3 7 11 PF12436 0.632
DOC_WW_Pin1_4 131 136 PF00397 0.675
DOC_WW_Pin1_4 206 211 PF00397 0.698
DOC_WW_Pin1_4 222 227 PF00397 0.557
DOC_WW_Pin1_4 295 300 PF00397 0.665
DOC_WW_Pin1_4 321 326 PF00397 0.725
DOC_WW_Pin1_4 332 337 PF00397 0.664
DOC_WW_Pin1_4 377 382 PF00397 0.707
DOC_WW_Pin1_4 383 388 PF00397 0.677
DOC_WW_Pin1_4 403 408 PF00397 0.565
DOC_WW_Pin1_4 60 65 PF00397 0.678
DOC_WW_Pin1_4 670 675 PF00397 0.545
LIG_14-3-3_CanoR_1 291 299 PF00244 0.620
LIG_14-3-3_CanoR_1 427 433 PF00244 0.773
LIG_BRCT_BRCA1_1 672 676 PF00533 0.608
LIG_CSL_BTD_1 132 135 PF09270 0.679
LIG_FHA_1 197 203 PF00498 0.740
LIG_FHA_1 206 212 PF00498 0.611
LIG_FHA_1 33 39 PF00498 0.745
LIG_FHA_1 435 441 PF00498 0.759
LIG_FHA_1 463 469 PF00498 0.692
LIG_FHA_1 471 477 PF00498 0.582
LIG_FHA_1 517 523 PF00498 0.600
LIG_FHA_1 651 657 PF00498 0.640
LIG_FHA_2 132 138 PF00498 0.683
LIG_FHA_2 157 163 PF00498 0.629
LIG_FHA_2 199 205 PF00498 0.709
LIG_FHA_2 359 365 PF00498 0.779
LIG_FHA_2 644 650 PF00498 0.653
LIG_FHA_2 94 100 PF00498 0.667
LIG_Integrin_isoDGR_2 490 492 PF01839 0.586
LIG_LIR_Apic_2 429 435 PF02991 0.680
LIG_LIR_Apic_2 673 679 PF02991 0.613
LIG_LIR_Nem_3 618 624 PF02991 0.678
LIG_MYND_1 391 395 PF01753 0.572
LIG_Pex14_1 400 404 PF04695 0.692
LIG_SH2_CRK 414 418 PF00017 0.620
LIG_SH2_CRK 432 436 PF00017 0.675
LIG_SH2_CRK 621 625 PF00017 0.676
LIG_SH2_GRB2like 414 417 PF00017 0.619
LIG_SH2_NCK_1 414 418 PF00017 0.707
LIG_SH2_SRC 648 651 PF00017 0.656
LIG_SH2_STAT5 295 298 PF00017 0.690
LIG_SH2_STAT5 414 417 PF00017 0.707
LIG_SH2_STAT5 439 442 PF00017 0.693
LIG_SH2_STAT5 634 637 PF00017 0.731
LIG_SH3_2 64 69 PF14604 0.600
LIG_SH3_3 189 195 PF00018 0.688
LIG_SH3_3 213 219 PF00018 0.657
LIG_SH3_3 293 299 PF00018 0.665
LIG_SH3_3 301 307 PF00018 0.602
LIG_SH3_3 319 325 PF00018 0.581
LIG_SH3_3 342 348 PF00018 0.671
LIG_SH3_3 389 395 PF00018 0.709
LIG_SH3_3 495 501 PF00018 0.635
LIG_SH3_3 609 615 PF00018 0.601
LIG_SH3_3 61 67 PF00018 0.662
LIG_SH3_3 621 627 PF00018 0.668
LIG_SH3_3 659 665 PF00018 0.568
LIG_SH3_3 84 90 PF00018 0.727
LIG_SH3_CIN85_PxpxPR_1 247 252 PF14604 0.643
LIG_SH3_CIN85_PxpxPR_1 307 312 PF14604 0.642
LIG_SxIP_EBH_1 401 414 PF03271 0.688
LIG_TRAF2_1 623 626 PF00917 0.664
LIG_TYR_ITIM 619 624 PF00017 0.676
LIG_WW_3 447 451 PF00397 0.656
MOD_CDC14_SPxK_1 66 69 PF00782 0.604
MOD_CDK_SPK_2 222 227 PF00069 0.714
MOD_CDK_SPK_2 60 65 PF00069 0.667
MOD_CDK_SPxK_1 63 69 PF00069 0.623
MOD_CDK_SPxxK_3 332 339 PF00069 0.639
MOD_CK1_1 127 133 PF00069 0.720
MOD_CK1_1 158 164 PF00069 0.709
MOD_CK1_1 225 231 PF00069 0.684
MOD_CK1_1 239 245 PF00069 0.552
MOD_CK1_1 259 265 PF00069 0.692
MOD_CK1_1 328 334 PF00069 0.735
MOD_CK1_1 520 526 PF00069 0.661
MOD_CK1_1 550 556 PF00069 0.720
MOD_CK1_1 63 69 PF00069 0.670
MOD_CK1_1 644 650 PF00069 0.653
MOD_CK1_1 93 99 PF00069 0.713
MOD_CK2_1 131 137 PF00069 0.683
MOD_CK2_1 156 162 PF00069 0.647
MOD_CK2_1 358 364 PF00069 0.684
MOD_CK2_1 643 649 PF00069 0.656
MOD_CK2_1 93 99 PF00069 0.784
MOD_GlcNHglycan 20 23 PF01048 0.706
MOD_GlcNHglycan 236 239 PF01048 0.750
MOD_GlcNHglycan 396 399 PF01048 0.624
MOD_GlcNHglycan 49 52 PF01048 0.654
MOD_GlcNHglycan 498 501 PF01048 0.629
MOD_GlcNHglycan 53 56 PF01048 0.638
MOD_GlcNHglycan 531 534 PF01048 0.766
MOD_GlcNHglycan 536 539 PF01048 0.709
MOD_GlcNHglycan 540 543 PF01048 0.595
MOD_GlcNHglycan 615 618 PF01048 0.670
MOD_GSK3_1 127 134 PF00069 0.718
MOD_GSK3_1 172 179 PF00069 0.693
MOD_GSK3_1 236 243 PF00069 0.678
MOD_GSK3_1 252 259 PF00069 0.692
MOD_GSK3_1 260 267 PF00069 0.615
MOD_GSK3_1 268 275 PF00069 0.552
MOD_GSK3_1 286 293 PF00069 0.631
MOD_GSK3_1 321 328 PF00069 0.789
MOD_GSK3_1 358 365 PF00069 0.681
MOD_GSK3_1 43 50 PF00069 0.743
MOD_GSK3_1 453 460 PF00069 0.716
MOD_GSK3_1 512 519 PF00069 0.680
MOD_GSK3_1 525 532 PF00069 0.654
MOD_GSK3_1 534 541 PF00069 0.618
MOD_GSK3_1 543 550 PF00069 0.668
MOD_GSK3_1 582 589 PF00069 0.627
MOD_GSK3_1 613 620 PF00069 0.695
MOD_GSK3_1 644 651 PF00069 0.654
MOD_GSK3_1 90 97 PF00069 0.776
MOD_N-GLC_1 520 525 PF02516 0.574
MOD_N-GLC_1 601 606 PF02516 0.658
MOD_NEK2_1 290 295 PF00069 0.582
MOD_NEK2_1 453 458 PF00069 0.652
MOD_NEK2_1 529 534 PF00069 0.704
MOD_NMyristoyl 1 7 PF02799 0.693
MOD_PIKK_1 147 153 PF00454 0.658
MOD_PIKK_1 172 178 PF00454 0.667
MOD_PIKK_1 181 187 PF00454 0.605
MOD_PIKK_1 272 278 PF00454 0.652
MOD_PIKK_1 290 296 PF00454 0.516
MOD_PIKK_1 386 392 PF00454 0.798
MOD_PIKK_1 553 559 PF00454 0.691
MOD_PIKK_1 91 97 PF00454 0.666
MOD_PK_1 256 262 PF00069 0.720
MOD_PK_1 641 647 PF00069 0.586
MOD_PKA_1 252 258 PF00069 0.723
MOD_PKA_1 272 278 PF00069 0.702
MOD_PKA_2 252 258 PF00069 0.723
MOD_PKA_2 268 274 PF00069 0.635
MOD_PKA_2 290 296 PF00069 0.624
MOD_PKA_2 362 368 PF00069 0.769
MOD_PKA_2 426 432 PF00069 0.721
MOD_PKA_2 47 53 PF00069 0.636
MOD_PKA_2 553 559 PF00069 0.704
MOD_Plk_1 453 459 PF00069 0.532
MOD_Plk_1 617 623 PF00069 0.653
MOD_Plk_1 641 647 PF00069 0.648
MOD_Plk_1 98 104 PF00069 0.706
MOD_Plk_4 428 434 PF00069 0.691
MOD_ProDKin_1 131 137 PF00069 0.675
MOD_ProDKin_1 206 212 PF00069 0.698
MOD_ProDKin_1 222 228 PF00069 0.559
MOD_ProDKin_1 295 301 PF00069 0.666
MOD_ProDKin_1 321 327 PF00069 0.725
MOD_ProDKin_1 332 338 PF00069 0.663
MOD_ProDKin_1 377 383 PF00069 0.705
MOD_ProDKin_1 403 409 PF00069 0.641
MOD_ProDKin_1 60 66 PF00069 0.677
MOD_ProDKin_1 670 676 PF00069 0.545
MOD_SUMO_for_1 221 224 PF00179 0.648
MOD_SUMO_rev_2 157 166 PF00179 0.657
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.608
TRG_DiLeu_BaLyEn_6 464 469 PF01217 0.579
TRG_ENDOCYTIC_2 621 624 PF00928 0.678
TRG_ER_diArg_1 251 253 PF00400 0.725
TRG_ER_diArg_1 272 274 PF00400 0.721
TRG_ER_diArg_1 400 402 PF00400 0.674
TRG_ER_diArg_1 410 412 PF00400 0.618
TRG_Pf-PMV_PEXEL_1 227 231 PF00026 0.777
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.619
TRG_Pf-PMV_PEXEL_1 374 379 PF00026 0.626
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.606

Homologs

Protein Taxonomy Sequence identity Coverage
A4H4N1 Leishmania braziliensis 46% 100%
A4HSV7 Leishmania infantum 100% 100%
E9AKU5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 99%
Q4QJ12 Leishmania major 86% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS