Squalene/oxidosqualene cyclases family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lanosterol synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S5H5R6_LEIDO

TriTrypDb:

LdBPK_060670.1 , LdCL_060011800 , LDHU3_06.0780

Length:

1007

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005811	lipid droplet	5	12
GO:0016020	membrane	2	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S5H5R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S5H5R6

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006720	isoprenoid metabolic process	4	12
GO:0006721	terpenoid metabolic process	5	12
GO:0006722	triterpenoid metabolic process	6	12
GO:0008152	metabolic process	1	12
GO:0008299	isoprenoid biosynthetic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0016104	triterpenoid biosynthetic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0000250	lanosterol synthase activity	5	2
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016871	cycloartenol synthase activity	5	6
GO:0031559	oxidosqualene cyclase activity	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.524
CLV_C14_Caspase3-7	905	909	PF00656	0.513
CLV_NRD_NRD_1	103	105	PF00675	0.411
CLV_NRD_NRD_1	141	143	PF00675	0.514
CLV_NRD_NRD_1	362	364	PF00675	0.725
CLV_NRD_NRD_1	529	531	PF00675	0.534
CLV_NRD_NRD_1	582	584	PF00675	0.470
CLV_NRD_NRD_1	670	672	PF00675	0.531
CLV_NRD_NRD_1	743	745	PF00675	0.531
CLV_NRD_NRD_1	819	821	PF00675	0.453

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SP71	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	35%	100%
A0A0N0P5W0	Leptomonas seymouri	74%	100%
A0A0S2IHL6	Kalopanax septemlobus	36%	100%
A0A0S4JCG8	Bodo saltans	52%	100%
A0A0U2U4F3	Barbarea vulgaris	36%	100%
A0A125SXN1	Lycopodium clavatum	33%	100%
A0A125SXN2	Lycopodium clavatum	32%	100%
A0A125SXN3	Lycopodium clavatum	39%	100%
A0A1X0NL88	Trypanosomatidae	55%	100%
A0A3R7KVQ6	Trypanosoma rangeli	57%	100%

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